1. Von Hippel-Lindau disease presenting as pancreatic neuroendocrine tumour.
- Author
-
Mount, S., Weaver, D., Taatjes, D., McKinnon, W., Hebert, J., Mount, S L, Weaver, D L, Taatjes, D J, McKinnon, W C, and Hebert, J C
- Abstract
A 21-year-old woman with a family history of von Hippel-Lindau disease presented with a mass in the head of the pancreas. Light microscopic features of the tumour suggested neuroendocrine differentiation and although it displayed positive immunostaining for the antigens expected in a neuroendocrine neoplasm, S-100 staining was also present. This unusual feature prompted further evaluation by routine and post-embedding protein-A gold immunoelectron microscopy, which demonstrated the presence of neuroendocrine granules. Tumour cell DNA content was normal by flow cytometry. Although this patient exhibited no other signs of von Hippel-Lindau disease, the presence of a pancreatic tumour with neuroendocrine differentiation demonstrated that she was affected. Future surveillance and genetic counselling will be influenced by this diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 1995
- Full Text
- View/download PDF