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Bone defect is a common clinical symptom which can arise from various causes. Currently, bone tissue engineering has demonstrated positive therapeutic effects for bone defect repair by using seeding cells such as mesenchymal stem cells and precursor cells. N-acetylcysteine (NAC) is a stable, safe and highly bioavailable antioxidant that shows promising prospects in bone tissue engineering due to the ability to attenuate oxidative stress and enhance the osteogenic potential and immune regulatory function of cells. This review systematically introduces the antioxidant mechanism of NAC, analyzes the advancements in NAC-related research involving mesenchymal stem cells, precursor cells, innate immune cells and animal models, discusses its function using the classic oral microenvironment as an example, and places particular emphasis on the innovative applications of NAC-modified tissue engineering biomaterials. Finally, current limitations and future prospects are proposed, with the aim of providing inspiration for targeted readers in the field. [ABSTRACT FROM AUTHOR]

What is the relationship between gender segregation in higher education and gender segregation in the labor market? Using Fossett's (2017) difference-of-means method for calculating segregation indices and data from the American Community Survey, we show that approximately 36% of occupational segregation among collegeeducated workers is associated with gender segregation across 173 fields of study, and roughly 64% reflects gender segregation within fields. A decomposition analysis shows that fields contribute to occupational segregation mainly through endowment effects (men's and women's uneven distribution across fields) than through the coefficient effects (gender differences in the likelihood of entering a male-dominated occupation from the same field). Endowment effects are highest in fields strongly linked to the labor market, suggesting that educational segregation among fields in which graduates tend to enter a limited set of occupations is particularly consequential for occupational segregation. Within-field occupational segregation is higher among heavily male-dominated fields than other fields, but it does not vary systematically by fields' STEM status or field-occupation linkage strength. Assuming the relationship between field segregation and occupational segregation is at least partly causal, these results imply that integrating higher education (e.g., by increasing women's representation in STEM majors) will reduce but not eliminate gender segregation in labor markets. [ABSTRACT FROM AUTHOR]