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The pain and fear caused by direct local injection of anesthetic or the poor experience with surface anesthetic cream increase the difficulty of clinical treatment for oral diseases. To address this problem, a hyaluronic acid microneedle patch (Li-HAMNs) that consists of fast-dissolving lidocaine hydrochloride (LDC)-loaded tips and a wet-adhesive backing layer made of polyvinyl alcohol (PVA)/carboxymethylcellulose sodium (CMC-Na) was fabricated to explore its potential use in dental topical anesthesia. Li-HAMNs could puncture the stratum corneum with an insertion depth of about 279 μm in the isolated porcine oral mucosal. The fast-dissolving tips could release LDC to improve the patients' convenience and compliance. Importantly, the backing layer, which has good adhesion ability and water-absorbing properties, could surmount the contraction and extension of oral masticatory muscles and the saliva scour. In the tail flick test, the topical anesthesia efficacy of the Li-HAMNs group was much better than clinical lidocaine cream (EMLA cream, LDC, 1.2 mg) in spite of a relatively lower LDC dose with Li-HAMNs (LDC, 0.5 mg). It is believed that the proposed adhesive microneedle patch could enhance transmucosal delivery of anesthetics and thus open a new chapter in the painless treatment of oral diseases. [ABSTRACT FROM AUTHOR]

Developing bio‐multifunctional patches with natural extracellular matrix‐like structures, excellent high adhesion in the wet state, self‐healing ability, antibacterial activity, and favorable cell responses for accelerating tissue healing is highly desirable in clinical applications. Herein, bio‐multifunctional composite hydrogels are developed by coupling carboxymethyl chitosan and 4‐arm poly (ethylene glycol) aldehyde for full‐thickness abdominal wall defect repair. The prepared hydrogels exhibit excellent self‐healing and mechanical properties, high adhesion in the wet state, and significant antibacterial ability. In vitro cellular experiments show that the hydrogels combined with recombinant bovine basic fibroblast growth factor remarkably promote cell proliferation and then accelerate full‐thickness abdominal wall defect repair in a rat model. The histomorphological evaluation shows that compared to the commercial polypropylene mesh used clinically, the designed hydrogel patches facilitate an increase in the thickness and integrity of the abdominal wall tissue by upregulating the production of Ki67, enhancing the formation of collagen, inducing neovascularization, and inhibiting inflammation by reducing the expression of IL‐6, TNF‐α, and IL‐1β. The results demonstrate that this novel bio‐multifunctional hydrogel patch holds great potential for the treatment of full‐thickness abdominal wall defects. [ABSTRACT FROM AUTHOR]

The carbonylative of aryl iodides with terminal alkynes was studied by using thermoregulated ligand-palladium as an efficient and reusable catalyst at 80 °C in water. The corresponding alkynone products were obtained in good to excellent yields under 1 atm of . The isolation of the products was readily achieved by extraction with ethyl acetate, and the catalyst recovered in water can be reused and recycled up to four times without significant loss in . Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]