Search

Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and devices. However, inks that can be used for printing layers with T5%>300 °C or hardness>200 MPa have been rarely reported. Cyanate ester (CE) polymers have excellent thermal stability, high strength, and low shrinkage compared to other common dielectric inks for inkjet 3D printing, but cannot be quickly shaped by ultraviolet (UV) irradiation or thermal treatment. Combining CEs with UV-curable monomers may be a possible way to accelerate crosslinking, but there are challenges from the adverse effects of the dilution of both monomers. In this study, dielectric inks with acrylate and cyanate moieties were developed. The low viscosity and surface tension of the CE precursor (Bisphenol E cyanate ester) were combined with photocurable acrylate diluent monomers and cross-linker to realize an ink suitable for inkjet 3D printing. An internal dual three-dimensional cross-linked network structure resin was prepared by a combination of photocuring and thermal curing with T5% up to 326.69 °C, hardness up to 431.84 MPa, dielectric constant of 2.70 at 8 GHz, and shrinkage of 1.64%. The developed dielectric inks can be applied to the 3D printing of printed circuit boards and other electronic devices that require dielectric properties. [ABSTRACT FROM AUTHOR]

Background: Intellectual developmental disorders (IDD) generally refers to the persistent impairment of cognitive activities and mental retardation caused by physical damage to the brain or incomplete brain development. We aimed to explore its genetic causes. Methods: In this study, 21 IDD patients were recruited. The Gesell developmental scales (GDS) and Wechsler intelligence scale for children (WISC) were used to assess the impaired level of intellectual development for all probands. A superconducting MRI scanner (Philips AcsNT 3.0 T Philips, Best, The Netherlands) was used to perform a plain MRI scan of the skull on the probands. The whole-exome sequencing was carried out using next-generation sequencing in all probands and their families. Results: Eight had seizures and four had typical characteristics of autism. Pregnancy and delivery were uneventful except for three patients. Moderate IDD (52.4%) accounted for the majority. The abnormal MRI results included ventriculomegaly, pachygyria, broadening external cerebral space, abnormal signal change and agenesis of corpus callosum. Eleven variants were identified, including the variant in CREBBP, MECP2, HCFC1, ATRX, RAB39B, CLCN4, DYRK1A and CASKgenes. The function areas result of gene-positive group were compared to that of gene-negative group. Not significant (p> 0.05) items were revealed after this analysis. Conclusion: Eleven variants were identified, including the variant in CREBBP, MECP2, HCFC1, ATRX, RAB39B, CLCN4, DYRK1A and CASK genes. The function areas result of gene-positive group were not significantly different from the gene-negative group. [ABSTRACT FROM AUTHOR]

Fulminant myocarditis (FM) is a life-threatening disease in children. With a rapid, progressive course of deterioration, it causes refractory cardiorespiratory failure even with optimal clinical intervention. We present the case of a 9-year-old girl with FM complicated by cardiogenic shock, malignant arrhythmia, and refractory cardiac arrest. She received effective cardiopulmonary resuscitation, therapeutic hypothermia, and other supportive treatments. However, the patient rapidly worsened into pulseless ventricular tachycardia and refractory cardiac arrest. Therefore, we performed extracorporeal membrane oxygenation (ECMO) to establish spontaneous circulation after the failure of standard resuscitation measures. The girl recovered with intact cardiac and neurocognitive functions after continued ECMO treatment for 221 hours. Therefore, ECMO is an effective rescue therapeutics for FM, especially when complicated with refractory cardiac arrest. [ABSTRACT FROM AUTHOR]