27 results on '"Grangeiro, Alexandre"'
Search Results
2. Telehealth effectiveness for pre‐exposure prophylaxis delivery in Brazilian public services: the Combine! Study.
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Grangeiro, Alexandre, Santos, Lorruan Alves do, Estevam, Denize Lotufo, Munhoz, Rosemeire, Arruda, Érico, de Moraes, Renata Amaral, de Quadros Winkler, Lisiane, Neves, Lis Aparecida de Souza, Santos, Juliane Cardoso Villela, Kruppa, Mariele, Zucchi, Eliana Miura, Escuder, Maria Mercedes, Leal, Andréa Fachel, Koyama, Mitti Ayako Hara, Peres, Maria Fernanda Tourinho, Couto, Marcia Thereza, and Neto, José Eluf
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PRE-exposure prophylaxis ,MUNICIPAL services ,SEXUALLY transmitted diseases ,TELEMEDICINE ,ANAL sex ,HIV infections - Abstract
Introduction: Pre‐exposure prophylaxis (PrEP) delivery based on user needs can enhance PrEP access and impact. We examined whether telehealth for daily oral PrEP delivery could change the indicators of care related to prophylactic use in five Brazilian public HIV clinics (testing centres, outpatient clinics and infectious disease hospitals). Methods: Between July 2019 and December 2020, clients on PrEP for at least 6 months could transition to telehealth or stay with in‐person follow‐up. Clients were clinically monitored until June 2021. A desktop or mobile application was developed, comprising three asynchronous consultations and one annual in‐person consultation visit. Predictors influencing telehealth preference and care outcomes were examined. The analysis encompassed intent‐to‐treat (first choice) and adjustments for sexual practices, schooling, age, duration of PrEP use and PrEP status during the choice period. Results: Of 470 users, 52% chose telehealth, with the adjusted odds ratio (aOR) increasing over time for PrEP use (aOR for 25–months of use: 4.90; 95% CI: 1.32–18.25), having discontinued PrEP at the time of the choice (aOR: 2.91; 95% CI: 1.40–6.06) and having health insurance (aOR: 1.91; 95% CI: 1.24–2.94) and decreasing for those who reported higher‐risk behaviour (aOR for unprotected anal sex: 0.51; 95% CI: 0.29–0.88). After an average follow‐up period of 1.6 years (95% CI: 1.5–1.7), the risk of discontinuing PrEP (not having the medication for more than 90 days) was 34% lower with telehealth (adjusted hazard ratio: 0.66; 95% CI: 0.45–0.97). When adjusted by mixed linear regression, no differences in adherence (measured by mean medication possession rate) were found between in‐person and telehealth (p = 0.486) or at pre‐ and post‐telehealth follow‐ups (p = 0.245). Sexually transmitted infections increased between the pre‐follow‐up and post‐follow‐up choices and were not associated with in‐person or telehealth (p = 0.528). No HIV infections were observed. Conclusions: Our findings indicate that telehealth for PrEP delivery can enhance service rationalization and reinforce the prevention cascade. This approach reduces prophylaxis interruptions and is mainly preferred by individuals with lower demands for healthcare services. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Important steps for PrEP uptake among adolescent men who have sex with men and transgender women in Brazil.
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Soares, Fabiane, Magno, Laio, Eustorgio Filho, Marcos, Duarte, Filipe Mateus, Grangeiro, Alexandre, Greco, Dirceu, and Dourado, Inês
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TRANSGENDER people ,TEENAGE boys ,HOMOPHOBIA ,RACE ,ANAL sex ,TEENAGERS - Abstract
HIV Pre-exposure prophylaxis (PrEP) is an effective prevention tool, but there are still few studies about PrEP uptake among adolescents. We aimed to analyze the PrEP uptake process and factors associated with daily oral PrEP initiation among adolescent men who have sex with men (aMSM) and transgender women (aTGW) in Brazil. Baseline data from the first demonstration PrEP cohort study among aMSM and aTGW 15–19 years old (yo) ongoing in three large Brazilian cities (PrEP1519). After completing informed consent procedures, participants were enrolled in the cohort from February/2019 to February/2021. A socio-behavioral questionnaire was applied. Factors associated with PrEP initiation were assessed using a logistic regression model with adjusted prevalence ratios (aPR) and 95% confidence intervals (95%CI). Among recruited participants, 174 (19,2%) were aged 15–17 yo and 734 (80,8%) 18–19 yo. The rate of PrEP initiation was 78.2% and 77.4% for 15–17 yo and 18–19 yo, respectively. Factors associated with PrEP initiation were: black or mixed race (aPR 2.31; 95%CI: 1.10–4.84) among the younger adolescents 15–17 yo; experienced violence and/or discrimination due to their sexual orientation or gender identity (aPR 1.21; 95%CI: 1.01–1.46); transactional sex (aPR 1.32; 95%CI: 1.04–1.68); and having had between 2 to 5 sexual partners in the previous three months (aPR 1.39; 95%CI: 1.15–1.68) among those 18–19 yo. Unprotected receptive anal intercourse in the previous six months was associated with PrEP initiation in both age groups (aPR 1.98; 95%CI: 1.02–3.85 and aPR 1.45; 95%CI: 1.19–1.76 among 15–17 yo and 18–19 yo, respectively). The biggest challenge to promoting PrEP use for aMSM and aTGW was in the first steps of the PrEP uptake process. Once they were linked to the PrEP clinic, initiation rates were high. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Reaching Out to Adolescents at High Risk of HIV Infection in Brazil: Demand Creation Strategies for PrEP and Other HIV Combination Prevention Methods.
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Magno, Laio, Soares, Fabiane, Zucchi, Eliana Miura, Eustórgio, Marcos, Grangeiro, Alexandre, Ferraz, Dulce, Greco, Dirceu, Escuder, Maria Mercedes, and Dourado, Ines
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HIV ,PRE-exposure prophylaxis ,MEN who have sex with men ,TRANSGENDER people - Abstract
Using baseline data from the PrEP1519 cohort, in this article we aimed to analyze: (i) the effectiveness of demand creation strategies (DCS) to enroll adolescent men who have sex with men (AMSM) and adolescent transgender women (ATGW) into an HIV combination prevention study in Brazil; (ii) the predictors of DCS for adolescents' enrollment; and (iii) the factors associated with DCS by comparing online and face-to-face strategies for enrollment. The DCS included peer recruitment (i.e., online and face-to-face) and referrals from health services and non-governmental organizations (NGOs). AMSM and ATGW who agreed to participate in the study could opt to enroll in either PrEP (PrEP arm) or to use other prevention methods (non-PrEP arm). Bivariate and multivariate analyses were conducted and logistic regression odds ratios were estimated. The DCS reached 4529 AMSM and ATGW, the majority of which were derived online (73.8%). Of this total, 935 (20.6%) enrolled to participate (76.6% in PrEP arm and 23.4% in non-PrEP arm). The effectiveness of enrolling adolescents into both arms was greater via direct referrals (235/382 and 84/382, respectively) and face-to-face peer recruitment (139/670 and 35/670, respectively) than online (328/3342). We found that a combination under DCS was required for successful enrollment in PrEP, with online strategies majorly tending to enroll adolescents of a higher socioeconomic status. Our findings reinforce the need for DCS that actively reaches out to all adolescents at the greatest risk for HIV infection, irrespective of their socioeconomic status. [ABSTRACT FROM AUTHOR]
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- 2023
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5. "I Can't Take This Shitty Quarantine Anymore": Sexual Behavior and PrEP Use Among Young Men Who Have Sex with Men and Transgender Women in Brazil During the COVID-19 Pandemic.
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Ferraz, Dulce, Rossi, Thais Aranha, Zucchi, Eliana Miura, de Deus, Luiz Fabio Alves, Mabire, Xavier, Ferguson, Laura, Magno, Laio, Grangeiro, Alexandre, Préau, Marie, Botelho, Fernanda Cangussu, Rodrigues, Ayra, Steele, Sabrina, and Dourado, Inês
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HIV prevention ,PRE-exposure prophylaxis ,CORONAVIRUSES ,MEN who have sex with men ,TRANSGENDER people - Abstract
This study analyzes how the COVID-19 pandemic affected sexual behavior and use of HIV prevention methods among young transgender women (YTGW) and young gay, bisexual and other men who have sex with men (YGBMSM) participating in an HIV pre-exposure prophylaxis (PrEP) demonstration study in Brazil. Online interviews with 39 participants aged 15–22 years old were conducted between September and November 2020 and analyzed based on social constructionism and human rights-based approaches to health. The pandemic disrupted interviewees' routines, negatively affecting their life conditions. Among those who did not have a steady partner, social distance measures led to temporary interruption of sexual encounters and increased sexting and solo sex. Conversely, for those who had a steady relationship such measures contributed to increasing sexual practices and intimacy. Participants who had sexual encounters during the pandemic reported having continued to use PrEP. However, home confinement with family, lack of privacy, loss of daily routines and changes in housing impaired PrEP adherence and attendance at follow-up consultations. These results highlight the importance of maintaining HIV-service delivery for these groups during a public health crisis, as well as to address the structural drivers of the epidemic with comprehensive HIV prevention policies and by ensuring access of YGBMSM and YTGW to social protection policies. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Seroprevalence of anti-SARS-CoV-2 antibodies and factors associated with infection among adolescent men who have sex with men and transgender women in Salvador, Brazil.
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Santos, Carina C., de M. Lima, Fernanda W., Magno, Laio, Soares, Fabiane, Ferraz, Dulce, Grangeiro, Alexandre, Zucchi, Eliana Miura, Préau, Marie, Mabire, Xavier, Matos, Helen R. S. S., and Dourado, Inês
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TRANSGENDER people ,MINORITY youth ,SEXUAL minorities ,IMMUNOGLOBULINS ,SEROPREVALENCE - Abstract
Background: Brazil was strongly affected by the COVID-19 pandemic and the impact of the pandemic on sexual and gender minorities' youth remains unknown. This study aimed to estimate the seroprevalence of SARS-CoV-2 antibodies and associated factors among adolescent men who have sex with men (AMSM) and transgender women (ATGW) participants of a human immunodeficiency virus (HIV) pre-exposure prophylaxis cohort study (PrEP1519). Methods: This is a cross-sectional design conducted between June and October 2020 in Salvador, Brazil. Serum samples were collected from AMSM and ATGW aged 16-21 years between June-October 2020. IgG and IgM anti-SARS-CoV-2 were detected by chemiluminescence immunoassay, and data were collected through a socio-behavioral questionnaire. Results: Among the 137 participants, the seroprevalence of anti-SARS-CoV-2 IgG and IgM was 20.4%; 16.8% of the participants were positive for IgG, and 11.7% for IgM. In the multivariable analysis, the seroprevalence was two times higher among those who never wore masks (OR= 2.22; 95% CI: 1.08-4.57) and among those who believed that they could be easily cured of the disease (OR= 2.05; 95% CI: 1.05-4.01). Conclusions: The high seroprevalence of SARS-CoV-2 antibodies among gender and sexual minority youth seems to be informed by behaviors and attitudes that contrast with public health measures and the potential severity of the disease when vaccination was still not available. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Sexual Violence and Low Rates of HIV Post-exposure Prophylaxis Access Among Female Sex Workers in Brazil.
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de Lima, Acácia Mayra Pereira, Magno, Laio, Luppi, Carla Gianna, Szwarcwald, Célia Landmann, Grangeiro, Alexandre, Santana, Elis Passos, Dourado, Inês, The Brazilian FSW Group, de Souza Júnior, Paulo Roberto Borges, Ferreira Jr., Orlando C., Damacena, Giseli Nogueira, da Silva, Neide Gravato, Bacuri, Rita, Brigido, Helena, Macena, Hermelinda Maia, Brito, Ana, Guimarães, Mark Drew Crosland, de Almeida, Wanessa da Silva, Luhm, Karin Regina, and Stella, Isete Maria
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HIV infection epidemiology ,PREVENTION of sexually transmitted diseases ,HEALTH services accessibility ,SEX work ,WOMEN ,SURVEYS ,SELF-disclosure ,SEX crimes ,DISEASE prevalence ,DESCRIPTIVE statistics ,HEALTH promotion ,ADULT education workshops - Abstract
Copyright of AIDS & Behavior is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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8. Autonomy and Care in Context: The Paradox of Sex Workers' Acceptability of HIV Self-Tests in São Paulo, Brazil.
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Murray, Laura Rebecca, Ferraz, Dulce, Zucchi, Eliana Miura, da Silva Sorrentino, Isa, and Grangeiro, Alexandre
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Cisgender female sex workers (CFSW) continue to face structural barriers to HIV prevention. We analyzed the acceptability of the oral HIV self-test (HIV-ST) among CFSW as part of a pragmatic trial on HIV prevention in Brazil. Data from in-depth interviews conducted with 12 women from diverse sex worker contexts and participant observation were analyzed using thematic analysis. CFSW valued autonomy in their workplaces and saw the HIV-ST as a possibility for self-care. Some feared clients' reactions, manager reprimands, and a positive result. HIV and sex work stigma largely drove self-care practices and perceived acceptability of the self-test. We argue that the autonomy offered by the self-test presents a paradox: increasing autonomy on the one hand while risking sidestepping structural dimensions of HIV vulnerability on the other. These nuances must be considered in interventions promoting the HIV-ST by considering the specificities of sex worker contexts, addressing stigma, and effectively involving CFSW and their organizations in intervention development. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Acceptability of daily pre-exposure prophylaxis among adolescent men who have sex with men, travestis and transgender women in Brazil: A qualitative study.
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Zucchi, Eliana Miura, Couto, Marcia Thereza, Castellanos, Marcelo, Dumont-Pena, Érica, Ferraz, Dulce, Félix Pinheiro, Thiago, Grangeiro, Alexandre, da Silva, Luís Augusto Vasconcelos, Dourado, Inês, Pedrana, Leo, Santos, Fernanda Soares de Resende, and Magno, Laio
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MEN who have sex with men ,TRANS women ,PRE-exposure prophylaxis ,TEENAGERS ,SOCIAL impact - Abstract
Background: Adolescents face socio-structural, personal and programmatic barriers to HIV prevention services, highlighting the importance of understanding knowledge and acceptability as essential aspects to promote their broader access to pre-exposure prophylaxis (PrEP). We analyzed the acceptability of PrEP among adolescent men who have sex with men (MSM), travestis and transgender women (TGW). Methods: A qualitative investigation was conducted as part of the formative research of the PrEP15-19 study, an ongoing demonstration study that analyzes the effectiveness of daily PrEP among adolescent MSM, travestis and TGW aged 15–19 in three Brazilian cities. A total of 37 semi-structured interviews and 6 focus groups were conducted. Building from thematic analysis focusing on participants' sexual encounters, perceptions about PrEP efficacy, and vulnerability contexts, we analyzed prospective acceptability of PrEP. Findings: Knowledge about PrEP was incipient and characterized by adolescents' frequent doubts about its prescription and efficacy. The 'ideal' use of PrEP appeared together with consistent condom use, especially in casual sex. PrEP use was also mentioned as depending on increased learning about prevention management over time. Main barriers to PrEP use included the incorporation of a daily medication into participants' routine and its impact on their social lives, especially related to stigma. Concerns over short- and long-term side effects were also reported as barriers to PrEP use. TGW and travestis contrasted using PrEP with the precarity of their life conditions, and some expressed a critical vision about PrEP by associating it with pharmaceuticalization and trans necropolitics. Conclusions: Participants' low knowledge and acceptability of PrEP are circumscribed by a rigid perception of condom as the ideal prevention method and the context of their sexual relations. Prospective acceptability highlights that the successful uptake of PrEP depends on overcoming barriers of access to health services and confronting transphobia and homophobia as part of care. [ABSTRACT FROM AUTHOR]
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- 2021
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10. P299: Association of provider type with sexually transmitted infection (STI) occurrence and pre-exposure prophylaxis (PrEP) nonadherence among key adolescent populations in Brazil.
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Bruxvoort, Katia, Delay, Mac, Dourado, Ines, Froehlich, Mallie, Grangeiro, Alexandre, Heffron, Renee, Leite, Beo, Long, Leann, MacCarthy, Sarah, and Magno, Laio
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- 2024
11. Adapting to the COVID-19 Pandemic: Continuing HIV Prevention Services for Adolescents Through Telemonitoring, Brazil.
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Dourado, Inês, Magno, Laio, Soares, Fabiane, Massa, Paula, Nunn, Amy, Dalal, Shona, Grangeiro, Alexandre, The Brazilian PrEP1519 Study Group, Caires, Priscilla, Jefferson, Carlos, Duarte, Filipe Mateus, Nascimento, Pedro Rafael, Fonseca, Thaís, Fernandes, Fabiane Neves, Nascimento, Lucília, da Silveira, Regis Alves, Lopes da Silva Lomba, Victor Guilherme, Goulart, Raphaella, Oliveira, Eduardo Araújo, and Verneck, Audre
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HIV prevention ,ADAPTABILITY (Personality) ,BEHAVIOR modification ,EPIDEMICS ,SEXUAL health ,MEDICAL care ,MENTAL health ,REWARD (Psychology) ,TELEMEDICINE ,SOCIAL support ,COVID-19 ,SOCIAL distancing ,ADOLESCENCE - Abstract
In this article the author talks about the COVID-19 pandemic which is impacting the delivery of health care services and although in the early stages, the results of disruptions are becoming clearer. It mentions that on March 20th, 2020 the Brazilian Ministry of Health (MoH) announced that all Brazilian states had coronavirus cases and issued guidelines on social distancing measures, such as voluntary home quarantine, and social isolation.
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- 2020
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12. Cardiovascular disease among people living with HIV in Brazil.
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Boettiger, David C., Escuder, Maria Mercedes, Law, Matthew G., Veloso, Valdiléa, Souza, Rosa A., Ikeda, Maria L. R., Alencastro, Paulo R., Tupinambás, Unai, Brites, Carlos, Grinsztejn, Beatriz, Ggomes, Jackeline O., Ribeiro, Sayonara, McGowan, Catherine C., Jayathilake, Karu, Castilho, Jessica L., Grangeiro, Alexandre, and de Alencastro, Paulo R
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CARDIOVASCULAR diseases ,CD4 lymphocyte count ,CAUCASIAN race ,ANTIRETROVIRAL agents ,HIGH-income countries - Abstract
Copyright of Tropical Medicine & International Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2020
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13. Vaccination coverage rates and predictors of HPV vaccination among eligible and non-eligible female adolescents at the Brazilian HPV vaccination public program.
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Faisal-Cury, Alexandre, Levy, Renata Bertazzi, Tourinho, Maria Fernanda, Grangeiro, Alexandre, and Eluf-Neto, José
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VACCINATION ,HUMAN papillomavirus vaccines ,SOCIODEMOGRAPHIC factors ,CERVICAL cancer ,POISSON regression ,IMMUNIZATION ,HUMAN sexuality ,REGRESSION analysis ,MEDICAL care ,MEDICAL protocols ,SURVEYS ,STUDENTS ,PAPILLOMAVIRUS diseases ,SCHOOLS ,SOCIAL classes ,ETHNIC groups ,PARENTS ,POISSON distribution - Abstract
Background: Since March 2014, the quadrivalent HPV vaccine has been incorporated into the Brazilian Unified Health Care System and began to be offered, without direct costs, for girls from 9 to 13 years of age. Older female adolescents would have the option to be vaccinated at private health care system being responsible for the payment of HPV vaccine. The present study aimed to evaluate the coverage rates and predictors of HPV vaccination in Brazil among two groups of female adolescents: eligible and non-eligible for the HPV vaccination public program.Methods: We used data from the 2015 Brazilian National Adolescent School-Based Health Survey, which involved a probabilistic sample of 5404 female adolescents students at public and private schools. Using a questionnaire, we gathered information on sociodemographic characteristics, sexual behavior, and respondent perception of parental supervision and have been vaccinated for HPV. Age-specific vaccination rates were analyzed in girls aged 9 to 13 at the time of public vaccination (eligible for public policy), as well among those 14 to 17 years old not eligible by the Ministry of Health for vaccination. We used Poisson regression models to investigate associated factors.Results: HPV vaccine coverage was 83.5 and 21.8% among eligible and non-eligible populations, respectively. In both populations, the chance of being vaccinated decreased with older age. In the eligible population there is a greater chance of being vaccinated among ethnic group "pardas" but not with other indicators of socioeconomic status. In the non-eligible population, there was a clear association between higher vaccine coverage and greater maternal education and living with the mother.Conclusion: Our findings highlight the importance of public policies to minimize inequities in access to cancer prevention measures in vulnerable adolescents. A public policy of HPV vaccination for older female adolescents would increase coverage with possible reduction of HPV-related diseases in this group of women. [ABSTRACT FROM AUTHOR]- Published
- 2020
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14. Reincidentes en el cuidado, pero sin derecho a la prevención: un análisis de la oferta de la profilaxis posexposición sexual al VIH en Porto Alegre, Brasil.
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Kauss, Bruno, Fachel Leal, Andréa, Grangeiro, Alexandre, and Thereza Couto, Marcia
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MEDICAL personnel ,SEXUALLY transmitted diseases ,PRE-exposure prophylaxis ,AIDS ,REPRODUCTIVE health services ,HIV ,PREVENTIVE medicine - Abstract
Copyright of Salud Colectiva is the property of Instituto de Salud Colectiva Universidad Nacional de Lanus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2020
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15. AIDS- and sexuality-related stigmas underlying the use of post-exposure prophylaxis for HIV in Brazil: findings from a multicentric study.
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Ferraz, Dulce, Couto, Marcia Thereza, Zucchi, Eliana Miura, Calazans, Gabriela Junqueira, dos Santos, Lorruan Alves, Mathias, Augusto, and Grangeiro, Alexandre
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- 2019
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16. Thematic synthesis HIV prevention qualitative studies in men who have sex with men (MSM).
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Mathias, Augusto, dos Santos, Lorruan Alves, Grangeiro, Alexandre, and Thereza Couto, Marcia
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HIV prevention ,HEALTH behavior ,MEDICAL information storage & retrieval systems ,MEDLINE ,PREVENTIVE health services ,SOCIAL stigma ,QUALITATIVE research ,SOCIAL support ,MEN who have sex with men ,META-synthesis - Abstract
Copyright of Colombia Medica is the property of Universidad del Valle and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2019
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17. Nonoccupational post-exposure prophylaxis for HIV after sexual intercourse among women in Brazil: Risk profiles and predictors of loss to follow-up.
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Grangeiro, Alexandre, Nascimento, Maria Mônica Paulino do, Zucchi, Eliana Miura, Ferraz, Dulce, Escuder, Maria Mercedes, Arruda, Érico, Lotufo, Denize, Munhoz, Rosemeire, and Couto, Marcia Thereza
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- 2019
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18. Hombres heterosexualmente activos, masculinidades, prevención de infección por VIH y búsqueda de profilaxis posexposición sexual consentida.
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Alves dos Santos, Lorruan, Thereza Couto, Marcia, Mathias, Augusto, and Grangeiro, Alexandre
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HIV infections ,MEDICAL care ,RISK perception ,CONDOM use ,MASCULINITY - Abstract
Copyright of Salud Colectiva is the property of Instituto de Salud Colectiva Universidad Nacional de Lanus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2019
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19. Rendering visible heterosexually active men in Brazil: A national study on sexual behaviour, masculinities and HIV risk.
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Couto, Marcia T., Grangeiro, Alexandre, Venturi, Gustavo, and Levy, Renata B.
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HETEROSEXUAL men ,HUMAN sexuality ,HIV prevention ,MASCULINITY - Abstract
The HIV epidemic has not spread widely among heterosexuals in countries with medium to high per capita income rates. To understand this phenomenon in Brazil, this article analyses data from a national survey to distinguish groups of heterosexually active men in relation to their risk of infection. The analysis used an odds ratio to estimate the chance of belonging to the group of greatest risk and factor analysis to understand patterns of masculinity. It was found that a pattern of restricted sexual behaviour (having a stable partner, a relatively reduced sexual network and infrequent extraconjugal activities) limited the spread of HIV. Fewer than 1 in 10 of men presented great risk of infection. The odds of belonging to this group rose according to sexual characteristics and cultural values. Men presenting a pattern of masculinity that showed satisfaction with one’s sexuality were 2.3 times more likely to belong to the group at great risk, while a pattern of physical self-care and attention to one’s health reduced such a risk. The study therefore shows that heterosexual men are not a homogeneous group. Gender norms influence the risk of HIV infection and a small portion of men should be considered within preventative policies. [ABSTRACT FROM AUTHOR]
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- 2018
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20. Zero knowledge and high interest in the use of long-acting injectable pre-exposure prophylaxis (PrEP) among adolescent men who have sex with men and transgender women in two capital cities in Brazil.
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Pedrana, Leo, Magno, Laio, Zucchi, Eliana Miura, da Silva, Luís Augusto Vasconcelos, Ferraz, Dulce, Grangeiro, Alexandre, Castellanos, Marcelo, Brasil, Sandra Assis, and Dourado, Inês
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Background: Adolescent men who have sex with men (aMSM) and transgender women (aTGW) are affected disproportionately by human immunodeficiency virus (HIV) infection. Although new methods of pre-exposure prophylaxis (PrEP), such as long-acting injectable (LAI-PrEP), have been approved by the Food and Drug Administration, their acceptability among aMSM/aTGW is not well known.Methods: Forty-eight semi-structured interviews were conducted to assess the knowledge and interest in LAI-PrEP among aMSM/aTGW enrolled in a daily oral PrEP cohort from two capital cities of Brazil since 2019.Results: Previous knowledge of LAI-PrEP remains scarce, but the high interest regarding its use has been reported. Interest in the use of LAI-PrEP is associated with eliminating the burden of daily responsibility or the risk of missing the necessary medications, lowering the costs of this method, increasing confidentiality, and decreasing the frequency of visiting PrEP clinics. The reported barriers to uptake included fear of injection, doubts on its effectiveness, side effects, and greater dependence on a health provider.Conclusions: There is an urgent need to strengthen the preventive strategies against HIV infection among the youth, enhance their knowledge and those of healthcare providers, and offer safe and new options. [ABSTRACT FROM AUTHOR]- Published
- 2022
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21. Health vulnerabilities in female sex workers in Brazil, 2016.
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Braga, Letícia Penna, Szwarcwald, Célia Landmann, Damacena, Giseli Nogueira, de Souza-Júnior, Paulo Roberto Borges, Dourado, Inês, de Brito, Ana Maria, Grangeiro, Alexandre, Crosland Guimarães, Mark Drew, and Brazilian FSW Group
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- 2022
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22. Pre-exposure and postexposure prophylaxes and the combination HIV prevention methods (The Combine! Study): protocol for a pragmatic clinical trial at public healthcare clinics in Brazil.
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Grangeiro, Alexandre, Couto, Márcia Thereza, Peres, Maria Fernanda, Luiz, Olinda, Zucchi, Eliana Miura, de Castilho, Euclides Ayres, Estevam, Denize Lotufo, Alencar, Rosa, Wolffenbüttel, Karina, Escuder, Maria Mercedes, Calazans, Gabriela, Ferraz, Dulce, Arruda, Érico, da Gloria Corrêa, Maria, Amaral, Fabiana Rezende, Villela Santos, Juliane Cardoso, Alvarez, Vivian Salles, and Kietzmann, Tiago
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Introduction: Few results from programmes based on combination prevention methods are available. We propose to analyse the degree of protection provided by postexposure prophylaxis (PEP) for consensual sexual activity at healthcare clinics, its compensatory effects on sexual behaviour; and the effectiveness of combination prevention methods and pre-exposure prophylaxis (PrEP), compared with exclusively using traditional methods. Methods and analysis: A total of 3200 individuals aged 16 years or older presenting for PEP at 5 sexually transmitted disease (STD)/HIV clinics in 3 regions of Brazil will be allocated to one of two groups: the PEP group—individuals who come to the clinic within 72 h after a sexual exposure and start PEP; and the non-PEP group—individuals who come after 72 h but within 30 days of exposure and do not start PEP. Clinical follow-up will be conducted initially for 6 months and comprise educational interventions based on information and counselling for using prevention methods, including PrEP. In the second study phase, individuals who remain HIV negative will be regrouped according to the reported use of prevention methods and observed for 18 months: only traditional methods; combined methods; and PrEP. Effectiveness will be analysed according to the incidence of HIV, syphilis and hepatitis B and C and protected sexual behaviour. A structured questionnaire will be administered to participants at baseline and every 6 months thereafter. Qualitative methods will be employed to provide a comprehensive understanding of PEP-seeking behaviour, preventive choices and exposure to HIV. Ethics and dissemination: This study will be conducted in accordance with the resolution of the School of Medicine Research Ethics Commission of Universidade de São Paulo ( protocol no. 251/14). The databases will be available for specific studies, after management committee approval. Findings will be presented to researchers, health managers and civil society members by means of newspapers, electronic media and scientific journals and meetings. [ABSTRACT FROM AUTHOR]
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- 2015
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23. The HIV-Brazil Cohort Study: Design, Methods and Participant Characteristics.
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Grangeiro, Alexandre, Escuder, Maria Mercedes, Cassanote, Alex Jones Flores, Souza, Rosa Alencar, Kalichman, Artur O., Veloso, Valdiléa, Ikeda, Maria Letícia Rodrigues, Barcellos, Nêmora Tregnago, Brites, Carlos, Tupinanbás, Unai, Lucena, Noaldo O., da Silva, Carlos Lima, Lacerda, Heloisa Ramos, Grinsztejn, Beatriz, and Castilho, Euclides Ayres
- Subjects
ANTIRETROVIRAL agents ,HIV infections ,QUALITY of life ,PUBLIC health ,MORTALITY ,FOLLOW-up studies (Medicine) - Abstract
Background: The HIV-Brazil Cohort Study was established to analyze the effectiveness of combination antiretroviral therapy (cART) and the impact of this treatment on morbidity, quality of life (QOL) and mortality. The study design, patients’ profiles and characteristics of cART initiation between 2003 and 2010 were described. Methodology/Principal Findings: Since 2003, the HIV-Brazil Cohort has been following HIV-infected adults receiving cART at 26 public health care facilities, using routine clinical care data and self-reported QOL questionnaires. When not otherwise available, data are obtained from national information systems. The main outcomes of interest are diseases related or unrelated to HIV; suppression of viral replication; adverse events; virological, clinical and immunological failures; changes in the cART; and mortality. For the 5,061 patients who started cART between 2003 and 2010, the median follow-up time was 4.1 years (IQR 2.2–5.9 years) with an 83.4% retention rate. Patient profiles were characterized by a predominance of men (male/female ratio 1.7∶1), with a mean age of 36.9 years (SD 9.9 years); 55.2% had been infected with HIV via heterosexual contact. The majority of patients (53.4%) initiated cART with a CD4
+ T-cell count ≤200 cells/mm3 . The medications most often used in the various treatment regimens were efavirenz (59.7%) and lopinavir/ritonavir (18.2%). The proportion of individuals achieving viral suppression within the first 12 months of cART use was 77.4% (95% CI 76.1–78.6). Nearly half (45.4%) of the patients presented HIV-related clinical manifestations after starting cART, and the AIDS mortality rate was 13.9 per 1,000 person-years. Conclusions/Significance: Results from cART use in the daily practice of health services remain relatively unknown in low- and middle-income countries, and studies with the characteristics of the HIV-Brazil Cohort contribute to minimizing these shortcomings, given its scope and patient profile, which is similar to that of the AIDS epidemic in the country. [ABSTRACT FROM AUTHOR]- Published
- 2014
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24. Pre-Exposure Prophylaxis Failure With a Multiple Drug-Resistant HIV-1 Clade C Virus in Brazil.
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Diaz, Ricardo S., Grangeiro, Alexandre, Estevam, Denize L., Galinskas, Juliana, Dias, Danilo, and Schechter, Mauro
- Published
- 2022
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25. Late Entry into HIV Care: Estimated Impact on AIDS Mortality Rates in Brazil, 2003-2006.
- Author
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Grangeiro, Alexandre, Escuder, Maria Mercedes, Menezes, Paulo Rossi, Alencar, Rosa, and de Castilho, Euclides Ayres
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HIV-positive persons ,CARING ,DEATH (Biology) ,PUBLIC health ,LYMPHOCYTES ,MEDICAL care ,HEALTH facilities ,HUMAN services ,NATIONAL health services - Abstract
Background: Worldwide, a high proportion of HIV-infected individuals enter into HIV care late. Here, our objective was to estimate the impact that late entry into HIV care has had on AIDS mortality rates in Brazil. Methodology/Principal Findings: We analyzed data from information systems regarding HIV-infected adults who sought treatment at public health care facilities in Brazil from 2003 to 2006. We initially estimated the prevalence of late entry into HIV care, as well as the probability of death in the first 12 months, the percentage of the risk of death attributable to late entry, and the number of avoidable deaths. We subsequently adjusted the annual AIDS mortality rate by excluding such deaths. Of the 115,369 patients evaluated, 50,358 (43.6%) had entered HIV care late, and 18,002 died in the first 12 months, representing a 16.5% probability of death in the first 12 months (95% CI: 16.3-16.7). By comparing patients who entered HIV care late with those who gained timely access, we found that the risk ratio for death was 49.5 (95% CI: 45.1-54.2). The percentage of the risk of death attributable to late entry was 95.5%, translating to 17,189 potentially avoidable deaths. Averting those deaths would have lowered the 2003-2006 AIDS mortality rate by 39.5%. Including asymptomatic patients with CD4
+ T cell counts .200 and ≤350 cells/mm³ in the group who entered HIV care late increased this proportion by 1.8%. Conclusions/Significance: In Brazil, antiretroviral drugs reduced AIDS mortality by 43%. Timely entry would reduce that rate by a similar proportion, as well as resulting in a 45.2% increase in the effectiveness of the program for HIV care. The World Health Organization recommendation that asymptomatic patients with CD4+ T cell counts ≤350 cells/mm³ be treated would not have a significant impact on this scenario. [ABSTRACT FROM AUTHOR]- Published
- 2011
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26. Trends and predictors of non‐communicable disease multimorbidity among adults living with HIV and receiving antiretroviral therapy in Brazil.
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Castilho, Jessica L, Escuder, Maria M, Veloso, Valdiléa, Gomes, Jackeline O, Jayathilake, Karu, Ribeiro, Sayonara, Souza, Rosa A, Ikeda, Maria L, Alencastro, Paulo R, Tupinanbas, Unai, Brites, Carlos, McGowan, Catherine C, Grangeiro, Alexandre, and Grinsztejn, Beatriz
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NON-communicable diseases ,COMORBIDITY ,TRENDS ,PROPORTIONAL hazards models ,POISSON regression - Abstract
Introduction: People living with HIV (PLHIV) on antiretroviral therapy (ART) experience high rates of non‐communicable diseases (NCDs). These co‐morbidities often accumulate and older adults may suffer from multimorbidity. Multimorbidity has been associated with loss of quality of life, polypharmacy, and increased risk of frailty and mortality. Little is known of the trends or predictors NCD multimorbidity in PLHIV in low‐ and middle‐income countries. Methods: We examined NCD multimorbidity in adult PLHIV initiating ART between 2003 and 2014 using a multi‐site, observational cohort in Brazil. NCDs included cardiovascular artery disease, hyperlipidemia (HLD), diabetes, chronic kidney disease, cirrhosis, osteoporosis, osteonecrosis, venous thromboembolism and non‐AIDS‐defining cancers. Multimorbidity was defined as the incident accumulation of two or more unique NCDs. We used Poisson regression to examine trends and Cox proportional hazard models to examine predictors of multimorbidity. Results: Of the 6206 adults, 332 (5%) developed multimorbidity during the study period. Parallel to the ageing of the cohort, the prevalence of multimorbidity rose from 3% to 11% during the study period. Older age, female sex (adjusted hazard ratio (aHR) = 1.30 (95% confidence interval (CI) 1.03 to 1.65)) and low CD4 nadir (<100 vs. ≥200 cells/mm3 aHR = 1.52 (95% CI: 1.15 to 2.01)) at cohort entry were significantly associated with increased risk of multimorbidity. Among patients with incident multimorbidity, the most common NCDs were HLD and diabetes; however, osteoporosis was also frequent in women (16 vs. 35% of men and women with multimorbidity respectively). Conclusions: Among adult PLHIV in Brazil, NCD multimorbidity increased from 2003 to 2014. Females and adults with low CD4 nadir were at increased risk in adjusted analyses. Further studies examining prevention, screening and management of NCDs in PLHIV in low‐ and middle‐income countries are needed. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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27. Validation of CD4+ T-cell and viral load data from the HIV-Brazil Cohort Study using secondary system data.
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Cassenote, Alex Jones Flores, Segurado, Aluísio Augusto Cotrim, Grangeiro, Alexandre, Escuder, Maria Mercedes, and Abe, Jair Minoro
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Background: The HIV-Brazil Cohort Study (HIV-BCS) is a research primarily based on data collection from medical records of people living with HIV/AIDS in Brazil. The aim of this study was to present the validating design and results for the laboratory biomarkers viral load and CD4+ T-cell count from the HIV-Brazil Cohort Study.Methods: A total of 8007 patients who were started cART from 2003 to 2013 were considered eligible for this study. Total follow-up time was 32,397 years. The median duration of follow-up was 3.51 years (interquartile range - IQR 1.63-6.13 years; maximum 11.51 years). We used secondary data from the Brazilian Laboratory Tests Control System (SISCEL). Incidence of lab testing rates per 100 person years (100 py) were used to compare the number of laboratory tests carried out among cohort sites considering different databases for CD4+ T-cell counts and HIV viral load assessments. Descriptive statistics including 95% confidence interval, Pearson correlation coefficient, Bland-Altman agreement analysis and kappa coefficient agreement were applied for analysis.Results: A total of 80,302 CD4+ T-cell counts and 79,997 HIV viral load assessments were observed in HIV-BCS versus 94,083 CD4+ T-cell counts and 84,810 viral loads from the Brazilian Laboratory Tests Control System. The general CD4+ T-cell HIV-BCS testing rate was 247 per 100 py versus 290 per 100 py and the viral load HIV-BCS testing rate was 246 per 100 py versus 261 per 100 py. The general correlation observed for the lowest quantitative CD4+ T-cell count before cART was 0.970 (p < 0.001) and for the log of the highest viral load before cART was 0.971 (p < 0.001). The general agreement coefficient for categorized CD4+ T-cell count was 0.932 (p < 0.001) and for viral load was 0.996 (p < 0.001).Conclusions: The current study confirms that biomarkers CD4+ T-cell count and viral load from the HIV-BCS have a high correlation and agreement with data from SISCEL, rendering both databases reliable and useful for epidemiological studies on HIV care in Brazil. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
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