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Research on medicinal plants is essential for their conservation, propagation, resistance to environmental stress, and domestication. The use of organic nutrition has been demonstrated to improve soil fertility and plant quality. It is also important to study the effects of the Basic Cation Saturation Ratio (BCSR) approach, which is a topic where there is currently controversy and limited scientific information. Evaluating the growth and yields of Agastache mexicana subsp. mexicana (Amm) in different environments is crucial for developing effective propagation and domestication strategies. This includes examining warm and subhumid environments with rain in summer in comparison to mild environments with summer rain. Significant differences were observed in the effects of cold, waterlogging, and heat stresses on the plant's biomass yield and the morphometric-quantitative modeling by means of isolines. The biomass yield was 56% higher in environment one compared to environment two, 19% higher in environment one with organic nutrition, and 48% higher in environment two with organic nutrition compared to using only BCSR nutrition. In the second harvesting cycle, the plants in environment one did not survive, while the plants in environment two managed to survive without needing additional nutrition. Statistical and mathematical analyses provided information about the population or sample. Additionally, further analysis using isolines as a new approach revealed new insights into understanding phenology and growth issues. [ABSTRACT FROM AUTHOR]

A spatial survival analysis was performed to identify some of the factors that influence the survival of patients with COVID-19 in the states of Guerrero, México, and Chihuahua. The data that we analyzed correspond to the period from 28 February 2020 to 24 November 2021. A Cox proportional hazards frailty model and a Cox proportional hazards model were fitted. For both models, the estimation of the parameters was carried out using the Bayesian approach. According to the DIC, WAIC, and LPML criteria, the spatial model was better. The analysis showed that the spatial effect influences the survival times of patients with COVID-19. The spatial survival analysis also revealed that age, gender, and the presence of comorbidities, which vary between states, and the development of pneumonia increase the risk of death from COVID-19. [ABSTRACT FROM AUTHOR]

The aim of this work is to estimate the effect of Imatinib, exosomes, and Imatinib-exosomes mixture in chronic myeloid leukemia (CML). For this purpose, mathematical models based on Gompertzian and logistic growth differential equations were proposed. The models contained parameters representing the effects of the three components on CML proliferation. Parameters estimation was performed under the Bayesian statistical approach. Experimental data reported in the literature were used, corresponding to four trials of a human leukemia xenograft in BALB/c female rats over a period of forty days. The models were fitted to the following growth dynamics: normal tumor growth, growth with exosomes, growth with Imatinib, and growth with exosomes-Imatinib mixture. For the proposed logistic growth model, it was determined that when using Imatinib treatment the growth rate is 0.93 (95% CrI: 84.33–99.64) slower and reduces the tumor volume to approximately 10% (95% CrI : 8.67–10.81). In the presence of exosome treatment, the growth rate is 0.83 (95% CrI: 1.52–16.59) faster and the tumor volume is expanded by 40% (95% CrI: 25.36–57.28). Finally, in the presence of Imatinib-exosomes mixture treatment, the growth rate is 0.82 (95% CrI: 76.87–88.51) slower and the tumor volume is reduced by 95% (95% CrI: 86.76–99.85). It is concluded that the presence of exosomes partially inactivates the effect of the Imatinib drug on tumor growth in a mouse xenograft model. [ABSTRACT FROM AUTHOR]

Traditionally the diagnosis of Metabolic syndrome (MetS) is binary (present/absent). The goal of this work is to propose a sex-specific continuous score to measure the severity of MetS in Mexican adults using waist circumference and body mass index as adiposity measures. MetSx-WC and MetSx-BMI indexes by sex were derived by confirmatory factor analysis (CFA) using data for 6567 adult participants of the National Health and Nutrition Survey 2018. The overall fit of the two proposed CFA models was excellent. We then validated these scores using a community-based health study of 862 university participants and determined that the reliability and strength of agreement between the MetSx-WC and MetSx-BMI scores were excellent. The ROC analysis of the resulting indexes indicates that they have excellent ability to discriminate a MetS classification according to the different criteria. The correlations of MetSx scores and surrogate markers of insulin resistance and obesity ranged from weak to strong. Subsequently, a retrospective study of 310 hospitalized patients with COVID-19 was used to determined that MetSx-BMI score was associated with the mortality of patients with COVID-19. The proposed indices provide a continuous measure in the identification of MetS risk in Mexican adults. [ABSTRACT FROM AUTHOR]

Objective: To evaluate three proportions of alcohol in traps with one and three windows and two different colors to capture Hypothenemus hampei Ferrari in Coffea arabica L. plants. Design/methodology/approach: The experiment followed a completely randomized design with a complete factorial arrangement and four replications. From March to July 2007, three mixtures of ethyl: methyl alcohol were evaluated in different proportions (1: 0, 0: 1 and 1: 1). In addition, green and transparent traps were used, designed with a single or three windows. The number of captured coffee berry borers, water loss, attractant evaporation and damaged fruits percentage was evaluated. The data were analyzed through an analysis of variance and a test of means differences (Tukey, p ≤ 0.05). Results: The mixture of ethyl: methyl alcohol 1: 1 was the best, with an average catch of 980 trapped - insects week-1. The single window of transparent color traps was the most efficient to avoid water loss, with an average loss of 1,129.79 mL and 905 mL respectively. Limitations on study/implications: The design and color of the traps did not influence the capture efficiency and the evaporation of the attractant during the evaluated months. Therefore, it should be further evaluated during other important phenological stages for the crop. Findings/conclusions: Transparent color traps with a window and 1: 1 ethyl: methyl alcohol were efficient for capturing H. hampei and lowering their population. [ABSTRACT FROM AUTHOR]

In this work, a simulation study is conducted to evaluate the performance of Bayesian estimators for the log–linear exponential regression model under different levels of censoring and degrees of collinearity for two covariates. The diffuse normal, independent Student-t and multivariate Student-t distributions are considered as prior distributions and to draw from the posterior distributions, the Metropolis algorithm is implemented. Also, the results are compared with the maximum likelihood estimators in terms of the mean squared error, coverages and length of the credibility and confidence intervals. [ABSTRACT FROM PUBLISHER]

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