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Background: Oncology databases that integrate genomic and clinical data have become valuable resources for precision medicine. However, the generalizability of these databases has not been comprehensively assessed. Objectives: To describe the demographics, clinical characteristics, treatments, and overall survival of breast cancer cohorts in GENIE‐BPC and three other databases. Methods: This study utilized GENIE‐BPC, SEER, SEER‐Medicare, and Merative MarketScan Research Databases. Women with invasive breast cancer were identified through EHR, cancer registries or ICD‐9/10‐CM codes. The ages were 18+ years or per database requirement. Treatments were based on EHR or HCPCS/NDC codes in claims. Overall survival was estimated as time from diagnosis to death. Results: Of female breast cancer patients in GENIE‐BPC (n = 775), SEER (n = 548 336), SEER‐Medicare (n = 68 914), and Marketscan (n = 109 499) databases, the median ages at initial diagnosis were 44, 62, 74, and 57 years, respectively. A greater proportion of patients in GENIE‐BPC, compared to SEER/SEER‐Medicare, had higher nuclear grades (%III–%IV: 57% vs. 26%/24%), advanced disease stage (%IV: 25.3% vs. 5%/3.6%), percent of triple negative breast cancer (19.7% vs. 10.2%/8.5%), and receipt of chemotherapy (85.0% vs. NA/22.3%). The 1‐, 3‐, and 5‐year overall survival rates were lower in GENIE‐BPC (78.5%, 60.5%, 55.5%) than in SEER (95.8%, 89.5%, 85.5%) and SEER‐Medicare (91.6%, 81.4%, 75.0%). Conclusion: Breast cancer patients in GENIE‐BPC were younger, had more advanced disease, had a higher proportion of triple negative breast cancer and recipients of chemotherapy, and had poorer overall survival. Researchers must use statistical adjustment when extrapolating results (e.g., biomarker prevalence) from GENIE‐BPC to the larger breast cancer population. [ABSTRACT FROM AUTHOR]

Background: Treatment of non-small lung cancer (NSCLC) has evolved in recent years, benefiting from advances in immunotherapy and targeted therapy. However, limited biomarkers exist to assist clinicians and patients in selecting the most effective, personalized treatment strategies. Targeted next-generation sequencing–based genomic profiling has become routine in cancer treatment and generated crucial clinicogenomic data over the last decade. This has made the development of mutational biomarkers for drug response possible. Methods: To investigate the association between a patient's responses to a specific somatic mutation treatment, we analyzed the NSCLC GENIE BPC cohort, which includes 2,004 tumor samples from 1,846 patients. Results: We identified somatic mutation signatures associated with response to immunotherapy and chemotherapy, including carboplatin-, cisplatin-, pemetrexed- or docetaxel-based chemotherapy. The prediction power of the chemotherapy-associated signature was significantly affected by epidermal growth factor receptor (EGFR) mutation status. Therefore, we developed an EGFR wild-type–specific mutation signature for chemotherapy selection. Conclusion: Our treatment-specific gene signatures will assist clinicians and patients in selecting from multiple treatment options. [ABSTRACT FROM AUTHOR]

Differences in cancer genomes between racial groups may impact tumor biology and health disparities. However, the discovery of race-associated mutations is constrained by the limited representation and sample size of different racial groups in prior genomic studies. We evaluated the influence of race on the frequency of gene mutations using the Genomics, Evidence, Neoplasia, Information, Exchange database, a large genomic dataset aggregated from clinical sequencing. Matched cohort analyses were used to identify histology-specific race-associated mutations including increased TERT promoter mutations in Black and Asian patients with gliomas and bladder cancers, and a decreased frequency of mutations in DNA repair pathway genes and subunits of the SWI/SNF chromatin complex in Asian and Black patients across multiple cancer types. The distribution of actionable mutations in oncogenes was also race-specific, demonstrating how targeted therapies may have a disparate impact on racial groups. Down-sampling analyses indicate that larger sample sizes are likely to discover more race-associated mutations. These results provide a resource to understand differences in cancer genomes between racial groups which may inform the design of clinical studies and patient recruitment strategies in biomarker trials. [ABSTRACT FROM AUTHOR]

Although driverless technology belongs to the frontier of science and technology, there is no sufficient actual data. From the lack of a comprehensive systematic evaluation method of traffic safety under driverless penetration, considering the impact of the three core systems of driverless perception, decision-making, control, and the complex road factors on the safety of driving, we review the main risk causal factors through the analysis of the accident causal model STAMP and put forward the fusion of the Leaky Noisy-OR Gate and Bayesian network model. The Bayesian network professional analysis tool GeNIe 2.0 was used to simulate, analyze, and evaluate the driverless traffic risk Bayesian network model, which accurately assessed the traffic safety risk under driverless penetration and diagnosed and identified the sensitive risk factors. The results of this study concluded that, in order to effectively deal with the future traffic safety risks of driverless vehicles, vehicle enterprises, research institutions, software and hardware suppliers in the field of driverless driving should strengthen the research and development and manufacturing of key components such as perception, and enhance the depth of research and development of AI decision-making software, which provides a new way of thinking about the management of the safety risk of driverless traffic and a theoretical basis for the development and implementation of risk control measures. [ABSTRACT FROM AUTHOR]

Copyright of Akofena is the property of Universite Felix Houphouet Boigny and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Backgorund: Colorectal cancer (CRC) is among the leading causes of cancer-related deaths among Hispanics living in the United States (USH). Understanding the most common carcinogenic molecular pathways that affect Hispanics with CRC is crucial to guide research efforts in developing new therapeutic modalities incorporating genomically diverse populations. Tumor profiling techniques help identify actionable alternatives to recommend treatment and improve survival in cancer patients. Methods: We conducted a secondary data analysis to evaluate the mutational profile of 218 CRC tumors in Hispanics living in Puerto Rico (PRH) who underwent next-generation sequencing (NGS) testing from 2015 to 2020. We compared the prevalence of CRC tumor somatic mutations in PRHs with the mutational profiles reported for CRC from The Cancer Genome Atlas (TCGA) Pan-Cancer Clinical Data, the AACR Project Genomics Evidence Neoplasia Information Exchange (GENIE)-Non-Hispanic, and GENIE-Hispanic datasets. Results: Among the top mutated genes in CRC tumors in PRHs were APC, TP53, and KRAS, which had significantly higher mutational frequencies in PRH compared to the examined datasets, including GENIE-Hispanics. The most frequent gene amplifications for PRH were CDX2, CDKN1B, and HNRNPA2B1. Targetable biomarkers for CRC, such as microsatellite instability-high (MSI), wild-type KRAS, wild-type NRAS, V600E BRAF, and ERBB2 gene amplifications were found in 2.0%, 43.8%, 97.8%, 3.9%, and 2.3%, respectively, of PRH patients. Conclusion: This is the first study to report the mutational profile of CRC tumors in PRHs and make comparisons to other non-Hispanic and USH populations. [ABSTRACT FROM AUTHOR]

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Copyright of ANAFORA is the property of Anafora and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The TempO-Seq S1500+ platform(s), now available for human, mouse, rat, and zebrafish, measures a discrete number of genes that are representative of biological and pathway co-regulation across the entire genome in a given species. While measurement of these genes alone provides a direct assessment of gene expression activity, extrapolating expression values to the whole transcriptome (~26 000 genes in humans) can estimate measurements of non-measured genes of interest and increases the power of pathway analysis algorithms by using a larger background gene expression space. Here, we use data from primary hepatocytes of 54 donors that were treated with the endoplasmic reticulum (ER) stress inducer tunicamycin and then measured on the human S1500+ platform containing ~3000 representative genes. Measurements for the S1500+ genes were then used to extrapolate expression values for the remaining human transcriptome. As a case study of the improved downstream analysis achieved by extrapolation, the "measured only" and "whole transcriptome" (measured + extrapolated) gene sets were compared. Extrapolation increased the number of significant genes by 49%, bringing to the forefront many that are known to be associated with tunicamycin exposure. The extrapolation procedure also correctly identified established tunicamycin-related functional pathways reflected by coordinated changes in interrelated genes while maintaining the sample variability observed from the "measured only" genes. Extrapolation improved the gene- and pathway-level biological interpretations for a variety of downstream applications, including differential expression analysis, gene set enrichment pathway analysis, DAVID keyword analysis, Ingenuity Pathway Analysis, and NextBio correlated compound analysis. The extrapolated data highlight the role of metabolism/metabolic pathways, the ER, immune response, and the unfolded protein response, each of which are key activities associated with tunicamycin exposure that were unrepresented or underrepresented in one or more of the analyses of the original "measured only" dataset. Furthermore, the inclusion of the extrapolated genes raised "tunicamycin" from third to first upstream regulator in Ingenuity Pathway Analysis and from sixth to second most correlated compound in NextBio analysis. Therefore, our case study suggests an approach to extend and enhance data from the S1500+ platform for improved insight into biological mechanisms and functional outcomes of diseases, drugs, and other perturbations. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal for the Scholarship of Teaching & Learning is the property of Society for Teaching & Learning in Higher Education and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Diet quality in older people with chronic obstructive pulmonary disease (COPD) is associated with better health and lung function. Social factors, such as social support, social networks and participation in activities, have been linked with diet quality in older age. A social network tool—GENIE (Generating Engagement in Network Involvement)—was implemented in a COPD community care context. The study aimed to assess the feasibility of the GENIE intervention to promote diet quality and other health behaviours in COPD. Methods: Twenty-two community-dwelling older adults with COPD were recruited from a local COPD service. Participants were offered usual care or the GENIE intervention. Process evaluation methods were used to assess intervention implementation, context and mechanisms of impact; these included observations of patient interactions with the intervention, documented in observational field notes and in films of a patient group discussion. Diet quality was assessed by food frequency questionnaire; 'prudent' diet scores were used to describe diet quality at baseline and at 3-month follow-up. Change in diet quality was expressed per month, from baseline to follow-up. Results: Feasibility data showed that the GENIE intervention could be implemented in this sample of community-living older people. The intervention was acceptable to clinicians and older people with COPD, especially for those with less severe disease, when facilitated appropriately and considering the levels of literacy of participants. There was no significant change in diet quality in the intervention group over the follow-up period (median change in prudent diet score per month (interquartile range (IQR), 0.03 (− 0.24–0.07)), whereas an overall fall in diet quality was observed in the control group (− 0.15 (− 0.24–0.03)). Conclusion: The process evaluation findings suggest that this intervention is feasible and acceptable to both patients and clinicians. Although the sample size achieved in this study was small, findings suggest that the intervention may have a protective effect against declines in diet quality, and other health behaviours, in an older COPD population. Findings from this feasibility study indicate that further evaluation of the GENIE intervention is warranted in a larger study, with a longer follow-up. Trial registration: ClinicalTrials.gov, NCT02935452. NIH U.S. National Library of Medicine. Registered 17 October 2016. [ABSTRACT FROM AUTHOR]

The TempO-Seq S1500+ platform(s), now available for human, mouse, rat, and zebrafish, measures a discrete number of genes that are representative of biological and pathway co-regulation across the entire genome in a given species. While measurement of these genes alone provides a direct assessment of gene expression activity, extrapolating expression values to the whole transcriptome (~26 000 genes in humans) can estimate measurements of non-measured genes of interest and increases the power of pathway analysis algorithms by using a larger background gene expression space. Here, we use data from primary hepatocytes of 54 donors that were treated with the endoplasmic reticulum (ER) stress inducer tunicamycin and then measured on the human S1500+ platform containing ~3000 representative genes. Measurements for the S1500+ genes were then used to extrapolate expression values for the remaining human transcriptome. As a case study of the improved downstream analysis achieved by extrapolation, the "measured only" and "whole transcriptome" (measured + extrapolated) gene sets were compared. Extrapolation increased the number of significant genes by 49%, bringing to the forefront many that are known to be associated with tunicamycin exposure. The extrapolation procedure also correctly identified established tunicamycin-related functional pathways reflected by coordinated changes in interrelated genes while maintaining the sample variability observed from the "measured only" genes. Extrapolation improved the gene- and pathway-level biological interpretations for a variety of downstream applications, including differential expression analysis, gene set enrichment pathway analysis, DAVID keyword analysis, Ingenuity Pathway Analysis, and NextBio correlated compound analysis. The extrapolated data highlight the role of metabolism/metabolic pathways, the ER, immune response, and the unfolded protein response, each of which are key activities associated with tunicamycin exposure that were unrepresented or underrepresented in one or more of the analyses of the original "measured only" dataset. Furthermore, the inclusion of the extrapolated genes raised "tunicamycin" from third to first upstream regulator in Ingenuity Pathway Analysis and from sixth to second most correlated compound in NextBio analysis. Therefore, our case study suggests an approach to extend and enhance data from the S1500+ platform for improved insight into biological mechanisms and functional outcomes of diseases, drugs, and other perturbations. [ABSTRACT FROM AUTHOR]

Der Beitrag fokussiert die Paratexte des Populären. Ausgangspunkt ist die Frage, warum ein solch hoher Begründungsaufwand zu leisten ist, um das vermeintlich ohnehin Evidente — Volksdichtung ist gut, natürlich und damit auch authentisch — erneut zu erweisen. Eine der Strategien, Authentizität herzustellen, ist die zunehmende Anonymisierung von Dichtung, wie an Beispielen von Sammlungen um 1800 gezeigt werden soll. The article focuses on the paratexts of collections of popular songs. The fundamental question it poses is: why did authors insist upon such a high degree of justification in order to prove what was supposedly already evident, i.e. that popular poetry is good, natural, and therefore authentic? One of the strategies of producing authenticity is the increasing anonymization of poetry, as is shown here with the help of examples of collections from around 1800. [ABSTRACT FROM AUTHOR]

Background: Significant numbers of variants detected in cancer patients are often left labeled only as variants of unknown significance (VUS). In order to expand precision medicine to a wider population, we need to extend our knowledge of pathogenicity and drug response in the context of VUS's.Methods: In this study, we analyzed variants from AACR Project GENIE Consortium APG (Cancer Discov 7:818-831, 2017) and compared them to the COSMIC database Forbes et al. (Nucleic Acids Res 43:D805-811, 2015) to identify recurrent variants that would merit further study. We filtered out known hotspot variants, inactivating variants in tumor suppressors, and likely benign variants by comparing with COSMIC and ExAC Lee et al. (Science 337:967-971, 2012).Results: We have identified 45,933 novel variants with unknown significance unique to GENIE. In our analysis, we found on average six variants per patient where two could be considered as pathogenic or likely pathogenic and the majority are VUS's. More importantly, we have discovered 730 recurrent variants that appear more than 3 times in GENIE but less than 3 in COSMIC. If we combine the recurrences of GENIE and COSMIC for all variants, 2586 are newly identified as occurring more than 3 times than when using COSMIC alone.Conclusions: Although it would be inappropriate to blindly accept these recurrent variants as pathogenic, they may warrant higher priority than other observed VUS's. These newly identified recurrent variants might affect the molecular profiles of approximately 1 in 6 patients. Further analysis and characterization of these variants in both research and clinical contexts will improve patient treatments and the development of new therapeutics. [ABSTRACT FROM AUTHOR]

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Data from a large autopsy series were analyzed to address questions pertinent to primary age-related tauopathy (PART) and Alzheimer's disease (AD): what factors are associated with increased severity of neurofibrillary degeneration in brains that lack neuritic amyloid plaques?; is there an association between Apolipoprotein E (APOE) alleles and PART pathologic severity independent of amyloid-β (Aβ) deposits?; and, how do the stains used to detect plaques and tangles impact the experimental results? Neuropathologic data were evaluated from elderly research volunteers whose brain autopsies were performed at University of Kentucky Alzheimer's Disease Center (UK-ADC; N = 145 subjects). All of the included subjects' brains lacked neuritic amyloid plaques according to the CERAD diagnostic criteria and the average final MMSE score before death was 26.8±4.6 stdev. The study incorporated evaluation of tissue with both silver histochemical stains and immunohistochemical stains to compare results; the immunohistochemical stains (Aβ and phospho-tau) were scanned and quantified using digital pathologic methods. Immunohistochemical stains provided important advantages over histochemical stains due to sensitivity and detectability via digital methods. When AD-type pathology was in its presumed earliest phases, neocortical parenchymal Aβ deposits were associated with increased medial temporal lobe neurofibrillary tangles. The observation supports the NIA-AA consensus recommendation for neuropathologic diagnoses, because even these "diffuse" Aβ deposits signal that AD pathobiologic mechanisms are occurring. Further, the data were most compatible with the hypothesis that the APOEɛ4 allele exerts its effect(s) via driving Aβ deposition, i.e., an "upstream" influence, rather than being associated directly with Aβ- independent PART pathology. [ABSTRACT FROM AUTHOR]

We analyzed all published reports of individuals not exposed to syntactic language until puberty: two feral children, who grew up without hearing any language, and eight deaf linguistic isolates, who grew up communicating to their families using homesign or kitchensign, a system of gestures which allows them to communicate simple commands but lacks much in the way of syntax. A common observation in these individuals is the lifelong difficulty understanding syntax and spatial prepositions, even after many years of rehabilitation. This debilitating condition stands in stark contrast to linguistic isolates' performance on memory as well as semantic tests: they could easily remember hundreds of newly learned words and identify previously seen objects by name. The lack of syntactic language comprehension in linguistic isolates may stem from inability to understand words and/or grammar or inability to mentally synthesize known objects into novel configurations. We have previously shown that purposeful construction of novel mental images is the function of the lateral prefrontal cortex (LPFC) ability to dynamically control posterior cortex neurons (Vyshedskiy et al. 2017). Here we have ranked all tests performed on linguistic isolates by their reliance on the LPFC control of the posterior cortex: a) the amount of posterior cortex territory that needs to be recruited by the LPFC and b) the number of disparate objects that have to be combined together by the LPFC in order to answer the test question. According to our analysis, linguistic isolates performed well in all tests that did not involve the LPFC control of the posterior cortex, showed decreasing scores in tests that involved greater recruitment of the posterior cortex by the LPFC, and failed in tests that involved greatest recruitment of posterior cortex necessary for mental synthesis of multiple objects. This pattern is consistent with inadequate frontoposterior connections in linguistic isolates. We discuss implications of these findings for the importance of early syntactic language exposure in formation of frontoposterior connections. [ABSTRACT FROM AUTHOR]

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Copyright of Dix-Neuf is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Der Beitrag wendet sich gegen die Karriere des Begriff s ,Werte', der seit dem 18. und 19. Jahrhundert die traditionelle Sprache der Tugendethik ablöste. Der Begriff ,Wert' setzt Subjektivismus und Pluralismus voraus. Die Vorstellung, Werte ließen sich von Philosophen oder gar von einem Philosophen ,schaffen', impliziert eine Überschätzung des Philosophen und der Philosophie überhaupt. This contribution opposes the career of the term ,values', which has replaced the traditional language of virtue ethics since the 18th and 19th centuries. The term ,value' presupposes subjectivism and pluralism. The idea that philosophers or even one philosopher can create values implies a hubris of the philosopher and of philosophy in general. [ABSTRACT FROM AUTHOR]

This study explores the identity and function of the mostly unnoticed figure of Sha'tiqatu, a creature who plays a pivotal role in the story of the Ugaritic King Kirta. The exploration of this under appreciated figure is situated in the context of Ugaritic apotropea and within the better documented Mesopotamian cultural backdrop. A counterpart article provides the philological and epigraphic analysis to the Sha'tiqatu Narrative found in KTU 1.16.5.10-1.16.6.14. [ABSTRACT FROM AUTHOR]

Copyright of Dix-Neuf is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The ubiquity of index-finger pointing, and its early emergence in child development, has suggested that such pointing may be biologically-determined. However, cross-cultural variation in the form of pointing has also been noted, with some observations of middle-finger pointing. Here we examine the limited corpus of publically-available video data on the signs and gestures of Genie, a child who suffered severe social and linguistic deprivation throughout her childhood. These data suggest that Genie favored the use of the middle finger in points, in ASL signs that have an index-finger target handshape, and in object exploration. We speculate that middle-finger pointing in children may reflect an articulatory preference that is not limited to pointing, but that may encompass a range of manual behaviors. [ABSTRACT FROM AUTHOR]

Almond is an extendible open-source virtual assistant designed to help people access Internet services and IoT (Internet of Things) devices. Both are referred to as skills here. Service providers can easily enable their devices for Almond by defining proper APIs (Application Programming Interfaces) for ThingTalk in Thingpedia. ThingTalk is a virtual assistant programming language, and Thingpedia is an application encyclopedia. Almond uses a large neural network to translate user commands in natural language into ThingTalk programs. To obtain enough data for the training of the neural network, Genie was developed to synthesize pairs of user commands and corresponding ThingTalk programs based on a natural language template approach. In this work, we extended Genie to support Chinese. For 107 devices and 261 functions registered in Thingpedia, 649 Chinese primitive templates and 292 Chinese construct templates were analyzed and developed. Two models, seq2seq (sequence-to-sequence) and MQAN (multiple question answer network), were trained to translate user commands in Chinese into ThingTalk programs. Both models were evaluated, and the experiment results showed that MQAN outperformed seq2seq. The exact match, BLEU, and F1 token accuracy of MQAN were 0.7, 0.82, and 0.88, respectively. As a result, users could use Chinese in Almond to access Internet services and IoT devices registered in Thingpedia. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal of Civil Engineering is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The supernatural and reality have more in common than one is led to believe. The relationship between what is real and what is myth fluctuates both in people's consciousness and in literature. Nobel Laureate Naguib Mahfouz, in his "Arabian Nights and Days" (1984), resorts to the ultimate resource of the Eastern supernatural, most famous in the Western world: the "Arabian Nights." This remains the most widely acknowledged record of Eastern supernatural creatures, among which are the jinn (the purpose of this study). Naguib Mahfouz, famed for his power to depict the real world, shows equal ingenuity at capturing the surreal in the form of a strong mix of supernatural and mystic presence. However, Mahfouz eliminates entirely from the story the familiar legendary monsters dwelling in the original work except for one, the jinn. This in itself is significant, since the figure of the jinn is not only still strongly lurking in Arabic folklore, but is also evident in modern Arabic life, unlike the other monsters that are deemed obsolete, being legendary. Mahfouz also keeps the episodic structure of the original Arabian Nights, displaying the adventures of each hero in each episode as they all encounter the jinn one way or the other . In order to explore these encounters, the Arabic understanding of religion, mysticism, and the supernatural must be probed, revealing an obscure culture that controls this intricate world of interrelated concepts. Ironically, by delving into this unique analysis of the Arabic perspective, life's most complicated questions are posed in a universal form: how far is man responsible for his actions, within the concept of destiny? How can a person reach redemption and deal with guilt? Yet surely the ultimate question remains whether the jinn exists, or if evil is innate in human nature, leading man to destruction and madness. [ABSTRACT FROM AUTHOR]

L'insomnie littéraire exprime la solitude du poète devant le monde endormi, mais elle permet aussi un tête à tête privilégié avec sa muse. Musset dans Les Nuits, Hugo dans Les Contemplations et Corbière dans Les Amours jaunes expriment cette expérience intime. Cependant l'articulation entre insomnie et création ne se manifeste pas sur le même mode chez ces trois poètes: dialogue amoureux avec la Muse, injonctions tyranniques et supplications, ou invectives ironiques. La 'lucidité' du poète romantique se voit ainsi réactualisée puisque, aiguisé par la fatigue, son génie le pousse au travail et convoque des possibilités de création infinies. Entre idéalisation, instrumentalisation, et dérision, le poète redéfinit son rapport à la création quand il voudrait s'abandonner. Literary insomnia expresses the solitude of the poet faced with a world which is asleep, but it is also the scene for a privileged tête-à-tête with his Muse. Musset in Les Nuits, Hugo in Les Contemplations and Corbière in Les Amours jaunes give expression to this intimate experience. However, the link between insomnia and artistic creation manifests itself in different ways in the work of these three poets: a loving dialogue with the Muse, tyrannical demands and pleas, or ironic invectives. Stimulated by fatigue, the poet's genius drives him to work and summons up infinite possibilities of creation. Between idealization, instrumentalization, and derision, the poet redefines his relationship to creativity at the point where he would like to let himself sink into sleep. [ABSTRACT FROM AUTHOR]

Using Gaussian inputs and treating interference as noise at the receivers has recently been shown to be sum capacity achieving for the two-user single-input single-output (SISO) Gaussian interference channel in a low interference regime, where the interference levels are below certain thresholds. In this paper, such a low interference regime is characterized for multiple-input multiple-output (MIMO) Gaussian interference channels. Conditions are provided on the direct and cross channel gain matrices under which using Gaussian inputs and treating interference as noise at the receivers is sum capacity achieving. For the special cases of the symmetric multiple-input single-output (MISO) and single-input multiple-output (SIMO) Gaussian interference channels, more explicit expressions for the low interference regime are derived. In particular, the threshold on the interference levels that characterize low interference regime is related to the input SNR and the angle between the direct and cross channel gain vectors. It is shown that the low interference regime can be quite significant for MIMO interference channels, with the low interference threshold being at least as large as the sine of the angle between the direct and cross channel gain vectors for the MISO and SIMO cases. [ABSTRACT FROM PUBLISHER]

Establishing the capacity region of a Gaussian interference network is an open problem in information theory. Recent progress on this problem has led to the characterization of the capacity region of a general two-user Gaussian interference channel within one bit. In this paper, we develop new, improved outer bounds on the capacity region. Using these bounds, we show that treating interference as noise achieves the sum capacity of the two-user Gaussian interference channel in a low-interference regime, where the interference parameters are below certain thresholds. We then generalize our techniques and results to Gaussian interference networks with more than two users. In particular, we demonstrate that the total interference threshold, below which treating interference as noise achieves the sum capacity, increases with the number of users. [ABSTRACT FROM AUTHOR]

GREEN A. E. and OWEN D. W. (1989) The changing geography of occupations in engineering in Britain, 1978–1987, Reg. studies 23, 27–42. This paper analyses the changing occupational structure and pattern of local specialization in the engineering industry and two contrasting sub-sectors, electronics and machinery, over a decade of radical change from 1978. Within the context of overall employment decline, professional engineers increased in absolute and relative importance across all sectors and local labour market areas. The initial main North-South dimension in the spatial division of labour remained apparent at the end of the period but there was some evidence of a tendency towards convergence in patterns of local occupational specialization. With changes in occupational structure, recruitment difficulties and skill shortages have arisen in both growing and declining occupations. GREEN A. E. et OWEN D. W. (1989) L'évolution géographique des catégories socio-professionnelles dans le génie en Grande-Bretagne de 1978 à 1987, Reg. Studies 23, 27–42. Cet article analyse l'évolution des catégories socio-professionnelles et la structure de la spécialisation locale au sein du génie et de deux sous-secteurs contrastés, à savoir l'électronique et la machinerie, sur une période de dix ans d'évolution radicale à partir de 1978. Dans le cadre du déclin global de l'emploi, le nombre d'ingénieurs professionnels a augmenté en termes absolus et relatifs dans tous les secteurs et dans tous les bassins d'emplois locaux. A la fin de la période en question l'optique Nord/Sud dans la division géographique du marché de l'emploi était toujours évidente, mais quelques preuves laissaient supposer une tendance vers la convergence des structures de la spécialisation locale en catégories socio-proessionnelles. Dans et les catégories en croissance et les catégories en déclin il s'est développé des difficultés de recrutement et une pénurie de compétences. GREEN A. E. und OWEN D. W. (1989) Wandel in der Geographie der Beschäftigungskategorien im Ingenieurswesen Grossbritanniens 1978–1987, Reg. Studies 23, 27–42. Dieser Aufsatz analysiert die im Wandel befindliche Struktur der Beschäftigungskategorien und Verteilung örtlicher Spezializierung im Ingenieurswesen und in den zwei kontrastierenden Teilgebieten Elektronik und Maschinenebau, die seit 1978 in einem Jahrzehnt radikaler Umwälzungen stattgefunden hat. Im Zusammenhang der allgemeinen Beschäftigungsabnahme gesehen hat die Zahl der Diplomingenicure auf allen Gebieten und in allen örtlichen Stellenmarktgebieten an absoluter und relativer Bedeutung zugenommen. Die anfänglich vorwiegende Nord-Süddimension in der räumlichen Aufteilung von Arbeitskräften blieb am Ende des Zeitabschnitts bestehen, doch gab es Anzeichen einer Tendenz zur Konvergenz der Verteilung örtlicher Berufsspeziallsierung. Auf zunehmend sowie auf weniger gefragten Arbeitsgebieten haben Veränderungen in der Beschäftigungsstruktur zu Schwierigkeiten bei der Anwerbung von Arbeitskräften und zu Engpässen bei bestimmten Fachkräften geführt. [ABSTRACT FROM PUBLISHER]