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Your search keyword '"Gangadharan, Sidharta P."' showing total 10 results
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2. Surface tension-assisted additive manufacturing.

Author

Ragelle, Héloïse, Tibbitt, Mark W., Shang-Yun Wu, Castillo, Michael A., Cheng, George Z., Gangadharan, Sidharta P., Anderson, Daniel G., Cima, Michael J., and Langer, Robert

Subjects
THIN films, SURFACE tension, POLYMER networks, MANUFACTURING processes, SURFACE coatings, HYDROGELS, LIQUID films
Abstract

The proliferation of computer-aided design and additive manufacturing enables on-demand fabrication of complex, three-dimensional structures. However, combining the versatility of cell-laden hydrogels within the 3D printing process remains a challenge. Herein, we describe a facile and versatile method that integrates polymer networks (including hydrogels) with 3D-printed mechanical supports to fabricate multicomponent (bio)materials. The approach exploits surface tension to coat fenestrated surfaces with suspended liquid films that can be transformed into solid films. The operating parameters for the process are determined using a physical model, and complex geometric structures are successfully fabricated. We engineer, by tailoring the window geometry, scaffolds with anisotropic mechanical properties that compress longitudinally (~30% strain) without damaging the hydrogel coating. Finally, the process is amenable to high cell density encapsulation and co-culture. Viability (>95%) was maintained 28 days after encapsulation. This general approach can generate biocompatible, macroscale devices with structural integrity and anisotropic mechanical properties. [ABSTRACT FROM AUTHOR]

Published
2018
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5. Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.

Author

Koyama, Shohei, Akbay, Esra A., Li, Yvonne Y., Herter-Sprie, Grit S., Buczkowski, Kevin A., Richards, William G., Gandhi, Leena, Redig, Amanda J., Rodig, Scott J., Asahina, Hajime, Jones, Robert E., Kulkarni, Meghana M., Kuraguchi, Mari, Palakurthi, Sangeetha, Fecci, Peter E., Johnson, Bruce E., Janne, Pasi A., Engelman, Jeffrey A., Gangadharan, Sidharta P., and Costa, Daniel B.

Published
2016
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10. HISTOPATHOLOGY OF TRACHEOBRONCHOMALACIA.

Author

Nataraj, Dilip, Sugimoto, Hikaru, Mariappan, Rajan, Ernst, Armin, Majid, Adnan, DeCamp, Malcolm M., Gangadharan, Sidharta P., Kent, Michael, Herth, Felix J., and Kalluri, Raghu

Subjects
TRACHEOBRONCHOMALACIA, HISTOPATHOLOGY, MEDICAL periodicals
Published
2009
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