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The environmental Kuznets curve (EKC) hypothesis posits an inverted U-shaped relationship between economic growth and environmental degradation. However, there is no consensus regarding the EKC hypothesis among countries and regions of different income groups. This study revisits the EKC hypothesis by employing cross-correlation analysis to explore the income–CO2 emissions relationship across 158 countries and 44 regions from 1990 to 2020. The empirical method utilizes a dynamic cross-correlation coefficient (CCC) approach, allowing for the assessment of lead-lag dynamics between income and CO2 emissions over time. By categorizing nations into the World Bank's income classifications, we found a heterogeneous EKC pattern highlighting distinct environmental–economic dynamics across different income groups. The findings indicate that high-income countries show a decoupling of economic growth from CO2 emissions; whereas, low-income countries still exhibit a positive correlation between both variables. This underscores the necessity for tailored policy interventions that promote carbon neutrality, while considering each country's unique development stage. Our research contributes to the ongoing issue of sustainable economic development by providing empirical evidence of the different pathways nations follow in balancing growth with environmental preservation. [ABSTRACT FROM AUTHOR]

Most statistical and machine learning models used for binary data modeling and classification assume that the data are balanced. However, this assumption can lead to poor predictive performance and bias in parameter estimation when there is an imbalance in the data due to the threshold election for the binary classification. To address this challenge, several authors suggest using asymmetric link functions in binary regression, instead of the traditional symmetric functions such as logit or probit, aiming to highlight characteristics that would help the classification task. Therefore, this study aims to introduce new classification functions based on the Lomax distribution (and its variations; including power and reverse versions). The proposed Bayesian functions have proven asymmetry and were implemented in a Stan program into the R workflow. Additionally, these functions showed promising results in real-world data applications, outperforming classical link functions in terms of metrics. For instance, in the first example, comparing the reverse power double Lomax (RPDLomax) with the logit link showed that, regardless of the data imbalance, the RPDLomax model assigns effectively lower mean posterior predictive probabilities to failure and higher probabilities to success (21.4% and 63.7%, respectively), unlike Logistic regression, which does not clearly distinguish between the mean posterior predictive probabilities for these two classes (36.0% and 39.5% for failure and success, respectively). That is, the proposed asymmetric Lomax approach is a competitive model for differentiating binary data classification in imbalanced tasks against the Logistic approach. [ABSTRACT FROM AUTHOR]

Background : Several surgical options for degenerative lumbar spinal stenosis (LSS) are available, but current guidelines do not recommend which one should be prioritized. Although previous network meta-analyses (NMAs) have been performed on this topic, they have major methodological problems and could not provide the convincing evidence and clinical practical information required. Methods: Randomized controlled trials (RCTs) comparing at least two surgical interventions were included by searching AMED, CINAHL, EMBASE, the Cochrane Library, and MEDLINE (inception to August 2023). A frequentist random-effects NMA was performed for physical function and adverse events due to any reason. For physical function, three follow-up time points were included: short-term (< 6 months post-intervention), mid-term (≥ 6 months but < 12 months), and long-term (≥ 12 months). Laminectomy was the reference comparison intervention. Results: A total of 43 RCTs involving 5017 participants were included in the systematic review and 28 RCTs encompassing 14 types of surgical interventions were included in the NMA. For improving physical function (scale 0–100), endoscopic-assisted laminotomy (mean difference: − 8.61, 95% confidence interval: − 10.52 to − 6.69; moderate-quality evidence), laminectomy combined with Coflex (− 8.41, − 13.21 to − 3.61; moderate quality evidence), and X-stop (− 6.65, − 8.60 to − 4.71; low-quality evidence) had small effects at short-term follow-up; no statistical difference was observed at mid-term follow-up (very low- to low-quality evidence); at long-term follow-up, endoscopic-assisted laminotomy (− 7.02, − 12.95 to − 1.08; very low-quality evidence) and X-stop (− 10.04, − 18.16 to − 1.93; very low-quality evidence) had a small and moderate effect, respectively. Compared with laminectomy, endoscopic-assisted laminotomy was associated with fewer adverse events due to any reason (odds ratio: 0.27, 0.09 to 0.86; low-quality evidence). Conclusions: For adults with degenerative LSS, endoscopic-assisted laminotomy may be the safest and most effective intervention in improving physical function. However, the available data were insufficient to indicate whether the effect was sustainable after 6 months. Trial registration: PROSPERO (CRD42018094180). [ABSTRACT FROM AUTHOR]

Gamma-terpinene (γ-TPN) is a cyclohexane monoterpene isolated from plant essential oils, such as tea tree (Melaleuca alternifolia), oregano (Origanum vulgare), rosemary (Rosmarinus officinalis L.), thyme (Thymus vulgaris Marchand), and eucalyptus (Eucalyptus sp.). Terpenes are widely studied molecules pharmacologically active on the cardiovascular system, hemostasis, and antioxidant actions. Herein, it was investigated the cytotoxic and antiplatelet activity of γ-TPN using different non-clinical laboratory models. For in silico evaluation, the PreADMET, SwissADME, and SwissTargetPrediction softwares were used. Molecular docking was performed using the AutoDockVina and BIOVIA Discovery Studio databases. The cytotoxicity of γ-TPN was analyzed by the MTT assay upon normal murine endothelial SVEC4-10 and fibroblast L-929 cells. Platelet aggregation was evaluated with platelet-rich (PRP) and platelet-poor (PPP) plasma from spontaneously hypertensive rats (SHR), in addition to SVEC4-10 cells pre-incubated with γ-TPN (50, 100, and 200 µM) for 24 h. SHR animals were pre-treated by gavage with γ-TPN for 7 days and divided into four groups (negative control, 25, 50, and 100 mg/kg). Blood samples were collected to measure nitrite using the Griess reagent. Gamma-TPN proved to be quite lipid-soluble (Log P = +4.50), with a qualified profile of similarity to the drug, good bioavailability, and adequate pharmacokinetics. It exhibited affinity mainly for the P2Y12 receptor (6.450 ± 0.232 Kcal/mol), moderate cytotoxicity for L-929 (CC50 = 333.3 µM) and SVEC 4-10 (CC50 = 366.7 µM) cells. The presence of γ-TPN in SVEC 4-10 cells was also able to reduce platelet aggregation by 51.57 and 44.20% at lower concentrations (50 and 100 µM, respectively). Then, γ-TPN has good affinity with purinergic receptors and an effect on the reversal of platelet aggregation and oxidative stress, being promising and safe for therapeutic targets and subsequent studies on the control of thromboembolic diseases. [ABSTRACT FROM AUTHOR]

This study evaluates the links between representative indices of companies with high environmental performance and the propensity of such indices to economic and financial shocks. Five indices, representing environmental segments and four global macroeconomic and financial variables, were analyzed over a thirteen-year period, which included various crisis moments, such as the sovereign debt crisis, the COVID-19 pandemic and the onset of the Russia/Ukraine conflict. Using dynamic and nonlinear models, our research reveals statistically significant and consistent relationships between the variables under investigation, particularly during periods of global financial and pandemic crises. The analysis revealed that the VIXCLS is the most influential global risk factor, with certain risk factors being influenced by environmental segments, particularly Alternative Energy. This influence can create conditions conducive to contagion risk and diminish the benefits of portfolio diversification. This study contributes to a deeper understanding of the connection between environmental investments and their vulnerability to significant global events and risks. [ABSTRACT FROM AUTHOR]

Polyelectrolyte complexes (PECs) of Xylan (Xyl) and Chitosan (Ch) were investigated as coating materials to enhance paper properties for food packaging applications. These complexes were blended with different contents of micro/nanofibrillated cellulose (M/NFC) (5–20 wt% of total dry coating weight) to explore potential synergistic effects. The rheological strength and gel properties of the resulting Xyl/Ch PEC-M/NFC formulations were assessed. Coated papers underwent comprehensive analyses, including examinations of morphology, oxygen and water vapor barrier properties, mechanical strength, and printing characteristics. The addition of M/NFC resulted in increased shear viscosity and yield stress of the coating formulations. Additionally, it enhanced the surface wettability of the coated papers, leading to higher contact angles when measured with water and castor oil. Xyl/Ch PEC coated paper exhibited a drastic reduction in Gurley air permeability and development of enhanced barrier properties compared to the base paper. On the other hand, the printing properties, including gamut area, gamut volume and optical density of the Xyl/Ch PEC coated papers, were superior to those of papers coated only with starch. These results demonstrate the promising potential of Xyl/Ch PEC-M/NFC coating formulations for enhancing paper properties and their suitability for food packaging applications. [ABSTRACT FROM AUTHOR]

Piecewise models have gained popularity as a useful tool in reliability and quality control/monitoring, particularly when the process data deviates from a normal distribution. In this study, we develop maximum likelihood estimators (MLEs) for the process capability indices, denoted as $ C_{pk} $ C pk , $ C_{pm} $ C pm , $ C^{*}_{pm} $ C pm ∗ and $ C_{pmk} $ C pmk , using a semiparametric model. To remove the bias in the MLEs with small sample sizes, we propose a bias-correction approach to obtain improved estimates. Furthermore, we extend the proposed method to situations where the change-points in the density function are unknown. To estimate the model parameters efficiently, we employ the profiled maximum likelihood approach. Our simulation study reveals that the suggested method yields accurate estimates with low bias and mean squared error. Finally, we provide real-world data applications to demonstrate the superiority of the proposed procedure over existing ones. [ABSTRACT FROM AUTHOR]

Background: Global policy and guidelines for low back pain (LBP) management promote physical activity and self-management yet adherence is poor and a decline in outcomes is common following discharge from treatment. Health coaching is effective at improving exercise adherence, self-efficacy, and social support in individuals with chronic conditions, and may be an acceptable, cost-effective way to support people in the community following discharge from treatment for LBP. Aim: This qualitative study aimed to understand which aspects of a community over-the-phone health-coaching program, were liked and disliked by patients as well as their perceived outcomes of the service after being discharged from LBP treatment. Methods: A purposive sampling approach was used to recruit 12 participants with chronic LBP, from a large randomised controlled trial, who were randomly allocated to receive a health coaching program from the Get Healthy Service® in Australia. Semi-structured interviews were conducted, and a general inductive thematic analysis approach was taken. Results: The main themes uncovered regarding the intervention included the positive and negative aspects of the health coaching service and the relationship between the participant and health coach. Specifically, the participants spoke of the importance of the health coach, the value of goal setting, the quality of the advice received, the benefits of feeling supported, the format of the coaching service, and LBP-specific knowledge. They also reported the health coach and the coaching relationship to be the primary factors influencing the program outcomes and the qualities of the coaching relationship they valued most were connection, communication, care, and competence. The sub-themes uncovered regarding the outcomes of the intervention included positive impacts (a greater capacity to cope, increased confidence, increased motivation and increased satisfaction) and negative impacts (receiving no personal benefit). Clinical implications: In an environment where self-management and self-care are becoming increasingly important, understanding the patient's experience as part of a coaching program is likely to lead to improved quality of health coaching care, more tailored service delivery and potentially more effective and cost-effective community-based care for individuals with chronic LBP in the community after being discharged from treatment. Trial Registration: The GBTH trial was prospectively registered with the Australian New Zealand Clinical Trials Registry (ACTRN12620000889954) on 10/9/2020. Ethical approval was prospectively granted by the Western Sydney Local Health District Human Research and Ethics Committee (2020/ETH00115). Written informed consent was obtained from all participants. The relevant sponsor has reviewed the study protocol and consent form. [ABSTRACT FROM AUTHOR]

This study investigated the impact of the people category of the Sustainable Development Goals (SDGs) on sustainable and conventional economic growth in Asia and the Pacific region, using a sample of 52 selected countries between 2000 and 2023. Employing two distinct models, model A1 for conventional economic growth and model A2 for sustainable economic growth, we explained the relationships between five SDG indicators: employed poverty rate, stunted children, expenditure on health, expenditure of education, and % of women MNAs on economic growth. This study employed a fixed-effect model and random-effect model to investigate the impact of the people category SDGs on traditional and sustainable economic growth. The comparative analysis of each SDG in both models revealed valuable insights. SDG 1, "employed poverty rate", has a positive impact on economic growth in both models, while SDG 2, "percentage of stunted child", did not significantly influence economic growth in either model. Moreover, SDG 3 and SDG 4, relating to "government's health expenditure per capita" and "government's Education education expenditure per capita", respectively, exhibited a positive impact on traditional and sustainable economic growth. Conversely, SDG 5, "percentage of women members of national parliament", displayed an insignificant impact on traditional and sustainable economic growth models. In conclusion, this study suggests that policymakers should prioritize targeted interventions to alleviate employed poverty, enhance healthcare, and boost education spending. Moreover, promoting women's representation in national parliaments should be approached with context-specific strategies to maximize its impact on economic growth. [ABSTRACT FROM AUTHOR]

Over the past years, transport mode recognition has become a large field of research. However, flight as a type of transportation has been mostly overlooked. A system for flight detection might be useful for context-aware applications, but more importantly, it can be used to automatically manage airplane mode on smartphones. Smartphones transmit radio frequency signals which could potentially interfere with aircraft systems, and it is therefore important that devices enable airplane mode to avoid this problem. This paper proposes flyDetect, a method for automatic flight mode detection and an embodiment in the form of an app that demonstrates the viability of the method. Thus, the system uses the accelerometer and barometer in an Android smartphone, can detect the start and end of a flight, and notify other apps or systems on the device when this happens. Our evaluation shows that flyDetect meets the requirements set for the solution, and the results are very promising. [ABSTRACT FROM AUTHOR]

Environmental reference conditions (RC) and historical trends are crucial for assessing the degree of freshwater impact and formulating restoration measures. This is particularly relevant for freshwater systems used as potable water sources. Using sediments from the Carlos Maggiolo reservoir (Minas, Uruguay), located in a watershed with a mining history, this study aimed to (1) establish metal (As, Cr, Cu, Ni, Pb, and Zn) RC using a predicted interval (PI) chemometric technique; (2) evaluate metal enrichment and toxicity over time and space; and (3) assess environmental changes examining geochemical proxies. Surface sediments from 29 stations were used to establish RC and a core from the dam area was sampled to infer past conditions. The sediments were submitted to partial digestion and analyzed by inductively coupled plasma optical emission spectrometry- ICP-OES. Enrichment factor (EF) calculated using both PI and bottom core values did not show significant differences over time. Over space and time, most metals primarily originated from natural sources (EF < 2). The PI in mg/kg was Cr: 23.74–37.32; Cu: 25.75–48.99; Ni: 16.29–25.55; Pb: 7.63–13.75; and Zn: 94.34–174.80. A stratigraphically constrained cluster analysis corroborated by a permutational multivariate analysis of variance categorized the reservoir into two zones: Zone I, before reservoir operation to ~ 1996, and Zone II from ~ 1997 to 2017. The average concentrations of the main metals of toxicological interest in zones I and II, respectively, were as follows: Cr 37.60 ± 1.59, 34.54 ± 1.49 mg/kg; Cu 49.76 ± 2.84, 44.55 ± 2.70 mg/kg; Ni 24.11 ± 0.67, 22.53 ± 1.22 mg/kg; Pb 12.40 ± 0.63, 13.52 ± 0.82 mg/kg; Zn 99.25 ± 3.12, 93.86 ± 4.42 mg/kg; Mn 1160.56 ± 68.88, 1441.61 ± 83.55 mg/kg; and P 1243.21 ± 271.56, 1128.42 ± 183.10 mg/kg. According to a principal component analysis, the period preceding reservoir operation until ~ 1985 was linked to mining activities and application of Cu2SO4, and the period from 1985s to 2000 was influenced by C and P concentrations due to increasing agricultural and afforestation activities in the watershed that consume P fertilizers. The most recent period, from 2000 to ~ 2017, was characterized by an increase in sedimentation rates mainly associated with erosion, particularly in the agricultural areas. This subsequent soil loss in the watershed could compromise the reservoir's useful life. This study contributes to a better understanding of metal geochemistry in subtropical reservoirs and aids in formulating effective recovery and restoration measures. [ABSTRACT FROM AUTHOR]

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Nematodes from the genus Meloidogyne are extremely harmful to agricultural crops due to their wide geographic distribution, variety of hosts, and strong reproductive capacity. The most used phytonematoid control method is the application of nematicides, which can also affect human health and the environment. Selenol ester derivatives have pharmaceutical applications, but little is known about their biological activities. We examined whether six selenol ester derivatives were nematicidal and ovicidal to the nematodes Caenorhabditis elegans and Meloidogyne incognita, and determined their toxicity to non-target organisms. The compound Se-p-methyl phenylselenobenzoate (2e) exhibited the lowest nematicidal and ovicidal Lethal concentration (LC50) to C. elegans (4.42 and 0.56 mg/L, respectively) and M. incognita (4.6 and 2.77 mg/L, respectively), which were similar or lower than the LC50 values for the control treatment with fluensulfone in C. elegans (4.07 and 6.05 mg/L, respectively) and M. incognita (43.07 and 49.63 mg/L, respectively). Compound 2e efficiently controlled the phytoparasite in greenhouse and reduced the number of galls and eggs present in tomato roots. Compared with the negative control, compound 2e was not toxic to other organisms such as Chlorella vulgaris algae, Galleria mellonella and Aedes aegypti larvae, and the aquatic protozoan Tetrahymena pyriformis. Our findings indicate that the selenol ester derivatives are potent and effective nematicides with no toxicity to the non-target organisms tested. [ABSTRACT FROM AUTHOR]

The objective of this study was to evaluate the effect of incorporating different concentrations of graphene oxide (GO) nanoparticles on the mechanical properties of a resin-modified glass ionomer cement (RMGIC). A commercial RMGIC (Resiglass R, Biodinâmica) was modified by incorporating 0.1% and 0.5% (by weight) of GO into the powder's material. An unmodified RMGIC was used as a control group. Powder samples were characterized using Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS). Specimens were fabricated and subjected to flexural strength (n = 15), modulus of elasticity (n = 15), Vicker's microhardness (n = 10), and surface roughness tests (n = 10). Data were analyzed using one-way ANOVA and Tukey's post hoc test (α = 5%). Experimental groups' powder demonstrated a homogeneous dispersion of GO. No statistically significant difference was observed in flexural strength (p = 0.067) and modulus of elasticity (p = 0.143) tests. The groups containing 0.1% and 0.5% GO showed significantly higher microhardness and lower surface roughness values (p < 0.001) compared to the control group. The incorporation of GO nanoparticles at concentrations of 0.1% and 0.5% improved the microhardness and surface roughness without negatively affecting the flexural strength and modulus of elasticity of an RMGIC. [ABSTRACT FROM AUTHOR]

This study aims to examine the influence of individual and organizational factors on the implementation of circular economy (CE) practices in SMEs in Bangladesh. A non-probability sampling technique is utilized to select a sample of 280 respondents from the textile and leather industries. Data are collected through a survey assessing individual factors such as environmental consciousness and innovation propensity, as well as organizational factors including leadership commitment and training and development programs. A frequency table is used to give the respondents' details, and skewness and kurtosis are conducted to find the data normality. Reliability and validity analyses are conducted to ensure the robustness of the measurement instruments. A correlation matrix is generated to examine the relationships between variables, followed by a multiple regression analysis to test the hypothesized relationships. The preliminary findings indicate a significant correlation between individual and organizational factors and the implementation of CE practices. The multiple regression analysis reveals that both sets of factors contribute significantly to explaining the variance in CE implementation. The results indicate that environmental consciousness, innovation propensity, leadership commitment, and training and development programs emerge as significant predictors of CE implementation within these industries. This study offers valuable insights and sheds light on the role of individual and organizational factors in shaping sustainable practices. The findings contribute to the explanatory literature on CE implementation, providing empirical evidence to inform policymaking and business strategies aimed at promoting sustainability in the SME sector and beyond. [ABSTRACT FROM AUTHOR]

Objective The aims of the study were to identify prognostic factors associated with health care outcomes in patients with musculoskeletal (MSK) conditions in primary care and to determine whether characteristics associated with choice of care modify treatment effects of a direct-access physical therapist–led pathway in addition to general practitioner (GP)–led care compared to GP-led care alone. Methods A secondary analysis of a 2-parallel-arm, cluster randomized controlled trial involving general practices in the United Kingdom was conducted. Practices were randomized to continue offering GP-led care or to also offer a direct-access physical therapist–led pathway. Data from adults with MSK conditions who completed the 6-month follow-up questionnaire were analyzed. Outcomes included physical health, opioid prescription, and self-reported health care utilization over 6 months. Treatment effect modifiers were selected a priori from associations in observational studies. Multivariable regression models identified potential prognostic factors, and interaction analysis tested for potential treatment effect modifiers. Results Analysis of 767 participants indicated that baseline pain self-efficacy, pain severity, and having low back pain statistically predicted outcomes at 6 months. Higher pain self-efficacy scores at baseline were associated with improved physical health scores, reduced opioid prescription, and less health care utilization. Higher bodily pain at baseline and having low back pain were associated with worse physical health scores and increased opioid prescription. Main interaction analyses did not reveal that patients' age, level of education, duration of symptoms, or MSK presentation influenced response to treatment, but visual trends suggested those in the older age group proceeded to fewer opioid prescriptions and utilized less health care when offered direct access to physical therapy. Conclusions Patients with MSK conditions with lower levels of pain self-efficacy, higher pain severity, and presenting with low back pain have less favorable clinical and health care outcomes in primary care. Prespecified characteristics did not modify the treatment effect of the offer of a direct-access physical therapist–led pathway compared to GP-led care. Impact Patients with MSK conditions receiving primary care in the form of direct-access physical therapist–led or GP-led care who have lower levels of self-efficacy, higher pain severity, and low back pain are likely to have a less favorable prognosis. Age and duration of symptoms should be explored as potential patient characteristics that modify the treatment response to a direct-access physical therapist–led model of care. [ABSTRACT FROM AUTHOR]

The aim of the current study is to identify grapevine rootstocks with the potential to tolerate excessive Cu concentrations. Four grapevine rootstock genotypes were tested: Paulsen 1103, IAC 572, SO4 and Isabel. The plants were cultivated in nutrition solution added to the following treatments: 0.3 µM Cu and 80 µM Cu. Growth, nutrient concentration in tissue and the physiological and biochemical parameters were assessed. Rootstocks showed different growth responses to Cu excess in the solution. SO4, IAC 572 and Isabel markedly reduced growth under Cu excess compared to plants in the control solution, whereas genotype Paulsen 1103 showed a less pronounced effect. The root system of all genotypes presented a Cu increase under a high Cu concentration, as well as higher POD activity and H2O2 concentration than the control. Isabel presented the greatest sensitivity to Cu excess, as shown by leaf wilting and yellowing. Paulsen 1103 rootstock presented smaller changes in the observed parameters in the high Cu concentration solution than in the control solution. Our results indicate that Paulsen 1103 is the most tolerant to Cu excess, whereas Isabel is the most sensitive. There are natural genetic variations in tolerance to this abiotic stress that typically affect grapevine plants. [ABSTRACT FROM AUTHOR]

Kaposi sarcoma (KS) is a neoplasm of vascular origin that promotes angiogenesis and the growth of endothelial cells triggered by the Kaposi Sarcoma‐associated Herpes Virus (KSHV). When associated with HIV, KSHV becomes more aggressive and rapidly evolves. The HIV‐1 TAT protein can be essential in developing AIDS‐associated KS by promoting angiogenesis and increasing KSHV replication. Therefore, we evaluated the genetic profile of the first exon of tat gene among groups of people living with HIV (PLHIV) with (case group, n = 36) or without KS, this later with (positive control group, n = 46) and without KSHV infection (negative control group, n = 24); all individuals under antiretroviral therapy. The genetic diversity, the DN/DS ratio, and the genetic entropy of the first exon of tat were higher in the case group, followed by the positive control group, which was higher than the negative control group. The number of tat codons under positive selection was seven in the case group, six in the positive control group, and one in the negative control group. The prevalence of HIV viral loads below the detection limit was equal in the case and positive control groups, which were lower than in the negative control group. The mean CD4+ T cell counts were higher in the negative control group, followed by the positive control group, and followed by the case group. These results emphasize the negative influence of KSHV in antiretroviral treatment, as well as the HIV‐specific TAT profile among PLHIV who developed KS. [ABSTRACT FROM AUTHOR]

Background: Scarce data related to the drug survival of biologic agents in psoriasis patients aged ≥65 years is available. Objectives: To evaluate the drug survival of interleukin (IL)‐23 or the IL‐17 inhibitors approved for the treatment of moderate‐to‐severe psoriasis in elderly patients (aged ≥65 years), compared with younger adult patients (aged <65 years), and to identify clinical predictors that can influence the drug survival. Methods: This retrospective multicentric cohort study included adult patients with moderate‐to‐severe psoriasis, dissecting two‐patient subcohorts based on age: elderly versus younger adults. Kaplan–Meier estimator and proportional hazard Cox regression models were used for drug survival analysis. Results: We included 4178 patients and 4866 treatment courses; 934 were elderly (1072 treatment courses), and 3244 were younger patients (3794 treatment courses). Drug survival, considering all causes of interruption, was higher in patients aged <65 years than in elderly patients overall (log‐rank p < 0.006). This difference was significant for treatment courses involving IL‐23 inhibitors (p < 0.001) but not for those with IL‐17 inhibitors (p = 0.2). According to both uni‐ and multi‐variable models, elder age was associated with an increased risk of treatment discontinuation (univariable analysis: HR: 1.229, 95% CI 1.062–1.422; p < 0.006; multivariable analysis: HR: 1.199, 95% CI 1.010–1.422; p = 0.0377). Anti‐IL‐23 agents were associated with a reduced likelihood of treatment discontinuation after adjusting for other variables (HR: 0.520, 95% CI 0.368–0.735; p < 0.001). Being previously treated with IL‐17 inhibitors increased the probability of discontinuation. Conclusions: Elderly patients with psoriasis have an increased risk of biologic treatment discontinuation compared with younger adult patients, particularly, if being treated with IL‐23 inhibitors. However, in stratified analyses conducted in elderly patients, IL‐23 inhibitors showed higher drug survival rates than IL‐17 inhibitors. [ABSTRACT FROM AUTHOR]

Imperfect repairs (IRs) are widely applicable in reliability engineering since most equipment is not completely replaced after failure. In this sense, it is necessary to develop methodologies that can describe failure processes and predict the reliability of systems under this type of repair. One of the challenges in this context is to establish reliability models for multiple repairable systems considering unobserved heterogeneity associated with systems failure times and their failure intensity after performing IRs. Thus, in this work, frailty models are proposed to identify unobserved heterogeneity in these failure processes. In this context, we consider the arithmetic reduction of age (ARA) and arithmetic reduction of intensity (ARI) classes of IR models, with constant repair efficiency and a power‐law process distribution to model failure times and a univariate Gamma distributed frailty by all systems failure times. Classical inferential methods are used to estimate the parameters and reliability predictors of systems under IRs. An extensive simulation study is carried out under different scenarios to investigate the suitability of the models and the asymptotic consistency and efficiency properties of the maximum likelihood estimators. Finally, we illustrate the practical relevance of the proposed models on two real data sets. [ABSTRACT FROM AUTHOR]

Hydrogen is undeniably one of the most promising options for producing energy with minimal environmental impact. However, current hydrogen production is still derived from carbon-intensive processes relying on fossil fuels. Biomass is a sustainable and versatile resource that can be converted into hydrogen through biological and thermochemical pathways from a large variety of feedstocks and technologies. This work reviews and compares existing biomass-to-hydrogen technologies, focusing on their characteristics, maturity level, benefits, limitations, and techno-economic and lifecycle environmental impacts. Less-developed biological conversion methods are characterized by low efficiencies and hydrogen productivity. More mature thermochemical routes enable higher efficiencies and hydrogen yields. Overall, while thermochemical processes suit centralized large-scale hydrogen production, biological pathways offer decentralized options, necessitating continued innovation for integration into future energy strategies. Some of these technologies, such as anaerobic digestion (best-case: 1.28 EUR/kgH2) and conventional gasification (best-case: 1.79 EUR/kgH2), emerge as promising, sustainable, and affordable alternatives for renewable hydrogen generation, offering production costs comparable to those of natural gas steam reforming (0.92–2.8 EUR/kgH2). [ABSTRACT FROM AUTHOR]

Propylparaben (PrP) and dichloropropylparaben (diClPrP) are found in soil worldwide, mainly due to the incorporation of urban sludge in crop soils and the use of non-raw wastewater for irrigation. Studies on the adverse effects of PrP on plants are incipient and not found for diClPrP. PrP and diClPrP were evaluated at concentrations 4, 40, and 400 µg/L for their phytotoxic potential to seeds of Allium cepa (onion), Cucumis sativus (cucumber), Lycopersicum sculentum (tomato), and Lactuca sativa (lettuce), and cytotoxic, genotoxic potential, and for generating oxygen-reactive substances in root meristems of A. cepa bulbs. PrP and diClPrP caused a significant reduction in seed root elongation in all four species. In A. cepa bulb roots, PrP and diClPrP resulted in a high prophase index; in addition, PrP at 400 µg/L and diClPrP at the three concentrations significantly decreased cell proliferation and caused alterations in a significant number of cells. Furthermore, diClPrP concentrations induced the development of hooked roots in onion bulbs. The two chemical compounds caused significant changes in the modulation of catalase, ascorbate peroxidase, and guaiacol peroxidase, disarming the root meristems against hydroxyl radicals and superoxides. Therefore, PrP and diClPrP were phytotoxic and cytogenotoxic to the species tested, proving dangerous to plants. [ABSTRACT FROM AUTHOR]

Alpha-terpineol is a monoterpene alcohol found in essential oils from medicinal plants with some well-known pharmacological activities and widely used in cosmetics. However, the toxicological effects and additional pharmacological activities need to be clarified. Thus, the study evaluated the toxic, cytotoxic, genotoxic, hemolytic, and oxidative potential of alpha-terpineol in non-clinical bioassays. Different concentrations of alpha-terpineol were used in bioassays, including MTT (50, 100, 200, and 400 μg/mL), Artemia salina (6.25–400 μg/mL), Allium cepa (10, 50, and 100 μg/mL), comet assay (100, 200, and 500 μg/mL), cytokinesis-block micronucleus (100, 250, and 500 μg/mL), confocal microscopy for apoptosis quantification (100 and 500 μg/mL), hemolysis and Saccharomyces cerevisiae central disk test (10, 35, and 75 μg/mL). For the MTT test, alpha-terpineol was more cytotoxic on melanoma murine B16–F10 cells rather than macrophages. For A. salina test, alpha-terpineol showed LC50 of 68.29 and 76.36 μg/mL for 24 h and 48 h of exposure time, respectively. Meanwhile, alpha-terpineol was also cytotoxic to meristematic cells, which revealed inhibition of cellular division and mutagenic action by formation of bridges and delayed anaphases. The compound increased damage index and frequency of damage corroborated by the presence of micronuclei, bridges and nuclear buds at 500 μg/mL, but it caused neither hemolysis, oxidative damage on the S. cerevisiae nor cell death in normal fibroblasts. The findings indicate alpha-terpineol has cytotoxic potential by cytogenetic and molecular mechanisms associated with apoptosis and probable target effects against melanoma cells. [ABSTRACT FROM AUTHOR]

This article presents a Statistical Process Control (SPC) framework considering the response process as a unit variable, which demands special treatment. This study designed a Shiny app related to data visualization and inferential estimation adopting SPC charts and Extreme Value Theory. We also proposed a new flexible unit probabilistic model (named FlexShape), which is simple yet overcomes skew information and bimodality in historical data, as part of the complex learning task. Results showed that the proposed framework enables it to handle unit data sets. As an example, we presented data storytelling from the water particle monitoring (relative humidity) from one Atacama Desert station, known to be one of the driest areas on Earth, across hidden patterns such as inundation and microweather. Finally, the developed framework makes possible any research on the univariate unit data decision-making, enabling the database import and adjusting some parametric models, and enabling the comparison of different units' distribution goodness-of-fit. [ABSTRACT FROM AUTHOR]

Background: Despite the well-known benefits of physical activity, physical inactivity is presently a global health pandemic. Allied healthcare providers, such as chiropractors, knowingly recognise the importance of physical activity and are prepared to routinely discuss and/or counsel patients on this topic; however, little is known about Australian chiropractors in the physical activity setting. Our aim was to explore and identify factors associated with physical activity promotion among Australian chiropractors, including their knowledge of the physical activity and sedentary behaviour guidelines and their own levels of physical activity. Methods: From February to May 2021, a convenience sample of Australian chiropractors completed an online survey. Items assessed by Likert scale included: physical activity promotion frequency, with the type, quantity, barriers, perceptions, and feasibility. We asked questions about their familiarity with, and knowledge of, Australian Physical Activity and Sedentary Behaviour Guidelines, chiropractors' own physical activity, and whether the chiropractors met activity guidelines. Survey responses were descriptively reported. Univariable logistic regression models explored factors explaining frequent physical activity promotion. Results: Of 217 respondents, 64% reported that they frequently (≥ 70%) recommended a more physically active lifestyle. Only 15% often performed pre-exercise screening, 73% frequently prescribed resistance exercise, 19% reported time as the most frequent barrier, while 37% reported being not at all familiar with the guidelines. Univariable logistic regression models found male chiropractors were more likely to promote physical activity, [odds ratio (OR) = 2.33; 95% confidence interval (CI): 1.32–4.12)], while chiropractors who frequently treat children 0–3 years (OR = 0.5; 95% CI: 0.28–0.87), children 4–18 years (OR = 0.42; 95% CI: 0.21–0.86), and pregnant women (OR = 0.5; 95% CI: 0.26–0.94) were less likely. Chiropractors were more likely to promote physical activity if they were familiar with the activity guidelines (OR = 2.9; 95% CI: 1.32–6.41), were confident promoting (OR = 11.6; 95% CI: 1.37–98.71) and prescribing physical activity programs (OR = 4.5; 95% CI: 2.03–9.99). Conclusion: Most chiropractors confidently and regularly integrate physical activity into practice. Yet, despite acknowledging its importance, one third of chiropractors reported poor knowledge of the Physical Activity and Sedentary Behaviour Guidelines. Identifying barriers to the awareness, and implementation of physical activity guidelines should be further explored within chiropractic clinical settings. [ABSTRACT FROM AUTHOR]

The relationship between education and societal development is unquestionable. Education contributes to achieving both societies' and individuals' social and economic goals. Quality education is recognized as one of the Sustainable Development Goals (SDGs), which, jointly with other behaviors and attitudes, could impact the development of societies in other fields like health and well-being, cultural preservation, environmental sustainability, and even peace and stability—all of them also listed as SDGs. However, the capacity, or not, to reach higher levels of compliance with quality in education (SDG 4) varies from country to country, according to the 2023 Sustainable Development Report results. Thus, the present study aims to identify the sufficient conditions for achieving higher levels of quality education (SDG 4) globally and to analyze how these conditions vary across different world regions. Applying a fuzzy set qualitative comparative analysis and using data from the 2023 Sustainable Development Report, we focus our analysis on four SDG 4 indicators—early education, primary education, lower secondary education, and literacy rate—across 117 countries, in order to assess the conditions for attaining higher levels of quality education. The results reveal there are specific and identifiable conditions that are sufficient for achieving higher levels of quality education on a global scale, with significant regional variations. These insights contribute to understanding the complex dynamics of educational quality and could be used as guidance for policymakers and educators aiming to improve educational outcomes worldwide. [ABSTRACT FROM AUTHOR]

Advanced lithium‐ion batteries (LIBs) are crucial to portable devices and electric vehicles. However, it is still challenging to further develop the current anodic materials such as graphite due to the intrinsic limited capacity and sluggish Li‐ion diffusion. Indium nitride (InN), which is a new type of anodic material with low redox potential (<0.7 V vs Li/Li+) and narrow bandgap (0.69 eV), may serve as a new high‐energy density anode material for LIBs. Here, the growth of 1D single crystalline InN nanowires is reported on Au‐decorated carbon fibers (InN/Au‐CFs) via chemical vapor deposition, possessing a high aspect ratio of 400. The binder‐free Au‐CFs with high conductivity can provide abundant sites and enhance binding force for the dense growth of InN nanowires, displaying shortened Li ion diffusion paths, high structural stability, and fast Li+ kinetics. The InN/Au‐CFs can offer stable and high‐rate Li delithiation/lithiation without Li deposition, and achieve a remarkable capacity of 632.5 mAh g−1 at 0.1 A g−1 after 450 cycles and 416 mAh g−1 at a high rate of 30 A g−1. The InN nanowires as battery anodes shall hold substantial promise for fulfilling superior long‐term cycling performance and high‐rate capability for advanced LIBs. [ABSTRACT FROM AUTHOR]

Methylparaben (MPB) and propylparaben (PPB) are produced in high volumes worldwide and constantly released into the environment. They are found in the soil mainly due to the incorporation of urban sewage sludge into agricultural soils and the use of wastewater in irrigation. No studies were found on the impact assessment of parabens in mixture in soil organisms. The main objective of this study was to assess the ecotoxicity of MPB and PPB in mixture to plants. MPB and PPB were evaluated separately at concentrations 0.1, 1, 10, and 100 ng/L, and in combinations MPB 0.1 × PPB 0.1, MPB 1 × PPB 1, MPB 10 × PPB 10, and MPB 100 × PPB 100. Individually, the two parabens were not phytotoxic and cytogenotoxic. In mixture, MPB and PPB caused a significant reduction in root elongation in seeds of A. cepa, C. sativus, L. esculentum, and L. sativa. In A. cepa bulbs, the interaction of MPB and PPB reduced root elongation by inhibiting cell division and causing disturbances to the mitotic spindle and chromosomal compaction in meristematic cells. Such disorders were triggered because MPB and PPB in combination inhibit the cells’ defense system, leading to excess hydrogen peroxide in root meristems. Therefore, there was a phytotoxic, cytotoxic, and genotoxic synergy between MPB and PPB in plants, from the MPB 0.1 × PPB 0.1 combination, demonstrating that these compounds in a mixture can negatively impact crop productivity and the development non-cultivated plants. [ABSTRACT FROM AUTHOR]

Cellulose nanofibrils (CNFs) are particles with a high aspect ratio. Typically, chemically pre-treated CNFs (containing anionic or cationic charged groups) consist of long fibrils (up to 2 μm) with very low thickness (less than 10 nm). Derived from their high aspect ratio, CNFs form strong hydrogels with high elasticity at low concentrations. Thus, CNF suspensions appear as an interesting rheology modifier to be applied in cosmetics, paints, foods, and as a mineral suspending agent, among other applications. The high viscosity results from the strong 3D fibril network, which is related to the good fibrillation of the material, allowing the nanofibrils to overlap. The overlap concentration (c*) was found to vary from ca. 0.13 to ca. 0.60 wt.% depending on the type and intensity of the pre-treatment applied during the preparation of the CNFs. The results confirm the higher tendency for the fibres treated with (3-chloro-2-hydroxypropyl) trimethylammonium chloride (CHPTAC) and 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) to form a 3D network, resulting in the lowest c*. For the TEMPO-oxidised CNF suspensions, it was also found that aggregation is improved at acidic pH conditions due to lower charge repulsion among fibrils, leading to an increase in the suspension viscosity as well as higher apparent yield stresses. TEMPO CNF suspensions with a low content of carboxylic groups tend to precipitate at moderately acidic pH values. [ABSTRACT FROM AUTHOR]

This study investigates the impact of geopolitical risk (GPR) on sustainable investments, focusing on five global environmental indices and two global GPR indices. Using Corrected Dynamic Conditional Correlation Generalised Autoregressive Conditional Heteroskedasticity (cDCC-GARCH) model and Diebold and Yilmaz's spillover analysis, we use daily data from January 2009 to October 2022, covering various market phases, including the European sovereign debt crisis, the COVID-19 pandemic, and the war in Ukraine. Results from the cDCC-GARCH model reveal high dynamic conditional correlations. During periods of high volatility, environmental indices displayed simultaneous and more intense responses, limiting investment diversification alternatives when considering only the environmental side. Diebold and Yilmaz's static analysis demonstrates that environmental segments are more influenced by systemic shocks than specific causes, with GPR's influence proving relatively weak. In the dynamic analysis, the spillover effects of GPR in environmental segments intensified during the pandemic crisis and the invasion of Ukraine, affecting market conditions. [ABSTRACT FROM AUTHOR]

Mutually entangled multi-photon states are at the heart of all-optical quantum technologies. While impressive progresses have been reported in the generation of such quantum light states using free space apparatus, high-fidelity high-rate on-chip entanglement generation is crucial for future scalability. In this work, we use a bright quantum-dot based single-photon source to demonstrate the high fidelity generation of 4-photon Greenberg-Horne-Zeilinger (GHZ) states with a low-loss reconfigurable glass photonic circuit. We reconstruct the density matrix of the generated states using full quantum-state tomography reaching an experimental fidelity to the target state of F GHZ 4 = (86.0 ± 0.4) % , and a purity of P GHZ 4 = (76.3 ± 0.6) % . The entanglement of the generated states is certified with a semi device-independent approach through the violation of a Bell-like inequality by more than 39 standard deviations. Finally, we carry out a four-partite quantum secret sharing protocol on-chip where a regulator shares with three interlocutors a sifted key with up to 1978 bits, achieving a qubit-error rate of 10.87%. These results establish that the quantum-dot technology combined with glass photonic circuitry offers a viable path for entanglement generation and distribution. [ABSTRACT FROM AUTHOR]

With the increase in the world population and economic activity, the production of sewage sludge has grown, and its management has become an environmental problem. The most traditional method of managing sewage sludge is to dispose of it in landfills and on farmland. One way to valorize sewage sludge is to use thermochemical conversion processes to produce added-value products such as biochar, biofuels, and renewable gases. However, due to the high moisture content, thermochemical conversion using processes such as pyrolysis and traditional gasification involves multiple pre-treatment processes such as material drying. Hydrothermal thermochemical processes usually require high pressures, which pose many challenges to their application on a large scale. In this work, the advantages and disadvantages of the different existing thermochemical processes for the recovery of sewage sludge were analyzed, as well as the resulting industrial and environmental challenges. A SWOT analysis was carried out to assess the different thermochemical processes in terms of technical feasibility, economic viability, and broader market considerations. [ABSTRACT FROM AUTHOR]

The development of anion-exchange membrane fuel cells (AEMFCs) has recently accelerated due to synergistic improvements yielding highly conductive membranes, stable ionomers, and enhanced alkaline electrocatalysts. However, cell durability, especially under realistic conditions, still poses a major challenge. Herein, we employ low-loadings of Pt-free Pd-based catalysts in the anode of AEMFCs and elucidate potential degradation mechanisms impacting long-term performance under conditions analogous to the real-world (high current density, H2-air (albeit CO2-free), and intermittent operation). Our high-performing AEMFCs achieve impressive performance with power densities approaching 1 W cm-2 and current densities up to 3.5 A cm-2. Over a 200 h period of continuous operation in H2-air at a current density of 600 mA cm-2, our model Pd/C-CeO2 anode cell exhibits record stability (~30 mV h-1 degradation) compared to the literature and up to 6× better stability than our Pd/C and commercial Pt/C anode cells. Following an 8 h shutdown, the Pd/C-CeO2 anode cell was restarted and continued for an additional 300 h with a higher degradation rate of ~600 mV h-1. Thorough in situ evaluations and post-stability analyses provide insights into potential degradation mechanisms to be expected during extended operation under more realistic conditions and provide mitigation strategies to enable the widespread development of highly durable AEMFCs. [ABSTRACT FROM AUTHOR]

This work intends to identify pollution sources along the margins of Guanabara Bay (GB; SE Brazil) through a multiproxy approach and Bayesian stable isotopic mixture model (BSIMM). For this purpose, 33 surface sediment samples were collected and analyzed for granulometry, geochemistry (heavy metals, total organic carbon—TOC, stable isotopes of carbon and nitrogen—δ13C and δ15N, Rock–Eval pyrolysis parameters—REPP), and physicochemical parameters. Metal concentrations (E) dissolved in water (EW), adsorbed by organic matter (EOM) and by Mn hydroxides (EMn), and total extracted concentrations (ET) were analyzed. Sampling was conducted in 2018 after an oil spill from Reduc Oil Refinery. Potential Ecological risk index (PERI), based on metals, classified 85% of the analyzed stations as having moderate to considerable ecological risk. The metals with the potential to cause the highest ecological risk were CdW, CdOM, PbOM, and HgOM. The combination of BSIMM and REPP data was an effective proxy for oil spill detection by indicating the presence of polycyclic aromatic hydrocarbons (PAHs). Relatively high TOC contents suggested that the analyzed stations are eutrophicated environments. BSIMM discriminated three groups of stations with different sources of organic matter (OM), endorsing the result previously shown by the cluster analysis: (A) Niterói region, Botafogo marina, Glória marina, Fiscal and Fundão islands with diffuse sources of OM, including marine phytoplankton and material of continental origin from highly polluted rivers and domestic sewage; (B) region near Fundão and Governador islands and Mangue Channel outlet with OM (≃70%) supplied by highly polluted streams and a small contribution of PAHs; (C) Duque de Caxias and Botafogo-Urca inlet with significant contributions of PAHs, materials from C-3 plants and rivers polluted by urban sewage. Results of linear regressions in conjunction with BSIMM indicate that HgMn and PbOM mainly affect Group A's stations. Although the eastern margin of GB (Niterói; Group A) showed greater oceanic interaction than the other groups, it presented substantial concentrations of metals, potentially harmful (i.e., Hg and Pb) to marine biota and human health. [ABSTRACT FROM AUTHOR]

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Safer analgesic drugs remain a hard challenge because of cardiovascular and/or gastrointestinal toxicity, mainly. So, this study evaluated in vivo the antiproliferative actions of a fraction with casearins (FC) from Casearia sylvestris leaves against human colorectal carcinomas and antihyperalgesic effects on inflammatory- or opiate-based pain relief and oncologic pain in Sarcoma 180 (S180)-bearing mice. Moreover, docking investigations evaluated the binding among Casearin X and NMDA(N-methyl-D-aspartate)-type glutamate receptors. HCT-116 colorectal carcinoma-xenografted mice were treated with FC for 15 days. Antinociceptive assays included chemically induced algesia and investigated mechanisms by pharmacological blockade. Intraplantar region S180-bearing animals received a single dose of FC and were examined for mechanical allodynia and behavior alterations. AutoDock Vina determined molecular interactions among Cas X and NMDA receptor subunits. FC reduced tumor growth at i.p. (5 and 10 mg/kg) and oral (25 mg/kg/day) doses (31.12–39.27%). FC reduced abdominal pain, as confirmed by formalin and glutamate protocols, whose antinociception activity was blocked by naloxone and L-NAME (neurogenic phase) and naloxone, atropine, and flumazenil (inflammatory phase). Meanwhile, glibenclamide potentiated the FC analgesic effects. FC increased the paw withdrawal threshold without producing changes in exploratory parameters or motor coordination. Cas X generated a more stable complex with active sites of the NMDA receptor GluN2B subunits. FC is a promising antitumor agent against colorectal carcinomas, has peripheral analgesic effects by desensitizing secondary afferent neurons, and inhibits glutamate release from presynaptic neurons and/or their action on cognate receptors. These findings emphasize the use of clerodane diterpenes against cancer-related pain conditions. [ABSTRACT FROM AUTHOR]

Efficiency in stock markets is essential for economic stability and growth. This study investigates the efficiency and herding behavior of the stock markets from the top economies of the world (known as G20 countries). We classify stock market indices using MSCI classification for the developed and emerging markets to provide a comparative examination using the latest data and by employing the robust multifractal detrended fluctuation (MFDFA) method. In addition to the full sample, the analysis uses sub-sample periods to reveal the hidden features and efficiencies of the G20 markets during the Russia–Ukraine War and COVID-19 for the first time. The findings show the availability of varied multifractality among all G20 stock markets during the overall and crisis periods, exhibit long-range correlations, and may support the fractal market hypothesis. In addition, Italy remains the least efficient, while Germany remains the most efficient stock market. The sub-sample results further reveal unevenness in the local fluctuations and resultant higher inefficiency considering the sheer magnitude and impact of crises on the G20 stock markets. However, the efficiency of developed stock markets performed better as compared to emerging markets. The study of G20 stock markets is useful and provides several implications for a wider audience. [ABSTRACT FROM AUTHOR]

Objective: Neighbourhood deprivation has been found to be associated with many health conditions, but its association with low back pain (LBP) and arthritis is unclear. This study aimed to examine the association between neighbourhood deprivation with LBP and arthritis, and its potential interaction with individual socioeconomic status (SES) on these outcomes. Methods: Monozygotic (MZ) twins from the Washington State Twin Registry were used to control for genetic and common environmental factors that could otherwise confound the purported relationship. Multilevel models were employed to examine the association between neighbourhood deprivation as well as individual-level SES with LBP/arthritis, adjusting for age, sex, body mass index (BMI) and residence rurality. Results: There were 6,380 individuals in the LBP sample and 2,030 individuals in the arthritis sample. Neighbourhood deprivation was not associated with LBP (P = 0.26) or arthritis (P = 0.61), and neither was its interaction with individual-level SES. People without a bachelor's degree were more likely to report LBP (OR 1.44, 95% CI 1.26–1.65) or both LBP and arthritis (OR 1.67, 95% CI 1.14–2.45) than those with a bachelor's degree, but not for arthritis alone (P = 0.17). Household income was not significantly associated with LBP (P = 0.16) or arthritis (p = 0.23) independent of age, sex, and BMI. Conclusion: Our study did not find significant associations between neighbourhood deprivation and the presence of LBP or arthritis. More research using multilevel modelling to investigate neighbourhood effects on LBP and arthritis is recommended. [ABSTRACT FROM AUTHOR]

Background: The prevalence of depression among people with chronic pain remains unclear due to the heterogeneity of study samples and definitions of depression. We aimed to identify sources of variation in the prevalence of depression among people with chronic pain and generate clinical prediction models to estimate the probability of depression among individuals with chronic pain. Methods: Participants were from the UK Biobank. The primary outcome was a "lifetime" history of depression. The model's performance was evaluated using discrimination (optimism-corrected C statistic) and calibration (calibration plot). Results: Analyses included 24,405 patients with chronic pain (mean age 64.1 years). Among participants with chronic widespread pain, the prevalence of having a "lifetime" history of depression was 45.7% and varied (25.0–66.7%) depending on patient characteristics. The final clinical prediction model (optimism-corrected C statistic: 0.66; good calibration on the calibration plot) included age, BMI, smoking status, physical activity, socioeconomic status, gender, history of asthma, history of heart failure, and history of peripheral artery disease. Among participants with chronic regional pain, the prevalence of having a "lifetime" history of depression was 30.2% and varied (21.4–70.6%) depending on patient characteristics. The final clinical prediction model (optimism-corrected C statistic: 0.65; good calibration on the calibration plot) included age, gender, nature of pain, smoking status, regular opioid use, history of asthma, pain location that bothers you most, and BMI. Conclusions: There was substantial variability in the prevalence of depression among patients with chronic pain. Clinically relevant factors were selected to develop prediction models. Clinicians can use these models to assess patients' treatment needs. These predictors are convenient to collect during daily practice, making it easy for busy clinicians to use them. [ABSTRACT FROM AUTHOR]

Tithonia diversifolia is a perennial bushy plant found in South America with significant ethnopharmacological importance as an antimalarial, antidiabetic, antibacterial, and anticancer agent. The aim of the present study was to determine the cytotoxicity of the ethanolic extract from leaves of T. diversifolia (TdE) on human cancer cell lines (HCT-116, SNB-19, NCIH-460 and MCF-7), as well as the mechanism of action involved in cell death and cellular modulation of oxidative stress. The TdE exhibited significant activity with IC50 values ranging from 7.12 to 38.41 μg/ml, with HCT-116 being the most sensitive cell line. Subsequent experiments were conducted with HCT-116 cell line. TdE decreased the number of viable cells, followed by induction of apoptotic events, increase in mitochondrial membrane permeabilization, and enhanced G2/M phase of the cell cycle. Pro-oxidative effects including elevated acidic vesicular organelle formation, lipid peroxidation, and nitric oxide by-products, as well as reduced levels of intracellular glutathione and reactive oxygen species production were also observed following incubation with TdE, which may lead to DNA damage followed by apoptotic cell death. These results demonstrate the potential of TdE ethanolic leaf extraction for biological activity and enhance the importance of continuing to study natural sources of plants for the development of anticancer agents. [ABSTRACT FROM AUTHOR]

Objective: Our objective was to evaluate the effectiveness of a three‐month physiotherapist‐delivered eHealth physical activity program compared with usual care to improve function in adults with low back pain or knee osteoarthritis in rural Australia. Methods: This was a parallel, two‐group, pragmatic, superiority, randomized controlled trial involving three‐ and six‐month posttreatment follow‐ups. There was a total of 156 adults with chronic nonspecific low back pain (n = 97) or knee osteoarthritis (n = 59) from rural Australia. The intervention involved an eHealth physical activity and an exercise program that included five to eight teleconsultations with a physiotherapist (primary time point three months) or usual care (eg, general practitioner, physiotherapy, and pain medication). The primary outcome was the Patient‐Specific Functional Scale (0–30), with a three‐point difference between groups being considered the minimum clinically important difference. Results: Participants receiving the eHealth intervention (n = 78) reported significantly greater and clinically worthwhile improvements in function (mean between‐group difference 3.6; 95% confidence interval [CI] 1.3–5.9) compared to participants receiving usual care (n = 78). Small but statistically significantly greater improvements in disability (7.2 of 100; 95% CI 2.1–12.3) and quality of life (4.5 of 100; 95% CI 0.0–9.0) also favored the eHealth group. No clinical or statistical differences between groups were found for the secondary outcomes of pain, coping skills, and physical activity levels. Conclusion: A physiotherapist‐delivered eHealth intervention is effective and provides clinically meaningful improvements in function compared to usual care for people with musculoskeletal pain in rural communities. These findings highlight the potential for eHealth‐based programs to improve access to evidence‐based exercise interventions for people with musculoskeletal pain in rural communities. [ABSTRACT FROM AUTHOR]

The growing impact of artificial intelligence (AI) on Humanity is unavoidable, and therefore, "AI literacy" is extremely important. In the field of education—AI in education (AIED)—this technology is having a huge impact on the educational community and on the education system itself. The present study seeks to assess the level of AI literacy and knowledge among teachers at Portalegre Polytechnic University (PPU), aiming to identify gaps, find the main opportunities for innovation and development, and seek the degree of relationship between the dimensions of an AI questionnaire, as well as identifying the predictive variables in this matter. As a measuring instrument, a validated questionnaire based on three dimensions (AI Literacy, AI Self-Efficacy, and AI Self-Management) was applied to a sample of 75 teachers in the various schools of PPU. This revealed an average level of AI literacy (3.28), highlighting that 62.4% of responses are at levels 3 and 4 (based on a Likert scale from 1 to 5). The results also demonstrate that the first dimension is highly significant for the total dimensions, i.e., for AI Literacy, and no factor characterizing the sample is a predictor, but finding a below-average result in the learning factor indicates a pressing need to focus on developing these skills. [ABSTRACT FROM AUTHOR]

The historical impacts of eutrophication processes were investigated in six subtropical reservoirs (São Paulo, Brazil) using a paleolimnological approach. We questioned whether the levels of pigment indicators of algal biomass could provide information about trophic increase and whether carotenoid pigments could offer additional insights. The following proxies were employed: organic matter, total phosphorus, total nitrogen, photosynthetic pigments (by high-performance liquid chromatography), sedimentation rates, and geochronology (by 210 Pb technique). Principal component analysis indicated a gradient of eutrophication. In eutrophic reservoirs (e.g., Rio Grande and Salto Grande), levels of lutein and zeaxanthin increased over time, suggesting growth of Chlorophyta and Cyanobacteria. These pigments were significantly associated with algal biomass, reflecting their participation in phytoplankton composition. In mesotrophic reservoirs, Broa and Itupararanga, increases and significative linear correlations (r > 0.70) between pigments and nutrients are mainly linked to agricultural and urban activities. In the oligotrophic reservoir Igaratá, lower pigment and nutrient levels reflected lesser human impact and good water quality. This study underscores eutrophication's complexity across subtropical reservoirs. Photosynthetic pigments associated with specific algal groups were informative, especially when correlated with nutrient data. The trophic increase, notably in the 1990s, may have been influenced by neoliberal policies. Integrated pigment and geochemical analysis offers a more precise understanding of eutrophication changes and their ties to human factors. Such research can aid environmental monitoring and sustainable policy development. [ABSTRACT FROM AUTHOR]

The transition to a low-carbon economy is imperative to reduce reliance on fossil fuels and mitigate pollution emissions. This preposition also aligns with the United Nations Sustainable Development Goals (SDGs-13), which highlight the climate change action. In this vein, Brazil has implemented the Decarbonization Credit (CBIOS) program to incentivize biofuel production and promote environmental sustainability through carbon credit emissions. To this end, the present study evaluates the effectiveness of the CBIO contract as a hedging tool for investors in the face of energy price fluctuations and decarbonization efforts. Specifically, we employ conditional dynamic correlation (DCC-GARCH) and optimal hedge ratio (HR) techniques to assess the relationship between CBIO and the futures and spot prices of sugar, oil, and ethanol. Our findings suggest that the current CBIO contract is not an effective hedge against energy spot and future prices. However, our analysis identifies a strengthening correlation between ethanol traded in Chicago and CBIO over time, highlighting the potential for an underlying contract to serve as an effective hedging tool in the future. Our study adds to the existing literature on carbon pricing mechanisms and their impact on financial markets, emphasizing the importance of sustainable energy policies and their potential to mitigate the risks associated with energy price volatility and decarbonization efforts. [ABSTRACT FROM AUTHOR]

Plant-parasitic nematodes (PPN) are the most damaging plant pathogens all over the world. Root-knot nematodes (RKNs), considered the most important phytonematodes globally, cause significant agricultural losses. Despite the availability of various strategies to manage these pathogenic agents, excessive use of nematicides poses a threat to human health and the environment. Compounds derived from plant sources are proposed as an alternative to new biocides, potentially offering advantages over synthetic components. Several species within the Fabaceae family, including those within the Arachis genus, have demonstrated potential as sources of nematotoxic compounds. As part of a research program aimed at exploring bioactive compounds and valorizing germplasm banks, this study evaluated the nematicidal and nematostatic effects of aqueous crude extracts (ACEs) obtained from nine Arachis species sourced from the Embrapa Active Germplasm Bank against M. incognita's second-stage juveniles (J2). The results indicate that Arachis stenosperma (ACE1) has promising nematocidal potential, with effectiveness exceeding 95% on dead nematodes for doses above 0.5 mg/mL. ACE1 has also demonstrated thermostability and lower harmful effects on bovine cells. This research provides a fresh outlook on the promising use of preserved germplasms to enhance Germplasm Storage Bank's value, given the underexplored potential of these biological assets. [ABSTRACT FROM AUTHOR]

The combined use of batteries and supercapacitors is an alternative to reconcile the higher energy density of batteries with the high power density of supercapacitors. The optimal sizing of this assembly, especially with the minimization of mass, is one of the challenges of designing the power system of an electric vehicle. The condition of the unpredictability of the power demand determined by the vehicle driver must also be added, which must be met by the power system without exceeding safe operating limits for the devices. This article presents a methodology for minimizing the mass of the electrical energy storage system (ESS) that considers the various aspects mentioned and a variety of battery technologies and supercapacitor values. The resulting minimum mass dimensioning is verified by simulation for different driving cycles under conditions of maximum power demand. The system also includes a tertiary source, such as a fuel cell, responsible for the vehicle's extended autonomy. In addition to sizing the ESS, the article also proposes a management strategy for the various sources to guarantee the vehicle's expected performance while respecting each device's operational limits. [ABSTRACT FROM AUTHOR]

This study is aimed at investigating the asymmetric and time-frequency co-movements and the hedge or safe-haven properties of carbon efficient indices, the MSCI ACWI Sustainable Impact, and MSCI World EGS indices, in relation to technology and innovation-themed investments. In doing so, the ADCC-GJR-GARCH and wavelet coherence techniques are applied to a daily return series ranging from January 2019 to January 2023. Findings of the ADCC-GJR-GARCH model show negative and insignificant asymmetric linkage among underlying indices during the sample period. The S&P 500 carbon efficient index (CEI) acts as a strong hedge or safe-haven for technology and innovation-themed indices during tranquil and tumultuous periods. The MSCI ACWI Sustainable Impact, MSCI World EGS, and carbon efficient indices except for S&P 500 CEI exhibit weak hedge or safe-haven attributes. Wavelet coherence reveals negative (positive) co-movements between the thematic and carbon efficient indices in short-term (medium-term and long-term) horizons with consistent leading behavior of thematic indices to carbon efficient indices outcomes. It justifies the presence of short-lived hedging or safe-haven characteristics in the thematic domain for investors. These strong and weak hedge or safe-haven characteristics of low carbon and sustainability indices reveal that adding low carbon efficient and sustainable investments to a portfolio result in considerable diversification benefits for investors who tend to take minimal risk in both tranquil and tumultuous periods. The current findings imply that financial institutions, thematic investing companies, and governments need to encourage carbon efficient technology transfer and innovation-themed investments by increasing the fund allocations in underlying asset classes. Policy-making and regulatory bodies can encourage investors to make carbon-efficient and thematic investments and companies to issue carbon-efficient stocks or investments to safeguard social and economic risks during fragile periods. These investments can offer greater opportunities to combat the intensity of economic shocks on portfolios for responsible or sustainable investors. [ABSTRACT FROM AUTHOR]

Background: Nurses play an important role in interprofessional pharmaceutical care. Curricula related to pharmaceutical care, however, vary a lot. Mapping the presence of pharmaceutical care related domains and competences in nurse educational programs can lead to a better understanding of the extent to which curricula fit expectations of the labour market. The aim of this study was to describe 1) the presence of pharmaceutical care oriented content in nursing curricula at different educational levels and 2) nursing students' perceived readiness to provide nurse pharmaceutical care in practice. Methods: A quantitative cross-sectional survey design was used. Nursing schools in 14 European countries offering educational programs for levels 4–7 students were approached between January and April 2021. Through an online survey final year students had to indicate to what extent pharmaceutical care topics were present in their curriculum. Results: A total of 1807 students participated, of whom 8% had level 4–5, 80% level 6, 12% level 7. Up to 84% of the students indicated that pharmaceutical care content was insufficiently addressed in their curriculum. On average 14% [range 0–30] felt sufficiently prepared to achieve the required pharmaceutical care competences in practice. In level 5 curricula more pharmaceutical care domains were absent compared with other levels. Conclusions: Although several pharmaceutical care related courses are present in current curricula of level 4–7 nurses, its embedding should be extended. Too many students perceive an insufficient preparation to achieve pharmaceutical care competences required in practice. Existing gaps in pharmaceutical care should be addressed to offer more thoroughly prepared nurses to the labour market. [ABSTRACT FROM AUTHOR]

Objective The purpose of this study was to evaluate the feasibility of a randomized controlled trial investigating the effectiveness of a multimodal program (PAT-Back) compared to best practice advice on pain and disability in older adults with chronic low back pain (LBP) in primary care. Methods This feasibility study took place in Fortaleza, Northeast Brazil. The PAT-Back intervention consisted of a program including exercises, pain education, and motivational text messages for the in-home component. The control group received an evidence-based educational booklet. Feasibility outcomes were recruitment, adherence and retention rates, level of difficulty of the education and intervention content, perception of utility of mobile technology, and adverse events. The feasibility criteria were previously defined. Results A total of 248 people were screened, of which 46 older adults were eligible. The retention rate was high (100% in the PAT-Back group and 95% in the control group). The adherence rate to intervention was partially met (60%), whereas the adherence rate to unsupervised exercises was adequate (75%), and perception about safety to perform home exercise was partially acceptable (70%) in the PAT-Back group. In addition, 100% of older adults reported which text messages motivated them to perform the exercises in the PAT-Back group. Difficulty reported by participants in understanding and performing the intervention was small in both groups. Six participants reported transient adverse events in both groups. Conclusion Older adults accepted both interventions. Results demonstrated that the program is feasible, although minor changes targeting adherence and safety in home exercise are needed. Impact This feasibility study supports progression to a full trial investigating the effectiveness of a multimodal program (PAT-Back) on pain and disability in older adults with chronic LBP within a primary health care setting in low to middle income countries where such data from the older population are scarce and the burden of LBP is increasing. [ABSTRACT FROM AUTHOR]

In a natural lake of southeastern Brazil (Lake Carioca), the current scarcity of limnetic cladocerans is attributed to the predatory activity of the dipteran Chaoborus larvae. The Inverted Trophic Cascade Hypothesis (ITCH) predicted that such predation pressure intensified after the decrease in native planktivorous fish populations, due to non-native piscivorous fish introductions. However, the ITCH is mainly based on recent data obtained when the non-native piscivorous fish have already disturbed the community of this Neotropical lake. In the present study, we used a paleolimnological approach aiming to provide evidence in support of ITCH. Specifically, we evaluated: (1) whether a great numerical increase of Chaoborus larvae and a sharp decline in the number of small cladocerans (Bosminidae) occurred in the recent past of Lake Carioca, and (2) whether the Bosmina tubicen size structure changed temporally in response to the dominant predator (from planktivorous fish to Chaoborus larvae). Samples from one sediment core collected in the deepest zone of the lake were concurrently used for radiometric dating, quantification of invertebrate subfossils, and measurement of B. tubicen size attributes. The radiometric dating was based on the analysis of 210Pb. Although we recorded an evident decline of Bosmina subfossils after the introduction of non-native piscivorous fish, we did not observe an increase of Chaoborus subfossils. Significant increases in the mean lengths of carapaces and mucros of B. tubicen were detected in Lake Carioca after the dominant predation regime changed from planktivorous fish to Chaoborus larvae. Despite the statistical significance, the differences for both attributes exhibited a small effect size and likely had limited ecological implications on the dynamics of local food web. Our results support one of the assumptions of the ITCH; showing that the negative effects of non-native piscivorous fish were not restricted to their prey (native planktivorous fish), but cascaded down, reaching the lower trophic levels (small limnetic cladocerans). This finding has relevant implications for the conservation and management of biodiversity in Neotropical lakes. It reinforces the need to better plan and control activities that historically have contributed to the spread of piscivorous fish outside their original areas such as aquaculture and sport fishing. [ABSTRACT FROM AUTHOR]