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Objectives: Fitness Age (FA) has been reported in Japan and South Korea as one way to assess an individual's overall health. To date, this method has not been used in North America. The objective of the current study was to assess the applicability of existing Fitness Age calculations for North American women. Methods: Thirty-seven North American working women aged 18 to 67 years completed a fitness test battery, as described by previous studies. The fitness test results were used with published regression equations to estimate each woman's FA which was subsequently adjusted to correct for biases in the data. Results: The data from the fitness tests were similar to those presented in the previously published literature with the exception of grip strength, trunk flexion, and body fat percentage which differed significantly compared to the populations assessed previously. These population differences appear to have impacted the applicability of the published methods for this population. Discussion: Because the FA estimates must be corrected according to a theoretical "ideal" to address population biases before they can be used, the authors propose using the deviation from this theoretical ideal rather than raw FA in future aging studies, as this is where the interesting inter-personal differences lay. [ABSTRACT FROM AUTHOR]

Objectives: Fitness Age (FA) has been reported in Japan and South Korea as one way to assess an individual's overall health. To date, this method has not been used in North America. The objective of the current study was to assess the applicability of existing Fitness Age calculations for North American women. Methods: Thirty-seven North American working women aged 18 to 67 years completed a fitness test battery, as described by previous studies. The fitness test results were used with published regression equations to estimate each woman's FA which was subsequently adjusted to correct for biases in the data. Results: The data from the fitness tests were similar to those presented in the previously published literature with the exception of grip strength, trunk flexion, and body fat percentage which differed significantly compared to the populations assessed previously. These population differences appear to have impacted the applicability of the published methods for this population. Discussion: Because the FA estimates must be corrected according to a theoretical "ideal" to address population biases before they can be used, the authors propose using the deviation from this theoretical ideal rather than raw FA in future aging studies, as this is where the interesting inter-personal differences lay. [ABSTRACT FROM AUTHOR]

The aims of this study were to investigate wrist postures and forces while operating the shovel during tree planting and to determine if different tree unloading techniques result in variations in wrist postures and forces. Experienced tree planters performed the planting task in a laboratory environment for three conditions: (1) symmetric tree unloading, and asymmetric unloading resulting in (2) right-loaded planting bags and (3) left-loaded planting bags. An optoelectric system and a shovel instrumented with strain gauges captured wrist posture and forces at the wrist, respectively. Wrist extension of up to 45° was observed, and this posture, in combination with varying degrees of wrist deviation, may be a primary risk factor for musculoskeletal pain. Average resultant forces at the wrist were moderately high (>30 N) for each unloading condition, indicating increased risk for the development of repetitive strain injuries such as carpal tunnel syndrome. No significant differences in wrist posture or forces existed between unloading conditions. Practitioner Summary:Wrist pain is a major musculoskeletal complaint among tree planters. This study measured wrist postures and forces at the wrist while operating the shovel during tree planting. The wrist extension observed, in combination with deviation, may be a key risk factor for musculoskeletal pain. Forces at the wrist indicate increased risk for repetitive strain injuries. [ABSTRACT FROM PUBLISHER]

Reproductive malignancies are a major cause of cancer death in women worldwide. CD40 is a TNF receptor family member, which upon activation may mediate tumor regression. However, despite the great potential of CD40 agonists, their use as a therapeutic option for reproductive cancers has never been investigated. Because CD40 ligation is a potent pathway of macrophage activation, an in vitro model of pro-inflammatory type-1 (Mϕ-1) and anti-inflammatory type-2 (Mϕ-2) macrophages was developed to determine whether and how macrophage CD40 pathway activation might influence endometrial tumor cell behavior. Analysis of tumor growth kinetic in the endometrial cancer xenograft model indicates that, when injected once into the growing tumors, CD40-activated Mϕ-1 greatly reduced, while CD40-activated Mϕ-2 increased tumor size when compared to control isotype-activated Mϕ-1 and Mϕ-2, respectively. In vitro assays indicated that CD40-activated Mϕ-2 increased cell viability but failed to promote cell invasion. CD40-activated Mϕ-1, in contrast, decreased cell survival but greatly increased cell invasion in tumor cells less susceptible to cell death by apoptosis; they also induced the expression of some pro-inflammatory genes, such as IL-6, LIF, and TNF-α, known to be involved in tumor promotion and metastasis. The presence of IFN-γ is minimally required for CD40-activated Mϕ-1 to promote tumor cell invasion, a process that is mediated in part through the activation of the PI3K/Akt2 signaling pathway in tumor cells. From these results, we speculate that some functions of CD40 in tumor-associated Mϕs might limit the therapeutic development of CD40 agonists in endometrial cancer malignancies. [ABSTRACT FROM AUTHOR]

Fourteenthand fifteenth-century medicine is characterised by a trickle-down effect which led to an increasing dissemination of knowledge in the vernacular. In this context, translations and compilations appear to be two similar endeavours aiming to provide access to contents pertaining to the particulars of medical practice. Nowhere is this phenomenon seen more clearly than in vernacular manuscripts on surgery. Our study proposes to compare for the first time two corpora of manuscripts of surgical compilations, in Middle French and Middle English respectively, in order to discuss form and matter in this type of book production. [ABSTRACT FROM AUTHOR]

Tree planters use various strategies to unload the seedlings from their bags. This study examines differences in upper limb and trunk joint angles during three load carriage conditions: (1) load evenly distributed to the right and left sides of the body - evenly loaded (2) load entirely on the right side - right loaded and (3) load entirely on the left side - left loaded. Data were collected in the field in Northern Ontario. Inertial motion sensors were placed on the right hand, right and left forearms and upper arms, sacrum, and T1 vertebrae. Using relative sensor orientation, joint angles were determined for the right wrist, right and left elbow and the trunk for the three load carriage conditions during normal planting tasks. The main findings were: 1) In the left loaded condition, the right wrist was less extended, the right elbow was more flexed, the trunk experienced less right-rotation, and the right and left forearms were less pronated than in either the evenly loaded or right loaded conditions. 2) In both the left and right loaded conditions, the left forearm was less pronated, and the trunk was less flexed than in the evenly loaded condition. Results suggest that asymmetrical tree load carriage results in more neutral postures than symmetrical tree load carriage. [ABSTRACT FROM AUTHOR]

Tree planting is extremely physical, seasonal, repetitive work with high risk for musculoskeletal injuries. Objectives: (1) To assess musculoskeletal symptoms in tree planters as they develop over the course of the planting season. (2) To investigate the effect of pre-season level of physical activity on development of musculoskeletal symptoms. Participants: 132 tree planters from two reforestation camps participated in the study. Methods: Three questionnaires were completed prior to the first work day of the planting season. Questionnaires included the International Physical Activity Questionnaire, a body map to report areas of musculoskeletal symptoms (MSS questionnaire), and a series of questions about planter demographics. A subset of study participants (n=14) also completed the MSS questionnaire each work shift during the planting season. Musculoskeletal symptoms in each area of the body were compared pre-and-post season using a paired t-test on data from the MSS questionnaire. Results and conclusions: Areas of the body with the greatest amount of musculoskeletal pain and discomfort were the feet, wrists and back, whereas areas with the highest frequency of reported pain were the upper, middle and lower back. Musculoskeletal symptoms worsened significantly over the course of the work season. Pre-season level of physical activity could not be correlated with development of musculoskeletal symptoms. [ABSTRACT FROM AUTHOR]

The aim of the study was to evaluate the effect of forearm support provided by the Workplace Board on perceived tension, comfort and productivity among pregnant and non-pregnant female computer workers. Ten pregnant and 18 non-pregnant women participated in the study. Participants completed three sets of tension/discomfort questionnaires at two week intervals. The first set was completed prior to any workstation intervention; the second set was completed after two weeks working with an ergonomically adjusted workstation; the third set was completed after two weeks working with the Workplace Board integrated into the office workstation. With the Workplace Board, decreased perceived tension was reported in the left shoulder, wrist and low back in non-pregnant women only. The Board was generally liked by all participants, and increased comfort and productivity in all areas, with the exception of a negative effect on productivity of general office tasks. The board is suitable for integration in most office workstations and for most users, but has no special benefits for pregnant women. [ABSTRACT FROM AUTHOR]