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2. DAS181 treatment of severe parainfluenza type 3 pneumonia in a lung transplant recipient.

Author

Drozd, D.R., Limaye, A.P., Moss, R.B., Sanders, R.L., Hansen, C., Edelman, J.D., Raghu, G., Boeckh, M., and Rakita, R.M.

Subjects
PARAINFLUENZA viruses, PNEUMONIA, TRANSPLANTATION of organs, tissues, etc., NEURAMINIDASE, PARAMYXOVIRUSES
Abstract

Parainfluenza virus ( PIV) may cause life-threatening pneumonia in lung transplant patients and there are no proven effective therapies. We report the use of inhaled DAS181, a novel sialidase fusion protein, to treat severe PIV type 3 pneumonia in a lung transplant patient. Treatment was well tolerated and associated with improvement in oxygenation and symptoms, along with rapid clearance of PIV. DAS181 should be systematically evaluated for treatment of PIV infection in transplant recipients. [ABSTRACT FROM AUTHOR]

Published
2013
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