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Treatment effect waning (TEW) refers to the attenuation of treatment effects over time. Assumptions of a sustained immuno-oncologic treatment effect have been a source of contention in health technology assessment (HTA). We review how TEW has been addressed in HTA and in the wider scientific literature. We analysed company submissions to English language HTA agencies and summarised methods and assumptions used. We subsequently reviewed TEW-related work in the ISPOR Scientific Presentations Database and conducted a targeted literature review (TLR) for evidence of the maintenance of immuno-oncology (IO) treatment effects post-treatment discontinuation. We found no standardised approach adopted by companies in submissions to HTA agencies, with immediate TEW most used in scenario analyses. Independently fitted survival models do however suggest TEW may often be implicitly modelled. Materials in the ISPOR scientific database suggest gradual TEW is more plausible than immediate TEW. The TLR uncovered evidence of durable survival in patients treated with IOs but no evidence that directly addresses the presence or absence of TEW. Our HTA review shows the need for a consistent and appropriate implementation of TEW in oncology appraisals. However, the TLR highlights the absence of direct evidence on TEW in literature, as TEW is defined in terms of relative treatment effects—not absolute survival. We propose a sequence of steps for analysts to use when assessing whether a TEW scenario is necessary and appropriate to present in appraisals of IOs. [ABSTRACT FROM AUTHOR]

Interventions designed to promote perspective taking are increasingly prevalent in educational settings, and are also being considered for applications in other domains. Thus far, these perspective-taking interventions (PTIs) have largely escaped philosophical attention, however they are sometimes prima facie morally problematic in at least two respects: they are neither transparent nor easy to resist. Nontransparent or hard-to-resist PTIs call for a moral defense and our primary aim in this paper is to provide such a defense. We offer two arguments for the view that an exemplar PTI is morally permissible even though it is plausibly neither transparent nor easy to resist. The first argument appeals to an analogy between PTIs and permissible deceptive research practices. The second appeals to the way in which PTIs draw participants' attention to their reasons for action. We also respond to the objection that, by imposing a particular conception of the good, PTIs violate liberal neutrality. [ABSTRACT FROM AUTHOR]

Permafrost-affected ecosystems of the Arctic–boreal zone in northwestern North America are undergoing profound transformation due to rapid climate change. NASA's Arctic Boreal Vulnerability Experiment (ABoVE) is investigating characteristics that make these ecosystems vulnerable or resilient to this change. ABoVE employs airborne synthetic aperture radar (SAR) as a powerful tool to characterize tundra, taiga, peatlands, and fens. Here, we present an annotated guide to the L-band and P-band airborne SAR data acquired during the 2017, 2018, 2019, and 2022 ABoVE airborne campaigns. We summarize the ∼80 SAR flight lines and how they fit into the ABoVE experimental design (Miller et al., 2023; https://doi.org/10.3334/ORNLDAAC/2150). The Supplement provides hyperlinks to extensive maps, tables, and every flight plan as well as individual flight lines. We illustrate the interdisciplinary nature of airborne SAR data with examples of preliminary results from ABoVE studies including boreal forest canopy structure from TomoSAR data over Delta Junction, AK, and the Boreal Ecosystem Research and Monitoring Sites (BERMS) area in northern Saskatchewan and active layer thickness and soil moisture data product validation. This paper is presented as a guide to enable interested readers to fully explore the ABoVE L- and P-band airborne SAR data (https://uavsar.jpl.nasa.gov/cgi-bin/data.pl). [ABSTRACT FROM AUTHOR]

In this article, we argue that rational persuasion can be a pro tanto wrong and that online platforms possess features that are especially conducive to this wrong. We begin by setting out an account of rational persuasion. This consists of four jointly sufficient conditions for rational persuasion and is intended to capture the core, uncontroversial cases of such persuasion. We then discuss a series of wrong-making features which are present in methods of influence commonly thought of as pro tanto wrong, such as manipulation and paternalism. It is next shown that these wrong-making features are also present in a range of cases that are, by the jointly sufficient conditions already established, rational persuasion, and so some forms of rational persuasion are pro tanto wrong, including in some ways that have not previously been remarked upon. Finally, we demonstrate that online settings possess a number of features that are especially conducive to wrongful rational persuasion. [ABSTRACT FROM AUTHOR]

Maintaining frozen ground stability in the Arctic and sub-Arctic is a continuing challenge, particularly with climate warming. One engineering solution to tackle this problem is the use of thermosyphons, an artificial ground cooling apparatus, to stabilize the frozen ground. Passive thermosyphons function when the above-ground condenser section is colder than the subsurface evaporator section. This occurs when the ambient air temperature is colder than the subsurface ground temperature. Passive thermosyphons absorb thermal energy from subsurface ground layers and reject it into the atmosphere. Therefore, this passive technology augments natural ground cooling during the cold winter months. Hybrid thermosyphons operate in passive and active (powered refrigeration) modes. For remote locations, the electrical requirements for active thermosyphons limit their application. However, solar power is a promising method to provide an electrical source to operate active and hybrid thermosyphons. This technical note presents the results from an experimental study that tested the use of a solar array system that powered a refrigeration unit, which provided active cooling to a hybrid thermosyphon. The energy that was generated from the solar array successfully operated the refrigeration unit, provided active cooling to the hybrid thermosyphon, and lowered soil temperatures. This study showed the potential for the future development and application of a more energy-efficient off-grid hybrid thermosyphon system. Maintaining frozen ground stability in the Arctic and sub-Arctic is a constant challenge, especially as the climate is warming. Engineering solutions, such as artificial ground freezing techniques to stabilize the frozen ground, are commonly used in cold climates. Freezing the ground with artificial freezing systems is achieved without power when air temperatures are below freezing. When air temperatures are above freezing, the passive system seizes; however, freezing could continue if linked to a mechanical refrigeration unit. The electrical requirements of this cooling technique, when temperatures are above freezing, severely restrict their use in remote areas. This technical note presents an experimental study where a solar array system was tested for powering a refrigeration unit connected to an artificial freezing system. Freezing was extended at warmer air temperatures (above freezing) with a refrigeration unit that was operated by solar array-generated energy. The refrigeration unit successfully operated, and soil temperatures decreased. Supplying this ground cooling technique with a solar powered system could be possible for future applications. [ABSTRACT FROM AUTHOR]

A commentary to the article "Philosophy, Reasons and Reproduction: Gene Editing and Genetic Selection," by J. McMahan and J. Savulescu published in the issue is presented. Topics covered include the problem with the authors' response to a possible objection to their claims concerning gene editing and genetic selection, the issue with the accounts of comparative benefit that the authors have in mind and the suggestion on how the authors should have responded.

Psychological literature indicates that actions performed with the assistance of cognition‐enhancing biomedical technologies are often deemed to be less praiseworthy than similar actions performed without such assistance. This study examines (i) whether this result extends to the bioenhancement of moral capacities, and (ii) if so, what explains the effect of moral bioenhancement on perceived praiseworthiness. The findings indicate that actions facilitated by morally bioenhanced individuals are considered less deserving of praise than similar actions facilitated by 'traditional' moral enhancement—for example, moral self‐education. This diminished praise does not seem to be driven by an aversion to (moral) bioenhancement per se. Instead, it appears to be primarily attributable to a perceived lack of effort exerted by bioenhanced individuals in the course of their moral enhancement. Our findings advance the philosophical discourse on the foundations of praise in the context of moral bioenhancement by elucidating the empirical basis underlying some assumptions commonly employed to argue for or against the permissibility of moral bioenhancement. [ABSTRACT FROM AUTHOR]

Permafrost degradation in peatlands is altering vegetation and soil properties and impacting net carbon storage. We studied four adjacent sites in Alaska with varied permafrost regimes, including a black spruce forest on a peat plateau with permafrost, two collapse scar bogs of different ages formed following thermokarst, and a rich fen without permafrost. Measurements included year‐round eddy covariance estimates of net carbon dioxide (CO2), mid‐April to October methane (CH4) emissions, and environmental variables. From 2011 to 2022, annual rainfall was above the historical average, snow water equivalent increased, and snow‐season duration shortened due to later snow return. Seasonally thawed active layer depths also increased. During this period, all ecosystems acted as slight annual sources of CO2 (13–59 g C m−2 year−1) and stronger sources of CH4 (11–14 g CH4 m−2 from ~April to October). The interannual variability of net ecosystem exchange was high, approximately ±100 g C m−2 year−1, or twice what has been previously reported across other boreal sites. Net CO2 release was positively related to increased summer rainfall and winter snow water equivalent and later snow return. Controls over CH4 emissions were related to increased soil moisture and inundation status. The dominant emitter of carbon was the rich fen, which, in addition to being a source of CO2, was also the largest CH4 emitter. These results suggest that the future carbon‐source strength of boreal lowlands in Interior Alaska may be determined by the area occupied by minerotrophic fens, which are expected to become more abundant as permafrost thaw increases hydrologic connectivity. Since our measurements occur within close proximity of each other (≤1 km2), this study also has implications for the spatial scale and data used in benchmarking carbon cycle models and emphasizes the necessity of long‐term measurements to identify carbon cycle process changes in a warming climate. [ABSTRACT FROM AUTHOR]

Rapid Arctic climate warming, amplified relative to lower-latitude regions, has led to permafrost thaw and associated thermokarst processes. Recent work has shown permafrost is a rich source of ice-nucleating particles (INPs) that can initiate ice formation in supercooled liquid clouds. Since the phase of Arctic clouds strongly affects the surface energy budget, especially over ice-laden surfaces, characterizing INP sources in this region is critical. For the first time, we provide a large-scale survey of potential INP sources in tundra terrain where thermokarst processes are active and relate to INPs in the air. Permafrost, seasonally thawed active layer, ice wedge, vegetation, water, and aerosol samples were collected near Utqiaġvik, Alaska, in late summer and analyzed for their INP contents. Permafrost was confirmed as a rich source of INPs that was enhanced near the coast. Sensitivity to heating revealed differences in INPs from similar sources, such as the permafrost and active layer. Water, vegetation, and ice wedge INPs had the highest heat-labile percentage. The aerosol likely contained a mixture of known and unsurveyed INP types that were inferred as biological. Arctic water bodies were shown to be potential important links of sources to the atmosphere in thermokarst regions. Therefore, a positive relationship found with total organic carbon considering all water bodies gives a mechanism for future parameterization as permafrost continues to thaw and drive regional landscape shifts. [ABSTRACT FROM AUTHOR]

Objective: We hypothesize that cut screws will deform in a manner that increases the core and outer diameters of the screw hole compared to uncut controls, and effects will be more pronounced in titanium screws. Materials and methods: We used biomechanical polyurethane foam blocks to simulate cortical bone. We organized four groups of stainless steel and titanium cut and uncut screws. Blocks were fitted with a jig to ensure perpendicular screw insertion. We imaged the blocks using digital mammography and measured them using PACS software. Power analysis determined a power of 0.95 and an alpha error of 0.05. Results: Highly statistically significant differences in core diameter were found after cutting stainless steel and titanium screws. Cutting stainless steel screws increased core diameter by 0.30 mm (95% CI, 0.16 to 0.45; p <.001). Titanium screws' core diameter increased by 0.45 mm (95% CI, 0.30 to 0.61; p <.001). No significant differences were found in the outer diameters of stainless steel and titanium screws after cutting. Conclusion: Titanium and stainless steel screw tracts demonstrated screw core diameter and screw thread pattern deformation after cutting. Titanium screws demonstrated more significant effects. [ABSTRACT FROM AUTHOR]

The rise of neurotechnologies, especially in combination with artificial intelligence (AI)-based methods for brain data analytics, has given rise to concerns around the protection of mental privacy, mental integrity and cognitive liberty – often framed as "neurorights" in ethical, legal, and policy discussions. Several states are now looking at including neurorights into their constitutional legal frameworks, and international institutions and organizations, such as UNESCO and the Council of Europe, are taking an active interest in developing international policy and governance guidelines on this issue. However, in many discussions of neurorights the philosophical assumptions, ethical frames of reference and legal interpretation are either not made explicit or conflict with each other. The aim of this multidisciplinary work is to provide conceptual, ethical, and legal foundations that allow for facilitating a common minimalist conceptual understanding of mental privacy, mental integrity, and cognitive liberty to facilitate scholarly, legal, and policy discussions. [ABSTRACT FROM AUTHOR]

Permafrost-affected ecosystems of the Arctic-boreal zone in northwestern North America are undergoing profound transformation due to rapid climate change. NASA's Arctic Boreal Vulnerability Experiment (ABoVE) is investigating characteristics that make these ecosystems vulnerable or resilient to this change. ABoVE employs airborne synthetic aperture radar (SAR) as a powerful tool to characterize tundra, taiga, peatlands, and fens. Here, we present an annotated guide to the L-band and P band airborne SAR data acquired during the 2017, 2018, 2019, and 2022 ABoVE airborne campaigns. We summarize the ~80 SAR flight lines and how they fit into the ABoVE experimental design. We provide hyperlinks to extensive maps, tables, and every flight plan as well as individual flight lines. We illustrate the interdisciplinary nature of airborne SAR data with examples of preliminary results from ABoVE studies including: boreal forest canopy structure from tomoSAR data over Delta Junction, AK and the BERMS site in northern Saskatchewan and active layer thickness and soil moisture data product validation. This paper is presented as a guide to enable interested readers to fully explore the ABoVE L55 and P-band SAR data. [ABSTRACT FROM AUTHOR]

Rapid Arctic climate warming, amplified relative to lower latitude regions, has led to permafrost thaw and associated thermokarst processes. Recent work has shown permafrost is a rich source of ice nucleating particles (INPs) that can initiate ice formation in supercooled liquid clouds. Since the phase of Arctic clouds strongly affects the surface energy budget, especially over ice-laden surfaces, characterizing INP sources in this region is critical. For the first time, we provide a large- scale survey of potential INP sources in tundra terrain where thermokarst processes are active and relate to INPs in the air. Permafrost, seasonally thawed active layer, ice wedge, vegetation, water, and aerosol samples were collected near Utqiaġvik, Alaska in late summer and analyzed for their INP contents. Permafrost was confirmed as a rich source of INPs that was enhanced near the coast. The aerosol likely contained a mixture of known and unsurveyed INP types that were inferred as biological. Arctic water bodies were shown to be important links of sources to the atmosphere in thermokarst regions. Therefore, a positive relationship found with total organic carbon gives a mechanism for future parameterization as permafrost continues to thaw and drive regional landscape shifts. [ABSTRACT FROM AUTHOR]

Rapid Arctic climate warming, amplified relative to lower latitude regions, has led to permafrost thaw and associated thermokarst processes. Recent work has shown permafrost is a rich source of ice nucleating particles (INPs) that can initiate ice formation in supercooled liquid clouds. Since the phase of Arctic clouds strongly affects the surface energy budget, especially over ice-laden surfaces, characterizing INP sources in this region is critical. For the first time, we provide a largescale survey of potential INP sources in tundra terrain where thermokarst processes are active and relate to INPs in the air. Permafrost, seasonally thawed active layer, ice wedge, vegetation, water, and aerosol samples were collected near Utqiaġvik, Alaska in late summer and analyzed for their INP contents. Permafrost was confirmed as a rich source of INPs that was enhanced near the coast. The aerosol likely contained a mixture of known and unsurveyed INP types that were inferred as biological. Arctic water bodies were shown to be important links of sources to the atmosphere in thermokarst regions. Therefore, a positive relationship found with total organic carbon gives a mechanism for future parameterization as permafrost continues to thaw and drive regional landscape shifts. [ABSTRACT FROM AUTHOR]

Small water bodies (i.e., ponds; <0.01 km2) play an important role in Earth System processes, including carbon cycling and emissions of methane. Detection and monitoring of ponds using satellite imagery has been extremely difficult and many water maps are biased toward lakes (>0.01 km2). We leverage high‐resolution (3 m) optical satellite imagery from Planet Labs and deep learning methods to map seasonal changes in pond and lake areal extent across four regions in Alaska. Our water maps indicate that changes in open water extent over the snow‐free season are especially pronounced in ponds. To investigate potential impacts of seasonal changes in pond area on carbon emissions, we provide a case study of open water methane emission budgets using the new water maps. Our approach has widespread applications for water resources, habitat and land cover change assessments, wildlife management, risk assessments, and other biogeochemical modeling efforts. Plain Language Summary: Small water bodies (<0.01 km2) are an important driver of many Earth system processes. Despite their importance, many existing water mapping products have difficulty detecting these small water features and their seasonal changes in surface area. We used deep learning and high‐resolution (3 m) satellite imagery to map and monitor seasonal changes in the areal extent of lakes and small ponds across four regions in Alaska. The resulting water maps accounted for considerably more water coverage than existing products. The maps also effectively tracked widespread seasonal changes in pond and lake area that were not previously identified. This demonstrates the importance of monitoring surface water at high spatial resolutions and across seasons. Key Points: Deep learning and 3 m resolution satellite imagery from Planet Labs can detect and track ponds and lakes >0.0001 km2Total surface area for ponds (<0.01 km2) in boreal forest and tundra environments can vary by 20%–40% throughout an individual seasonPonds can contribute to a broad range (8%–37%) of total methane emissions from lakes and ponds in northern boreal forest and tundra [ABSTRACT FROM AUTHOR]

In discussions of nudging, transparency is often taken to be important; it is often suggested that a significant moral consideration to take into account when nudging is whether the nudge is transparent. Another consideration taken to be relevant is whether the nudge is easy to resist. Sometimes, these two considerations are taken to be importantly related: if we have reason to make nudges easy to resist, then we have reason to make them transparent, insofar as a nudge's transparency is relevant to whether the nudge is easy to resist. In this paper, we critically scrutinize this view. First, we draw out the purported connections between transparency and resistibility, combining them into what we call the Resistibility-to-Transparency Argument (RTA). Then, we do some conceptual groundwork elaborating on different forms of transparency mentioned in the debate. With this in place, we argue that in order to be plausible, the RTA must appeal to certain forms of transparency; those on which the transparency of a nudge depends on the nudgee's ability to become aware of the relevant facts about the nudge. We then argue against the common assumption that in order for a nudge to be easy to resist for an individual, that individual needs to have the capacity to easily become aware of the relevant nudge facts. We conclude that the connection between the easy resistibility of a nudge and its transparency is, at best, a weak one. [ABSTRACT FROM AUTHOR]

In recent years, there has been increased academic interest in the human right to freedom of thought (RFoT). Scholars from various disciplines are currently debating the content and scope of this right. In his annual thematic report of 2021, the United Nations Special Rapporteur on Freedom of Religion or Belief paid explicit and comprehensive attention to the RFoT, encouraging further clarification of the content and scope of the right. This paper aims to contribute to this end, setting the stage for further research, by offering a multidisciplinary analysis of the RFoT's scope, relation to other rights, practical significance and moral foundations. [ABSTRACT FROM AUTHOR]

Shoreline erosion over the last few decades along the Point Hope, Alaska, USA coastline has led to considerable loss of tundra behind the beach. Analysis of available remote sensing, morphology, and hydrodynamic datasets are used to inform the time scales and mechanisms of coastal land loss at Point Hope, in part through integration of these data into an analytical retreat model originally developed for coastal foredunes. At shorter time scales, these analyses indicate that steeper local beach slopes influence higher wave runup that can enhance the scale of tundra retreat at a particular section of coast. Coastal stretches that are most vulnerable to wave attack of the tundra scarp appear to shift with time related to complex spatio‐temporal variability in shoreline change rates. These local beach erosion rates primarily control the retreat of the tundra at decadal scales. However, independent of the fronting beach morphology, the largest erosion events throughout the region generally occur when there is the coincidence of both high wave energy and elevated still water levels. Additional exploratory modeling results indicate that future changes to sea level and changes in wave energy will further enhance the magnitude of tundra erosion. Plain Language Summary: Coastal regions of the Arctic are experiencing some of the greatest rates of land loss on earth, which is increasingly threatening resources in remote communities. Understanding how, when, and why this erosion occurs is critical for assessing the potential for future retreat of beach and tundra systems and to design and implement adaptation strategies to these hazards. This work uses topographic data to quantify the magnitude of landscape losses along a section of rapidly retreating shoreline in Point Hope, Alaska. The analysis of these data, in conjunction with information about the ocean climate, are used to inform the drivers and timescale of erosion. It is found that the tundra at this site erodes in a similar fashion to coastal foredunes, with the height that the water reaches on the shoreline during storms being an important factor in how much volume is lost from the tundra and how fast it retreats landward. Although individual storms are important factors driving erosion of the tundra at short time scales, the rate of tundra loss over longer time intervals is primarily controlled by how fast the local shoreline is retreating. Key Points: At decadal time scales, net shoreline changes primarily control the rate of tundra retreat adjacent to an Arctic beach systemTundra retreat events are driven by the confluence of high wave energy and still water levels that are most probable in the fallIn‐situ measurements suggest global hydrodynamic models reasonably resolve oceanographic processes in remote parts of the Chukchi Sea [ABSTRACT FROM AUTHOR]

The Holocene Epoch (11,700 years ago to the present) marks the development of the present-day boreal ecosystems in interior Alaska. The composition and genetics of soil microbes have the potential to alter how nutrient cycling and vegetation respond to warming and cooling events, but very little is known about how boreal soils have varied over time. Here, we use DNA sequencing on both modern soils and well-preserved paleosols developed during several episodes of the Holocene to extract information on soil bacteria, archaea, and fungi present in interior Alaska during the past 8000 years (8 ka). Community composition of bacteria and fungi in the ancient paleosols was different from modern soils, with a higher relative abundance of Proteobacteria, Chloroflexi, and Verrucomicrobia in the modern soils. The most dramatic shift in interior Alaska's soil microbiome occurred ca. 7 ka, when species diversity was lowered and functional diversity became higher after 7 ka. This suggests that function was truly low, the early Holocene ecosystems were functionally redundant, and/or that true functional diversity was not captured due to a lack of genetic resolution in existing sequence databases. The cause of this observed shift cannot be directly answered in this work; however, these data suggest that ca. 7 ka was a critical period when microbial taxa and function shifted dramatically. This is important for understanding how the soil microbiome responds to climate changes and impacts the succession of vegetation. [ABSTRACT FROM AUTHOR]

Temporal patterns in stream chemistry provide integrated signals describing the hydrological and ecological state of whole catchments. However, stream chemistry integrates multi-scale signals of processes occurring in both the catchment and stream. Deconvoluting these signals could identify mechanisms of solute transport and transformation and provide a basis for monitoring ecosystem change. We applied trend analysis, wavelet decomposition, multivariate autoregressive state-space modeling, and analysis of concentration–discharge relationships to assess temporal patterns in high-frequency (15 min) stream chemistry from permafrost-influenced boreal catchments in Interior Alaska at diel, storm, and seasonal time scales. We compared catchments that varied in spatial extent of permafrost to identify characteristic biogeochemical signals. Catchments with higher spatial extents of permafrost were characterized by increasing nitrate concentration through the thaw season, an abrupt increase in nitrate and fluorescent dissolved organic matter (fDOM) and declining conductivity in late summer, and flushing of nitrate and fDOM during summer rainstorms. In contrast, these patterns were absent, of lower magnitude, or reversed in catchments with lower permafrost extent. Solute dynamics revealed a positive influence of permafrost on fDOM export and the role of shallow, seasonally dynamic flowpaths in delivering solutes from high-permafrost catchments to streams. Lower spatial extent of permafrost resulted in static delivery of nitrate and limited transport of fDOM to streams. Shifts in concentration–discharge relationships and seasonal trends in stream chemistry toward less temporally dynamic patterns might therefore indicate reorganized catchment hydrology and biogeochemistry due to permafrost thaw. [ABSTRACT FROM AUTHOR]

Neurointerventions—interventions that physically or chemically modulate brain states—are sometimes imposed on criminal offenders for the purposes of diminishing the risk that they will recidivate, or, more generally, of facilitating their rehabilitation. One objection to the nonconsensual implementation of such interventions holds that this expresses a disrespectful message, and is thus impermissible. In this paper, we respond to this objection, focusing on the most developed version of it—that presented by Elizabeth Shaw. We consider a variety of messages that might be expressed by nonconsensual neurointerventions. Depending on the message, we argue either that such interventions do not invariably express this message, that expressing this message is not invariably disrespectful, or that the appeal to disrespect is redundant. [ABSTRACT FROM AUTHOR]

Andreas Schmidt and Neil Levy have recently defended nudging against the objection that nudges fail to treat nudgees as rational agents. Schmidt rejects two theses that have been taken to support the objection: that nudges harness irrational processes in the nudgee, and that they subvert the nudgee's rationality. Levy rejects a third thesis that may support the objection: that nudges fail to give reasons. I argue that these defences can be extrapolated from nudges to some nonconsensual neurointerventions; if Schmidt's and Levy's defences succeed, then some nonconsensual neurointerventions neither harness irrationality, nor subvert rationality, nor fail to give reasons. This, I claim, poses a challenge both to opponents of nonconsensual neurointerventions, and to defenders of nudging. [ABSTRACT FROM AUTHOR]

It is often said that the institutions of criminal justice ought or—perhaps more often—ought not to rehabilitate criminal offenders. But the term 'criminal rehabilitation' is often used without being explicitly defined, and in ways that are consistent with widely divergent conceptions. In this paper, we present a taxonomy that distinguishes, and explains the relationships between, different conceptions of criminal rehabilitation. Our taxonomy distinguishes conceptions of criminal rehabilitation on the basis of (i) the aims or ends of the putatively rehabilitative measure, and (ii) the means that may be used to achieve the intended end. We also explore some of the implications of each conception, some of the payoffs of a taxonomy of the kind we offer, and some areas for future work. [ABSTRACT FROM AUTHOR]

Some suggest that gene editing human embryos to prevent genetic disorders will be in one respect morally preferable to using genetic selection for the same purpose: gene editing will benefit particular future persons, while genetic selection would merely replace them. We first construct the most plausible defence of this suggestion—the benefit argument—and defend it against a possible objection. We then advance another objection: the benefit argument succeeds only when restricted to cases in which the gene-edited child would have been brought into existence even if gene editing had not been employed. Our argument relies on a standard account of comparative benefit which has recently been criticised on the grounds that it succumbs to the so-called 'pre-emption problem'. We end by considering how our argument would be affected were the standard account revised in an attempt to evade this problem. We consider three revised accounts and argue that, on all three, our critique of the benefit argument stands. [ABSTRACT FROM AUTHOR]

Landslides occur in Polk County, North Carolina, primarily along the Columbus Promontory of Blue Ridge Escarpment (BRE), which has 400 m of topographic relief and slopes typically >20°. Bedrock is characterized as late Proterozoic to early Paleozoic metamorphic rocks within Paleozoic thrust sheets. On May 18, 2018, ~200 mm of rainfall over a 3- to 4-hour period triggered numerous debris flows and slides along the BRE, causing one fatality and severe damage to homes and roads. The State Emergency Operations Center tasked the North Carolina Geological Survey to assess slope stability ahead of search and rescue operations and assess damage along the North Pacolet River valley. The loss of life and destruction from the 2018 storm and ongoing threats to infrastructure prompted us to map landslides throughout Polk County in 2019-2021 to fully document the 2018 landslides and place them in the context of past and ongoing landsliding. We mapped 920 varied types of landslides and attribute 241 to the 2018 storm, making it one of the largest events in North Carolina since 2004 with respect to landslide numbers and spatial frequency. The highest concentrations of landslide features in Polk County are along the slopes of the BRE, especially the Pacolet River and Green River valleys. These rivers exploit post-orogenic brittle fractures to form linear reentrants where the May 2018 and other landslides are concentrated. This article describes our landslide response and mapping efforts and relates our findings to the geomorphic and geologic framework and to past landslide events in the region. [ABSTRACT FROM AUTHOR]

The current debate on closed-loop brain devices (CBDs) mainly focuses on their use in a medical context; possible criminal justice applications have only received incidental scholarly attention. Unlike in medicine, in criminal justice, CBDs might be offered on behalf of the State and for the purpose of protecting security, rather than realizing healthcare aims. It would be possible to deploy CBDs in the rehabilitation of convicted offenders, similarly to the much-debated possibility of employing other brain interventions in this context. Although such use of CBDs could in principle be consensual, there are significant differences between the choice faced by a criminal offender offered a CBD in the context of criminal justice, and that faced by a patient offered a CBD in an ordinary healthcare context. Employment of CBDs in criminal justice thus raises ethical and legal intricacies not raised by healthcare applications. This paper examines some of these issues under three heads: autonomy, human rights, and accountability. [ABSTRACT FROM AUTHOR]

Permafrost underlies one-quarter of the Northern Hemisphere but is at increasing risk of thaw from climate warming. Recent studies across the Arctic have identified areas of rapid permafrost degradation from both top-down and lateral thaw. Of particular concern is thawing syngenetic "yedoma" permafrost which is ice-rich and has a high carbon content. This type of permafrost is common in the region around Fairbanks, Alaska, and across central Alaska expanding westward to the Seward Peninsula. A major knowledge gap is relating belowground measurements of seasonal thaw, permafrost characteristics, and residual thaw layer development with aboveground ecotype properties and thermokarst expansion that can readily quantify vegetation cover and track surface elevation changes over time. This study was conducted from 2013 to 2020 along four 400 to 500 m long transects near Fairbanks, Alaska. Repeat active layer depths, near-surface permafrost temperature measurements, electrical resistivity tomography (ERT), deep (> 5 m) boreholes, and repeat airborne light detection and ranging (lidar) were used to measure top-down permafrost thaw and map thermokarst development at the sites. Our study confirms previous work using ERT to map surface thawed zones; however, our deep boreholes confirm the boundaries between frozen and thawed zones that are needed to model top-down, lateral, and bottom-up thaw. At disturbed sites seasonal thaw increased up to 25 % between mid-August and early October and suggests measurements to evaluate active layer depth must be made as late in the fall season as possible because the projected increase in the summer season of just a few weeks could lead to significant additional thaw. At our sites, tussock tundra and spruce forest are associated with the lowest mean annual near-surface permafrost temperatures while mixed-forest ecotypes are the warmest and exhibit the highest degree of recent temperature warming and thaw degradation. Thermokarst features, residual thaw layers, and taliks have been identified at all sites. Our measurements, when combined with longer-term records from yedoma across the 500 000 km 2 area of central Alaska, show widespread near-surface permafrost thaw since 2010. Projecting our thaw depth increases, by ecotype, across the yedoma domain, we calculate a first-order estimate that 0.44 Pg of organic carbon in permafrost soil has thawed over the past 7 years, which, for perspective, is an amount of carbon nearly equal to the yearly CO 2 emissions of Australia. Since the yedoma permafrost and the variety of ecotypes at our sites represent much of the Arctic and subarctic land cover, this study shows remote sensing measurements, top-down and bottom-up thermal modeling, and ground-based surveys can be used predictively to identify areas of the highest risk for permafrost thaw from projected future climate warming. [ABSTRACT FROM AUTHOR]

A central question in the current neurolegal and neuroethical literature is how brain-reading technologies could contribute to criminal justice. Some of these technologies have already been deployed within different criminal justice systems in Europe, including Slovenia, Italy, England and Wales, and the Netherlands, typically to determine guilt, legal responsibility, or recidivism risk. In this regard, the question arises whether brain-reading could permissibly be used against the person's will. To provide adequate legal protection from such non-consensual brain-reading in the European legal context, ethicists have called for the recognition of a novel fundamental legal right to mental privacy. In this paper, we explore whether these ethical calls for recognising a novel legal right to mental privacy are necessary in the European context. We argue that a right to mental privacy could be derived from, or at least developed within in the jurisprudence of the European Court of Human Rights, and that introducing an additional fundamental right to protect against (forensic) brain-reading is not necessary. What is required, however, is a specification of the implications of existing rights for particular neurotechnologies and purposes. [ABSTRACT FROM AUTHOR]

When it comes to determining how healthcare resources should be allocated, there are many factors that could—and perhaps should—be taken into account. One such factor is a patient's responsibility for his or her illness, or for the behavior that caused it. Policies that take responsibility for the unhealthy lifestyle or its outcomes into account—responsibility-sensitive policies—have faced a series of criticisms. One holds that agents often fail to meet either the control or epistemic conditions on responsibility with regard to their unhealthy lifestyles or their outcomes. Another holds that even if patients sometimes are responsible for these items, we cannot know whether a particular patient is responsible for them. In this article, we propose a type of responsibility-sensitive policy that may be able to surmount these difficulties. Under this type of policy, patients are empowered to change to a healthier lifestyle by being given what we call a 'Golden Opportunity' to change. Such a policy would not only avoid concerns about patients' fulfilment of conditions on responsibility for their lifestyles, it would also allow healthcare authorities to be justified in believing that a patient who does not change her lifestyle is responsible for the unhealthy lifestyle. We conclude with a discussion of avenues for further work, and place this policy in the broader context of the debate on responsibility for health. [ABSTRACT FROM AUTHOR]

We collected ground‐penetrating radar (GPR) and frequency‐domain electromagnetic induction (FDEM) profiles in 2011 and 2012 to identify the extent of permafrost relative to surface biomass and solar insolation around Twelvemile Lake near Fort Yukon, Alaska. We compared a Landsat‐derived biomass estimate and modeled solar insolation from a digital elevation model to the geophysical measurements. We show correspondence between vegetation type and biomass relative to permafrost extent and seasonal freeze–thaw. Thicker permafrost (≥25 m) was covered by greater biomass, and seasonal thaw depths in these regions were minimal (1 m). Shallow (1–3 m depth) and thin (20–50 cm) newly forming permafrost or frozen layers from the previous winter occurred below northward oriented slopes with thin biomass cover. South‐facing slopes exhibited permafrost when there was enough biomass to shield incoming solar energy. We developed an artificial neural network to predict permafrost extent across the broader region by mapping GPR‐observed instances of permafrost to FDEM, biomass, and terrain observations with 90.2% accuracy. We identified a strong linear correlation (r = −0.77) between permafrost probability and seasonal thaw depth, indicating that our models may also be used to explore thaw patterns and variability in active layer thickness. This study highlights the combined influence of biomass and terrain on the presence of permafrost and the value of evaluating such parameters via remote sensing to predict permafrost spatial or temporal variability. Incorporating diverse geophysical datasets with in‐situ validation into machine learning models demonstrates a useful approach to upscale estimated permafrost extent across large Arctic expanses. [ABSTRACT FROM AUTHOR]

Background: Ankle instability is common and previous studies have documented greater than 85% good-to-excellent outcomes based upon both patient-reported outcome measures and subjective evaluation of ability to return to previous activity levels after lateral ankle stabilization in the civilian population. However, patient-reported outcomes and performance may differ in the military population. The military oftentimes requires servicemembers to navigate uneven terrain and ladderwells, which can stress ankles differently than in their civilian counterparts. There has been limited evidence regarding patient outcomes after lateral ankle stabilization within a military population and its elucidation is important in optimizing outcomes for our servicemembers. Furthermore, the potential benefit of fibular periosteum augmentation with lateral ankle stabilization procedures in a military population has not been described. The results of using this extra tissue to reinforce the repair are important in determining whether its routine incorporation is indicated in the military.Questions/purposes: In an active-duty military population, we asked: (1) What proportion of patients who underwent lateral ankle stabilization using anatomic repair techniques with or without fibular periosteum augmentation achieved good-to-excellent outcomes based on the Foot and Ankle Disability Index (FADI) score at a minimum follow-up interval of 2 years? (2) Was the proportion of patients who achieved a good-to-excellent FADI score higher among those treated with fibular periosteum augmentation than those treated without? (3) Did the likelihood of achieving a good-to-excellent outcome after lateral ankle stabilization vary based on whether the procedure was performed by a fellowship-trained sports or foot and ankle orthopaedic surgeon versus a podiatrist?Methods: Between 2007 and 2017, 15 surgeons (six orthopaedic surgeons and nine podiatrists) performed 502 lateral ankle stabilizations. We excluded 4% (18 of 502) of patients because they were not active-duty at the time of surgery, and we excluded 12% (56 of 502) of lateral ankle stabilizations because they were performed as part of other potentially confounding foot or ankle procedures. We considered 60% (303 of 502) as lost to follow-up because the patients could not be contacted at least 2 years after surgery, they declined to participate, or they did not fully answer the questionnaires. This left 125 patients for analysis. Of those, 79% (99 of 125) had a procedure with fibular periosteum augmentation and 21% (26 of 125) had a procedure without augmentation. During the study period, five fellowship-trained orthopaedic foot and ankle surgeons and two podiatrists always used fibular periosteum augmentation. Orthopaedic surgeons performed 75% (94 of 125) of the procedures, and the other 25% (31 of 125) were performed by podiatrists. Whether a servicemember was treated by one specialty or the other was simply based upon whom they were referred to for care. Orthopaedic surgeons tended to perform procedures with augmentation (five with versus one without) and podiatrists tended to perform procedures without augmentation (two with versus seven without). To help account for this confounding factor, we performed separate analyses for procedures performed with versus without augmentation in addition to procedures performed by orthopaedic surgeons versus podiatrists. We retrospectively contacted each patient to obtain their self-reported overall result, FADI outcome score, and postoperative military capabilities. The minimum follow-up duration was 2 years; overall mean follow-up duration was 7 years. The fibular periosteum augmentation group mean follow-up was 7 ± 4 years and without augmentation was 6 ± 3 years. The orthopaedic surgeons group mean follow-up was 7 ± 3 years and the podiatrists group was 7 ± 3 years. We obtained postoperative FADI scores via phone interview along with data regarding the patients' postoperative military capabilities, but did not have preoperative FADI scores.Results: Pooling both surgical treatments, 67% (84 of 125) of the patients reported good-to-excellent results and 33% (41 of 125) reported very poor-to-fair results. We found no difference in the proportion of patients treated with fibular periosteal augmentation who achieved a good or excellent score on the FADI than was observed among the patients treated without periosteal augmentation (68% [67 of 99] versus 65% [17 of 26]; odds ratio 1 [95% CI 0 to 2]; p = 0.81). The proportion of patients who achieved a good or excellent score on the FADI did not differ depending on whether the procedure was performed by an orthopaedic surgeon or a podiatric surgeon (66% [62 of 94] versus 71% [22 of 31]; OR 1 [95% CI 1 to 2]; p = 0.66).Conclusion: The patient-reported outcome scores after lateral ankle stabilization in our study of military servicemembers at a minimum of 2 years and a mean of 7 years were far lower than have been reported in studies on civilians. Indeed, our findings may represent a best-case scenario because more patients were lost to follow-up than were accounted for, and in general, surgical results among missing patients are poorer than among those who return for follow-up. Variability in the addition of fibular periosteum augmentation and whether an orthopaedic surgeon or podiatrist performed the procedure did not account for these findings. With one third of patients reporting very-poor-to-fair results after these reconstructions, and many patients lost to follow-up, we recommend surgeons counsel their servicemember patients accordingly before surgery. Specifically, that there is a one third chance they will need permanent restrictions or have to leave the military postoperatively; analogously, we believe that our findings may apply to similarly active patients outside the military, and we question whether these procedures may not be serving such patients as well as previously believed.Level Of Evidence: Level III, therapeutic study. [ABSTRACT FROM AUTHOR]

The Tanana Flats in central Alaska are a hot spot for thermokarst that is rapidly transforming the landscape. Time series analysis of high‐resolution imagery showed that permafrost degradation increased the area of three large fens by 26% from 1949 to 2018, but surprisingly permafrost also aggraded in small areas. Permafrost soils in adjacent birch forests frequently had fen peat near the surface indicating recent permafrost degradation and aggradation. We attribute groundwater as the primary driver of recent permafrost degradation, while climate extremes (especially cold, less snowy winters) caused recent permafrost aggradation, but only after ecological succession provided conditions favorable for permafrost formation. Near‐surface groundwater temperatures during early winters (2–6°C during 2011–2014) contributed to a near steady rate of lateral permafrost degradation (0.36 m/yr) over three periods. Fairbanks climate records (1904–2019) showed large ranges in mean winter temperatures (12°C) and snow depths (69 cm) between cold, less snowy winters and warm, snowy winters. During ecological succession from the collapsing margins to the fen centers over a ~250‐yr period, vegetation transitioned from aquatic forbs to shrubs and mosses, water depths decreased, and the soil carbon stock of new peat increased. These interactions among permafrost, groundwater, climate warming, and succession complicate our ability to project future ecological transitions and soil carbon changes across this dynamic boreal lowland landscape. The more frequent warm, snowy winters since 2014 and model projections for warmer winters, however, indicate that the region has crossed a tipping point where permafrost will no longer form and permafrost loss is irreversible. Key Points: Fens have repeatedly undergone permafrost aggradation and degradation over the last 500 years, but future permafrost formation is unlikelyGroundwater promoted widespread, long‐term permafrost degradation, while climate extremes caused recent permafrost aggradation, but only in late successional stagesClimate, hydrology, ecosystem, and permafrost interactions complicate ecological transitions and soil carbon changes across the peatlands [ABSTRACT FROM AUTHOR]

Permafrost is an extreme habitat yet it hosts microbial populations that remain active over millennia. Using permafrost collected from a Pleistocene chronosequence (19 to 33 ka), we hypothesized that the functional genetic potential of microbial communities in permafrost would reflect microbial strategies to metabolize permafrost soluble organic matter (OM) in situ over geologic time. We also hypothesized that changes in the metagenome across the chronosequence would correlate with shifts in carbon chemistry, permafrost age, and paleoclimate at the time of permafrost formation. We combined high-resolution characterization of water-soluble OM by Fourier-transform ion-cyclotron-resonance mass spectrometry (FT-ICR MS), quantification of organic anions in permafrost water extracts, and metagenomic sequencing to better understand the relationships between the molecular-level composition of potentially bioavailable OM, the microbial community, and permafrost age. Both age and paleoclimate had marked effects on both the molecular composition of dissolved OM and the microbial community. The relative abundance of genes associated with hydrogenotrophic methanogenesis, carbohydrate active enzyme families, nominal oxidation state of carbon (NOSC), and number of identifiable molecular formulae significantly decreased with increasing age. In contrast, genes associated with fermentation of short chain fatty acids (SCFAs), the concentration of SCFAs and ammonium all significantly increased with age. We present a conceptual model of microbial metabolism in permafrost based on fermentation of OM and the buildup of organic acids that helps to explain the unique chemistry of ancient permafrost soils. These findings imply long-term in situ microbial turnover of ancient permafrost OM and that this pooled biolabile OM could prime ancient permafrost soils for a larger and more rapid microbial response to thaw compared to younger permafrost soils. [ABSTRACT FROM AUTHOR]

Earth's high latitudes are projected to experience warmer and wetter summers in the future but ramifications for soil thermal processes and permafrost thaw are poorly understood. Here we present 2750 end of summer thaw depths representing a range of vegetation characteristics in Interior Alaska measured over a 5 year period. This included the top and third wettest summers in the 91-year record and three summers with precipitation close to mean historical values. Increased rainfall led to deeper thaw across all sites with an increase of 0.7 ± 0.1 cm of thaw per cm of additional rain. Disturbed and wetland sites were the most vulnerable to rain-induced thaw with ~1 cm of surface thaw per additional 1 cm of rain. Permafrost in tussock tundra, mixed forest, and conifer forest was less sensitive to rain-induced thaw. A simple energy budget model yields seasonal thaw values smaller than the linear regression of our measurements but provides a first-order estimate of the role of rain-driven sensible heat fluxes in high-latitude terrestrial permafrost. This study demonstrates substantial permafrost thaw from the projected increasing summer precipitation across most of the Arctic region. [ABSTRACT FROM AUTHOR]

Changes in the frequency and extent of wildfires are expected to lead to substantial and irreversible alterations to permafrost landscapes under a warming climate. Here we review recent publications (2010–2019) that advance our understanding of the effects of wildfire on surface and ground temperatures, on active layer thickness and, where permafrost is ice‐rich, on ground subsidence and the development of thermokarst features. These thermal and geomorphic changes are initiated immediately following wildfire and alter the hydrology and biogeochemistry of permafrost landscapes, including the release of previously frozen carbon. In many locations, permafrost has been resilient, with key characteristics such as active layer thickness returning to pre‐fire conditions after several decades. However, permafrost near its southern limit is losing this resiliency as a result of ongoing climate warming and increasingly common vegetation state changes. Shifts in fire return intervals, severity and extent are expected to alter the trajectories of wildfire impacts on permafrost, and to enlarge spatial impacts to more regularly include the burning of tundra areas. Modeling indicates some lowland boreal forest and tundra environments will remain resilient while uplands and areas with thin organic layers and dry soils will experience rapid and irreversible permafrost degradation. More work is needed to relate modeling to empirical studies, particularly incorporating dynamic variables such as soil moisture, snow and thermokarst development, and to identify post‐fire permafrost responses for different landscape types and regions. Future progress requires further collaboration among geocryologists, ecologists, hydrologists, biogeochemists, modelers and remote sensing specialists. [ABSTRACT FROM AUTHOR]

Telementoring platforms can help transfer surgical expertise remotely. However, most telementoring platforms are not designed to assist in austere, pre-hospital settings. This paper evaluates the system for telementoring with augmented reality (STAR), a portable and self-contained telementoring platform based on an augmented reality head-mounted display (ARHMD). The system is designed to assist in austere scenarios: a stabilized first-person view of the operating field is sent to a remote expert, who creates surgical instructions that a local first responder wearing the ARHMD can visualize as three-dimensional models projected onto the patient's body. Our hypothesis evaluated whether remote guidance with STAR could lead to performing a surgical procedure better, as opposed to remote audio-only guidance. Remote expert surgeons guided first responders through training cricothyroidotomies in a simulated austere scenario, and on-site surgeons evaluated the participants using standardized evaluation tools. The evaluation comprehended completion time and technique performance of specific cricothyroidotomy steps. The analyses were also performed considering the participants' years of experience as first responders, and their experience performing cricothyroidotomies. A linear mixed model analysis showed that using STAR was associated with higher procedural and non-procedural scores, and overall better performance. Additionally, a binary logistic regression analysis showed that using STAR was associated to safer and more successful executions of cricothyroidotomies. This work demonstrates that remote mentors can use STAR to provide first responders with guidance and surgical knowledge, and represents a first step towards the adoption of ARHMDs to convey clinical expertise remotely in austere scenarios. [ABSTRACT FROM AUTHOR]

Approximately one fourth of the Earth's Northern Hemisphere is underlain by permafrost, earth materials (soil, organic matter, or bedrock), that has been continuously frozen for at least two consecutive years. Numerous studies point to evidence of accelerated climate warming in the Arctic and sub-Arctic where permafrost is located. Changes to permafrost biochemical processes may critically impact ecosystem processes at the landscape scale. Here, we sought to understand how the permafrost metabolome responds to thaw and how this response differs based on location (i.e. chronosequence of permafrost formation constituting diverse permafrost types). We analyzed metabolites from microbial cells originating from Alaskan permafrost. Overall, permafrost thaw induced a shift in microbial metabolic processes. Of note were the dissimilarities in biochemical structure between frozen and thawed samples. The thawed permafrost metabolomes from different locations were highly similar. In the intact permafrost, several metabolites with antagonist properties were identified, illustrating the competitive survival strategy required to survive a frozen state. Interestingly, the intensity of these antagonistic metabolites decreased with warmer temperature, indicating a shift in ecological strategies in thawed permafrost. These findings illustrate the impact of change in temperature and spatial variability as permafrost undergoes thaw, knowledge that will become crucial for predicting permafrost biogeochemical dynamics as the Arctic and Antarctic landscapes continue to warm. [ABSTRACT FROM AUTHOR]