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Under servitization (one paradigm of non-ownership-transfer) business model such as sharing, a manufacturer is responsible not only for product design but also for maintenance. This paper deals with joint decision of product quality and maintenance under servitization. A model minimising total cost is formulated to obtain the optimal product quality, maintenance effort and maintenance times. We find that the total cost first decreases then increases with product quality, maintenance effort and maintenance times. Moderate quality and maintenance effort level are the best for the manufacturer, because too high or too low quality and effort cause too high total cost. However, preventive maintenance should be implemented as many times as possible until the failure cost is reduced to zero as long as each maintenance can save cost. Moreover, in the optimal joint decision, the product quality, maintenance effort and maintenance times are negatively correlated in pairs. In addition, we explore the impact of unit failure cost, product lifecycle, production cost, maintenance cost, and failure intensity on the manufacturer's optimal decisions. In extensions, we further take penalty cost, exponential failure distribution, discount rate, and customer usage into account. This paper provides insight for the manufacturer to jointly consider product design and maintenance under servitization. [ABSTRACT FROM AUTHOR]

The compression-induced structural transition (ST) and grain refinement of BCC Fe nanowires have been investigated based on atomistic simulations. It is found that high strain rate compression can cause nanowires to reach higher pressures and meet ST conditions, and the threshold stress of ST is found to be much lower than that of bulk materials. Thus, the compression process of nanowires at high strain rates includes elastic deformation, ST and its reverse process, grain refinement, and buckling instability. The occurrence of grain refinement is due to the fact that after undergoing ST and its reverse process, the (001) cross section of the nanowire can be transformed into different (111) planes. Furthermore, the dependence of stress threshold and nucleation structure on strain rate is revealed. When the strain rate increases to a certain threshold, HCP nucleation is found to occur on the side surface of the nanowire, but its reverse process will quickly occur due to the pressure release on the side. With the strain rate increase, the stress threshold of ST no longer satisfies a constant power-law change, and the power-law index will increase. When the strain rate exceeds 5 × 1010 s−1, the elastic deformation prior to ST also exhibits strong nonequilibrium characteristics, causing a sharp increase in the number of HCP nuclei. Especially, the nanowires will ultimately be in a disordered state, rather than a nanocrystalline structure. Also, the cylindrical and prismatic nanowires are both considered to understand the influence of boundary morphology, and the differences in nucleation and the similarity in deformation are explained. Note that, as the strain rate increases, the cylindrical nanowires undergo HCP nucleation directly, while the prismatic nanowires undergo significant twinning deformation first. [ABSTRACT FROM AUTHOR]

Citrus yellow vein-clearing virus (Potexvirus citriflavivenae; CYVCV) is an increasing threat to citrus cultivation. Notably, the role of zinc finger proteins (ZFPs) in mediating viral resistance in citrus plants is unclear. In this study, we demonstrated that ZFPs ClSUP and ClDOF3.4 enhanced citrus defense responses against CYVCV in Eureka lemon (Citrus limon 'Eureka'). ClSUP interacted with the coat protein (CP) of CYVCV to reduce CP accumulation and inhibited its silencing suppressor function. Overexpression of CISUP triggered reactive oxygen species (ROS) and salicylic acid (SA) pathways, and enhanced resistance to CYVCV infection. In contrast, ClSUP silencing resulted in increased CP accumulation and down-regulated ROS and SA-related genes. ClDOF3.4 interacted with ClSUP to facilitate its interactions with CP. Furthermore, ClDOF3.4 synergistically regulated the accumulation of ROS and SA with ClSUP and accelerated down-regulation of CP accumulation. Transgenic plants co-expressing ClSUP and ClDOF3.4 significantly decreased the CYVCV. These findings provide a new reference for understanding the interaction mechanism between the host and CYVCV. [ABSTRACT FROM AUTHOR]

Objective: Although quetiapine has been approved for use in schizophrenic patients, its individualized dosage regimen remains unclear, especially with respect to drug–drug interactions (DDIs). Thus, we investigated the potential DDIs and optimal initial dosage of quetiapine in schizophrenic patients based on population pharmacokinetics (PPK). Methods: Ninety-six schizophrenic patients treated with quetiapine were included to establish the PPK model, which also includes coadministration of multiple drugs. Results: It was found that the patient weights and fluvoxamine or duloxetine coadministration affected quetiapine clearance in schizophrenic patients. Without fluvoxamine or duloxetine coadministration, 16 and 12 mg/kg/day of quetiapine were recommended to schizophrenic patients whose weights were in the ranges of 40–50 and 50–120 kg, respectively. With fluvoxamine coadministration, 8 mg/kg/day of quetiapine was recommended to patients with weights in the range of 40–120 kg. With duloxetine coadministration, 8 mg/kg/day of quetiapine was recommended to patients with weights in the 40–120 kg range. With simultaneous coadministration of fluvoxamine and duloxetine, 4 mg/kg/day of quetiapine was recommended to patients with weights in the 40–120 kg range. Conclusion: The present study was a pilot effort at investigating the potential DDIs and optimal initial dosage of quetiapine in schizophrenic patients based on PPK. The initial dosages of quetiapine administered to the patients were optimized according to the coadministration of fluvoxamine or duloxetine. [ABSTRACT FROM AUTHOR]

Mitochondrial dysfunction is one of the hallmarks in the pathophysiology of prion disease and other neurodegenerative diseases. Various metabolic dysfunctions are identified and considered to contribute to the progression of some types of neurodegenerative diseases. In this study, we evaluated the status of glycolysis pathway in prion-infected rodent and cell models. The levels of the key enzymes, hexokinase (HK), phosphofructokinase (PFK), and pyruvate kinase (PK) were significantly increased, accompanying with markedly downregulated mitochondrial complexes. Double-stained IFAs revealed that the increased HK2 and PFK distributed widely in GFAP-, Iba1-, and NeuN-positive cells. We also identified increased levels of AMP-activated protein kinase (AMPK) and the downstream signaling. Changes of AMPK activity in prion-infected cells by the AMPK-specific inhibitor or activator induced the corresponding alterations not only in the downstream signaling, but also the expressions of three key kinases in glycolysis pathway and the mitochondrial complexes. Transient removal or complete clearance of prion propagation in the prion-infected cells partially but significantly reversed the increases of the key enzymes in glycolysis, the upregulation of AMPK signaling pathway, and the decreases of the mitochondrial complexes. Measurements of the cellular oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) showed lower OCR and higher ECAR in prion-infected cell line, which were sufficiently reversed by clearance of prion propagation. Those data indicate a metabolic reprogramming from oxidative phosphorylation to glycolysis in the brains during the progression of prion disease. Accumulation of PrPSc is critical for the switch to glycolysis, largely via activating AMPK pathway. [ABSTRACT FROM AUTHOR]

The presence of alkali metals in flue gas can lead to catalyst poisoning, which can significantly impact the de-NOx efficiency of the catalyst. There is a lack of specific studies on the influence of potassium (K) poisoning on the efficiency of γ-Fe2O3. In this study, the mechanism of K poisoning on the γ-Fe2O3 surface was studied based on DFT, and the influence of K on molecular adsorption and SCR reaction process was analyzed. The results show that the K2O and KCl provide O, K, and Cl ions when deposited on the catalyst surface. The adsorption and dehydrogenation processes of NH3 were enhanced to varying degrees near the O and Cl iron sites, but the subsequent generation and decomposition of NH2NO were inhibited. On the sites near K cations, the adsorption, dehydrogenation, and subsequent SCR reaction processes of NH3 are hindered, and the adverse effects on the reaction are greater on the Fe sites closer to K. As well as the presence of K can to some extent promote the adsorption of NO and O2. [ABSTRACT FROM AUTHOR]

Objective: The objective of this study was to evaluate the psychometric properties of the EQ-5D (3L and 5L) and SF-6Dv2 in a group of Chinese patients with late-on Pompe disease (PD), and compare their performance in this patient group. Methods: The data used in this study were obtained from a web-based and cross-sectional survey conducted in China. All participants completed the 3L, 5L, and SF-6Dv2. Information about their sociodemographic status and health conditions was also collected. The measurement properties were assessed by examining ceiling and floor effects, evaluating convergent validity, known-group validity, and test–retest reliability (Intraclass correlation coefficient [ICC] and Gwet's AC). Results: A total of 117 PD patients completed the questionnaire. All dimensions of the 3L showed strong ceiling effects, ranging between 17.1 and 42.7%. All three measures showed good test–retest reliability, with ICC values ranging from 0.85 to 0.87. The Gwet's AC values showed that four out of five dimensions of the 3L showed very good agreement. All hypothesized correlations between the 3L, 5L, SF-6Dv2, and items of WHODAS were supported, indicating satisfactory convergent validity. The 5L showed stronger correlations (|r|= 0.53–0.84) with WHODAS than the other two measures. The outcomes of ANOVA indicated that the 5L had higher F-statistics than the 3L and SF-6Dv2, indicating a stronger discriminant ability to differentiate most condition groups. Conclusion: The 5L demonstrates lower ceiling and floor effects, higher discriminant ability, and better convergent validity than the SF-6Dv2 and 3L in patients with PD. In addition, the 5L may generate a larger utility gain compared to the other two instruments when conducting cost-effectiveness analysis. [ABSTRACT FROM AUTHOR]

Background: The novel nanomaterials PNA-TN (PN) and PNA-TN-Dox (PND) have been shown to have strong inhibitory effects on breast cancer; however, it is unclear whether PN and PND have anti-head and neck squamous cell carcinoma (HNSCC) activity, and their potential mechanisms of activity are unknown. So, our study aims to explore the therapeutic effects of PN and PND on HNSCC and their possible mechanisms. Methods: We used a series of phenotypic research to evaluate the effects of PN + Laser (L) and PND + L on the biological function of HNSCC cells in vitro and in vivo. We subsequently used mechanism research to examine changes in mRNA and protein expression related to apoptosis, epithelial‒mesenchymal transition (EMT), and the JNK signalling pathway. Results: Our study revealed that PN and PND have strong inhibitory effects on HNSCC cells both in vitro and in vivo. In vitro, PN and PND significantly inhibited the proliferation, migration, invasion and EMT ability of HNSCC cells and promoted apoptosis; the inhibitory effect in the PND + L group was significantly greater than that in the PN + L group. In vivo, both treatments led to significant reductions in tumour volume and weight. Notably, the tumour volume and weight in the PND + L group were significantly lower than those in the PN + L group. Mechanism research confirmed that PN + L activated the expression of apoptosis-related proteins and inhibited the expression of EMT-related proteins via the JNK pathway. Furthermore, the anti-HNSCC effect of PN + L was blocked after the use of a JNK pathway inhibitor. Conclusion: Treatment with PN + L or PND + L significantly inhibited the malignant progress of HNSCC cells, and the therapeutic effect of PND + L was significantly stronger than that of PN + L. The JNK signalling pathway is a key mechanism by which PN exerts its anti-HNSCC activity. [ABSTRACT FROM AUTHOR]

Smart actuators convert environmental changes into mechanical energy. However, the actuation performance and robustness of smart actuators are limited by the weak interlaminar force and poor adhesion between layers. Herein, we report moisture-responsive actuators integrated with slippery liquid-infused porous surfaces (SLIPSs). The difference in adsorption capacity of water molecules further increases because the SLIPS layer is isolated from air by the lubricating oil film. Compared with the initial (graphene oxide/candle soot, GO/CS) bilayer film, the integrated SLIPS layer improved the bending performance by 12.6% and shortened the response–recovery time by one-third. Moreover, the GO/SLIPS actuator exhibited excellent long-term stability over 10 000 cycles due to the lubricating oil's capillary fluidity. In addition, a moisture-controlled water-transport device based on a GO/SLIPS film was demonstrated. [ABSTRACT FROM AUTHOR]

The family Clausiliidae was proposed as a model for studying the diversity of breeding biology in land snails. This study assembled a nearly complete mitogenome (15,417 bp) for the clausiliid snail Euphaedusa aculus. The mitogenome includes 13 protein-coding genes (PCGs), two ribosomal RNAs, and 22 transfer RNAs, with a gene order consistent with other clausiliids. Most PCGs use ATN start codons and complete stop codons, except for atp6, nad4, and nad5, which start with TTG, and atp6, cox3, and nad3, which have incomplete stop codons. Phylogenetic analyses revealed that E. aculus is closely related to E. planostriata. This mitogenome provides a valuable molecular resource for future evolutionary research on land snails. [ABSTRACT FROM AUTHOR]

Moving away from an individual and pathological framework and instead drawing on a social-relational model of disability, this article examines the experiences of mothers with autistic children in navigating between caregiving and working life in China. Conducting narrative analysis of 14 in-depth interviews with mothers of autistic children, we argue that their decisions to make adjustments to work are situated in social and relational dynamics of disabled and gendered cultural ideologies, inaccessibility to healthcare, education, and social services, as well as filial familial relationship. As a result, they have to adjust their careers and personal life, such as resigning from previous work and becoming full-time mothers. Although these women constantly experienced a strong sense of loss in terms of their personal and social identity, some developed new perspectives seeing disability, normality, and the meaning of 'good mother' in the process of negotiating their work life and motherhood role. Points of Interests: Mothers of autistic children in China experience social and relational barriers in caregiving and working life. Mothers adjust to their careers and personal life by quitting their previous jobs and becoming full-time mothers, changing positions, or switching to part-time employment. The unavailability of healthcare and social service, as well as the discrimination of the education system against children with autism, significantly affect their mothers' work and family life. Autistic children encounter exclusion in the filial family in China. Grandparents and fathers of autistic children often refuse to participate in childcare arrangements. As a result, mothers had to bear the care responsibility alone. Some mothers described their personal journey of 'walking out'. They rejected the idea that autism is a form of abnormality needed to be cured. They also organized to advocate for social inclusion and policy changes. [ABSTRACT FROM AUTHOR]

Background: Recurrent pregnancy loss (RPL) affects women's reproductive health seriously, with immune dysfunction playing a key role in its cause, yet the exact mechanisms remain elusive. We aim to investigate potential mechanisms and identify biomarkers linked to RPL. Methods: Immune cytokine testing and metabolomic profiling were conducted on the serum of 34 RPL patients and 30 healthy individuals. The metabolic pathways of the differential metabolites were analyzed, and specific metabolites were validated through targeted profiling. Potential biomarkers were identified, and the relationships between immune cytokines and differential metabolites were explored. Results: In the RPL group, serum interleukin-6 and interleukin-10 levels were significantly higher, while interleukin-2 and interferon-g were significantly lower. A total of 296 differential metabolites were detected by untargeted metabolomic profiling between the RPL and control groups, with most linked to amino acid metabolism. Targeted metabolomic profiling of amino acid metabolism revealed upregulation of indole-3-acetic acid, tyrosine, glycine, isoleucine, tryptophan, lysine, aspartic acid, arginine, leucine, threonine, glutamic acid, cystine, and phenylpyruvic acid (PPA) in the RPL group. Moreover, PPA and 5-hydroxy-Ltryptophan showed great potential in predicting RPL in a diagnostic model. Cystine and tyrosine were associated with immune cytokines in correlation analysis. Conclusion: The study highlights the role of amino acid metabolism in RPL pathogenesis, suggesting that PPA and 5-HTP may be potential predictive indicators, while cystine and tyrosine may potentially regulate immune responses related to RPL. Further investigation into the molecular mechanisms underlying these findings could potentially result in the creation of novel diagnostic and therapeutic approaches for RPL. [ABSTRACT FROM AUTHOR]

Background: Schizophrenia is a persistent incurable mental disorder and is characterized by the manifestation of negative emotions and behaviors with anxiety and depression, fear and insecurity, self-harm and social withdrawal. The intricate molecular mechanisms underlying this phenomenon remain largely elusive. Accumulating evidence points towards the gut microbiota exerting an influence on brain function via the gut-brain axis, potentially contributing to the development of schizophrenia. Therefore, the objective of this study is to delineate the gut microbial composition and metabolic profile of fecal samples from individuals with schizophrenia. Methods: Liquid chromatography-mass spectrometry (LC-MS) and 16S ribosomal RNA (16S rRNA) gene sequencing were employed to analyze fecal metabolites and gut microbiota profiles in a cohort of 29 patients diagnosed with schizophrenia and 30 normal controls. The microbial composition of fecal samples was determined through the 16S rRNA gene sequencing, and microbial a-diversity and b-diversity indices were calculated. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were performed to analyze the distribution of samples. The metabolites and gut microbiota exhibiting differential expression were identified through the application of biological variance criteria. Co-occurrence analysis of bacteria and metabolites was conducted using the spearman's rank correlation coefficient and visualized in a circular layout with the Cytoscape software. Results: The findings of the study indicated a lack of substantial evidence supporting significant disparities in a-diversity and b-diversity between individuals with schizophrenia and normal controls. In terms of metabolomics, a discernible pattern in sample distribution between the two groups was observed. Our analysis has revealed 30 bacterial species and 45 fecal metabolites that exhibited notable differences in abundance between individuals diagnosed with schizophrenia and normal controls. These alterations in multilevel omics have led to the development of a co-expression network associated with schizophrenia. The perturbed microbial genes and fecal metabolites consistently demonstrated associations with amino acid and lipid metabolism, which play essential roles in regulating the central nervous system. Conclusion: Our results offered profound insights into the impact of imbalanced gutmicrobiota and metabolismon brain function in individuals with schizophrenia. [ABSTRACT FROM AUTHOR]

Most existing funnel control methods for nonlinear MIMO systems have a critical limitation: the initial tracking error must be within the funnel region to ensure system stability. This limitation reduces their practical applicability. This paper proposes a novel low-complexity non-smooth funnel control scheme that uses a transition process to decouple the funnel boundary design from the initial conditions, allowing for more flexibility in designing the funnel boundary irrespective of the initial error. The scheme also employs a non-smooth funnel transformation based on the transition error, which effectively reduces the tracking error to a smaller steady-state funnel region. The controller has a simple structure similar to a proportional controller, which makes it computationally efficient and easy to implement. Moreover, the controller incorporates a predefined time-convergent funnel boundary to guarantee that the tracking error converges to the steady-state funnel region within a user-specified time. These enhancements improve the robustness, adaptability, and tracking performance of the control system. The stability of the closed-loop system is rigorously established by Lyapunov theory, and the effectiveness of the proposed scheme is demonstrated by simulations and experiments of a SCARA robot. [ABSTRACT FROM AUTHOR]

Background: The type 2 diabetes mellitus (T2DM) pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage, and it was found that dichloromethane extracted part (SDP) had a significant hypoglycemic effect. Therefore, the components of SDP were analyzed, and the specific mechanism of its anti-T2DM was explored. Methods: We used a high-fat, high-sugar diet in combination with streptozotocin to induce a T2DM rat model, and the model rats were divided into two groups according to body weight and blood glucose. Triglyceride, oral glucose tolerance test, fasting blood glucose, low density lipoprotein cholesterol, superoxide dismutase, insulin, glycated hemoglobin, total cholesterol, nonesterified free fatty acids, alanine aminotransferase, high-density lipoprotein cholesterol, aspartate aminotransferase, malondialdehyde, and glutathione peroxidase were measured, organ indices were calculated, and pathological sections of pancreas and liver were observed. The 16S rRNA V3-V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal flora. Based on the above indicators, the anti-T2DM mechanism of SDP in Schisandra sphenanthera was analyzed. Results: After six weeks of administration, the biochemical indices of diabetic rats were diminished compared to the control group. And SDP could significantly increase the gut microbial a-diversity index, resulting in significant changes in the flora of T2DM rats, with increased richness and diversity, reduced harmful flora, and significantly back-regulated the levels of acetic acid, propionic acid, and butyric acid. Conclusion: SDP can improve the symptoms associated with elevated blood glucose, dyslipidemia, elevated fasting insulin levels, and damaged glucose tolerance in rats. SDP against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect; its main active components may be lignans and terpenoids. [ABSTRACT FROM AUTHOR]

Introduction: Different initial manifestations of peritoneal dialysis-associated peritonitis (PDAP) may depend on the type of pathogenic organism. We investigated the association between the clinical characteristics of PDAP and susceptibility to vancomycin and investigated the possibility of using vancomycin monotherapy alone as an initial treatment regimen for some PDAP patients to avoid unnecessary antibiotic exposure and secondary infection. Methods: Patients with culture-positive PDAP were retrospectively analyzed and divided into two groups: peritonitis with only cloudy effluent (PDAP-cloudy) or with cloudy effluent, abdominal pain and/or fever (PDAP-multi). The bacterial culture of PD effluent and antibiotic sensitivity test results were compared between groups. Logistic regression was used to investigate factors predicting susceptibility to vancomycin. Results: Of 162 episodes of peritonitis which had a positive bacterial culture of PD fluid, 30 peritonitis were in the PDAP-cloudy group, and 132 peritonitis were in the PDAP-multi group. Thirty (100%) peritonitis in the PDAP-cloudy group had gram-positive bacterial infections, which was significantly greater than that in the PDAP-multi group (51.5%) (P < 0.001). Twenty-nine (96.7%) peritonitis in the PDAP-cloudy group were susceptible to vancomycin, compared to 67 (50.8%) in the PDAP-multi group (P < 0.001). The specificity of PDAP-cloudy for vancomycin-sensitive peritonitis was 98.48%. Only one patient (3.3%) in the PDAP-cloudy group experienced vancomycin-resistant peritonitis caused by Enterococcus gallinarum, which could neither be covered by vancomycin nor by the initial antibiotic regimen recommended by the current ISPD guidelines. The presence of only cloudy effluent was an independent predictor of susceptibility to vancomycin according to multivariate analysis (OR = 27.678, 95% CI 3.191-240.103, p = 0.003), in addition to PD effluent WBC counts (OR = 0.988, 95% CI 0.980–0.996, p = 0.004), diabetes mellitus (OR = 3.646, 95% CI 1.580–8.416, p = 0.002), first episode peritonitis (OR = 0.447, 95% CI 0.207–0.962, p = 0.039) and residual renal creatinine clearance (OR = 0.956, 95% CI 0.918–0.995, p = 0.027). Addition of these characteristics increased the AUC to 0.813 (95% CI 0.0.749–0.878, P < 0.001). The specificity of presenting with only cloudy effluent for vancomycin-sensitive peritonitis was 98.48%. Conclusions: Cloudy dialysate, as the only symptom at PDAP onset, was an independent predictor of vancomycin-sensitive PDAP, which is an important new insight that may guide the choice of initial antibiotic treatment. [ABSTRACT FROM AUTHOR]

Background: Due to the high cost of enzyme replacement therapy (ERT), most of adults with late-onset Pompe disease (LOPD) who received ERT used the medication with insufficient dosefs in China. Objective: To compare the change in quality of life (QoL) between adults with LOPD receiving under-dose ERT and no ERT, and identify factors associated with the change of QoL. Methods: A retrospective matched cohort study was conducted among adult patients with LOPD in a nationwide Pompe registry in China. Eligible participants were those who completed two investigations, and didn't expose to ERT at baseline or before. The treated group were those who used ERT during follow-up; the untreated group received general care. The treated and untreated group were matched with a ratio of 1:2. QoL was assessed by the SF-12 and EQ-5D-5L. The dose of ERT was evaluated by the ratio of actual vials patients used divided by the indicated vials patients should use. The treated patients were further classified into mild and severe under-dose users by the median ratio. Multivariate linear regression analyses were performed to estimate the average treatment effect in the treated groups and identify factors associated with the changes of QoL scores. Results: The study sample included 5 mild under-dose users, 6 severe under-dose users, and 22 untreated participants. Compared with the untreated group, mild under-dose ERT had no significant effect on the changes of QoL scores. In contrast, severe under-dose ERT was associated with a decline of physical QoL (β = -6.19, p = 0.001), but an increase of overall health state (β = 19.69, p = 0.032). A higher score of physical QoL (β = -0.74, p = 0.001) and overall health state (β = -0.69, p<0.001) at baseline was associated with decline in corresponding scores at follow-up. Being female was a contributor to the worsening of the overall health state (β = -22.79, p = 0.002), while being employed or at school was a predictor of improvement in mental QoL (β = 5.83, p = 0.002). Conclusions: A Pompe-disease specific instrument based on patient experiences is warranted to closely monitor changes in QoL on a routine basis. It is desirable for patients with severe under-dose ERT to discuss with physicians whether to adjust treatment strategies. [ABSTRACT FROM AUTHOR]

Programmed cell death (PCD) is a fundamental biological process for maintaining cellular equilibrium and regulating development, health, and disease across all living organisms. Among the various types of PCD, apoptosis plays a pivotal role in numerous diseases, notably cancer. Cancer cells frequently develop mechanisms to evade apoptosis, increasing resistance to standard chemotherapy treatments. This resistance has prompted extensive research into alternative mechanisms of programmed cell death. One such pathway is oncosis, characterized by significant energy consumption, cell swelling, dilation of the endoplasmic reticulum, mitochondrial swelling, and nuclear chromatin aggregation. Recent research suggests that oncosis can impact conditions such as chemotherapeutic cardiotoxicity, myocardial ischemic injury, stroke, and cancer, mediated by specific oncosis-related proteins. In this review, we provide a detailed examination of the morphological and molecular features of oncosis and discuss various natural or small molecule compounds that can induce this type of cell death. Additionally, we summarize the current understanding of the molecular mechanisms underlying oncosis and its role in both normal physiology and pathological conditions. These insights aim to illuminate future research directions and propose innovative strategies for leveraging oncosis as a therapeutic tool against human diseases and cancer resistance. [ABSTRACT FROM AUTHOR]

Programmed cell death (PCD) is a fundamental biological process for maintaining cellular equilibrium and regulating development, health, and disease across all living organisms. Among the various types of PCD, apoptosis plays a pivotal role in numerous diseases, notably cancer. Cancer cells frequently develop mechanisms to evade apoptosis, increasing resistance to standard chemotherapy treatments. This resistance has prompted extensive research into alternative mechanisms of programmed cell death. One such pathway is oncosis, characterized by significant energy consumption, cell swelling, dilation of the endoplasmic reticulum, mitochondrial swelling, and nuclear chromatin aggregation. Recent research suggests that oncosis can impact conditions such as chemotherapeutic cardiotoxicity, myocardial ischemic injury, stroke, and cancer, mediated by specific oncosis-related proteins. In this review, we provide a detailed examination of the morphological and molecular features of oncosis and discuss various natural or small molecule compounds that can induce this type of cell death. Additionally, we summarize the current understanding of the molecular mechanisms underlying oncosis and its role in both normal physiology and pathological conditions. These insights aim to illuminate future research directions and propose innovative strategies for leveraging oncosis as a therapeutic tool against human diseases and cancer resistance. [ABSTRACT FROM AUTHOR]

Objectives: Olanzapine is used for treating bipolar disorder (BPD); however, the optimal initial dosing regimen is unclear. The present study aimed to investigate the optimal olanzapine initial dosage in patients with BPD via model-informed precision dosing (MIPD) based on a real-world study. Methods: Thirty-nine patients with BPD from the real-world study were collected to construct the MIPD model. Results: Weight, combined used quetiapine influenced olanzapine clearances in patients with BPD, where the clearance rates were 0.152:1 in patients with or without quetiapine under the same weight. We simulated olanzapine doses once a day or twice a day, of which twice a day was optimal. Without quetiapine, for twice-a-day olanzapine doses, 0.80, 0.70, and 0.60 mg/kg/day were suitable for 40- to 56-kg BPD patients, 56- to 74-kg BPD patients, and 74- to 100-kg BPD patients, respectively. With quetiapine, for twice-a-day olanzapine doses, 0.05 mg/kg/day was suitable for 40- to 100-kg BPD patients. Conclusion: This study was the first to investigate the optimal olanzapine initial dosage in patients with BPD via MIPD based on a real-world study, providing clinical reference for the precision medication of olanzapine in BPD patients. [ABSTRACT FROM AUTHOR]

This paper investigates the containment control problem of linear multiagent systems (MASs) with multiple non‐autonomous leaders on a directed graph. First, an event‐triggered compensator is designed for each follower to estimate the convex combination of non‐autonomous leaders' states. The compensator is designed with the following three features: (1) It can estimate the convex combination of non‐autonomous leaders' states over directed graphs; (2) it is fully distributed; and (3) the designed event‐triggered mechanisms (ETMs) are composite dynamic ETMs, and each follower does not have to monitor the sampling errors continuously. Then, a state observer is developed for each follower based on the output feedback. Based on the designed compensator and state observer, an event‐triggered controller is developed, ensuring that each follower's state converges exponentially to an arbitrarily small neighborhood centered on the convex combination of leaders' states. Additionally, the proposed DETMs are free of Zeno behavior. Finally, the effectiveness of the developed control protocol is verified by two simulation examples. [ABSTRACT FROM AUTHOR]

Rock slopes with weak intercalated layer are prone to slide because of engineering disturbance or water intrusion deterioration, which poses severe threats to human life and property safety. Identifying the water-induced deterioration characteristics of such interfaces, as well as the potential failure mechanism of such slope is of great importance for scientific prevention. The right abutment slope of Gushan Reservoir is composed of thick quartz sandstone and thin argillaceous shale interlayer inclined downstream, dip angle of about 10°. Besides, relief joints with a steep tendency to the valley at the top of the slope were found. Once the shear strength of the shale decreases due to the reservoir impoundment, the slope might slide, threatening the safety of the dam. For this reason, basic data of the slope were presented by field geological and UAV aerial survey. Then, the strength deterioration law of shale induced by water was revealed by large in-situ direct shear tests. Finally, the potential failure mechanism of the slope under different conditions, as well as the feasibility of the proposed reinforcement scheme were analyzed utilizing three-dimensional numerical simulation. The results showed that the shear strength of the saturated shale was about 50% of that under natural state. The stability of the slope would decrease due to the strength deterioration of the weak interlayer, and the sliding along the weak layer might occur, resulting in local deformation at the right end of the dam. Concrete plugs to be arranged along the potential sliding surface was an effective reinforcement measure for such slope. These results might provide a reference for the stability evaluation and reinforcement design of similar slopes. [ABSTRACT FROM AUTHOR]

Purpose: The present study aims to explore the effects of tacrolimus on proteinuria in patients with idiopathic membranous nephropathy (IMN) and recommend an appropriate dosage schedule via machine learning method. Methods: The Emax model was constructed to analyze the effects of tacrolimus on proteinuria in patients with IMN. Data were mined from published literature and machine learning was built up with Emax model, among which the efficacy indicator was proteinuria change rates from baseline. 463 IMN patients were included for modeling, and tacrolimus therapeutic window concentrations were 4–10 ng/ml. Results: In machine learning model, the Emax from tacrolimus effecting proteinuria in IMN patients was −72.7%, the ET50 was 0.43 months, and the time to achieving 25% Emax, 50% Emax, 75% Emax, and 80% (plateau) Emax of tacrolimus on proteinuria in patients with IMN were 0.15, 0.43, 1.29, and 1.72 months, respectively. Conclusion: For achieving better therapeutic effects from tacrolimus on proteinuria in patients with IMN, tacrolimus concentration range need to be maintained at 4–10 ng/ml for at least 1.72 months. [ABSTRACT FROM AUTHOR]

Introduction: Due to the widespread use of social media by young adults, the alcohol industry has been increasingly using social media marketing (SMM) to target potential customers. This study examines the prevalence and factors associated with past‐month exposure to alcohol SMM among young Chinese adults, a group with rapidly increasing uptake of alcohol consumption. Methods: An anonymous, random telephone survey was conducted between June and August 2021 on Hong Kong Chinese residents between 18 and 34 years old (n = 675). Results: Of respondents, 52.3% reported past‐month exposure to alcohol SMM (68.6% of past‐month drinkers and 48.0% of non‐past‐month drinkers, p < 0.05) while 71.6% reported exposure to non‐SMM alcohol marketing. Direct alcohol SMM exposure was reported by 40.9% (e.g., business‐to‐consumer postings, alcohol banner ads) while 27.4% of respondents reported exposure to indirect alcohol SMM marketing (e.g., shared/'liked' alcohol brand posts). Of those exposed to alcohol SMM, 13.7–15.5% reported that the various forms indirect alcohol SMM influenced them to drink more (vs. 6.2–8.9% for direct alcohol SMM). Being male, lower‐income, university educated and spirits/cocktail drinker were independently associated with exposure to direct alcohol SMM (ORmv 1.71–3.14). Past‐month exposure to indirect alcohol SMM was independently associated with lower income, not working full‐time and drinking any type of alcohol (ORmv 1.59–4.44). Discussion and Conclusion: The comparative effectiveness of indirect SMM on influencing young adults drinking intentions may be a form of peer endorsement of drinking. The pervasiveness of alcohol SMM and lack of alcohol SMM policies may indicate the need for greater alcohol marketing regulation in this region. [ABSTRACT FROM AUTHOR]

Key Clinical Message: We report a rare case of thyroid diffuse large B‐cell lymphoma with a BRAFV600E mutation, which mimics poorly differentiated thyroid cancer in fine needle aspiration cytology. [ABSTRACT FROM AUTHOR]

In the past, hydrogen sulfide (H2S) was recognized as a toxic and dangerous gas; in recent years, with increased research, we have discovered that H2S can act as an endogenous regulatory transmitter. In mammals, H2S‐catalyzing enzymes, such as cystathionine‐β‐synthase, cystathionine‐γ‐lyase, and 3‐mercaptopyruvate sulfurtransferase, are differentially expressed in a variety of tissues and affect a variety of biological functions, such as transcriptional and posttranslational modification of genes, activation of signaling pathways in the cell, and metabolic processes in tissues, by producing H2S. Various preclinical studies have shown that H2S affects physiological and pathological processes in the body. However, a detailed systematic summary of these roles in health and disease is lacking. Therefore, this review provides a thorough overview of the physiological roles of H2S in different systems and the diseases associated with disorders of H2S metabolism, such as ischemia–reperfusion injury, hypertension, neurodegenerative diseases, inflammatory bowel disease, and cancer. Meanwhile, this paper also introduces H2S donors and novel release modes, as well as the latest preclinical experimental results, aiming to provide researchers with new ideas to discover new diagnostic targets and therapeutic options. [ABSTRACT FROM AUTHOR]

The current work aimed to evaluate the effect of ensiling density on the fermentation quality and aerobic stability of Pennisetum giganteum silages. The silage was ensiled in laboratory silos (1 L), and three treatments were designed according to different ensiling densities: (1) low density (LD, 750 kg/m3); (2) medium density (MD, 900 kg/m3); and (3) high density (HD, 1050 kg/m3). During ensiling, the silage was sampled for a fermentation quality analysis. All silages were well preserved, as indicated by the high lactic acid (LA) content and low pH (<4.2). The MD treatment had the highest acetic acid content (24.9 g/kg dry matter) and the HD treatment had the lowest ammonia nitrogen (NH3-N) content (68.2 g/kg total nitrogen, TN) among all silages after 45 days of ensiling. The aerobic stability of HD, MD, and LD persisted for 51 h, 54 h, and 48 h, respectively. The NH3-N contents of HD and MD were below 80 g/kg TN during aerobic exposure. These results show that the increase in ensiling density improved the fermentation quality and aerobic stability of Pennisetum giganteum silages. [ABSTRACT FROM AUTHOR]

Autonomous indoor humidity control is gaining more and more attention but is limited by the trade-offs among pore volume, pore size and water stability of water adsorbents. We solve this problem by using a unique coordination network topology combined with hydrolytically stable M(III) carboxylate clusters. By extending the ligand length from 9.0 to 11.2 and 13.7 Å, the pore volume significantly increases from 0.99 to 1.40 and 1.78 cm3 g−1, which proportionally increases the saturated water adsorption capacity. Meanwhile, the pore size slightly increases from 10.4 to 11.0 and 13.5 Å, which restricts the isotherm inflection pressure and hysteresis width to meet the requirement of indoor humidity control. Large single-crystals suitable for X-ray diffraction studies were obtained by using Fe(III) salts, while isostructural frameworks with sufficiently high water stabilities were synthesized by using Cr(III) salts, which offer record working capacity of 0.90 and 1.10 g g−1 for indoor humidity control. [ABSTRACT FROM AUTHOR]

Background: Appropriately defining and using the minimal important change (MIC) and the minimal clinically important difference (MCID) are crucial for determining whether the results are clinically significant. The aim of this study is to survey the status of randomized controlled trials (RCTs) for insomnia interventions to assess the inclusion and interpretation of MIC/MCID values. Methods: We conducted a cross-sectional study to survey the status of RCTs for insomnia interventions to assess the inclusion and appropriate interpretation of MIC/MCID values. A literature search was conducted by searching the main sleep medicine journals indexed in PubMed, the Excerpta Medica Database (EMBASE), and the Cochrane Central Register of Controlled Trials (CENTRAL) to identify a broad range of search terms. We included RCTs with no restriction on the intervention. The included studies used the Insomnia Severity Index (ISI) or the Pittsburgh Sleep Quality Index (PSQI) questionnaire as the outcome measures. Results: 81 eligible studies were identified, and more than one-third of the included studies used MIC/MCID (n = 31, 38.3%). Among them, 21 studies with ISI as the outcome used MIC defined as a relative decrease ranging from 3 to 8 points. The most frequently used MIC value was a 6-point decrease (n = 7), followed by 8-point (n = 6) and 7-point decrease (n = 4), a 4 to 5-points decrease (n = 3), and a 30% reduction from baseline; 6 studies used MCID values, ranging from 2.8 to 4 points. The most frequently used MCID value was a 4-point decrease in the ISI (n = 4). 4 studies with PSQI as the outcome used a 3-point change as the MIC (n = 2) and a 2.5 to 2.7-point difference as MCID (n = 2). 4 non-inferiority design studies considered interval estimation when drawing clinically significant conclusions in their MCID usage. Conclusions: The lack of consistent MIC/MCID interpretation and usage in outcome measures for insomnia highlights the urgent need for further efforts to address this issue and improve reporting practices. [ABSTRACT FROM AUTHOR]

As drilling wells continue to move into deep ultra-deep layers, the requirements for temperature resistance of drilling fluid treatments are getting higher and higher. Among them, blocking agent, as one of the key treatment agents, has also become a hot spot of research. In this study, a high temperature resistant strong adsorption rigid blocking agent (QW-1) was prepared using KH570 modified silica, acrylamide (AM) and allyltrimethylammonium chloride (TMAAC). QW-1 has good thermal stability, average particle size of 1.46 mm, water contact angle of 10.5°, has a strong hydrophilicity, can be well dispersed in water. The experimental results showed that when 2 wt% QW-1 was added to recipe A (4 wt % bentonite slurryþ0.5 wt% DSP-1 (filtration loss depressant)), the API filtration loss decreased from 7.8 to 6.4 mL. After aging at 240 °C, the API loss of filtration was reduced from 21 to 14 mL, which has certain performance of high temperature loss of filtration. At the same time, it is effective in sealing 80-100 mesh and 100-120 mesh sand beds as well as 3 and 5 mm ceramic sand discs. Under the same conditions, the blocking performance was superior to silica (5 mm) and calcium carbonate (2.6 mm). In addition, the mechanism of action of QW-1 was further investigated. The results show that QW-1 with amide and quaternary ammonium groups on the molecular chain can be adsorbed onto the surface of clay particles through hydrogen bonding and electrostatic interaction to form a dense blocking layer, thus preventing further intrusion of drilling fluid into the formation [ABSTRACT FROM AUTHOR]

Two-dimensional (2D) coordination polymers have attracted great attention for catalysis because of their abundant exposed active sites. Here, we show that bending the local structure of 2D coordination polymers can inverse the electrocatalytic selectivity. A series of ultrathin nanosheets based on isoreticular/isostructural/isomeric 2D Cu(I) triazolate coordination polymers were successfully prepared. By introducing an amino group on the triazolate ligand, the shape of the 2D layer transforms from planar into wavy, which inverses the electrocatalytic selectivity from the HER (selectivity ∼ 80%) to the CO2RR (selectivity ∼ 76%, C2H4 up to 52%). Computational simulations showed that the wavy structure allows the amino groups to form attractive hydrogen-bonding interactions with the key reaction intermediates of the CO2RR for C2H4 and steric hindrance with the key reaction intermediates of the HER, giving lower and higher reaction energy barriers, respectively. [ABSTRACT FROM AUTHOR]

Energy‐saving and value‐added management in advanced catalysis is highly desirable but is challenged by the limitations of multifunctional catalysts and catalytic modules. Herein, an azo‐linked phthalocyanine‐porphyrin covalent organic framework (COF) with the ultrathin layered nanostructure grown on carbon nanotubes (NiPc‐azo‐H2Pp@CNTs) has been designed and synthesized, which can serve as a highly active and stable bifunctional heterojunction electrocatalyst for selective paired‐electrosynthesis through coupling anodic iodide oxidation reaction and cathodic CO2 conversion. Particularly, the inbuilt local microenvironment conferred by the dihydroporphyrin moieties in COF can act as a proton reservoir to promote the proton relay at the heterojunction interface during the electrocatalytic process. Moreover, through the cascade construction of dual electrocatalytic/organocatalytic modules, the cathode‐generated CO can be further converted to dimethyl carbonate with a yield of 6.21 mmol L−1 h−1, while the anode‐produced iodine can be derived into iodoform on the hundred‐milligram scale. It is worth noting that the value‐added cascade synthesis mediated by paired‐electrolysis using the distinctive and high‐powered electrocatalysts will help advance the sustainable development of industrial intelligent manufacturing. [ABSTRACT FROM AUTHOR]

Immune checkpoint inhibitors (ICI) have emerged as a promising therapeutic option for melanoma, which demonstrating improved clinical outcomes in melanoma patients regardless of specific genetic mutations. However, the identification of reliable biomarkers for predicting immunotherapy response and prognosis remains a challenge. In this study, we performed genetic profiling of the melanoma patients with different subtypes and evaluated the efficacy of ICI treatment. A total of 221 melanoma patients were included in our cohort, consisting primarily of acral lentiginous melanoma (ALM), cutaneous malignant melanoma (CMM), and mucosal malignant melanoma (MMM). Genetic analysis revealed BRAF mutations was predominant in CMM and NRAS mutations was prevalent in ALM. Copy number variants (CNVs) and structural variants (SV) were also detected, with CCND1 and CDK4 being the most affected genes in CNV and BRAF, ALK and RAF1 being the druggable targets in SV. Furthermore, NRAS mutations were associated with a poor prognosis in ALM, while TERT mutations were linked to unfavorable outcomes in CMM after receiving PD-1 therapy. Additionally, ALK expression exhibited improved outcomes in both ALM and CMM subtypes. Our study provides a comprehensive genomic and pathological profiling of Chinese melanoma patients, shedding light on the molecular landscape of the disease. Furthermore, numbers of gene mutations and ALK expression were identified as prognostic indicators. These findings contribute to the understanding of melanoma genetics in the Chinese population and have implications for personalized treatment approaches. [ABSTRACT FROM AUTHOR]

The benefits of physical exercise on human health make it desirable to identify new approaches that would mimic or potentiate the effects of exercise to treat metabolic diseases. However, whether far-infrared (FIR) hyperthermia therapy could be used as exercise mimetic to realize wide-ranging metabolic regulation, and its underling mechanisms remain unclear. Here, a specific far-infrared (FIR) rays generated from graphene-based hyperthermia devices might promote exercise capacity and metabolisms. The material characterization showed that the graphene synthesized by chemical vapour deposition (CVD) was different from carbon fiber, with single-layer structure and high electrothermal transform efficiency. The emission spectra generated by graphene-FIR device would maximize matching those adsorbed by tissues. Graphene-FIR enhanced both core and epidermal temperatures, leading to increased blood flow in the femoral muscle and the abdominal region. The combination of microbiomic and metabolomic analysis revealed that graphene-FIR modulates the metabolism of the gut-muscle axis. This modulation was characterized by an increased abundance of short-chain fatty acids (SCFA)-producing bacteria and AMP, while lactic acid levels decreased. Furthermore, the principal routes involved in glucose metabolism, such as glycolysis and gluconeogenesis, were found to be altered. Graphene-FIR managed to stimulate AMPK activity by activating GPR43, thus enhancing muscle glucose uptake. Furthermore, a microbiota disorder model also demonstrated that the graphene-FIR effectively restore the exercise endurance with enhanced p-AMPK and GLUT4. Our results provided convincing evidence that graphene-based FIR therapy promoted exercise capacity and glucose metabolism via AMPK in gut-muscle axis. These novel findings regarding the therapeutic effects of graphene-FIR suggested its potential utility as a mimetic agent in clinical management of metabolic disorders. [ABSTRACT FROM AUTHOR]

Background: The present study aimed to investigate the drug-drug interaction and initial dosage optimization of aripiprazole in patients with schizophrenia based on population pharmacokinetics. Research design and methods: A total of 119 patients with schizophrenia treated with aripiprazole were included to build an aripiprazole population pharmacokinetic model using nonlinear mixed effects. Results: The weight and concomitant medication of fluoxetine influenced aripiprazole clearance. Under the same weight, the aripiprazole clearance rates were 0.714:1 in patients with or without fluoxetine, respectively. In addition, without fluoxetine, for the once-daily aripiprazole regimen, dosages of 0.3 and 0.2 mg kg-1 day-1 were recommended for patients with schizophrenia weighing 40-95 and 95-120 kg, respectively, while for the twice-daily aripiprazole regimen, 0.3 mg kg-1 day-1 was recommended for those weighing 40-120 kg. With fluoxetine, for the once-daily aripiprazole regimen, a dosage of 0.2 mg kg-1 day-1 was recommended for patients with schizophrenia weighing 40-120 kg, while for the twice-daily aripiprazole regimen, 0.3 and 0.2 mg kg-1 day-1 were recommended for those weighing 40-60 and 60-120 kg, respectively. Conclusion: This is the first investigation of the effects of fluoxetine on aripiprazole via drug-drug interaction. The optimal aripiprazole initial dosage is recommended in patients with schizophrenia. [ABSTRACT FROM AUTHOR]

Engineering construction (such as water conservancy project, road engineering, and so on) in mountain areas bring mass of waste soil and rock fragment, whose stability is critical to the ecological environment and the safe operation of engineering facilities. The biggest waste dump of the Pumped Storage Power Station Project in Hunyuan County, Shanxi Province, China, with a volume of 7 million m³ and a maximum height of 240 m, is to be located at the origin of Mahua Valley. To assess the potential risk of the waste dump, reconnaissance, geomorphological analysis was undertaken to provide basic data. The potential failure area and volume was determined utilizing Flac3D depending on strength reduction method. The kinematic process and the potential hazards after failure was presented by Particle flow code. The results showed that the factor of safety of the waste dump under heavy precipitation was 1.15, less than the stability requirement of slope in hydropower station, and the potential failure volume was about 4.8 million m³. The scenario-based debris mass run-out paths indicated that, considering the worst cases scenario, the ground ventilation platform and ventilation tunnel exit on the right bank of the gully might be destroyed rapidly by landslide debris. Besides, the debris flow would accumulate at the gully mouth, and even run into the lower reservoir. Thus, more attention should be taken to increase the stability of the waste dump. These results are useful information for decision support and future hazard assessment of such engineering project. [ABSTRACT FROM AUTHOR]

To assess the correlation between preoperative neutrophil‐to‐lymphocyte ratio (NLR) and risk of postoperative delirium (POD) in older patients undergoing noncardiac surgery. PubMed, Web of Science, Embase, and Scopus were systematically retrieved from inception until February 2023. Two authors independently conducted the selection of literature, data extraction and statistical analysis. In this meta‐analysis, Review Manager 5.4 was used for statistical analysis, and the mean difference (MD) and 95% confidence intervals (CIs) of preoperative NLR between the POD group and non‐POD group were calculated. We utilised the Newcastle–Ottawa Scale (NOS) to evaluate the quality of literature. Further, our meta‐analysis used a random‐effects model, and publication bias was evaluated by conducting a funnel plot. The correlation between preoperative NLR and POD was the primary outcome, and the secondary outcome was the association of other prognostic factors with the risk of POD. This meta‐analysis included seven studies with 2424 patients, of whom 403 were diagnosed with POD with an incidence of 16.63%. Results indicated a positive correlation between preoperative NLR and the risk of POD (MD = 1.06, 95% CI: 0.64–1.49; P < 0.001). Further, our results found that neutrophil counts, advanced age, longer surgery time, diabetes, and elevated C‐reactive protein were significantly associated with POD (MD = 0.98, 95% CI: 0.40–1.56; P = 0.001; MD = 4.20, 95% CI: 2.90–5.51; P < 0.001; MD = 0.15, 95% CI: 0.05–0.25; P < 0.01; OR = 1.42, 95% CI: 1.08–1.86; P = 0.01; MD = 1.26, 95% CI: 0.36–2.16; P < 0.01). Other factors including lymphocyte counts, hypertension and male gender were not significantly associated with POD (MD = −0.11, 95% CI: −0.27 to 0.05; P > 0.05; OR = 1.20, 95% CI: 0.91–1.58, P > 0.05; OR = 1.28, 95% CI: 1.00–1.63; P = 0.05). Our meta‐analysis indicated a positive correlation between preoperative NLR and the risk of POD in older noncardiac surgery patients. [ABSTRACT FROM AUTHOR]

Objective: The objective of this study was to examine the psychometric properties of the EQ-5D-Y-3 L, Patient Reported Outcomes Measurement System 25-item version profile v2.0 (PROMIS-25), and Pediatric Quality of Life Inventory™ version 4.0 Generic Core Scale (PedsQL 4.0) in Chinese pediatric patients with spinal muscular atrophy (SMA). Methods: The data used in this study were obtained via a web-based cross-sectional survey. Parents of pediatric patients with SMA completed the proxy-reported EQ-5D-Y-3 L, PedsQL 4.0, and PROMIS-25 measures. Information about socioeconomic and health status was also obtained. The ceiling and floor effects, factorial structure, convergent validity, and known-group validity of the three measures were assessed. Results: Three hundred and sixty-three parents of children aged from 5 to 12 completed the questionnaires. Strong floor effects were observed for the physical function components of the PROMIS-25 (41.3%) and PedsQL 4.0 (67.8%). For EQ-5D-Y-3 L, 84.6% of the respondents reported having "a lot of" problems with the dimensions "walking" and "looking after myself." Minimal ceiling or floor effects were observed for the EQ-5D-Y-3 L index value. The confirmatory factor analysis supported a six-factor structure for the PROMIS-25, but did not support a four-factor structure for the PedsQL 4.0. All hypothesized correlations of the dimensions among the three measures were confirmed, with coefficients ranging from 0.28 to 0.68. Analysis of variance showed that EQ-5D-Y-3 L demonstrated better known-group validity than the other two measures in 14 out of 16 comparisons. Conclusions: The EQ-5D-Y-3 L showed better discriminant power than the other two measures. The physical health dimensions of all three measures showed the significant floor effects. These findings provide valuable insights into the effectiveness of these measures at capturing and quantifying the impact of SMA on patients' health-related quality of life. [ABSTRACT FROM AUTHOR]

The covalent organic frameworks/polymers configurated with metal‐N4 conjugated structures offer an exceptional platform for efficient electrochemical CO2 reduction reaction (eCO2RR). However, understanding the impact of the structure‐mediated local microenvironment and integrating CO2 electroreduction with follow‐up utilization toward extending chemical valorization of CO2 are still far from sufficient. Herein, a set of covalent phenanthroline‐porphyrin polymers are designed to decode the microenvironment modulation originating from built‐in structures, and the optimized one delivered an extraordinary performance for eCO2RR with ≈100% Faradaic efficiency of CO under stabilized CO2‐electrolysis of 70 h. The experimental and theoretical analyses suggest that the regulation of the Co‐N4 electronic structures and microenvironment convoys the stabilized formation of key reaction intermediate *COOH. Furthermore, through CO‐mediated electro/thermocatalytic tandem processes, the aminocarbonylation of aryl iodides and amines with high yields has been convincingly implemented over the coordinated Pd sites, which is remarkably helpful to propel extending chemical valorization of CO2. [ABSTRACT FROM AUTHOR]