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Deep learning has been effective for histology image analysis in digital pathology. However, many current deep learning approaches require large, strongly- or weakly labeled images and regions of interest, which can be time-consuming and resource-intensive to obtain. To address this challenge, we present HistoPerm, a view generation method for representation learning using joint embedding architectures that enhances representation learning for histology images. HistoPerm permutes augmented views of patches extracted from whole-slide histology images to improve classification performance. We evaluated the effectiveness of HistoPerm on 2 histology image datasets for Celiac disease and Renal Cell Carcinoma, using 3 widely used joint embedding architecture-based representation learning methods: BYOL, SimCLR, and VICReg. Our results show that HistoPerm consistently improves patch- and slide-level classification performance in terms of accuracy, F1-score, and AUC. Specifically, for patch-level classification accuracy on the Celiac disease dataset, HistoPerm boosts BYOL and VICReg by 8% and SimCLR by 3%. On the Renal Cell Carcinoma dataset, patch-level classification accuracy is increased by 2% for BYOL and VICReg, and by 1% for SimCLR. In addition, on the Celiac disease dataset, models with HistoPerm outperform the fully supervised baseline model by 6%, 5%, and 2% for BYOL, SimCLR, and VICReg, respectively. For the Renal Cell Carcinoma dataset, HistoPerm lowers the classification accuracy gap for the models up to 10% relative to the fully supervised baseline. These findings suggest that HistoPerm can be a valuable tool for improving representation learning of histopathology features when access to labeled data is limited and can lead to whole-slide classification results that are comparable to or superior to fully supervised methods. [ABSTRACT FROM AUTHOR]

Focuses on issues related to clinical drug therapy trials in the U.S. Aims of the drug trials; Results of the drug trials; Limitations of the drug trials.

Focuses on picking the right nonsteroid drug for rheumatoid arthritis. Incidence of rheumatoid arthritis in North America; Drugs commonly prescribed for the disease; Importance of physical therapy.

Discusses the potential health hazards of excessive intake of vitamin supplements. Consideration in the use of vitamin supplements; Mechanism of action of large doses of vitamins; Toxicity of niacin in large dosage. INSET: VITAMIN TOXICITY.

Provides information on cancer chemotherapy. Beliefs that characterize modern chemotherapy; Effectiveness of doxorubicin against solid tumors; Some chemotherapeutic agents. INSET: Anecdote: Wanna bet? by JULIANNA KSICINSKI, R.N..

Provides information on the management of anaerobic bacteria in obstetric-gynecology cases. Most frequent anaerobic infectious agents; Clinical signs of anaerobic infection; Diagnosis; Measures that could minimize the risk of acquiring an anaerobic bacterial infection.

Provides guidelines for preventing drug toxicity in renal failure. Complicating factors in renal failure; Administration of half-life of drugs; Adjustment in drug therapy.

Focuses on the medical applications of radiopharmaceuticals. Reasons for the safety of radionuclides to humans; Details on some safety precautions on the use of radiopharmaceuticals; Procedures on the diagnostic use of pharmaceuticals; Therapeutic uses of radiopharmaceuticals.

Focuses on the test and therapy for venereal diseases. Reasons for the increased cases of gonorrhea; Types of test for syphilis; Treatment and management of patients with gonorrhea.

Few doctors suffer under burgeoning state relicensing laws. Most physicians have no trouble complying with recent laws in 15 states, requiring continuing medical education, or CME, to keep their licenses.... CME has therefore become a booming business, with universities and other groups offering 8,081 courses in 1979-80, up from 4,862 in 1975-76. [ABSTRACT FROM AUTHOR]

Restates the established facts about tranquilizers and sedatives and presents a rational basis for their clinical use. Classification among groups of drugs; Action of ionic bromide drugs; Urea derivatives in the field of sedatives; Antihistaminics; Rauwolfia alkaloids; Phenothiazines; Atropine group; Chlordiazepoxide.

Discusses the role of nurses in helping patients control bronchial asthma. Features of bronchial asthma; Drugs used to relieve symptoms of bronchial asthma; Need to teach patients how to use an inhaler; Information on the use of aerosol dispensers of steroid drugs.

Provides guidelines for treating heroin addiction. Health risks of heroin addicts; Recommended forms of drug therapy; Proper management of the addiction.

Provides information on bioavailability. Factors that affect bioavailability; Efforts of pharmaceutical chemists to standardize the manufacturing process; Methods of measuring bioavailability.

A letter to the editor is presented in response to an article about cardiac resynchronization therapy (CRT) by Turitto and El-Sherif.

Details several drug interactions which commonly occur in the gastrointestinal tract. Acid-base reactions; Binding or complexation of drugs; Drug-induced malabsorption.

Presents information on drug-induced changes in vital signs and blood pressure. Ampicillin; Cephalothin; Epinephrine.

Presents a lists of known instances of drug-induced changes in urine color. Urine color change due to amitriptyline; Impact of levodopa on urine color; Effect of metronidazole on urine color.