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In the present investigation, effect of pure green tea catechin, (+)-catechin hydrate was studied on plasma uric acid, plasma nitrite, cardiac lipid peroxidation, reduced glutathione and cardiac antioxidant enzymes in high sucrose high fat diet fed rats for a period of 12 weeks. Our results indicate that feeding high sucrose high fat diet resulted in the development of oxidative stress in rats and (+)-catchin hydrate has antioxidant effect. High sucrose high fat diet decreased plasma uric acid and increased plasma nitrite levels. Further lipid peroxidation increased and reduced glutathione levels decreased in heart of high sucrose high fat diet fed rats. Activity of antioxidant enzymes (SOD, GST, GR and GPx) was significantly reduced in high sucrose high fat fed rats. Catechin supplementation improved plasma uric acid and nitrite levels and reduced lipid peroxidation. Further there was normalization in reduced Glutathione levels and activities of cardiac antioxidant enzymes upon administration of (+)-catechin hydrate. It can be concluded that high sucrose high fat diet produces oxidative stress in rats and administration of catechin is helpful to combat oxidative stress. [ABSTRACT FROM AUTHOR]

Perinatal tuberculosis is insufficiently understood and has been rarely reported even in areas endemic for the disease, and unless a high index of suspicion is maintained the diagnosis can be missed. Differentiation of congenital from early postnatally acquired tuberculosis is only of epidemiological importance. We hereby report one case of congenital tuberculosis and three cases of perinatal tuberculosis, and problems faced during investigation and management and emphasize need for improved screening of women at risk and sensitization of the medical community about this entity. [ABSTRACT FROM AUTHOR]