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Background: As hypothermic circulatory arrest (HCA) is being more frequently induced in patients undergoing aortic arch surgery, its safety at different degrees has become a crucial area of study. The aim of this study was to assess the surgical outcomes of mild hypothermic circulatory arrest (MI-HCA) during aortic arch surgery. Methods: Acute type A aortic dissection (ATAAD) patients who underwent total arch replacement (TAR) and frozen elephant trunk (FET) surgery between January 2014 and December 2023 were enrolled in this study. The patients were divided into two groups according to the minimum nasopharyngeal temperature: the moderate hypothermic circulatory arrest (MHCA) group (20–28 °C) and the MI-HCA group (> 28 °C). The inverse probability of treatment weighting (IPTW) was used to balance differences in the baseline characteristics. Perioperative variables were analysed via pairwise comparisons, multivariable logistic regression, and subgroup forest plots to assess the impact of MI-HCA on surgical outcomes. Results: A total of 447 patients were included in this study, and the mean minimum nasopharyngeal temperature was 24.80 (23.98, 27.30) °C in the MHCA group and 30.10 (29.80, 30.70) °C in the MI-HCA group. The incidence of acute kidney injury (AKI) in the MI-HCA group was lower than that in the MHCA group (52% vs. 78%, p < 0.01). In the multivariable logistic regression analysis, MI-HCA was identified as an independent protective factor for AKI (OR = 0.354, 95% CI 0.177–0.689; p = 0.003). Additionally, compared with MHCA, MI-HCA was not associated with an increased incidence of stroke, spinal cord injury, or in-hospital mortality. After IPTW, the preoperative and intraoperative data of the patients were balanced, and the incidence of AKI in the MI-HCA group was still lower than that in the MHCA group (83.26% vs. 53.61%, p = 0.004). The subgroup forest plot also demonstrated that MI-HCA was a protective factor for postoperative AKI. Conclusions: The surgical outcomes of MI-HCA in ATAAD patients were satisfactory. Compared with MHCA, MI-HCA provided sufficient protection for distal organs, the brain, and the spinal cord, with a significantly lower incidence of AKI. These results indicate that MI-HCA could be a better approach for ATAAD surgery. [ABSTRACT FROM AUTHOR]

Effective recycling and utilization of waste glass is a critical issue that urgently needs to be addressed. This study aims to explore the feasibility of using ground waste glass powder (particle size ≤ 75 μm) as a supplementary cementitious material to partially replace cement in the preparation of low-carbon and environmentally friendly grouting materials. The research systematically evaluates the impact of waste glass powder (WGP) on the fresh properties (particularly the stability and rheological characteristics) of cement-based grouting materials under various conditions, including WGP content (0–40%), the addition of NaOH activator (Na2O content of 4%) or not, and water–solid ratio (w/s = 0.5, 0.65, 0.8, 1.0). The results indicate that, in the absence of activator, the addition of WGP generally increases the amount of free liquid exudation in the grout, reducing its stability; however, under low w/s ratios, appropriate amounts of WGP can enhance stability. When the w/s ratio is high and the WGP content is large, the grout stability decreases significantly. The addition of NaOH activator (Na2O content of 4%) significantly reduces free liquid exudation, enhancing the stability of the grout, especially when the w/s ratio is less than 1.0. Furthermore, the Herschel–Bulkley Model was experimentally validated to accurately describe the rheological behavior of waste glass–cement slurries, with all R2 values exceeding 0.99. WGP and alkaline activator have significant effects on the rheological properties of the grout. Although they do not change its flow pattern, they significantly affect shear stress and viscosity. The viscosity of the slurry is influenced by the combined effects of w/s ratio, WGP content, and alkaline activator, with complex interactions among the three. The application of these research findings in the field of grouting engineering not only contributes to significantly reducing glass waste but also promotes the production of sustainable cement-based composites, lowering carbon dioxide emissions by reducing cement usage, and thereby alleviating environmental burdens. [ABSTRACT FROM AUTHOR]

Highly filled polymer fibers offer huge promise for radiation protection safety and wear comfort of personal protective equipment (PPE) in radiation environments. However, it usually sacrifices mechanical properties that directly related to practical usability. Here, as high as 75 wt% PbWO4 (PWO) particles have been filled in polyvinyl alcohol (PVA) fiber via tailoring their size and shape for enhanced γ‐rays shielding and good mechanical properties. Clearly shown that 0 dimensional (0‐D) PWO exhibits better dispersion and compatibility between the interfaces than 1‐D PWO in highly filled PVA fibers. In addition, 70 wt% 0‐D PWO/PVA fibers display better mechanical properties than 70 wt% 1‐D PWO/PVA fibers. Note that 75 wt% 0‐D PWO/PVA fibers show 1.02 cN/dtex of tensile strength. However, 75 wt% 1‐D PWO/PVA fibers fail to be fabricated smoothly. Importantly, the overlapped fabrics with 75 wt% 0‐D PWO/PVA fibers display 43.05% of γ‐ray shielding (105 keV) meanwhile it offers good air and water vapor permeability for wear comfort. The superior γ‐ray shielding ascribes the polymer fibers with the higher filling in comparison with its counterpart, which provides a practical means to design radiation protection safety and wear comfort of articles. Highlights: This work breaks the upper limit of filling in polymer fibersFiller structure can weigh the integrated properties of polymer fibers.0‐D PWO particles promote interfacial compatibility in highly filled fibers.Radiation protection safety and wear comfort of articles tend to be designed. [ABSTRACT FROM AUTHOR]

Background: High sodium intake has been linked to various health outcomes; however, its association with constipation remains unclear, particularly in adult males. This population-based study aimed to investigate the association between daily sodium intake and constipation using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2010. Methods: Using data from the NHANES database spanning from 2005 to 2010, a cross-sectional study including 7116 adult male participants from the United States was performed to assess the relationship between daily sodium intake and constipation. Multivariable logistic regression models were used, adjusting for various potential confounders, to evaluate this association. Restricted cubic spline (RCS) methods were applied to explore potential nonlinear trends in the association, and subgroup analyses were conducted through forest plots to examine interactions among different subgroups (P for interaction). Results: The study found that an increase in daily sodium intake was significantly associated with a reduced risk of constipation. Trend analysis indicated a statistically significant trend across all models, where increased daily sodium intake was associated with lower constipation risk, with (OR: 0.78, 95% CI: 0.71 ~ 0.85; P < 0.001) in Model 1; (OR: 0.79, 95% CI: 0.73 ~ 0.87; P < 0.001) in Model 2; and (OR: 0.82, 95% CI: 0.69 ~ 0.97; P = 0.023) in Model 3 (P for trend < 0.05 in all models). On the contrary, RCS analysis did not reveal a nonlinear association between daily sodium intake and constipation risk (P = 0.528). Subgroup analysis further supported a consistent negative association between daily sodium intake and constipation risk across different subgroups, with no significant interactions found (all P values > 0.05). Conclusions: This study demonstrates a negative association between daily sodium intake and constipation risk among adult males, suggesting that sodium intake might influence intestinal function. [ABSTRACT FROM AUTHOR]

Background: Osteoarthritis (OA) is a prevalent degenerative joint disease that causes disability and diminishes quality of life. The pathogenesis of OA remains poorly understood, creating an urgent need for biomarkers to aid research, diagnosis, and treatment. Methods: This study integrated transcriptome data from the GEO database with bioinformatics analyses to identify biomarkers associated with OA. The bioinformatics methods utilized include the Limma package, WGCNA, PPI network analysis, and machine learning algorithms. Genetic variants were used as instrumental variables to evaluate the potential causal impact of circulating white blood cell (WBC) counts on OA. Data sources encompassed the largest genome-wide analysis for OA and a comprehensive GWAS summary for circulating WBC counts. Four mendelian randomization (MR) methods were employed to investigate the genetic association, with a primary focus on findings from the inverse variance-weighted (IVW) method. Results: Total of 233 OA-related genes were identified, showing significant enrichment in pathways associated with WBC function. Key biomarkers, including CD4, CSF1R, and TYROBP, were upregulated in OA samples and exhibited strong diagnostic potential. MR analysis findings provided evidence of a genetic association between elevated neutrophil counts and a reduced risk of OA across sites (IVW: OR = 0.97, 95% CI 0.93–1.00, p = 0.047). Additionally, higher circulating WBC counts, particularly neutrophil counts, were associated with a suggestive decrease in hip OA (WBC IVW: OR = 0.94, 95% CI 0.89–0.99, p = 0.015; neutrophil IVW: OR = 0.93, 95% CI 0.88–0.99, p = 0.017). Conversely, reverse MR analysis found no evidence to support a genetic effect of OA on circulating WBC counts. Conclusion: Our findings suggest that elevated neutrophil counts may offer protective effects against OA, underscoring the interplay between the immune functions and OA pathogenesis. CD4, CSF1R, and TYROBP emerge as promising OA biomarkers, meriting further validation in prospective studies. [ABSTRACT FROM AUTHOR]

Global warming has profound effects on precipitation patterns, leading to more frequent and extreme precipitation events over the world. These changes pose significant challenges to the sustainable development of socio-economic and ecological environments. This study evaluated the performance of the new generation of the mesoscale Weather Research and Forecasting (WRF) model in simulating long-term extreme precipitation events over the Minjiang River Basin (MRB) of China from 1981 to 2020. We calculated 12 extreme precipitation indices from the WRF simulations and compared them with observations. The spatio-temporal variations of extreme precipitation were further analyzed in terms of intensity, frequency, and duration. The results indicated that the WRF model can appropriately reproduce the spatial distribution of extreme precipitation indices with acceptable biases. The performance is significantly better for intensity and frequency indices compared to duration indices. Except for PRCPTOT and R10mm, WRF accurately captures the interannual variations of extreme precipitation. Meanwhile, the results of the pre-whitening Mann-Kendall (PWMK) test suggested that WRF can identify significant increasing trends in extreme precipitation, particularly for R95p, R99p, and R50mm. This study provides valuable insights for extreme precipitation forecasting and warning in other mountainous regions. [ABSTRACT FROM AUTHOR]

Background: Neoadjuvant chemoradiotherapy for rectal cancer improves surgical outcomes and reduces recurrence but can cause low anterior resection syndrome (LARS), affecting quality of life. This study aims to predict the risk of LARS in male patients with mid-low rectal cancer after laparoscopic total mesorectal excision (TME). Methods: Clinical data from 203 male patients with mid-low rectal cancer who underwent neoadjuvant therapy and laparoscopic resection were collected. Patients were divided into training (n=143) and validation (n=60) cohorts. LARS risk factors were identified using logistic regression, and a predictive model was constructed and validated using ROC curve, Hosmer-Lemeshow test, calibration curve, and decision curve analysis (DCA). Results: LARS occurred in 53.6% of the patients in this study. Multivariate logistic regression analysis revealed that BMI ≥ 25 kg/m², tumor distance from the anal margin < 5 cm, radiotherapy, and anastomotic leakage were independent risk factors for postoperative LARS in patients (P < 0.05). The areas under the ROC curves for the training cohort and validation cohort were 0.866 (95% CI: 0.807-0.925) and 0.724 (95% CI: 0.595-0.853), respectively, with both groups showing good goodness-of-fit test results (P > 0.05). The DCA curve indicated that the model had a high clinical utility. Conclusions: BMI ≥ 25 kg/m², tumor distance from the anal margin < 5 cm, radiotherapy, and anastomotic leakage are independent risk factors for the occurrence of LARS after neoadjuvant therapy combined with laparoscopic TME in male patients with mid-low rectal cancer. These factors should be emphasized in clinical practice, and corresponding preventive measures should be promptly implemented. [ABSTRACT FROM AUTHOR]

Simple Summary: Fructus Aurantii (FA) is rich in flavonoids, which can effectively promote digestion and improve intestinal health, possessing a strong potential to serve as an alternative to antibiotics. In this experiment, the addition of Fructus Aurantii extract increased the relative abundance of beneficial bacteria in feces, stimulated the secretion of gastrointestinal hormones, improved digestion ability and growth performance. This study investigated the effects of Fructus Aurantii extract (FAE) on growth performance, nutrient apparent digestibility, serum parameters, fecal microbial composition, and short-chain fatty acids (SCFAs) in finishing pigs. In total, 75 Duroc × Landrace × Yorkshire pigs (equally divided by sex), with an initial body weight of 79.49 ± 4.27 kg, were randomly assigned to three treatment groups. The pigs were fed either a basic diet (CON) or a basal diet supplemented with 500 mg/kg of FAE (FAE500) and 1000 mg/kg of FAE (FAE1000). The FAE1000 group exhibited a significantly higher final body weight (FBW) (p < 0.05), and the average daily feed intake (ADFI) showed an increasing tendency in the FAE500 and FAE1000 groups (p = 0.056) compared to the CON group. Additionally, the inclusion of FAE resulted in the significantly higher apparent digestibility of crude ash (Ash), gross energy (GE), and crude protein (CP) (p < 0.05), with a tendency to the increased digestibility of dry matter (DM) (p = 0.053). Dietary FAE supplementation led to elevated serum levels of reduced glutathione (GSH) and decreased levels of serum L-lactic dehydrogenase (LDH), along with a tendency to increase serum glucose (GLU) levels (p = 0.084). The FAE500 group demonstrated higher serum concentrations of motilin (MTL) and gastrin (GAS) (p < 0.05), and a tendency for reduced serum glucagon-like peptide-1 (GLP-1) level (p = 0.055) compared to the CON group. Furthermore, alpha diversity analysis revealed that the FAE500 group significantly increased the Chao 1 and Observed_species indexes (p < 0.05). Similarly, beta diversity analysis indicated that FAE feeding altered the fecal microbial structure (p = 0.083). Notably, compared with the control group, CF231, Pediococcus, and Mogibacterium displayed higher relative abundance in the feces of the FAE500 group, whereas Tenericutes showed a reduction in relative abundance (p < 0.05). Additionally, the relative abundance of Tenericute was negatively correlated with the digestibility of DM, GE, Ash, and CP (p < 0.05). Serum MTL and GAS levels correlated positively with the Coprococcus, Dorea, Pediococcus, and Mogibacterium relative abundances (p < 0.05). Collectively, dietary FAE supplementation could enhance growth performance by boosting beneficial bacteria in feces, stimulating gastrointestinal hormone secretion, and improving nutrient digestibility. [ABSTRACT FROM AUTHOR]

Objective: Hypertension is a leading global risk factor for disability and death. Irbesartan, a potent angiotensin II receptor blocker, requires continuous safety monitoring. We conducted a disproportionality analysis of irbesartan-related adverse drug events (ADEs) using the FDA's FAERS and Japan's JADER databases. Methods: We extracted irbesartan-related ADE reports from FAERS (Q1 2004 to Q1 2024) and JADER (Q2 2008 to Q4 2023). We used Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayesian Geometric Mean (EBGM) for signal detection. Sensitivity analyses were conducted to exclude comorbid medications, and subgroup analyses by age and gender were performed to explore ADE occurrence in specific populations. Th time to onset (TTO) of ADEs was assessed using Weibull distribution test and Kaplan-Meier curves. Results: A total of 5,816 (FAERS) and 366 (JADER) reports were analyzed, with irbesartan-related preferred terms (PTs) involving 27 System Organ Classes (SOCs) in FAERS and 22 in JADER. Three SOCs met detection thresholds in both databases: "metabolism and nutrition disorders," "cardiac disorders," and "renal and urinary disorders." We identified 219 positive signals in FAERS and 20 in JADER, including known signals like hyperkalemia, hypotension, and acute kidney injury. Notably, newly identified signals such as acute pancreatitis (n = 50, ROR: 7.76 [5.88–10.25]) and rhabdomyolysis (n = 50, ROR: 7.76 [5.88–10.25]) in FAERS and respiratory failure (n = 7, ROR: 6.76 [3.20–14.26]) in JADER could have significant clinical implications, as they may lead to severe outcomes if not recognized and managed promptly. Subgroup analyses revealed both similarities and differences in signal detection across gender and age groups. Sensitivity analyses, excluding concomitant medications, confirmed the persistence of key positive signals, including hyperkalemia, angioedema, acute pancreatitis, and agranulocytosis. ADEs mainly occurred within 1 month (34.14%) and after 1 year (32.32%) after dosing, with a median onset of 107 days. Conclusion: This study provides valuable real-world evidence on the safety profile of irbesartan. The identification of new safety signals underscores the necessity of updating drug labels, particularly for assessing and managing high-risk patients. Additionally, the TTO analysis emphasizes the importance of sustained vigilance for adverse events over time. In conclusion, our findings contribute to a more comprehensive understanding of irbesartan's safety, aiding healthcare professionals in optimizing its use in clinical practice. [ABSTRACT FROM AUTHOR]

There is a debate over whether to transect or completely reduce the hernia sac during laparoscopic tension-free repair of inguinal hernia. This study endeavors to systematically assess the efficacy and safety of two approaches, namely transected sac (TS) and completely reduced sac (RS), in laparoscopic tension-free repair of inguinal hernia. Utilizing a meta-analysis methodology, we aim to provide a comprehensive analysis of these techniques. A comprehensive search was conducted across PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov databases to identify comparative studies focusing on laparoscopic tension-free repair of inguinal hernia, specifically comparing TS and RS techniques. The selected studies were subjected to meta-analysis using RevMan 5.3 software. A total of 8 studies, involving 2995 patients with inguinal hernia, were included in the analysis. The meta-analysis results revealed that the TS group had a higher incidence of seroma compared to the RS group [OR = 1.74, 95% CI (1.35, 2.25), P < 0.0001], and a prolonged time to return to normal activity postoperatively [MD = 0.99, 95% CI (0.85, 1.14), P < 0.00001]. However, no statistically significant differences were observed between the two groups in terms of operation time [MD = −1.75, 95% CI (− 8.72, 5.22), P = 0.62], incidence of postoperative pain [OR = 1.00, 95% CI (0.41, 2.44), P = 1.00], overall postoperative complication rate [OR = 0.98, 95% CI (0.43, 2.20), P = 0.95], and recurrence rate fOR = 2.53, 95% CI (0.61, 10.39), P = 0.20]. Transected sac in laparoscopic inguinal hernia repair is associated with an increased incidence of seroma and a longer recovery time for patients to return to normal activity. Clinical trial registration Registration number is INPLASY20223110070 [ABSTRACT FROM AUTHOR]

MicroRNAs (miRNAs) have key roles in the pathological processes of neuropathic pain. Here, our aim was to elucidate the function of miR‐200a‐3p as well as its related regulatory mechanism in neuropathic pain. An animal model of neuropathic pain was established by chronic constriction injury (CCI) induction. The knockdown experiments are performed by injecting a lentiviral construct intrathecally. MiR‐200a‐3p and bromodomain‐containing protein 3 (BRD3) expression in rat spinal cord was determined using RT‐qPCR. The mechanical, thermal, and cold responses in animals were assessed at the indicated time after surgery. The levels of inflammatory cytokines in rat spinal cord were measured by ELISA. The changes in NF‐κB signaling‐related molecules in rat spinal cord were determined using western blot and immunofluorescence. MiR‐200a‐3p was underexpressed in CCI rats in a time‐dependent manner. Overexpression of miR‐200a‐3p decreased mechanical hyperalgesia and thermal sensitivity to attenuate neuropathic pain in rats. BRD3 was targeted by miR‐200a‐3p. Additionally, downregulation of BRD3 inhibited neuropathic pain progression. Moreover, overexpression of BRD3 rescued the effect of miR‐200a‐3p on NF‐κB signaling and neuropathic pain in CCI rats. MiR‐200a‐3p attenuates neuropathic pain via downregulating BRD3 to block NF‐κB signaling. [ABSTRACT FROM AUTHOR]

Understanding and accurately predicting cellular traffic data is vital for communication operators and device users, as it facilitates efficient resource allocation and ensures superior service quality. However, large-scale cellular traffic data forecasting remains challenging due to intricate temporal variations and complex spatial relationships. This article proposes a Knowledge Graph Driven Decomposition Approach (KGDA) for precise cellular traffic prediction. The KGDA breaks down the impact of static environmental factors and dynamic autocorrelations of cellular traffic time series, enabling the capture of overall traffic changes and understanding of traffic dependence on past values. Specifically, we propose an urban knowledge graph to capture the static environmental context of base stations, mapping these entities into the same latent space while retaining static environmental knowledge. The cellular traffic is divided into a regular pattern and fluctuating residual components, with the KGDA comprising four modules: a Knowledge Graph Representation Learning model, a traffic regular pattern prediction module, a traffic residual dynamic prediction module, and an attentional fusion module. The first leverages graph neural networks to extract spatial contexts and predict regular patterns, the second utilizes the Bi-directional Long Short-Term Memory (Bi-LSTM) model to capture autocorrelations of traffic time series, and the final module integrates the patterns and residuals to produce the final prediction result. Comprehensive experiments demonstrate that our proposed model outperforms state-of-the-art models by more than 10% in forecasting cellular traffic. [ABSTRACT FROM AUTHOR]

Aim: Diabetic cognitive impairment (DCI), considered one of the most severe and commonly overlooked complications of diabetes, has shown inconsistent findings regarding the metabolic profiles in DCI patients. This systematic review and meta‐analysis aimed to identify dysregulated metabolites as potential biomarkers for early DCI, providing valuable insights into the underlying pathophysiological mechanisms. Materials and Methods: A systematic search of four databases, namely PubMed, Embase, Web of Science and Cochrane, was conducted up to March 2024. Subsequently, a qualitative review of clinical studies was performed followed by a meta‐analysis of metabolite markers. Finally, the sources of heterogeneity were explored through subgroup and sensitivity analyses. Results: A total of 774 unique publications involving 4357 participants and the identification of multiple metabolites were retrieved. Of these, 13 clinical studies reported metabolite differences between the DCI and control groups. Meta‐analysis was conducted for six brain metabolites and two metabolite ratios. The results revealed a significant increase in myo‐inositol (MI) concentration and decreases in glutamate (Glu), Glx (glutamate and glutamine) and N‐acetylaspartate/creatine (NAA/Cr) ratios in DCI, which have been identified as the most sensitive metabolic biomarkers for evaluating DCI progression. Notably, brain metabolic changes associated with cognitive impairment are more pronounced in type 2 diabetes mellitus than in type 1 diabetes mellitus, and the hippocampus emerged as the most sensitive brain region regarding metabolic changes associated with DCI. Conclusions: Our results suggest that MI, Glu, and Glx concentrations and NAA/Cr ratios within the hippocampus may serve as metabolic biomarkers for patients with early‐stage DCI. [ABSTRACT FROM AUTHOR]

The detection of heavy metal ions and organic pollutants from water sources remains critical challenges due to their detrimental effects on human health and the environment. Herein, a nitrogen and sulfur co-doped carbon quantum dot (NS-CQDs) fluorescent sensor was developed using a microwave-assisted carbonization method for the detection of Fe3+ ions and hydroquinone (HQ) in aqueous solutions. NS-CQDs exhibit excellent optical properties, enabling sensitive detection of Fe3+ and HQ, with detection limits as low as 3.40 and 0.96 μM. Notably, with the alternating introduction of Fe3+ and HQ, NS-CQDs exhibit significant fluorescence (FL) quenching and recovery properties. Based on this property, a reliable "on-off-on" detection mechanism was established, enabling continuous and reversible detection of Fe3+ and HQ. Furthermore, the low cytotoxicity of NS-CQDs was confirmed through successful imaging of HeLa cells, indicating their potential for real-time intracellular detection of Fe3+ and HQ. This work not only provides a green and rapid synthesis strategy for CQDs but also highlights their versatility as fluorescent probes for environmental monitoring and bioimaging applications. [ABSTRACT FROM AUTHOR]

Organophosphorus compounds have been widely used as achiral and chiral ligands in organic synthesis (PPh3, BINAP, dppe, Duphos, Xantphos, PPFA, Chiraphos, SEGPHOS), flame retardants, functional materials (LED, PV), as well as agrochemicals and medicines due to their broad biological activities. As the privileged versatile building blocks, 1,n‐enynes have been successfully applied in the synthesis of various functionalized cyclic compounds based on their two active unsaturated chemical bonds (C═C double and C≡C triple bonds). With the development of highly selective and efficient methods in organic chemistry, various organophosphorus cyclic compounds synthesis through radical cascade strategy has attracted considerable attention in recent years. In here, we have summarized the recent main achievements in the radical cascade reactions of 1,n‐enynes with phosphorus‐centered radicals. Furthermore, we also displayed the detailed reaction mechanisms in this review. [ABSTRACT FROM AUTHOR]

The fundamental issues limiting the development of zinc–air batteries (ZABs) are the slow kinetics of the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) as well as the limited operating environment. Herein, a membrane air cathode with a unique nanostructure integrating superior bifunctional oxygen electrocatalytic activity was prepared by electrospinning and a simple heat treatment strategy. The membrane is composed of one-dimensional multilevel carbon nanofibers covered by the S, N codoped carbon nanotubes encapsulating the nanoscale Co/Co9S8 homogeneous heterostructure (Co/Co9S8@MCF). Because of the tailored built-in electric field facilitating the transport of ions, the ohmic contact property of the heterostructure, and the intrinsic conductivity of the carbon substrate promoting the electron transport of the overall material, cross-linked carbon nanotubes with rich defects form a large specific surface area and porous structure, which provide a pathway for ion transport, and the encapsulation of the heterostructure by carbon nanotubes enhances the stability of the nanostructure; the synthesized Co/Co9S8@MCF exhibits superior bifunctional electrocatalytic properties. The aqueous ZAB based on the Co/Co9S8@MCF air cathode demonstrates a peak power density of 225.32 mW cm–2, a high discharge specific capacity of 719.52 mAh g–1, and long-term cycling stability for over 200 h at 5 mA cm–2. Therefore, designing the internal and external nanostructures of the heterostructure provides an opportunity for preparing high-performance ZABs. [ABSTRACT FROM AUTHOR]

Background: Irinotecan is a standard chemotherapeutic agent in small cell lung cancer (SCLC), however, as a common adverse reaction, diarrhea limits the use of irinotecan. Shengjiang Xiexin decoction (SXD) has been used in various gastrointestinal diseases in China two thousand years ago. We designed this clinical trial to supply more evidences on the use of SXD as prophylaxis for irinotecan-induced diarrhea, especially for high-risk population predicted by gene testing of uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1). Methods: In this clinical trial, 120 patients with SCLC were recruited from six hospitals in China. They received two cycles of chemotherapy, meanwhile they were randomized to receive SXD or placebo for 14 days of oral administration in each cycle of chemotherapy. The primary outcome is the incidence of diarrhea. And secondary outcomes include the the degree of diarrhea and neutropenia, the number of chemotherapy cycles with diarrhea, first occurrence time and duration of diarrhea. To evaluate the effect of SXD on the intestine, a rat model with delayed-onset diarrhea induced by irinotecan was established, and the expression of inflammatory factors including IL-1β, IL-6 and TNF-α, anti-inflammatory factors including IL-10, TGF- β in jejunal tissue was detected by ELISA. Results: 101 patients (53 in SXD group, 48 in placebo group) completed the trial. The incidence of diarrhea in SXD group and placebo group were 26.42% (14/53) and 52.08% (25/48), respectively (P < 0.05), and the degree of diarrhea also had significant differences (P < 0.05). In UGT1A1 high-risk population, the incidence of diarrhea in two groups were 9.09% and 66.67% (P < 0.05), but there was no significant differences in UGT1A1 low-risk population. The incidence of neutropenia with degree 1–3 between two groups was 20.75% vs 20.83%, 13.21% vs 18.57%, 9.43% vs 20.83% (P < 0.05). No severe adverse events were reported in any group. And animal studies had shown SXD reduced content of IL-1β, IL-6, TNF-α, increased content of IL-10, TGF-β in jejunum tissue. Conclusions: SXD had a prophylactic effect in the diarrhea induced by irinotecan, especially for UGT1A1 high-risk population, and this effect from SXD appeared to be maintained the completion of chemotherapy schedule. The mechanism of action of SXD was related to the regulation of inflammatory factors. Trial registration Chinese Clinical Trial Register: ChiCTR1800018490. Registered on 20 September 2018. https://www.chictr.org.cn/showproj.html?proj=25250. The preliminary protocol of this clinical study has been published in the journal "Trials" in the form of protocol before this paper (Deng et al. in Trials 21:370, 2020). [ABSTRACT FROM AUTHOR]

In this paper, we are concerned with the two-dimensional (2D) incompressible magnetohydrodynamic (MHD) equations with velocity dissipation given by (- Δ) α and magnetic diffusion given by reducing about the square root of logarithmic diffusion from standard Laplacian diffusion. More precisely, we establish the global regularity of solutions to the system as long as the power α is a positive constant. In addition, we prove several global a priori bounds for the case α = 0 . Finally, for the case α = 0 , it is also shown that the control of the direction of the magnetic field in a suitable norm is enough to guarantee the global regularity. In particular, our results significantly improve previous works and take us one step closer to a complete resolution of the global regularity issue on the 2D resistive MHD equations, namely, the case when the MHD equations only have standard Laplacian magnetic diffusion. [ABSTRACT FROM AUTHOR]

Wave-powered boats can harness wave energy to drive hydrofoils to generate propulsion, and the arrangement position between dual hydrofoils has an obvious effect on the magnitude of propulsion generated. In this paper, the effects of the arrangement position between dual hydrofoils on the propulsion of wave-powered boats are studied. An instantaneous equivalent model of dual hydrofoils based on the local frame at the equivalent position is developed according to the relative motion principle, and the propulsion of the rear hydrofoil is calculated, and the reliability of the equivalent model results was verified through experiments. Through the augment optimization calculation based on the validated model mentioned above, the propulsion of the rear hydrofoil with different arrangement positions is obtained and the corresponding positions of the hydrofoil with larger propulsion are listed. Subsequently, a fluid-structure coupling model is established on the basis of the results obtained from the optimization calculation, and the dynamic response of the wave-powered boat is solved under different arrangement positions. It is evident that different horizontal and vertical arrangement positions of the dual hydrofoils have different effects on the propulsion performance. This is primarily due to the different influences of the wake vortices generated by the front hydrofoil acting on the rear hydrofoil, causing different fluctuations during its rotation process, thereby affecting propulsion. Overall, a reasonable arrangement position can effectively improve the propulsion of the wave-powered boat. The relevant research in this paper can provide a reference for similar hydrofoil arrangement designs of the wave-powered boat. [ABSTRACT FROM AUTHOR]

Background Process mining was widely used in healthcare settings to analyse patient pathways, providing insights about patient care and resource allocation. This study aimed to apply process mining to explore service utilization and pathways of patients with alcohol use disorders in receiving the community-based Drug and Alcohol Service to establish a baseline for evaluating improvement initiatives. Methods Patients' encounters with the Drug and Alcohol Service and their direct care activities (i.e. Intake, Assessment, and treatment service activities) that occurred in these encounters were analysed to depict the actual pathways. Patterns were uncovered from these actual pathways using a process mining tool Disco. Patients with alcohol use disorders were divided into two groups—patients who use polysubstance and those who do not—to compare their service utilization and pathway patterns. Results Five hundred seventy-one patients with alcohol use disorders incurred 1447 encounters, comprising 13,974 activities. The top three actual pathways with at least three activities were: (i) pathway 'Intake-> Withdrawal Management-> Withdrawal Management' (170 (11.7%) encounters and 130 (22.8%) patients); (ii) pathway 'Intake-> Adult Counselling-> Adult Counselling' (161 (11.1%) encounters and 126 (22.1%) patients); and (iii) pathway 'Intake-> Assessment-> Withdrawal Management' (155 (10.7%) encounters and 129 (22.6%) patients). However, 313 (21.6%) encounters did not proceed beyond the Intake stage. When the patients started their pathways from Intake, their immediate next activities were frequently Withdrawal Management, Assessment or Adult Counselling. Compared to those who do not use polysubstance, patients who use polysubstance had a higher proportion of Intake (19.3% vs 11.8%, P  < .001), Involuntary Treatment (4.0% vs 1.0%, P  < .001) and Magistrate Early Referral into Treatment (6.4% vs.3%, P  < .001), but a lower proportion of Withdrawal Management (31.2% vs 39.0%, P  < .001) and Adult Counselling (27.8% vs 37.6%, P  < .001). Conclusion This study contributes to an in-depth understanding of service utilization and pathways of patients with alcohol use disorders within the community-based Drug and Alcohol Service. Future studies should investigate their reasons for dropping out after Intake. [ABSTRACT FROM AUTHOR]

Objective: This meta-analysis aims to compare the clinical efficacy of mesh non-fixation and fixation in laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair, systematically evaluating the application value of the mesh non-fixation technique in clinical settings. Methods: A computerized search of PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov databases was conducted to identify randomized controlled trials (RCTs) comparing mesh non-fixation and fixation in TAPP inguinal hernia repair. Meta-analysis was performed using RevMan 5.3 software, and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) evidence grading system was employed for outcome quality assessment. Publication bias analysis was performed using Begg's test. A trial sequential analysis (TSA) was performed using TSA 0.9.5.10 Beta software. Results: A total of nine RCTs involving 1,879 inguinal hernia patients were included. Meta-analysis results demonstrated that, compared to the fixation group, the non-fixation group exhibited significantly lower seroma occurrence rate [RR = 0.43, 95% CI (0.20, 0.89), P = 0.02, heterogeneity P = 0.28, I²=22%], Visual Analog Scale (VAS) pain score at 6 months postoperatively [MD=-0.21, 95% CI (-0.29, -0.12), P < 0.00001, heterogeneity P = 0.34, I²=0%], and cost [MD=-3.23 thousand yuan, 95% CI (-4.26, -2.19), P < 0.00001, heterogeneity P = 0.0003, I²=92%]. There were no statistically significant differences in overall complication rate [RR = 0.88, 95% CI (0.62, 1.23), P = 0.45, heterogeneity P = 0.11, I²=44%], overall infection event rate [RR = 0.96, 95% CI (0.36, 2.56), P = 0.93, heterogeneity P = 0.62, I²=0%] and recurrence rate [RR = 0.75, 95% CI (0.28, 1.99), P = 0.56, heterogeneity P = 0.44, I²=0%] between the two groups. The results of the TSA indicated that the observed lower seroma occurrence rate in the non-fixation group compared to the fixation group requires further validation through the inclusion of additional RCTs. Conclusion: Mesh non-fixation in TAPP inguinal hernia repair is deemed safe and does not elevate the risk of hernia recurrence. However, given certain limitations in this study, future comprehensive and reliable validation will require further multicenter, high-quality, large-sample double-blind RCTs. [ABSTRACT FROM AUTHOR]

Aim: Tirzepatide, a newly developed dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, has received approval for treating type 2 diabetes (T2D) and is currently being studied for its potential in long-term weight control. We aim to explore the safety and efficacy of once-weekly subcutaneous tirzepatide for weight loss in T2D or obese patients. Methods: A comprehensive search was performed on various databases including PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov from inception up to April 29, 2024, to identify randomized controlled trials (RCTs) that assessed the efficacy of once-weekly tirzepatide compared to a placebo in adults with or without T2D. The mean difference (MD) and risk ratio (RR) were calculated for continuous and dichotomous outcomes, respectively. The risk of bias was evaluated using the RoB-2 tool (Cochrane), while the statistical analysis was conducted utilizing RevMan 5.4.1 software. Results: Seven RCTs comprising 4795 individuals ranging from 12 to 72 weeks were identified. Compared to the placebo group, tirzepatide at doses of 5, 10, and 15 mg demonstrated significant dose-dependent weight loss. The mean difference (MD) in the percentage change in body weight (BW) was −8.07% (95% CI −11.01, −5.13; p < 0.00001), −10.79% (95% CI −13.86, −7.71; p < 0.00001), and −11.83% (95% CI −14.52, −9.14; p < 0.00001), respectively. Additionally, the MD in the absolute change in BW was −7.5 kg (95% CI −10.9, −4.1; p < 0.0001), −11.0 kg (95% CI −16.9, −5.2; p = 0.0002), and −11.5 kg (95% CI −16.2, −6.7; p < 0.00001), for the 5, 10, and 15 mg doses, respectively. All three doses of tirzepatide also significantly reduced body mass index and waist circumference. Furthermore, it led to a greater percentage of patients experiencing weight loss exceeding 5, 10, 15, 20, and 25%. Moreover, tirzepatide showed great success in reducing blood pressure, blood sugar levels, and lipid profiles. In terms of safety, gastrointestinal side effects were the most frequently reported adverse events in all three doses of tirzepatide groups, which were generally mild-to-moderate and transient. Conclusion: Tirzepatide treatment could lead to remarkable and sustained weight loss that is well-tolerated and safe, representing a novel and valuable therapeutic strategy for long-term weight management. [ABSTRACT FROM AUTHOR]

Objective To investigate the characteristics of continuous glucose monitoring (CGM) in type 1 diabetic patients with fast-glycator phenotype. Methods This was a cross-sectional retrospective study. Patients diagnosed with type 1 diabetes mellitus (T1DM) and wearing CGM for 10 d and more from the T1DM-specific Disease Clinic, the Second Xiangya Hospital of Central South University were enrolled from April 2017 to August 2023 to collect laboratory glycated hemoglobin A1c (HbA1c). Calculation of CGM parameters including time in range (TIR), mean blood glucose (MBG) and mean amplitude of glucose excursions (MAGE), are derived from the data collected by CGM devices worn by the participants. Based on the results of MBG, the estimated HbA1c was calculated, and then the hemoglobin glycation index (HGI) was computed by comparing the laboratory HbA1c with the MBG-estimated HbA1c. Patients were divided into non-fast glycator phenotype group (HGI≤0.4) and fast-glycator phenotype group (HGI>0.4). Comparison of differences between groups using two independent samples t-test or Mann-Whitney U test. Results We included 377 patients with T1DM, of whom 299 were in the non-fast glycator phenotype group and 78 in the fast-glycator phenotype group. Individuals with fast-glycator phenotype exhibited poorer glycemic control compared to those with non-fast glycator phenotype, as evidenced by higher HbA1c levels [(8.53±1.41) % vs. (6.95±0.90)%, P<0.001], lower TIR [(61.36±15.81) % vs. (67.31±18.31) %, P=0.010], and higher MAGE [(8.01±2.06) mmol/L vs. (7.37±2.38) mmol/L, P=0.015]. However, in patients with suboptimal HbA1c, CGM parameters showed inconsistent changes with HbA1c in fast glycation group, with CGM parameters demonstrating better glycemic control than those in the non-fast glycation group, characterized by higher level of TIR [(61.34±16.3)% vs. (51.99±16.3%)%, P<0.001] and lower level of MAGE [(8.10±2.09) mmol/L vs. (9.23±2.11) mmol/L, P=0.001]. Conclusion T1DM in fast-glycator phenotype group had worse glycemic control than the non-fast glycator phenotype group, and exhibited inconsistencies between CGM parameters and HbA1c. [ABSTRACT FROM AUTHOR]

Currently, multifunctional MXene‐integrated wearable textiles (MWTs) are particularly appealing due to their various applications such as health monitoring, smart protection, and medical treatment. However, scalable manufacture of durable, stable, and high‐performance multifunctional MWTs still face challenges due to the poor oxidation stability of MXene and low utilization of precursor titanium aluminum carbide (MAX). Herein, an improved preparation strategy for zinc ion (Zn2+) intercalation is proposed to create high antioxidative MXene (ZM) and exceptionally conductive and printable gel ink based on MXene sediments (ZMS‐ink), while multifunctional wearable textiles are fabricated using spray‐coating and screen‐printing techniques on cellulosic nonwoven textiles (CNWs), achieving the complete utilization of MXene precursor. Benefiting from the inherent disordered stacking and porous structure of CNWs, along with the highly conductive ZM and ZMS‐ink, as‐prepared smart, wearable and green‐based pressure sensor offered proper breathability, high sensitivity (2602.26 kPa−1), wide sensing range (0–141 kPa), and excellent cycling stability (>5000 cycles). Additionally, the sensor exhibited efficient photothermal/photodynamic therapy antibacterial activity and exceptional electromagnetic interference shielding performance (57.5 dB). Therefore, this work paves the way for the future development of integrated and scalable multifunctional wearable devices building on the environmental‐friendly CNWs incorporated with fully utilized MAX, offering a green and cost‐effective approach. [ABSTRACT FROM AUTHOR]

Background: Plant growth-promoting rhizobacteria (PGPR), as a group of environmentally friendly bacteria growing in the rhizosphere of plants, play an important role in plant growth and development and resistance to environmental stresses. However, their limited understanding has led to the fact that their large-scale use in agriculture is still scarce, and the mechanisms by which beneficial bacteria are selected by plants and how they interact with them are still unclear. Method: In this study, we investigated the interaction between the auxin-producing strain Bacillus aryabhattai LAD and maize roots, and performed transcriptomic and metabolomic analyses of Bacillus aryabhattai LAD after treatment with maize root secretions(RS). Results: Our results show that there is a feedback effect between the plant immune system and bacterial auxin. Bacteria activate the immune response of plant roots to produce reactive oxygen species(ROS), which in turn stimulates bacteria to synthesize IAA, and the synthesized IAA further promotes plant growth. Under the condition of co-culture with LAD, the main root length, seedling length, root surface area and root volume of maize increased by 197%, 107%, 89% and 75%, respectively. In addition, the results of transcriptome metabolome analysis showed that LAD was significantly enriched in amino acid metabolism, carbohydrate metabolism and lipid metabolism pathways after RS treatment, including 93 differentially expressed genes and 45 differentially accumulated metabolites. Conclusion: Our findings not only provide a relevant model for exploring the effects of plant-soil microbial interactions on plant defense functions and thereby promoting plant growth, but also lay a solid foundation for the future large-scale use of PGPR in agriculture for sustainable agricultural development. [ABSTRACT FROM AUTHOR]

As one of the key ways to realize the industrialization and green development of construction, prefabricated construction is conducive to saving resources and energy and improving labor productivity and quality. Aiming to solve the problem of the lack of standardization in the design of prefabricated residential buildings, which leads to the components not being universally used and the industrial characteristics not being fully embodied, while excessive standardization leads to a lack of personalization and flexibility, the modular design theory is applied to the standardized design of prefabricated residential buildings in this study. The application route of modular design theory in the standardized design is constructed, that is, "system decomposition—module design—module combination". Taking residential buildings within a height of 54 m as an example, each basic functional module is standardized and combined into standard plans. At the same time, the functional space module design based on modular coordination and the module combination design based on the trinity of "modulus, pattern, and mode" are discussed. This research is of great significance for giving full play to the comprehensive benefits of prefabricated concrete structures in quality improvement, cost reduction, and rapid assembly. [ABSTRACT FROM AUTHOR]

Pre-trained language models (PLMs) are proficient at understanding context in plain text but often struggle with the nuanced linguistics of task-oriented dialogues. The information exchanges in dialogues and the dynamic role-shifting of speakers contribute to complex coreference and interlinking phenomena across multi-turn interactions. To address these challenges, we propose Coreference-Enhanced Contrastive Pre-training (CECPT), an innovative pre-training framework specifically designed to enhance dialogue modeling. CECPT utilizes unsupervised dialogue datasets to capture both semantic richness and structural coherence. Our experimental results demonstrate that the CECPT model significantly outperforms established baselines in three critical applications: intent recognition, dialogue act prediction, and dialogue state tracking. These findings suggest that CECPT is more adept at following the information flow within dialogues and accurately linking statuses to their respective references. [ABSTRACT FROM AUTHOR]

Background: Understanding the potential risk factors of heart diseases is key to effectively managing cardiac diseases. The present study quantifies the association of identified risk factors. In addition, the study has compared the association of mortality with hypertension, uncontrolled diabetes, and uncontrolled hyperlipidemia using Grey Relational Approach (GRA) for stroke, lung diseases, smoking, stress, obesity, and lack of exercise. Method: Data on risk factors of heart failure were collected from the Global Burden of Disease (GBD) study (2001–2017). From the GBD database, variables have selected the top leading risk factors responsible for mortality from cardiac diseases. Data on risk factors was analyzed using the GRA procedure (utilizing Grey [8.0] software). In the GRA method, the correlation was categorized into three components: GRA – Deng (assesses the effect of one variable specified by data on the other variables), GRA- absolute (assesses the association between variables measured), and GRA-SS (assessed the overall association between the variables measured). Stroke, lung diseases, smoking, stress, obesity, and lack of exercise were taken as dependent variables and their impact was assessed. Hypertension (high grade) uncontrolled diabetes, and uncontrolled hyperlipidemia were considered as independent variables. The relationship between dependent and independent variables was assessed. Results: Overall correlational analysis showed that type 2 diabetes (T2DM) is the risk factor that has a strong relationship with causing heart failure and thereby increases morbidity and mortality among Chinese patients. After T2DM, the second highest risk factor associated was severe dyslipidemia which is responsible for causing heart failure. High-grade hypertension is one-third most common risk factor in causing heart failure. GRA – Deng analysis showed that T2DM is the top risk factor associated with heart failure, followed by high-grade hypertension and severe dyslipidemia (uncontrolled). GRA-absolute analysis showed that severe dyslipidemia is the top risk factor associated with heart failure, followed by high-grade hypertension and T2DM (uncontrolled). GRA-SS analysis showed that high-grade hypertension is the top risk factor associated with heart failure, followed by severe dyslipidemia and T2DM (uncontrolled). Conclusions: The study reported that T2DM, severe dyslipidemia, and high-grade hypertension as strongly correlated with the development of heart failure after considering other several key risk factors (stroke, lung diseases, smoking, stress, obesity, and lack of exercise). Level of evidence: IV. Technical efficacy: Stage 5. [ABSTRACT FROM AUTHOR]

The high proportion of new energy into the power grid leads to a significant uneven distribution trend of the inertia of the power grid, which seriously affects the safe and stable operation of the power grid. It is urgent to carry out the inertia evaluation of the new energy power system. In view of the insufficient accuracy of the equivalent inertia evaluation method of a single inertia center in evaluating large-scale power systems, this paper first proposed the equivalent inertia evaluation method of new energy power system in the region, and proposed the evaluation index of network area inertia to reveal the weak inertia network area. Secondly, for the inertia evaluation of new energy power system nodes, monitoring devices should be installed at each bus node. As the system construction cost is too high, a node inertia evaluation model of new energy power system is established to reduce the number of monitoring devices installed. Finally, in view of the unclear basis and inaccurate location of the frequency monitoring node selection model in the evaluation of equivalent inertia, a correlation model of equivalent inertia and node inertia is established to characterize the correlation between any node inertia and system equivalent inertia in the system. The consistency of the position of the equivalent inertia evaluation frequency monitoring node and the maximum inertia node of the system was derived, and the accuracy of the maximum inertia node as a frequency monitoring node was verified by the inertia center method and the frequency center method. [ABSTRACT FROM AUTHOR]

Background: Acute abdominal conditions during pregnancy are significant risks to maternal and fetal health, necessitating timely diagnosis and intervention. The choice of surgical approach is a major concern for obstetricians. Objective: To evaluate the safety and efficacy of the TU-LESS procedure for acute abdomen in late pregnancy. Methods: We retrospectively analyzed 12 patients who underwent TU-LESS for acute abdominal conditions in the third trimester from 2020 to 2023. We reviewed medical records for clinical characteristics, surgical interventions, postoperative complications, and pregnancy outcomes. Results: The study included patients with a median age of 27 (range 20–35) and a BMI of 24.33 kg/m2 (range 21.34–31.96). The median gestational age at surgery was 30 weeks (range, 28 + 3–32 + 4 weeks), with surgeries lasting an average of 60 min (range, 30–163 min). Blood loss was 2–20 mL, and the median hospital stay post-surgery was 6 days (range, 2–16 days). There were no significant complications. The median time to delivery after TU-LESS was 56 days (range, 26–66 days), resulting in 8 full-term deliveries, 2 preterm cesareans, and 2 preterm vaginal deliveries. All newborns were healthy, with no fetal losses or neonatal deaths. Conclusion: TU-LESS, performed by experienced obstetricians and gynecologists with proper preoperative preparation, is safe and effective for managing acute abdomen in late pregnancy, without the need to delay surgery due to gestational age. [ABSTRACT FROM AUTHOR]

The aim of this study is to explore the therapeutic effects of Mg-Sr-Ca containing bioactive glass nanoparticles sodium alginate hydrogel modified mineralized collagen scaffold (Mg-Sr-Ca-BGNs-SA-MC) on the repair of osteoporotic bone defect. During the study, Mg-Sr-Ca containing bioactive glass nanoparticles (Mg-Sr-Ca-BGNs) were synthesized using the sol-gel method, and the Mg-Sr-Ca-BGNs-SA-MC scaffold was synthesized by a simple method. The Mg-Sr-Ca-BGNs and the Mg-Sr-Ca-BGNs-SA-MC scaffold were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The elements of Mg, Sr, Ca and Si were effectively integrated into Mg-Sr-Ca-BGNs. SEM analysis revealed the presence of Mg-Sr-Ca-BGNs on the scaffold's surface. Furthermore, the cytotoxicity of the scaffolds were assessed using a live/dead assay. The result of the live/dead assay demonstrated that the scaffold materials were non-toxic to cell growth. More importantly, the in vivo study indicated that implanted scaffold promoted tissue regeneration and integration with newly formed bone. Overall, the Mg-Sr-Ca-BGNs-SA-MC scaffold is suitable for guided bone regeneration and beneficial to repair of osteoporotic bone defects. [ABSTRACT FROM AUTHOR]

Herein, the effect of fluoropolymer binders on the properties of polymer-bonded explosives (PBXs) was comprehensively investigated. To this end, fluorinated semi-interpenetrating polymer networks (semiIPNs) were prepared using different catalyst amounts (denoted as F23-CLF-30-D). The involved curing and phase separation processes were monitored using Fourier-transform infrared spectroscopy, differential scanning calorimetry, a haze meter and a rheometer. Curing rate constant and activation energy were calculated using a theoretical model and numerical method, respectively. Results revealed that owing to its co-continuous micro-phase separation structure, the F23-CLF-30-D3 semi-IPN exhibited considerably higher tensile strength and elongation at break than pure fluororubber F2314 and the F23- CLF-30-D0 semi-IPN because the phase separation and curing rates matched in the initial stage of curing. An arc Brazilian test revealed that F23-CLF-30-D-based composites used as mock materials for PBXs exhibited excellent mechanical performance and storage stability. Thus, the matched curing and phase separation rates play a crucial role during the fabrication of high-performance semi-IPNs; these factors can be feasibly controlled using an appropriate catalyst amount. [ABSTRACT FROM AUTHOR]

Technology advances have enhanced competition in insurance industry. This paper investigates a class of dynamic asset and liability management(ALM) games among insurers with mean-variance of relative log return performance. We obtain the unique time-consistent equilibrium ALM strategies explicitly. The results show that competition leads to the increases of insurers risky asset investment and the insurance liability. The equilibrium solution implies that social utility(relative concerns) leads to social learning(herd effect) in the complete information market. In particular, the peer relative concern can induce preference interaction. We find the Granger causal relationship between industry competition and herd behavior in the empirical data. Finally, we conduct sensitivity analysis of the competition outcome with respect to risk parameters. [ABSTRACT FROM AUTHOR]

In this study, we propose a big data-based method for characterizing the feature distributions of multiple technologies within a specific domain. Traditional approaches, such as Gartner's hype cycle or S-curve model, portray the developmental trajectory of individual technologies. However, these approaches are insufficient to encapsulate the aggregate characteristic distribution of multiple technologies within a specific domain. Thus, this study proposes an innovative method in terms of four proposed features, namely versatility, significance, commerciality, and disruptiveness, to characterize the technologies within a given domain. The research methodology involves that the features of technologies are quantitively portrayed using the representative keywords and volumes of returned search results from Google and Google Scholar in two-dimensional analytical spaces of technique and application. We demonstrate the applicability of this method using 452 technologies in the domain of intelligent robotics. The results of our assessment indicate that the versatility values are normally distributed, while the values of significance, commerciality, and disruptiveness follow power-law distributions, in which few technologies possess higher feature values. We also show that significant technologies are more likely to be commercialized or cause potential disruption, as such technologies have higher scores in these features. Further, we validly prove the robustness of our approach by comparing historical trends with the literature and characterizing technologies in reduced analytical spaces. Our method can be widely applied in analyzing feature distributions of technologies in different domains, and it can potentially be exploited in decisions like investment, trade, and science policy. [ABSTRACT FROM AUTHOR]

For some long span cable supported bridges, the longitudinal diaphragms in main girder are designed as steel truss to reduce structural self-weight. However, unanticipated fatigue cracking in critical details of longitudinal steel truss diaphragm may occur after only a few years of service, resulting in stiffness weakening and stress redistribution. Based on an actual cable-stayed bridge, this paper presents a fatigue analysis of longitudinal steel truss diaphragms and provide an effective strengthening measure to elongate the fatigue life. Using traffic information from bridge toll station, the fatigue vehicle models were established. Then, a multi-scale finite element (FE) model was developed to help determining critical details of potential cracking and calculating the vehicle induced stress. After obtaining the required parameters, fatigue life of the specific critical detail was estimated base on damage accumulation law. The result agrees well with field observation. To ensure the performance of steel girder, the strengthening measure that replace diagonal tubes in longitudinal steel truss diaphragm with bolted channel steels was proposed and then applied. The assessment result indicated that the provided strengthening measure achieves satisfactory effects. It can also provide experience and partial reference for maintenance of similar structures. [ABSTRACT FROM AUTHOR]

Cable-driven parallel robots (CDPRs) have been gaining much attention due to their many advantages over traditional parallel robots or serial robots, such as their markedly large workspace and lightweight design. However, one of the main issues that needs to be urgently solved is the tension in the distribution of CDPRs due to two reasons. The first is that a cable can only be stretched but not compressed, and the other is the redundancy of the parallel robot. To address the problem, an optimization method for tension distribution is proposed in the paper. The structural design of the parallel robot is first discussed. The dynamics model of the parallel robot is established by the Newton–Euler method. Based on the minimum variance of cables' tension, an optimization method of tension distribution is presented for the parallel robot. Furthermore, the tension extreme average term is introduced in the optimization method, and the firefly algorithm is applied to obtain the optimal solution for tension distribution. Finally, the proposed approach is tested in the simulation case where the end-effector of the robot moves in a circular motion. Simulation results demonstrate that the uniformity and continuity of tension are both outstanding for the proposed method. In contrast with traditional solving methods, the efficiency of this method is largely improved. [ABSTRACT FROM AUTHOR]

Simple Summary: Thymic neuroendocrine tumors (Th-NETs) are rare, with limited research on prognostic markers and treatments. Our retrospective study evaluated clinicopathological characteristics and therapeutic strategies for Th-NETs, filling gaps in existing studies. We highlighted the importance of biomarkers such as serum neuron-specific enolase, inflammatory factors, and oxygen 6-methylguanine-DNA methyltransferase, as well as the roles of surgical interventions, postoperative therapies, and temozolomide-based chemotherapy in improving patient survival. Our findings confirmed the crucial role of surgical treatment and the potential benefits of postoperative adjuvant radiotherapy. Furthermore, temozolomide-based chemotherapy demonstrated efficacy in Th-NETs treatment, with the neutrophil-to-lymphocyte ratio and serum neuron-specific enolase proving to be valuable prognostic markers necessitating further research. Background: Thymic neuroendocrine tumors (Th-NETs) are rare and aggressive, with a scarcity of research on predicting patient prognosis. Our study aimed to assess the impact of prognostic markers and temozolomide (TMZ)-based chemotherapy on survival in Th-NETs. Methods: We retrospectively reviewed the medical records of patients diagnosed with Th-NETs between 2013 and 2023 at our institution. We collected clinicopathological data, including tumor pathological grading, staging, serum concentrations of neuron-specific enolase (NSE) and pro-gastrin-releasing peptide, levels of inflammatory factors, and expression of oxygen 6-methylguanine-DNA methyltransferase (MGMT). Treatment details (such as surgery and chemotherapy) and survival outcomes were also documented. Results: A total of 32 patients were included in our study after excluding those without complete available information. The median progression-free survival (PFS) was 12.5 months (95%CI, 8–16 months) for 19 patients who received TMZ-based chemotherapy. Twenty-one patients underwent surgery as the primary treatment, demonstrating a median disease-free survival (DFS) of 51.0 months. The inflammatory factor neutrophil-to-lymphocyte ratio (NLR) was an independent prognostic indicator of DFS in postoperative patients and PFS in TMZ-treated patients. The overall 3-, 5-, and 10-year survival rates were 86.6%, 69.5%, and 33.8%, respectively. Ki67 level exceeding 10% (p = 0.048) and absence of surgical resection (p = 0.003) were significantly associated with worse overall survival (OS). Conclusion: Surgical treatment was currently the primary method for treating Th-NETs, and postoperative adjuvant therapy was an essential consideration for specific patient cohorts. Despite widespread positive MGMT expression, TMZ-based chemotherapy showed promise. Some potential prognostic biomarkers such as NLR and NSE need more attention. [ABSTRACT FROM AUTHOR]

How to efficiently deal with waste acids and bases produced by industry has constantly been a tough question for scientists and engineers. Such acid–base wastewaters are normally treated by mixing to give neutral products (i.e., water and salts) and heat which is hard to collect and reuse. Therefore, there is a need for innovative approaches with high efficiencies and high-value added products. Here, we report an air/metal hydride battery with the function of both treating acid–base wastewaters and gathering the waste heat energy in the form of electricity. Remarkably, the proposed battery could exhibit a high coulombic efficiency of up to ca. 94%, along with an effective reduction in the acidity/alkalinity of waste acids/bases and a decent amount of electricity. The proposed battery device also demonstrates a stable operation in semi-flow mode over a two-day timescale, showcasing its potential scalability and long-term stability. Moreover, life cycle assessment results indicate that electricity retrieved from the treatment process is a key contributor to reducing environmental impacts. This work offers alternative opportunities for accelerating the transition to a waste acid–base circular economy. [ABSTRACT FROM AUTHOR]

Olanzapine is an atypical antipsychotic drug and a potent muscarinic M3 receptor (M3R) antagonist. Olanzapine has been reported to cause metabolic disorders, including dyslipidemia. Anaplastic lymphoma kinase (Alk), a tyrosine kinase receptor well known in the pathogenesis of cancer, has been recently identified as a key gene in the regulation of thinness via the regulation of adipose tissue lipolysis. This project aimed to investigate whether Olanzapine could modulate the hepatic Alk pathway and lipid metabolism via M3R. Female rats were treated with Olanzapine and/or Cevimeline (an M3R agonist) for 9 weeks. Lipid metabolism and hepatic Alk signaling were analyzed. Nine weeks' treatment of Olanzapine caused metabolic disturbance including increased body mass index (BMI), fat mass accumulation, and abnormal lipid metabolism. Olanzapine treatment also led to an upregulation of Chrm3, Alk, and its regulator Ptprz1, and a downregulation of Lmo4, a transcriptional repressor of Alk in the liver. Moreover, there were positive correlations between Alk and Chrm3, Alk and Ptprz1, and a negative correlation between Alk and Lmo4. However, cotreatment with Cevimeline significantly reversed the lipid metabolic disturbance and adipose tissue accumulation, as well as the upregulation of the hepatic Alk signaling caused by Olanzapine. This study demonstrates evidence that Olanzapine may cause metabolic disturbance by modulating hepatic Alk signaling via M3R, which provides novel insight for modulating the hepatic Alk signaling and potential interventions for targeting metabolic disorders. [ABSTRACT FROM AUTHOR]

Motivation Identifying cancer genes remains a significant challenge in cancer genomics research. Annotated gene sets encode functional associations among multiple genes, and cancer genes have been shown to cluster in hallmark signaling pathways and biological processes. The knowledge of annotated gene sets is critical for discovering cancer genes but remains to be fully exploited. Results Here, we present the DIsease-Specific Hypergraph neural network (DISHyper), a hypergraph-based computational method that integrates the knowledge from multiple types of annotated gene sets to predict cancer genes. First, our benchmark results demonstrate that DISHyper outperforms the existing state-of-the-art methods and highlight the advantages of employing hypergraphs for representing annotated gene sets. Second, we validate the accuracy of DISHyper-predicted cancer genes using functional validation results and multiple independent functional genomics data. Third, our model predicts 44 novel cancer genes, and subsequent analysis shows their significant associations with multiple types of cancers. Overall, our study provides a new perspective for discovering cancer genes and reveals previously undiscovered cancer genes. Availability and implementation DISHyper is freely available for download at https://github.com/genemine/DISHyper. [ABSTRACT FROM AUTHOR]

Bioactive glass nanoparticles (BGNs) are applied widely in tissue regeneration. Varied micro/nanostructures and components of BGNs have been designed for different applications. In the present study, nanorod-shaped mesoporous zinc-containing bioactive glass nanoparticles (ZnRBGNs) were designed and developed to form the bioactive content of composite materials for hard/soft tissue repair and regeneration. The nanostructure and components of the ZnRBGNs were characterized, as were their cytocompatibility and radical-scavenging activity in the presence/absence of cells and their ability to modulate macrophage polarization. The ZnRBGNs possessed a uniform rod shape (length ≈ 500 nm; width ≈ 150 nm) with a mesoporous structure (diameter ≈ 2.4 nm). The leaching liquid of the nanorods at a concentration below 0.5 mg/mL resulted in no cytotoxicity. More significant improvements in the antioxidant and M1-polarization-inhibiting effects and the promotion of M2 polarization were found when culturing the cells with the ZnRBGNs compared to when culturing them with the RBGNs. The doping of the Zn element in RBGNs may lead to improved antioxidant and anti-inflammatory effects, which may be beneficial in tissue regeneration/repair. [ABSTRACT FROM AUTHOR]

The redox mediated photoelectrochemical (PEC) or electrochemical (EC) alkene oxidation process is a promising method to produce high value‐added epoxides. However, due to the competitive reaction of water oxidation and overoxidation of the mediator, the utilization of the electricity is far below the ideal value, where the loss of epoxidation's faradaic efficiency (FE) is ≈50%. In this study, a Br−/HOBr‐mediated method is developed to achieve a near‐quantitative selectivity and ≈100% FE of styrene oxide on α‐Fe2O3, in which low concentration of Br− as mediator and locally generated acidic micro‐environment work together to produce the higher active HOBr species. A variety of styrene derivatives are investigated with satisfied epoxidation performance. Based on the analysis of local pH‐dependent epoxidation FE and products distribution, the study further verified that HOBr serves as the true active mediator to generate the bromohydrin intermediate. It is believed that this strategy can greatly overcome the limitation of epoxidation FE to enable future industrial applications. [ABSTRACT FROM AUTHOR]

The solid-state phase transformations from body-centered cubic (bcc) transition metals such as V, Nb, Ta, Cr, Mo, and W to hexagonal close-packed (hcp) transition metal hemicarbides and heminitrides (M2C and M2N) were investigated in this work. It is thought that three-dimensional overall lattice distortions induced by complex ordering between interstitial atoms (C, N) and structural vacancies in the transition metal parents are the key-driving force for these structural changes. Moreover, these phase transformation paths were described by ab initio simulations and symmetry analyses. Different transformation paths are categorized, and the reasons for the inability to complete the transformation from bcc to hcp are identified, while all paths that can be transformed into hcp structures follow a unified formation pattern. The number of atoms required for this pattern is defined for a specific set of ordered atoms known as transformation units. These units can be incorporated into the main phase transformation crystallography, describing transformation processes from the atomic-level transformation units to a long-range strain-free interface comprising of the transformation units and interface defects, at microscopic and macroscopic scales. The dynamic origins of the formal crystallographic requirements in interstitials-induced transformations are also elucidated as well. The research can provide some physical significance of coherent terraces within step structures in phase transformation crystallography. [ABSTRACT FROM AUTHOR]

Type A acute aortic dissection (TA-AAD) patients are prone to life-threatening complications and death. This study aimed to analyze the association between eosinophil (EOS) recovery and clinical outcomes in TA-AAD. A total of 274 patients with TA-AAD were eligible for inclusion, and 54 patients died within 1 month. The patients with poor clinical outcomes showed significantly lower EOS count within 8 days after surgery. The time-dependent ROC analysis showed that EOS recovery days predicted 1-month death with an AUC of 0.886 and a cutoff of 6 days. EOS recovery within 6 days was associated with a lower incidence of postoperative infection, a poorer prognosis, and a lower risk of 1-month and 6-month mortality than those requiring more recovery days. Collectively, postoperative early recovery of EOS predicted lower mortality and better prognosis and may be applied as an effective, rapid, and simple tool for the risk stratification and prognostic prediction of patients with TA-AAD. Clinical trial registration number: NCT05409677. [ABSTRACT FROM AUTHOR]

In order to enhance the competitiveness with a‐Si and IGZO products, LTPS tablet product with comprehensive advantages in performance and cost have been developed. In this article, innovative technologies including 8‐Photo‐Mask process and only 1‐IC‐Chip solution are applied, and the performances such as low frame rate, active pens and narrow borders can meet the request of customer. [ABSTRACT FROM AUTHOR]

Background: Although CDKN2A alteration has been explored as a favorable factor for tumorigenesis in pan-cancers, the association between CDKN2A point mutation (MUT) and intragenic deletion (DEL) and response to immune checkpoint inhibitors (ICIs) is still disputed. This study aims to determine the associations of CDKN2A MUT and DEL with overall survival (OS) and response to immune checkpoint inhibitors treatment (ICIs) among pan-cancers and the clinical features of CDKN2A-altered gastric cancer. Methods: This study included 45,000 tumor patients that underwent tumor sequencing across 33 cancer types from four cohorts, the MSK-MetTropism, MSK-IMPACT, OrigiMed2020 and TCGA cohorts. Clinical outcomes and genomic factors associated with response to ICIs, including tumor mutational burden, copy number alteration, neoantigen load, microsatellite instability, tumor immune microenvironment and immune-related gene signatures, were collected in pan-cancer. Clinicopathologic features and outcomes were assessed in gastric cancer. Patients were grouped based on the presence of CDKN2A wild type (WT), CDKN2A MUT, CDKN2A DEL and CDKN2A other alteration (ALT). Results: Our research showed that CDKN2A-MUT patients had shorter survival times than CDKN2A-WT patients in the MSK MetTropism and TCGA cohorts, but longer OS in the MSK-IMPACT cohort with ICIs treatment, particularly in patients having metastatic disease. Similar results were observed among pan-cancer patients with CDKN2A DEL and other ALT. Notably, CDKN2A ALT frequency was positively related to tumor-specific objective response rates to ICIs in MSK MetTropism and OrigiMed 2020. Additionally, individuals with esophageal carcinoma or stomach adenocarcinoma who had CDKN2A MUT had poorer OS than patients from the MSK-IMPACT group, but not those with adenocarcinoma. We also found reduced levels of activated NK cells, T cells CD8 and M2 macrophages in tumor tissue from CDKN2A-MUT or DEL pan-cancer patients compared to CDKN2A-WT patients in TCGA cohort. Gastric cancer scRNA-seq data also showed that CDKN2A-ALT cancer contained less CD8 T cells but more exhausted T cells than CDKN2A-WT cancer. A crucial finding of the pathway analysis was the inhibition of three immune-related pathways in the CDKN2A ALT gastric cancer patients, including the interferon alpha response, inflammatory response, and interferon gamma response. Conclusions: This study illustrates the CDKN2A MUT and DEL were associated with a poor outcome across cancers. CDKN2A ALT, on the other hand, have the potential to be used as a biomarker for choosing patients for ICI treatment, notably in esophageal carcinoma and stomach adenocarcinoma. [ABSTRACT FROM AUTHOR]

In this work, a donor‐acceptor (D‐A) type ligand is prepared to construct Cu(I) and Ag(I) complexes. These complexes possess similar molecular structures, distributions of molecular orbitals, and distributions of electrons and holes in excited states. However, they exhibit distinct photophysical properties, such as luminescent spectra and transient photo‐luminescent decay spectra. Through analysis of deep‐lying molecular orbitals in a tetrahedral field, it is determined that the variation in d‐p π conjugation between the metal cation's d‐orbitals and the π orbitals of the electron‐acceptor part of the D‐A ligand is the reason for the different photophysical properties. This research contributes to an in‐depth understanding of the role of metal ions in luminescent complexes, providing insights from the perspective of coordination chemistry. [ABSTRACT FROM AUTHOR]