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Background: Chronic urticaria (CU) is a vexing problem and patients of CU suffer from the morbidity that arise from irritable itch and weals and are also subjected to a huge antihistamine pill burden. The symptoms are more in autoreactive urticaria (AU) where auto-antibodies in blood flares-up the condition. Search for newer effective modalities which can reduce pill burden is a felt need. Aims: This study evaluates the effectiveness of autologous serum therapy (AST) in CU and also determines its usefulness in AU. Materials and Methods: Double blind, parallel group, randomized, controlled study. Fifty four patients were given AST and 57 patients were given injection normal saline (placebo), along with cetirizine in an on-demand basis in both groups. AST/Placebo was given weekly for nine weeks and followed-up for a total period of 24 weeks. AU was diagnosed by autologous serum skin test. Urticaria total severity score (TSS), Urticaria activity score (UAS), Dermatologic life quality index (DLQI) was used as primary effectiveness variables. Safety parameters assessed were the spontaneously reported adverse events and laboratory parameters. Results: TSS showed significant improvement from baseline, 7 th week and 8 th week onwards in AST group and placebo group respectively. Group comparison showed significant improvement 4 th week onwards. UAS showed similar results. DLQI showed significant improvement in AST group compared to placebo at the end of study. Both AU and non-AU patients showed comparable improvement of TSS. Conclusion: AST shows promise in treatment of urticaria regardless of the autoreactive nature. [ABSTRACT FROM AUTHOR]

Angiokeratoma corporis diffusum (ACD) is a rare clinical type of angiokeratoma and has been reported, mostly, in association with various life threatening conditions, of which Fabry disease is the most known. Rarely, it has been reported as an isolated finding without any systemic features. A 23-year-old male presented with numerous red papules of various sizes with a history of intermittent bleeding. Histopathology findings were consistent with angiokeratoma and our case was diagnosed as ACD. We herein present a case of cutaneous variant of ACD without any associated systemic associations. Also, the conditions associated with ACD have been briefly discussed. [ABSTRACT FROM AUTHOR]

The article describes the case of a 42-year-old woman who was diagnosed with lichen sclerosus. The patient presented with multiple itchy white papules and atrophic plaques over trunk and extremities. Skin biopsy was done from papule over left flank. Lichen sclerosus is a chronic disease of unknown etiology. It affects genitalia more frequently than non-genital skin.

The article discusses the case of a 65-year-old female with a small painful swelling on left index finger. Single nodule was noted on periungual area of left index finger of the patient on examination. The patient was diagnosed with glomus tumour (GT), a rare benign neoplasm. A discussion on GT, including its clinical features, common differential diagnoses, and treatment, is included.

Inverse (flexural) psoriasis is characterized by shiny, pink to red, sharply-demarcated thin plaques. Frequency of isolated involvement of these areas is very rare and the morphology is frequently altered by maceration and friction. All this leads to diagnostic confusion. We describe two cases of inverse psoriasis with isolated involvement of axillae. One patient presented with dry mildly scaly plaque, while the other presented with macerated plaque. Histopathology was consistent with the diagnosis of inverse psoriasis. Although there are previous reports, but localization of lesions only to axillae in a case of inverse psoriasis is unique. [ABSTRACT FROM AUTHOR]

A 17-year-old girl presented with multiple perifollicular hemorrhagic lesions on legs for 2 weeks. There was history of intermittent gum bleeding for last 2 months. Clinical examination revealed follicular keratosis and broken twisted hair (corkscrew hair), in addition to hemorrhagic lesions. Perifollicular hemorrhagic lesions and corkscrew hair are virtually pathognomonic for scurvy. When specifically asked, mother revealed that the girl was on self-imposed diet with almost no citrus fruits. Based on history and clinical findings, diagnosis of scurvy was made. The response to vitamin C supplementation was very good and all the lesions disappeared within one month. Scurvy has been reported in increasing numbers in recent literature; hence, recognition of scurvy is essential to avoid many serious complications including internal bleeding and even, death. [ABSTRACT FROM AUTHOR]

The article presents a case of porokeratotic eccrine ostial and dermal duct nevus (PEODDN), a rare disorder of keratinization, with unique clinical and histopathological findings. Topics discussed include the characteristics of PEODDN, diseases reportedly associated with PEODDN, and the limited treatment options for PEODDN.

The article discusses the case of a man with a solitary painful mass on his chest diagnosed as eccrine spiradenoma. A description of the lesion and nodule, the patient's history, and the mass and epithelial cords found under histopathological examination are presented. The nine unique tumors to be considered when diagnosing painful skin tumors, the occurrence of spiradenomas in Brooke-Spiegler syndrome, and the treatment option are discussed.

The article presents a case study of four-year-old girl with generalized vesiculabollous eruptions for five months. The patient has small fluid filled lesions in the body that gradually increased in size and ruptured that form erosion, with burning sensation of the mouth during food intake. Clinical differential diagnoses include chronic bullous disease of childhood (CBDC), Epidermolysis bullosa, and porphyria. The patient responded well to prednisolone treatment.

The article discusses the clinical case of a four-year-old girl who was diagnosed with generalized benign acanthosis nigricans. The patient presented with asymptomatic generalized hyperpigmentation, spread throughout her body and became thickened and rugose. Medical examination on the patient revealed hyperkeratosis, acanthosis and papillomatosis. Clinical information on generalized benign acanthosis nigricans is also given.

The article describes the condition of a nine-year old boy who was diagnosed with a Pachyonychia congenita affecting only the nails. It states that the condition, extremely rare, is due to the mutation in keratin gene and characterized by dystrophic, thickened nails, symmetric focal palmoplantar keratoderma and oral leukokeratosis. The two types of the condition are also discussed, namely the Jadassohn-Lewandowski syndrome and the Jackson-Lawler syndrome.