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Carbon fusion reactions 12 C( 12 C,p) 23 Na and 12 C( 12 C, α ) 20 Ne play a key role in the evolution of massive stars and in explosive scenarios such as type-Ia supernovae and super-bursts in binary stars. A direct determination of their cross sections is extremely challenging and discrepancies exist between different data sets in the literature. Here we report the results of a direct measurement performed at the CIRCE Tandem Accelerator Laboratory in Caserta (Italy), using Δ E - E detectors for unambiguous charge identification. Cross sections were measured in the energy range E c. m. = 2.51 - 4.36 MeV with energy steps between 10 and 25 keV in the centre of mass. To our knowledge these represent the finest energy steps to date. Results are presented in the form of partial and summed astrophysical S ~ -factors for individual proton- and α -particle channels. Branching ratios of individual proton- and α -particle groups were found to vary significantly with energy. Angular distributions, albeit limited to three angles, were also found to be non-isotropic, which could be a potential explanation for the discrepancies observed among different data sets. Further efforts are ongoing to extend measurements to lower energies. [ABSTRACT FROM AUTHOR]

Carbon fusion reactions 12 C( 12 C,p) 23 Na and 12 C( 12 C, α ) 20 Ne play a key role in the evolution of massive stars and in explosive scenarios such as type-Ia supernovae and super-bursts in binary stars. A direct determination of their cross sections is extremely challenging and discrepancies exist between different data sets in the literature. Here we report the results of a direct measurement performed at the CIRCE Tandem Accelerator Laboratory in Caserta (Italy), using Δ E - E detectors for unambiguous charge identification. Cross sections were measured in the energy range E c. m. = 2.51 - 4.36 MeV with energy steps between 10 and 25 keV in the centre of mass. To our knowledge these represent the finest energy steps to date. Results are presented in the form of partial and summed astrophysical S ~ -factors for individual proton- and α -particle channels. Branching ratios of individual proton- and α -particle groups were found to vary significantly with energy. Angular distributions, albeit limited to three angles, were also found to be non-isotropic, which could be a potential explanation for the discrepancies observed among different data sets. Further efforts are ongoing to extend measurements to lower energies. [ABSTRACT FROM AUTHOR]

Durability tests of thermal protection system (TPS) materials for space vehicles is of paramount importance in developing TPS materials. The limits of the presently used techniques and the need for higher accuracy and precision demand new reliable and more sensitive measurement methods. In this paper we present the validation of a new on-line and non intrusive technique to estimate the TPS material recession rate which exploits the surface layer implantation of radioactive 7Be ions and the measurement of its characteristic γ-rays during the recession test. [ABSTRACT FROM AUTHOR]

Retraction Note: Direct measurements of the 12C + 12C reactions cross-sections towards astrophysical energies After publication, we discovered a mistake in the script used to calculate beam energy losses from tabulated stopping powers. We deeply regret any inconvenience that this retraction may cause, and we apologize to the scientific community and to the readers of EPJA for any harm that may have been caused by the publication of this paper. [Extracted from the article]

The basement membrane (BM) is a layer of specialized extracellular matrix that surrounds normal prostate glands and preserves tissue integrity. Lack or discontinuity of the BM is a prerequisite for tumor cell invasion into interstitial spaces, thus favoring metastasis. Therefore, BM maintenance represents a barrier against cancer development and progression. In the study, we show that miR-205 participates in a network involving ΔNp63α, which is essential for maintenance of the BM in prostate epithelium. At the molecular level, ΔNp63α is able to enhance miR-205 transcription by binding to its promoter, whereas the microRNA can post-transcriptionally limit the amount of ΔNp63α protein, mostly by affecting ΔNp63α proteasomal degradation rather than through a canonical miRNA/target interaction. Functionally, miR-205 is able to control the deposition of laminin-332 and its receptor integrin-β4. Hence, pathological loss of miR-205, as widely observed in prostate cancer, may favor tumorigenesis by creating discontinuities in the BM. Here we demonstrate that therapeutic replacement of miR-205 in prostate cancer (PCa) cells can restore BM deposition and 3D organization into normal-like acinar structures, thus hampering cancer progression. [ABSTRACT FROM AUTHOR]

The assessment of the radiological impact of a decommissioned nuclear power plant is presented here through the results of an environmental monitoring survey carried out in the area surrounding the Garigliano Power Plant. The levels of radioactivity in soil, water, air and other environmental matrices are shown, in which α, β and γ activity and the γ equivalent dose rate are measured. Radioactivity levels of the samples from the Garigliano area are analyzed and then compared with those from a control zone situated more than 100 km away. Moreover, a comparison is made with a previous survey carried out in 2001. The analyses and comparisons show no significant alteration in the radiological characteristics of the area surrounding the plant, with the overall radioactivity depending mainly on the global fallout and natural sources. [ABSTRACT FROM AUTHOR]

Lonidamine is an antitumor agent with a peculiar mechanism of action, since it differentially impairs the energy metabolism of normal and neoplastic cells. We investigated the effects of lonidamine on the activity of DNA-damaging antitumor agents against the MX-1 human breast carcinoma xenograft. Athymic mice bearing measurable s.c. tumors were treated by a single injection of doxorubicin (i.v.), cyclophosphamide (i.v.), or cisplatin (i.p.) followed by repeated daily injections of lonidamine (i.p. or p.o.). A potentiation of the activity of all these DNA-damaging drugs was achieved when each was given in combination with lonidamine, but for doxorubicin and cyclophosphamide the increase in antitumor activity paralleled the increase in lethal toxicity. In contrast, a therapeutic advantage of the combination was achieved for cisplatin and lonidamine as compared with cisplatin alone. Indeed, 6 mg/kg of cisplatin plus lonidamine cured all tumors, whereas the maximum tolerated dose of cisplatin alone (12 mg/kg) cured only six of eight tumors. In addition, the study indicated that the duration of lonidamine administration after injection of the cytotoxic drug influenced the tumor response and that prolonged treatment resulted in greater efficacy. These results document the ability of lonidamine to modulate the pharmacological activity of DNA-damaging drugs, thus suggesting that lonidamine may be a clinically useful cisplatin modulator. [ABSTRACT FROM AUTHOR]

A new detection array called GASTLY (GAs-Silicon Two-Layer sYstem) has been designed to detect and identify low-energy light particles emitted in nuclear reactions of astrophysical interest. Devoted to the measurement of nanobarn cross-sections, the system is optimised for large solid angle coverage and for low-energy detection thresholds. The array consists of eight modules, each comprising an ionisation chamber and a large area silicon strip detector. Its modularity and versatility allow for use in a variety of experiments. Here we report on the performance of the array as obtained during its commissioning phase with standard α-particle sources and during in-beam tests with an intense 12C beam. Typical energy resolutions ΔE( FWHM )/E of about 3% and 2% were obtained for the ionisation chambers and the silicon detectors, respectively. The status of the development of individual strip readout, based on ASIC technology, is also presented. [ABSTRACT FROM AUTHOR]

The 12C(12C,p)23Na and 12C(12C,α)20Ne fusion reactions are among the most important in stellar evolution since they determine the destiny of massive (M≃8-10M⊙) stars. However, experimental low-energy investigations of such reactions are significantly hampered by ubiquitous natural hydrogen and deuterium contaminants in the carbon targets. The associated beam-induced background completely masks the reaction products of interest thus preventing cross-section measurements at the relevant energies of astrophysical interest, E cm <2 MeV. In this work, we report about an investigation aimed at assessing possible deuterium reductions on both natural graphite and Highly Ordered Pyrolytic Graphite targets as a function of target temperature. Our results indicate that reductions up to about 80% can be attained on both targets in the temperature range investigated, T≃200-1200∘C. A further reduction by a factor of 2.5 in absolute deuterium content is observed when the scattering chamber is surrounded by a dry nitrogen atmosphere so as to minimise light-particles uptake within the chamber rest gas (and thus on target) through air leaks. The results from this study will inform the choice of optimal experimental conditions and procedures for improved measurements of the 12C + 12C reactions cross-sections at the low energies of astrophysical interest. [ABSTRACT FROM AUTHOR]

7Be(p,γ)8B has an important role in nuclear astrophysics, having a direct impact on both the high energy component of solar neutrinos and the 7Li abundance after the Big Bang Nucleosynthesis. All direct measurements providing useful information on this reaction so far used the same approach, i.e. a proton beam on a radioactive 7Be target. The overall precision and accuracy of the estimate of the astrophysical rate of this reaction are limited by the discrepancy between the results of existing measurements, possibly due to the complicated stoichiometry and beam induced deterioration of the radioactive targets. The ERNA (European Recoil separator for Nuclear Astrophysics) collaboration planned a new experiment in inverse kinematics exploiting the intense 7Be beam available at CIRCE (Center for Isotopic Research on Cultural and Environmental heritage), Caserta, Italy. The 8B recoils are produced in a windowless hydrogen gas target and detected after the efficient mass separation provided by ERNA. Here we present the commissioning of the experimental setup and a first cross section measurement at E cm ≈812 keV. [ABSTRACT FROM AUTHOR]