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Background: Patellar tendinopathy (PT) is a common problem in jumping athletes. Management can be challenging and treatment outcome is not always successful. In combination with tendon loading exercises, hydrolyzed collagen/vitamin C supplementation appears to have a promising effect on the recovery of tendinopathy. The aim of this study is to evaluate whether the use of oral supplementation of hydrolyzed collagen and vitamin C in combination with progressive tendon loading exercises (PTLE) is superior to PTLE and placebo on VISA-P score (which rates pain, function, sports participation) after 24 weeks for athletes with PT. Methods: The JUMPFOOD study is a double-blinded, two-armed randomized controlled trial, in which the effectiveness of oral supplementation of hydrolyzed collagen/vitamin C combined with PTLE compared to PTLE with placebo on pain and recovery of function in athletes with PT will be investigated. Seventy-six athletes aged 16–40 years, with symptoms of PT for at least 12 weeks, who play sports at least once a week will be included. All participants will receive education, advice with regard to load management and a PTLE program according to the Dutch guidelines for anterior knee pain. In addition, the intervention group will receive daily 10 g hydrolyzed collagen and 40 mg vitamin C supplementation for 24 weeks whereas the control group receives 10 g maltodextrin placebo supplementation. Measurements will take place at baseline and at 12 and 24 weeks' follow-up. Primary outcome is the VISA-P score, which evaluates pain, function, and sports participation. For secondary outcome measures, data with regard to pain during functional tests, flexibility measurements, blood withdrawals, imaging characteristics of the tendon, and health questionnaires will be collected. During the follow-up period, participants will register sports participation, amount of training and tendon load, pain during sports, co-medication, and side-effects in a digital weekly diary. Discussion: The JUMPFOOD study is the first large RCT to study the effectiveness of hydrolyzed collagen/vitamin C supplementation in combination with the PTLE program in athletes with patellar tendinopathy. If supplementation of collagen/vitamin C appears to be effective, this treatment can be implemented in daily sports medicine practice to improve the treatment outcome of patients with PT. Trial registration: ClinicalTrials.gov NCT05407194. Registered on 7 June 2022. [ABSTRACT FROM AUTHOR]

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This qualitative study explores the youth-initiated mentoring (YIM) approach for youth at risk for out-of-home placement. In this approach, a youth nominates someone from within their social network, and positions this person as a YIM to function as an ally for the youth and as a partner for parents and professional caregivers. Through interviews with six youth, six YIMs, and seven parents (N = 19), we examined the positioning of a YIM and sustainability. The results indicated that attitudes from participants toward asking someone or being asked to become a YIM varied from enthusiastic to cautious. Participants reported increased contact intensity and relationship quality. Two parents did not experience YIM as beneficial. Most participants expected that the YIM–mentee relationship lasts after professional care terminates. The results reveal that YIM is experienced as an ally, but it also has the potential to increase relational conflicts between social network members. [ABSTRACT FROM AUTHOR]

Abstract: In this meta‐analytic review, we examined the relation between natural mentoring and youth outcomes in four domains: academic and vocational functioning, social‐emotional development, physical health, and psychosocial problems. Natural mentoring relationships are thought to foster positive youth development and buffer against the risks associated with the tumultuous years of adolescence. Two separate meta‐analyses were conducted on the presence of a natural mentor and the quality of the natural mentoring relationship, including thirty studies from 1992 to present. The findings indicated that the presence of a natural mentor was significantly associated with positive youth outcomes (r = .106). A larger effect size was found for the quality of the natural mentoring relationship in terms of relatedness, social support, and autonomy support (r = .208). The largest effect sizes were found for social‐emotional development and academic and vocational functioning. Risk‐status (e.g., teenage mothers, homeless youth, youth in foster care, and youth of alcoholic parents) did not moderate the relation between presence and quality of natural mentoring relationships and youth outcomes, which may indicate that natural mentors are generally beneficial for all youth regardless of risk‐status. Implications for theory and practice concerning the quality of the natural mentoring relationship are discussed. [ABSTRACT FROM AUTHOR]

When picking up objects using a pinch grip, there are usually numerous places at which one could place the thumb and index finger. Yet, people seem to consistently place them at or close to the centre of mass (COM), presumably to minimize torque and therefore the required grip force. People also prefer to grasp objects by parallel surfaces and ones with higher friction coefficients (rough surfaces), to prevent the object from slipping when they lift it. Here, we examine the trade-off between friction and COM. Participants were asked to grasp and lift aluminium bars of which one end was polished and therefore smooth and the other was rough. Their finger positions were recorded to determine how they grasped the objects. The bars were oriented horizontally in the frontal plane, with the centre aligned with the participants' body midline. The bars varied in the horizontal offset between the COM and the edge of the rough region. The offset could be 0, 1 or 2 cm. We expected participants to grasp closer to the rough area than the centre of the bar. Completely rough bars and completely smooth bars served as control conditions. The slipperiness of the surface that was grasped affected the height of the grasping points, indicating that participants adjusted their grasping behaviour to the slipperiness of the surface. However, the tendency to grasp closer to the rough area was minimal. This shows that the judged COM largely determines how an object is grasped. Friction has very limited influence. [ABSTRACT FROM AUTHOR]

In this review we discuss the use of conventional (computed tomography, magnetic resonance imaging, ultrasound) and advanced muscle imaging modalities (diffusion tensor imaging, magnetic resonance spectroscopy) in hereditary and acquired myopathies. We summarize the data on specific patterns of muscle involvement in the major categories of muscle disease and provide recommendations on how to use muscle imaging in this field of neuromuscular disorders. [ABSTRACT FROM AUTHOR]

Purpose – Multinationals are increasingly pressured by stakeholders to commit to environmental sustainability that exceeds their own firm borders. As a result, multinationals have started to commit to environmental supply chain sustainability programs (ESCSPs). However, little is known about whether such commitment is rewarded or punished by financial markets, and if the stock price reaction differs depending on the type of firm that commits to such a program. This paper aims to discuss these issues. Design/methodology/approach – The authors conduct an event study followed by two-equation Heckman modeling, using a sample of 66 multinationals that committed to the ESCSP of the Carbon Disclosure Project (CDP). Findings – It was found that generally there is a marginally significant negative stock price reaction to announcement of participation in this ESCSP (i.e. −0.8 percent, p<0.10). However, the authors argue and show that firms in industries that have historically faced more pressure from consumers are less likely to announce their participation. If one corrects for this industry bias, then the negative stock price reaction is even more pronounced (i.e. −3.2 percent, p<0.05). Research limitations/implications – Using objective data, the study provides insights into the shareholder wealth effects of firms that commit to the ESCSP of the CDP. As such, the sample does not cover firms that set up their own ESCSPs. Practical implications – The paper is valuable for practitioners and investors who are interested in finding out if participation in ESCSPs is financially attractive, and for (governmental) policy makers who may want to be assured that there is sufficient incentive for firms to pursue environmental supply chain sustainability. Originality/value – This is the first paper that captures how financial markets react to announcements of ESCSPs. [ABSTRACT FROM AUTHOR]

Background and study aims: Time limitations and unwanted health effects may act as barriers to participation in colorectal cancer (CRC) screening. The aim of the study was to measure the time requirements and health effects of colonoscopy and computed tomography colonography (CTC) screening. Patients and methods: Thiswas a prospective diary study in a consecutive sample within a randomized controlled CRC screening trial, comparing primary colonoscopy and CTC screening for average-risk individuals aged 50-74 years. The diary ended when all screening-related complaints had passed. Results: The diary was returned by 75% (241/322) of colonoscopy and 75% (127/170) of CTC screenees. The median interval between leaving home and returning from the examination was longer for colonoscopy (4 hours and 18 minutes [4:18], interquartile range [IQR] 3:30-5:00) than for CTC (2:30 hours, IQR 2:06-3:00; P<0.001). Similarly, the time to return to routine activities was longer after colonoscopy (3:54 hours, IQR 1:48- 15:00) than after CTC (1:36 hours, IQR 0:54- 4:42). The duration of screening-related symptoms after the examination was shorter for colonoscopy (11:00 hours, IQR 2:54-20:00) than for CTC (22:00 hours; IQR 5:30-47:00; P<0.001). Abdominal complaints were reported more frequently after CTC. Anxiety, pain, and quality of life worsened during the screening process, with no differences between the two examinations. Conclusions: Compared with colonoscopy, CTC screening required less time and allowed screenees to return to their daily activities more quickly. In contrast, CTC was associated with a twofold longer duration of screening-related symptoms. Feelings of anxiety, pain, and quality of life scores were similar during colonoscopy and CTC screening. These results should be incorporated into cost-effectiveness analyses of CRC screening techniques. [ABSTRACT FROM AUTHOR]

Background:Little is known about the effect of participating in a colorectal cancer (CRC) screening programme on quality of life (QOL), neither for participants with a negative nor for those with a positive test result. These findings, however, are important to evaluate the impact of CRC screening.Methods:Participants from CRC screening trials were sent a questionnaire, which included validated measures on generic health-related QOL, generic anxiety and screen-specific anxiety. Both faecal immunochemical test (FIT) and flexible sigmoidoscopy (FS) participants, either with negative or positive test results, were addressed.Results:The response rate was 73% (1289 out of 1772) for FIT and 78% (536 out of 689) for FS participants, with mean ages varying from 63-66 years. Positive FIT participants had worse physical (PCS-12, 47.1 vs 48.3, P=0.02), but equal mental QOL scores (MCS-12, 51.1 vs 51.6, P=0.26). Positive and negative FS participants had similar QOL scores. Both FIT and FS participants with a positive test result reported more screen-specific anxiety than negative FIT and FS participants. Positive and negative FS participants had similar generic anxiety scores.Conclusion:Our findings indicate that the burden of participating in CRC screening may be limited. Conducting a prospective study to confirm these results is recommended. [ABSTRACT FROM AUTHOR]

Background: Guidelines underline the role of individual preferences in the selection of a screening test, as insufficient evidence is available to recommend one screening test over another. We conducted a study to determine the preferences of individuals and to predict uptake for colorectal cancer (CRC) screening programmes using various screening tests.Methods: A discrete choice experiment (DCE) questionnaire was distributed among naive subjects, yet to be screened, and previously screened subjects, aged 50-75 years. Subjects were asked to choose between scenarios on the basis of faecal occult blood test (FOBT), flexible sigmoidoscopy (FS), total colonoscopy (TC) with various test-specific screening intervals and mortality reductions, and no screening (opt-out).Results: In total, 489 out of 1498 (33%) screening-naïve subjects (52% male; mean age+/-s.d. 61+/-7 years) and 545 out of 769 (71%) previously screened subjects (52% male; mean age+/-s.d. 61+/-6 years) returned the questionnaire. The type of screening test, screening interval, and risk reduction of CRC-related mortality influenced subjects' preferences (all P<0.05). Screening-naive and previously screened subjects equally preferred 5-yearly FS and 10-yearly TC (P=0.24; P=0.11), but favoured both strategies to annual FOBT screening (all P-values <0.001) if, based on the literature, realistic risk reduction of CRC-related mortality was applied. Screening-naive and previously screened subjects were willing to undergo a 10-yearly TC instead of a 5-yearly FS to obtain an additional risk reduction of CRC-related mortality of 45% (P<0.001).Conclusion: These data provide insight into the extent by which interval and risk reduction of CRC-related mortality affect preferences for CRC screening tests. Assuming realistic test characteristics, subjects in the target population preferred endoscopic screening over FOBT screening, partly, due to the more favourable risk reduction of CRC-related mortality by endoscopy screening. Increasing the knowledge of potential screenees regarding risk reduction by different screening strategies is, therefore, warranted to prevent unrealistic expectations and to optimise informed choice. [ABSTRACT FROM AUTHOR]

Describes the results of a sampling program to test a management-oriented, predictive model of the buildup of lead, copper and zinc contaminants in sediments in sheltered estuaries in Auckland, New Zealand. Stormwater contamination of urban estuaries; Study site characteristics; Chemical and statistical analyses.

An abstract of the conference paper "Prenatally diagnosed ventriculomegaly: Associations and outcome," by L. Dam and colleagues is presented.

An underlying assumption of laboratory-based toxicity tests is that the sensitivity of organisms in the laboratory (in vitro) is comparable to that in the field (in situ). We tested this assumption by exposing estuarine amphipods (Chaetocorophium cf. lucasi) to a concentration series of cadmium-spiked sediments in vitro and in situ for 10 d. In situ exposures were conducted within plastic-mesh cages on an intertidal mudflat. To characterize exposure, we. measured interstitial water cadmium concentrations OWCO, acid volatile sulfide (AVS), and simultaneously extracted Cd (SEMcd) at the beginning and end of the exposures. Between day 0 and day 10, AVS decreased in both in vitro and in situ exposures, while IWcd levels declined less in vitro (median 27%) than in situ (median 76%). Despite more extreme conditions of temperature (10-36 deg.C) and salinity (18-22%o) in situ. in vitro and in situ exposures showed comparable survival responses based on SEMcd/AVS (LC50 [95% CI]: 1.6 [1.46-1.78] and 1.8 [1.761.83], respectively), with the onset of marked mortality above a SEMcd/AVS value of aboutone and minimal survival (<5%) above a value of two. Based on IWcd concentrations, however, sensitivity was significantly greater in vitro (LC50 = 0.41 mg Cd/L [0. 1710.959], in situ LC50 = 1.6 mg Cd/L [1.15-2.16]). We concluded that, in our tests, amphipod sensitivity in vitro was equal to or greater than its sensitivity in situ. [ABSTRACT FROM AUTHOR]