Search

Methamphetamine HCl was synthesized using three variations of the hydriodic acid/red phosphorus (HI/Pred) synthetic route. A Plackett-Burman experimental design was used to determine how reaction parameters affected the isotopic composition of the product. Isotope ratio mass spectrometry results showed only the source of precursor 13C was significant in determining product δ13C; the manufacturer, reaction temperature, time, scale, and source of HI were not significant. The precursor was also the main determinant of product δ2H, with smaller contributions from the HI source for one method. From precursor to product, large δ2H depletion occurred for most samples. Deuterium nuclear magnetic resonance spectroscopy (2H NMR) was used to investigate the specific site of this. Significant fraction of deuterium was observed only at the benzylic position, the site of hydrogen addition during synthesis. Methamphetamine synthesized from ephedrine was shown to be depleted in this position. [ABSTRACT FROM AUTHOR]

Abstract  In a dynamic experiment to obtain the high-rate stress–strain response of a ductile specimen, it takes a finite amount of time for the strain rate in the specimen to increase from zero to a desired level. The strain in the specimen accumulates during this strain-rate ramping time. If the desired strain rate is high, the specimen may yield before the desired rate is attained. In this case, the strain rates at yielding and early plastic flow are lower than the desired value, leading to inaccurate determination of the yield strength. Through experimentation and analysis, we examined the validity and accuracy of the flow stresses for ductile materials in a split Hopkinson pressure (SHPB) bar experiment. The upper strain-rate limit for determining the dynamic yield strength of ductile materials with a SHPB is identified. [ABSTRACT FROM AUTHOR]