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Isavuconazole is a new triazole with an expanded-spectrum and potent activity against moulds and yeasts. It has been authorized for use in adults for the treatment of invasive aspergillosis and for mucormycosis. The only commercially available isavuconazole susceptibility test is the minimum inhibitory concentration (MIC) strip isavuconazole test. The objective of this study was to assess the in vitro activity of isavuconazole using gradient concentration MIC strips, compared with the EUCAST broth microdilution reference method. A total of 147 clinically relevant fungal isolates comprising 120 Aspergillus sp. and 27 Scedosporium apiospermum complex were tested for susceptibility to isavuconazole using the EUCAST broth microdilution method and by the MIC strip isavuconazole test. The percent essential agreement between the two methods was calculated within a 1-fold dilution. The geometric means for the MICs using the EUCAST reference methods and the strip test were respectively: 0.60 mg/l and 0.65 mg/l for A. fumigatus, 0.70 mg/l and 0.77 mg/l for A. flavus, 1.50 mg/l and 1.25 mg/l for A. niger, 0.41 mg/l and 0.38 mg/l for A. terreus, 1.22 mg/l and 1.08 mg/l for S. apiospermum complex. The isavuconazole MIC strips showed good agreement with the EUCAST reference method. Isavuconazole MIC strips could be useful for susceptibility testing of Aspergillus sp. and S. apiospermum complex. [ABSTRACT FROM AUTHOR]

Purpose: To compare the efficacy of five versus one session of Behavioral Counseling in a 12-week intervention to increase self-efficacy and family and friend support for activity, and examine self-efficacy and support as mediators of activity among 46 urban women. Methods: A randomized, controlled trial conducted during 2004 in Omaha, Nebraska. Outcomes were analyzed with Repeated Meaures-ANOVA and path analysis. Findings: No significant change was observed in self-efficacy in the five-session group, but a significant decrease was observed in the one-session group (p = .005). Family and friend support increased significantly in the five-session group (p < .001, p = .019). The intervention effect on activity was mediated through change in self-efficacy and family support. Conclusions: Five behavioral counseling sessions maintained self-efficacy and increased family and friend support although the intervention did not directly affect activity. Implications: The intervention can be replicated within various community settings. [ABSTRACT FROM AUTHOR]

The problem of comparing geographic flows is explored. We present a simple statistical method and compare it to a cartographic method. Each is applied to a specific example in which migration flows are contrasted with fiscal transfers. The analysis suggests that while neither method is adequate by itself, there might be great advantages to using them in tandem. [ABSTRACT FROM AUTHOR]

Mammalian pancreatic ribonucleases form a family of homologous proteins that has been extensively investigated. The primary structures of these enzymes were used to derive phylogenetic trees. These analyses indicate that the presence of three strictly homologous enzymes in the bovine species (the pancreatic, seminal, and cerebral ribonucleases) is due to gene duplication events which occurred during the evolution of ancestral ruminants. In this paper we present evidence that confirms this finding and that suggests an overall structural conservation of the putative ribonuclease genes in ruminant species. We could also demonstrate that the sequences related to ox ribonuclease coding regions present in genomic DNA of the giraffe species are the orthologues of the bovine genes encoding the three ribonucleases mentioned above. [ABSTRACT FROM AUTHOR]

A method is presented for the graphic display of proximity matrices as a complement to the common data analysis techniques of hierarchical clustering. The procedure involves the use of computer generated shaded matrices based on unclassed choropleth mapping in conjunction with a strategy for matrix reorganization. The latter incorporates a combination of techniques for seriation and the ordering of binary trees. [ABSTRACT FROM AUTHOR]

Comments on different number of ways to measure the similarity of geographic flows. Failure of cosine-based similarity measure to account for rotations between flows; Utility of modern statistical methods; Assessment of the scholarly contributions of academic geographers.