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In his commentary on Psalm 118(LXX):73a, "Your hands made me and fashioned me" (Tract.118Ps. 10.1–8), Hilary of Poitiers provides a unique perspective on the creation of humanity and on its exceptional dignity. I will examine key aspects of Hilary's exegesis of this verse, namely, the identification of the hands of God, the interpretation of the two verbs "made" and "fashioned", and the connections with Genesis 1:26 and 2:7. I will also compare Hilary's interpretation of Ps 118:73a to the views expressed by other authors such as Theophilus, Irenaeus, Origen, Tertullian, Ambrose, and Didymus, with the purpose of contextualising Hilary's novel understanding of human dignity within the larger framework of Early Christian interpretations of Genesis. [ABSTRACT FROM AUTHOR]

Purpose: Treatment with statins requires close monitoring of serum creatine kinase (CK) levels to prevent myopathy, a common and potentially serious dose-dependent adverse effect of these drugs. We have investigated the correlation between elevated CK levels and polymorphisms in the genes encoding transporters involved in statin disposition. Methods: Patients with and without statin-induced elevated serum CK levels were genotyped for polymorphisms in SLCO1B1 ( SLCO1B1 A388G and SLCO1B1 T521C), ABCB1 ( ABCB1 C1236T and ABCB1 C3435T) and ABCG2 ( ABCG2 C421A). Results: Patients carrying SLCO1B1 T521C or ABCB1 C1236T single nucleotide polymorphisms (SNPs) had an odds ratio (OR) for statin-induced elevated serum CK levels of 8.86 ( p < 0.01) and 4.67 ( p < 0.05), respectively, while patients carrying the SLCO1B1 A388G SNP had an OR of 0.24 ( p < 0.05). An arbitrary score based on genotype combination discriminated patients with and without CK elevation at a specificity of 97 % and a sensitivity of 39 %. Conclusion: Genotyping of the SLCO1B1, ABCB1 and ABCG2 genes deserves consideration as a clinical approach to improve statin safety while concomitantly reducing the burden of blood tests for CK measurements. [ABSTRACT FROM AUTHOR]