1. Hypertension in a neonate with 11 β-hydroxylase deficiency.
- Author
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Mimouni, M., Kaufman, H., Roitman, A., Morag, Ch., and Sadan, N.
- Abstract
A female newborn infant with ambiguous genitalia was found to have hypertension (121/82 mm Hg) immediately after birth. The plasma testosterone (T) (0.73 nmol/l), Δ4-androstenedione (Δ4-A) (5.9 nmol/l), dehydroepiandrosterone (DHEA) (8.9 nmol/l), as well as 17 OH-hydroxyprogesterone (17 OHP) (152 nmol/l) were elevated. The diagnosis of 11β-hydroxylase deficiency was finally established on the basis of elevated plasma eleven-deoxycortisol (compound S) (>0.6 μmol/l) and confirmed by the normalisation of the blood pressure during hydrocortisone therapy. Our case is probably the youngest patient with 11β-hydroxylase deficiency in whom the hypertension was found at birth. [ABSTRACT FROM AUTHOR]
- Published
- 1985
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