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CO2 emissions reduction is a top element of transport policy agenda. Among other mitigation policy measures, eco-driving techniques have proven to be effective in reducing fuel consumption and CO2 emissions. The aim of this paper is to compare the impacts of adopting eco-driving in different cities, road segments, traffic, and driver features. It intends to gain an insight into how city size and driving characteristics can reduce fuel consumption and CO2 emissions in order to develop specific eco-driving strategies. Field trials were conducted in two Spanish cities (Madrid and Caceres). 24 drivers, with different driving experiences, drove two different vehicles (petrol and diesel) along roads with different characteristics. The experiment was divided into two periods of 2 weeks; after the first one, drivers received an eco-driving training course. The impacts of eco-driving were measured comparing before and after results. They showed that eco-driving is highly effective in reducing fuel consumption and CO2 emissions in both, large-congested and small, cities. Savings between 5% and 12% were achieved. The efficiency increases with road capacity and decreased with city size. Eco-driving appears to be more effective in small, uncongested cities. In addition, limiting speeds on high capacity roads has proven to be a good energy saving measure. [ABSTRACT FROM AUTHOR]

Study Question: Are the levels of total circulating cell-derived microparticles (cMPs) and circulating tissue factor-containing microparticles (cMP-TF) increased in patients with endometriosis?Summary Answer: The levels of total cMP, but not cMP-TF, were higher in patients with endometriosis, and these were attributed to higher levels in patients with deep infiltrating endometriosis (DIE).What Is Known Already: Previous studies have reported elevated levels of total cMP in inflammatory conditions as well as higher levels of other inflammatory biomarkers in endometriosis. Increased expression of tissue factor (a transmembrane receptor for Factor VII/VIIa) in eutopic and ectopic endometrium from patients with endometriosis has been described. There is no previous data regarding total cMP and cMP-TF levels in patients with endometriosis.Study Design, Size, Duration: A prospective case-control study including two groups of patients was carried out. The E group included 65 patients with surgically confirmed endometriosis (37 with DIE lesions) and the C group comprises 33 women without surgical findings of any form of endometriosis. Patients and controls were recruited during the same 10-month period. Controls were the next patient without endometriosis undergoing surgery, after including two patients with endometriosis.Participants/materials, Setting, Methods: Venous blood samples for total cMP and cMP-TF determinations were obtained at the time of surgery, before anesthesia at a tertiary care center. To assess total cMP, an ELISA functional assay was used and cMP-TF activity in plasma was measured using an ELISA kit.Main Results and the Role Of Chance: Total cMP levels in plasma were higher in the E group compared with the C group (P < 0.0001). The subanalysis of endometriosis patients with DIE or with ovarian endometriomas without DIE showed that total cMP levels were higher in the DIE group (P = 0.001). There were no statistically significant differences in cMP-TF levels among the groups analyzed.Limitations, Reasons For Caution: This is a preliminary study in which the sample size was arbitrarily decided, albeit in keeping with previous studies analyzing cMP in other inflammatory diseases and other biomarkers in endometriosis. The control group included patients with other pathologies as well as healthy controls, and blood samples were taken at different phases of the cycle.Wider Implications Of the Findings: Elevated total cMP levels in DIE patients may reflect an inflammatory and/or procoagulant systemic status in these patients. Further studies are warranted to confirm our findings and to assess the role of cMP levels in the pathophysiology of DIE.Study Funding/competing Interests: This study was supported in part by a grant from FIS-PI11/01560 and FIS-PI11/00977 within the 'Plan Nacional de I + D + I' and co-funded by the 'ISCIII-Subdirección General de Evaluación' and 'Fondo Europeo de Desarrollo Regional (FEDER)' and by the grant 'Premi Fi de Residència Emili Letang 2015' from the Hospital Clínic of Barcelona. The authors have no competing interests to disclose. [ABSTRACT FROM AUTHOR]

STUDY QUESTIONS: Are the levels of biologically active and the most toxic dioxin-like substances in adipose tissue of patients with deep infiltrating endometriosis (DIE) higher than in a control group without endometriosis? SUMMARY ANSWER: DIE patients have higher levels of dioxins and polychlorinated biphenyls (PCBs) in adipose tissue compared with controls without endometriosis. WHAT IS KNOWN ALREADY: Some studies have investigated the levels of dioxin-like substances, in serum samples, in patients with endometriosis, with inconsistent results. STUDY DESIGN, SIZE, DURATION: Case-control study including two groups of patients. The study group (DIE group) consisted of 30 patients undergoing laparoscopic surgery because of DIE. In all patients, an extensive preoperative work-up was performed including clinical exploration, magnetic resonance imaging (MRI) and transvaginal sonography. All patients with DIE underwent a confirmatory histological study for DIE after surgery. The non-endometriosis control group (control group), included the next consecutive patient undergoing laparoscopic surgery in our center due to adnexal benign gynecological disease (ovarian ortubal procedures other than endometriosis) after each DIE patient, and who did not present any type of endometriosis. PARTICIPANTS/MATERIALS, SETTING, METHODS: During the surgical procedure 1 -2 g of adipose tissue from the omentum were obtained. Dioxin-like substances were analyzed in adipose tissue in DIE patients and controls without endometriosis. MAIN RESULTS AND THE ROLE OF CHANCE: The total toxic equivalence and concentrations of both dioxins and PCBs were significantly higher in patients with DIE in comparison with the control group (P, 0.05), mainly due to the significantly higher values of the two most toxic dioxins (2,3,7,8-tetrachlorodibenzo-p-dioxin [2,3,7,8-TCDD] and 1,2,3,7,8-pentachlorodibenzo-p-dioxin [1,2,3,7,8-PeCDD]) (P, 0.01 for each compound). The levels of furan 2,3,4,7,8-PeCDF were statistically higher in the DIE group compared with controls. Only four congeners of PCBs had toxic equivalence values and concentrations that were statistically higher in patients with DIE, but these included the most toxic and carcinogenic PCB-126 (PCB-1 14 P, 0.05; PCB-156 P, 0.05; PCB-189 P = 0.04; PCB-126 P, 0.01). LIMITATIONS, REASONS FOR CAUTION: Since few patients were recruited, the study is only exploratory. Our results need to be confirmed in larger and more heterogeneous population studies since environmental and even genetic factors involved in determining dioxins and PCBs widely vary in different countries. Furthermore, the strict eligibility criteria used may preclude generalization of the results to other populations and the surgery-based sampling frame may induce a selection bias. Finally, adipose tissue was obtained only from the omentum, and not from other adipose tissue of the body. WIDER IMPLICATIONS OF THE FINDINGS: Our results suggest a potential role of dioxin-like substances in the pathogenesis of DIE. Further studies are warranted to confirm our findings. [ABSTRACT FROM AUTHOR]

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Many in vitro studies have used cell cultures to focus on the relationships between cyclo-oxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) isoforms. We have investigated the time-course of regulation and the role of COX-2 and iNOS in a model of experimental inflammation in mice, the air pouch injected with zymosan. This study demonstrates that there is an early acute phase (4 h) mediated mainly by eicosanoids, with high levels of prostaglandin E2 (PGE2) produced by cyclo-oxygenase-1. In addition, in the later phase (from 12 h) there is a participation of nitric oxide (NO) and PGE2 accompanied by co-induction of both iNOS and COX-2. These enzymes were detected in migrating leukocytes as well as in macrophages lining the air pouch. Administration of NS398 or indomethacin inhibited PGE2 levels and COX activity, but also nitrite levels and iNOS activity, which was accompanied by a reduction in iNOS expression. Aminoguanidine inhibited nitrite levels and iNOS activity in addition to exerting inhibitory effects on the COX pathway. Treatment of animals with dexamethasone reduced nitrite and PGE2 concentrations in air pouch exudates, as well as iNOS and COX-2 expression in migrating cells. Our results indicate that PGE2 and NO may play in vivo mutual modulatory roles in the inflammatory response caused by zymosan injection into the mouse air pouch, a suitable model to study drugs acting on those pathways. [ABSTRACT FROM AUTHOR]

This paper considers the equalisation problem in Quadrature Phase-Shift Keying (QPSK) modulated signals which have been distorted by the passage through a transmission channel. The channel is modelled as a Rician fading channel to simulate the behaviour of the transmission channel in the mobile satellite context. The equalisation is treated as the generalisation of the channel behaviour, and some algorithms with the structure of an artificial neural network using the Multilayer Perceptron, Volterra Series and Radial Basis Function are described. Results for the BER performance of typical transversal equalisers, with Square-Root Kalman adaptation algorithm, and algorithms with artificial neural network structure are also reported and evaluated. Improved performance is exhibited by the artificial neural network approaches. [ABSTRACT FROM AUTHOR]

Primary cultures of adult rat liver parenchymal cells showed a progressive rise of gamma-glutamyl transpeptidase (GGT) activity (E.C. 2.3.2.2.) after the first 5 days of culture. The presence of dexamethasone and other synthetic glucocorticoids in the culture medium partially prevented this increase. [ABSTRACT FROM AUTHOR]

An abstract of the conference paper "Growth deficit in term small-for-gestational fetuses with normal umbilical artery Doppler is associated with adverse outcome," by J. Coloma and colleagues is presented.