1. Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age.
- Author
-
Li Wang, Zhe Su, Yu-Chuan Li, Bing-Yan Cao, Chang Su, and Chun-Xiu Gong
- Subjects
GLUCOSE metabolism ,LIPID metabolism ,PREPROCEDURAL fasting ,HDL cholesterol ,SMALL for gestational age ,DATA analysis ,T-test (Statistics) ,RESEARCH funding ,GLUCAGON-like peptide 1 ,NUTRITIONAL assessment ,INTERVIEWING ,ENZYME-linked immunosorbent assay ,KRUSKAL-Wallis Test ,PEPTIDE hormones ,HUMAN growth ,INSULIN ,LDL cholesterol ,MANN Whitney U Test ,CHI-squared test ,GLUCOSE metabolism disorders ,BLOOD sugar ,GASTROINTESTINAL hormones ,CHOLESTEROL ,ONE-way analysis of variance ,STATISTICS ,SOMATOMEDIN ,TRIGLYCERIDES ,DATA analysis software ,BIOMARKERS - Abstract
Objective: Children born small for gestational age (SGA) are at a greater risk of developing insulin resistance, type 2 diabetes, and cardiovascular disease in adulthood. Gastrointestinal peptides, some secreted by intestinal L cells, regulate glucose and lipid metabolism and act on the hypothalamus to regulate energy homeostasis. The aim of this study was to explore whether gastrointestinal peptides are involved in metabolic disorders in SGA, which remains unclear. Methods: The secretion of glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) were investigated in prepubertal children born SGA, the differences between catch-up growth and persistent short stature were compared, and correlation with glucose and lipid metabolism was analyzed. GLP-1, PYY, insulin-like growth factor 1, glucose, insulin, and lipid concentrations were analyzed in prepubertal children aged 4-10 years, stratified into three groups: short-SGA (SGA-s), catch-up growth SGA, and normal growth appropriate for gestational age (AGA). Results: Fasting GLP-1 and PYY concentrations were significantly lower in the SGA group than in the AGA group (p<0.05), and the GLP-1 level in infants born SGA with catch-up growth was lower than that in the SGA-s group (p<0.05). In the SGA population, GLP-1 showed a weak negative correlation with catch-up growth (r=-0.326) and positive correlation with fasting insulin (r=0.331). Conclusion: Lower GLP-1 concentrations may be associated with abnormal glucose metabolism in prepubertal children born SGA with catch-up growth. This is indirect evidence that impaired intestinal L cell function may be involved in the development of metabolic complications in SGA children. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF