1. Intratumoral T-cell repertoires in DNA mismatch repair-proficient and -deficient colon tumors containing high or low numbers of tumor-infiltrating lymphocytes.
- Author
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Kim, Jin K., Chin-Tung Chen, Keshinro, Ajaratu, Khan, Asama, Firat, Canan, Vanderbilt, Chad, Segal, Neil, Stadler, Zsofia, Jinru Shia, Balachandran, Vinod P., and Weiser, Martin R.
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DNA mismatch repair ,COLON tumors ,TUMOR-infiltrating immune cells ,LYMPHOCYTE count ,T cells ,DNA - Abstract
Colon tumors with deficient DNA mismatch repair (dMMR) are generally infiltrated by T cells more densely than tumors with proficient mismatch repair (pMMR). However, high numbers of tumor-infiltrating lymphocytes (TILs) are found in select pMMR tumors, and low numbers of TILs are seen in select dMMR tumors. In this study, we compared T-cell repertoires in 20 pMMR and 27 dMMR colon tumors with high and low TIL counts. We found that T cells in dMMR tumors are more clonal and their repertoire is less rich compared with T cells in pMMR tumors. In the dMMR group, T cells in TIL-high tumors were more clonal and their repertoire was less rich compared with T cells in TIL-low tumors, but in the pMMR group, T-cell diversity in TIL-high tumors was comparable to T-cell diversity in TIL-low tumors. These findings suggest that T cells clonally expand in dMMR tumors, possibly in response to MMR deficiency-induced tumor neoantigens. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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