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Summary: This article proposes an enhanced adaptive disturbance rejection control strategy for sensorless control of permanent magnet synchronous motor. The traditional fixed bandwidth quadrature phase‐locked loop (Q‐PLL) is insufficient to meet system dynamics in the event of sudden speed changes or motor disturbances, resulting in a significant decrease in control performance. Meanwhile, conventional extended state observers usually rely on a fixed high gain for fast convergence, which raises concerns about their sensitivity to noise. To overcome these challenges, the proposed method introduces a third‐order adaptive cascaded linear extended state observer (ACLESO) in place of the conventional PLL to accurately estimate the speed, phase, and overall disturbances, ensuring timely and accurate estimation of the total disturbance. Then, a speed controller based on linear state error feedback control law (LSEFCL) was designed to enhance the dynamic performance of the system. Based on the stability analysis using the Lyapunov function, finally, extensive experimental tests were carried out to verify the validity of the proposed method. [ABSTRACT FROM AUTHOR]

To address the flow field noise problem in twin-screw air compressors, multi-physical-field coupling technology is employed to perform flow field noise calculations for the compressor. Based on the structural characteristics and noise generation principles of the twin-screw compressor, a noise reduction design method is proposed that employs a Helmholtz resonator and a three-chamber perforated muffler at the exhaust end. The muffler's structural optimization is performed using a genetic algorithm, and the effectiveness of the noise reduction method is validated through calculations. The results indicate that the Helmholtz resonator effectively mitigates airflow pulsation at the exhaust port, stabilizing the flow and reducing low-frequency noise at the exhaust end. Additionally, the designed three-chamber perforated muffler achieves noise reduction across a broad frequency range. With this noise reduction method, the exhaust port noise of the twin-screw compressor is reduced from 100–114 dB to 37–68 dB. These findings provide valuable insights for vibration and noise reduction in twin-screw air compressors. [ABSTRACT FROM AUTHOR]

In the early stages of residential project investment, accurately estimating the engineering costs of residential projects is crucial for cost control and management of the project. However, the current cost estimation of residential engineering in China is primarily carried out by cost personnel based on their own experience. This process is time-consuming and labour-intensive, and it involves subjective judgement, which can lead to significant estimation errors and fail to meet the rapidly developing market demands. Data collection for residential construction projects is challenging, with small sample sizes, numerous attributes, and complexity. This paper adopts a hybrid method combining a grey relational analysis, Lasso regression, and Backpropagation Neural Network (GAR-LASSO-BPNN). This method has significant advantages in handling high-dimensional small samples and multiple correlated variables. The grey relational analysis (GRA) is used to quantitatively identify cost-driving factors, and 14 highly correlated factors are selected as input variables. Then, regularization through Lasso regression (LASSO) is used to filter the final input variables, which are subsequently input into the Backpropagation Neural Network (BPNN) to establish the relationship between the unit cost of residential projects and 12 input variables. Compared to using LASSO and BPNN methods individually, the GAR-LASSO-BPNN hybrid prediction method performs better in terms of error evaluation metrics. The research findings can provide quantitative decision support for cost estimators in the early estimation stages of residential project investment decision-making. [ABSTRACT FROM AUTHOR]

Liver fibrosis can cause hepatitis B virus (HBV)‐associated hepatocellular carcinoma. Menstrual blood‐derived mesenchymal stem cells (MenSCs) can ameliorate liver fibrosis through paracrine. Single‐cell RNA sequencing (scRNA‐seq) may be used to explore the roadmap of activated hepatic stellate cell (aHSC) inactivation to target liver fibrosis. This study established HBV transgenic (HBV‐Tg) mouse model of carbon tetrachloride (CCl4)‐induced liver fibrosis and demonstrated that MenSCs migrated to the injured liver to improve serological indices and reduce fibrotic accumulation. RNA‐bulk analysis revealed that MenSCs mediated extracellular matrix accumulation and cell adhesion. Liver parenchymal cells and nonparenchymal cells were identified by scRNA‐seq in the control, CCl4, and MenSC groups, revealing the heterogeneity of fibroblasts/HSCs. A CellChat analysis revealed that diminished intercellular adhesion molecule (ICAM) signaling is vital for MenSC therapy. Specifically, Icam1 in aHSCs acted on Itgal/Itgb2 and Itgam/Itgb2 in neutrophils, causing decreased adhesion. The expression of Itgal, Itgam, and Itgb2 was higher in CCl4 group than in the control group and decreased after MenSC therapy in neutrophil clusters. The Lcn2, Pglyrp1, Wfdc21, and Mmp8 had high expression and may be potential targets in neutrophils. This study highlights interacting cells, corresponding molecules, and underlying targets for MenSCs in treating HBV‐associated liver fibrosis. [ABSTRACT FROM AUTHOR]

Mesenchymal stem cells (MSCs) transplantation is a promising strategy for osteoporosis treatment. However, limited sources and poor tissue-homing efficiency limit their clinical capabilities. In this study, we isolated a kind of MSCs from women's menstrual blood (MenSCs) noninvasively and established a novel MSCs bone marrow-targeted delivery system by utilizing water-in-oil-in-water droplet microfluidics. MenSCs were encapsulated within β-cyclodextrin-functionalized alginate microcapsules loaded with zoledronates, which has a high affinity for bone. With this delivery system, MenSCs could be preferentially delivered to the bone marrow tissues via intravenous infusion, and restored bone mass by remodeling the bone marrow niche in situ in ovariectomized mouse models. Moreover, scRNA-seq analysis demonstrated that those MenSCs homed to the bone marrow recruited CD4+FOXP3+ natural regulatory T (nTreg) cells by secreting CCL28. The recruited nTreg promoted CD8+ T cells to secret Wnt family member 10B (WNT10B), activating the Wnt signaling in osteoblasts and thus promoting bone formation in situ in the bone marrow. This study reveals a promising application of MenSCs in postmenopausal osteoporosis treatment and highlights the clinical value of MenSCs by encouraging women to reserve autologous MenSCs before menopause to prevent and alleviate postmenopausal osteoporosis. [ABSTRACT FROM AUTHOR]

Objectives: Cardiovascular magnetic resonance (CMR) imaging is routinely performed for assessing right ventricular (RV) systolic but not diastolic function. We aimed to investigate CMR-based assessment of RV diastolic function in pediatric patients with repaired tetralogy of Fallot (rTOF), compared to transthoracic echocardiography (TTE) measurements. Methods: A total of 130 consecutive pediatric patients with rTOF who underwent clinically indicated CMR and same-day TTE were included. Forty-three controls were recruited. Phase-contrast images were used to measure trans-tricuspid valve flow velocities during early (E) and late diastolic (A) phases (measured in cm/s). Feature tracking of the tricuspid annulus was performed to derive early (e′) and late diastolic (a′) myocardial velocities (measured in cm/s). RV diastolic function was evaluated by E/A ratio, E/e′ ratio, and E-wave deceleration time (measured in milliseconds). Regression analyses were utilized to identify potential variables associated with RV diastolic dysfunction (DD). The performance of CMR-derived parameters in diagnosing RV DD was assessed using receiver-operating characteristic analyses. Results: Good agreement was found between CMR and TTE measurements (ICC 0.70–0.89). Patients with RV DD (n = 67) showed significantly different CMR-derived parameters including E and e′ velocities, and E/A and E/e′ ratio, compared to patients without DD (n = 63) (all p < 0.05). CMR-derived E and e′ velocities and E/e′ ratio were independent predictors of RV DD. E/e′ of 5.8 demonstrated the highest discrimination of RV DD (AUC 0.76, sensitivity 70%, specificity 86%). Conclusions: CMR-derived parameters showed good agreement with TTE parameters in determining RV DD. CMR-derived E/e′ was proved to be the most effective in identifying RV DD. Clinical relevance statement: This study demonstrated the feasibility and efficacy of CMR in assessing diastolic function in pediatric patients. RV DD was presented in over half of patients according to current TTE guidelines, highlighting the need for assessing RV diastolic function during follow-up. Key Points: • Routinely acquired cine and phase-contrast cardiovascular magnetic resonance (CMR) images yielded right ventricular (RV) diastolic parameters which demonstrated good agreement with transthoracic echocardiography (TTE) measurements. • There was a high prevalence of RV diastolic function impairment in pediatric patients with repaired tetralogy of Fallot (rTOF). • CMR is a reliable complementary modality of TTE for RV diastolic function evaluation. [ABSTRACT FROM AUTHOR]

This study examined the associations of long-term exposure to ambient fine particulate matter (PM2.5) compositions/ozone with methylation of peripheral brain-derived neurotrophic factor (BDNF) promoters. A total of 101 participants were recruited from a cohort in Shijiazhuang, Hebei province, China. They underwent baseline and follow-up surveys in 2011 and 2015. DNA methylation levels were detected by bisulfite-PCR amplification and pyrosequencing. Participants' three-year average levels of PM2.5 compositions and ozone were estimated. Bayesian kernel machine regression (BKMR) models were used to examine the joint effects of pollutants on methylation levels. Exposure to PM2.5 compositions and ozone mixtures at the 75th percentile was associated with increased methylation levels at CpG2 of BDNF promoter (203%, 95% CI: 89, 316) than the lowest level of exposure, and sulfate dominated the effect in the BKMR models.Our findings provide clues to the epigenetic mechanisms for the associations of PM2.5 compositions and ozone with BDNF. [ABSTRACT FROM AUTHOR]

Novel cross-linked fluorinated acrylate latex was successfully synthesized via the semi-continuous seeded emulsion polymerization, in which methyl methacrylate (MMA) and butyl acrylate (BA) were used as the main monomers, and dodecafluoroheptyl methacrylate (DFMA) and N–N methylene bisacrylamide (MBA) were used as the fluorine monomer and the cross-linked monomer, respectively. Potassium persulfate (KPS) and mixed surfactants of sodium lauryl sulfate and alkyl alcohol polyether (EFS-470) were used as the initiator and emulsifier, respectively. The structure of resultant latex film was characterized by Fourier transform infrared spectroscopy (FTIR). The latex films were tested by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), contact angle (CA), cross-linked degree and X-ray diffractometer (XRD). The particle size and its distribution of the latex were measured by the nanoparticle size analyzer and transmission electron microscope (TEM). The factors that have an influence on the properties of the latex and the film are investigated in detail. The stability of the resultant latex was good. The average particles of the latex and its distribution were small and uniform, respectively. In comparison with the conventional latex film, the thermal stability and hydrophobicity of the novel latex film were improved obviously. [ABSTRACT FROM AUTHOR]

Virtual machine (VM) consolidation aims to run VMs on the least number of physical machines (PMs). The optimal consolidation significantly reduces energy consumption (EC), quality of service (QoS) in applications, and resource utilization. This paper proposes a prediction-based multi-objective VM consolidation approach to search for the best mapping between VMs and PMs with good timeliness and practical value. We use a hybrid model based on Auto-Regressive Integrated Moving Average (ARIMA) and Support Vector Regression (SVR) (HPAS) as a prediction model and consolidate VMs to PMs based on prediction results by HPAS, aiming at minimizing the total EC, performance degradation (PD), migration cost (MC) and resource wastage (RW) simultaneously. Experimental results using Microsoft Azure trace show the proposed approach has better prediction accuracy and overcomes the multi-objective consolidation approach without prediction (i.e. Non-dominated sorting genetic algorithm 2, Nsga2) and the renowned Overload Host Detection (OHD) approaches without prediction, such as Linear Regression (LR), Median Absolute Deviation (MAD) and Inter-Quartile Range (IQR). [ABSTRACT FROM AUTHOR]

Background and Aims Patients with acute myeloid leukaemia (AML) suffer from severe myocardial injury during daunorubicin (DNR)-based chemotherapy and are at high risk of cardiac mortality. The crosstalk between tumour cells and cardiomyocytes might play an important role in chemotherapy-related cardiotoxicity, but this has yet to be demonstrated. This study aimed to identify its underlying mechanism and explore potential therapeutic targets. Methods Cardiac tissues were harvested from an AML patient after DNR-based chemotherapy and were subjected to single-nucleus RNA sequencing. Cardiac metabolism and function were evaluated in AML mice after DNR treatment by using positron emission tomography, magnetic resonance imaging, and stable-isotope tracing metabolomics. Plasma cytokines were screened in AML mice after DNR treatment. Genetically modified mice and cell lines were used to validate the central role of the identified cytokine and explore its downstream effectors. Results In the AML patient, disruption of cardiac metabolic homeostasis was associated with heart dysfunction after DNR-based chemotherapy. In AML mice, cardiac fatty acid utilization was attenuated, resulting in cardiac dysfunction after DNR treatment, but these phenotypes were not observed in similarly treated tumour-free mice. Furthermore, tumour cell-derived interleukin (IL)-1α was identified as a primary factor leading to DNR-induced cardiac dysfunction and administration of an anti-IL-1α neutralizing antibody could improve cardiac functions in AML mice after DNR treatment. Conclusions This study revealed that crosstalk between tumour cells and cardiomyocytes during chemotherapy could disturb cardiac energy metabolism and impair heart function. IL-1α neutralizing antibody treatment is a promising strategy for alleviating chemotherapy-induced cardiotoxicity in AML patients. [ABSTRACT FROM AUTHOR]

Diabetes imposes a huge burden worldwide. Islet transplantation is an alternative therapy for diabetes. However, tacrolimus, a kind of immunosuppressant after organ transplantation, is closely related to post-transplant diabetes mellitus. Mesenchymal stem cells (MSCs) have attracted interest for their potential to alleviate diabetes. In vivo experiments revealed that human menstrual blood-derived stem cells (MenSCs) treatment improved tacrolimus-induced blood glucose, body weight, and glucose tolerance disorders in mice. RNA sequencing was used to analyze the potential therapeutic targets of MenSCs. In this study, we illustrated that cystathionine β-synthase (CBS) contributed to tacrolimus -induced islet dysfunction. Using β-cell lines (MIN6, β-TC-6), we demonstrated that MenSCs ameliorated tacrolimus-induced islet dysfunction in vitro. Moreover, MenSC reduced the tacrolimus-induced elevation of CBS levels and significantly enhanced the viability, anti-apoptotic ability, glucose-stimulated insulin secretion (GSIS), and glycolytic flux of β-cells. We further revealed that MenSCs exerted their therapeutic effects by inhibiting CBS expression to activate the IL6/JAK2/STAT3 pathway. In conclusion, we showed that MenSCs may be a potential strategy to improve tacrolimus-induced islet dysfunction. [ABSTRACT FROM AUTHOR]

The metal cross-linking fluorinated polyacrylate colloid has a high cross-linking density, high transparency, high heat resistance and hydrophobicity. In this paper, the metal cross-linking fluorinated polyacrylate colloid is synthesized via the semi-continuous seeded emulsion polymerization technology, which uses the self-made magnesium acrylate, calcium acrylate and zinc acrylate as metal crosslinker and dodecafluoroheptyl methacrylate as a fluorine monomer. In this study, the ablation effect of the metal ions is weakened by the increased amount of environmentally friendly and polymerizable anion emulsifier DNS-86. The demulsification phenomenon of emulsion is successfully overcome through destroying the double layer structure of micelles or colloid particles by polyvalent metal ions. The colloidal particle size is smaller and the particle size distribution of the colloid is more uniform. Colloidal film has a good hydrophobicity and the glass transition temperature and the thermal decomposition temperature are high. [ABSTRACT FROM AUTHOR]

We have achieved the first total synthesis of pallamolides A−E. Of these compounds, pallamolides B−E possess intriguing tetracyclic skeletons with novel intramolecular transesterifications. Key transformations include highly diastereoselective sequential Michael addition reactions to construct the bicyclo[2.2.2]octane core with the simultaneous generation of two quaternary carbon centers, a one‐pot SmI2‐mediated intramolecular ketyl–enoate cyclization/ketone reduction to generate the key oxabicyclo[3.3.1]nonane moiety, and an acid‐mediated deprotection/oxa‐Michael addition/β‐hydroxy elimination cascade sequence to assemble the tetracyclic pallamolide skeleton. Kinetic resolution of ketone 14 through Corey–Bakshi–Shibata reduction enabled the asymmetric synthesis of pallamolides A−E. [ABSTRACT FROM AUTHOR]

We have achieved the first total synthesis of pallamolides A−E. Of these compounds, pallamolides B−E possess intriguing tetracyclic skeletons with novel intramolecular transesterifications. Key transformations include highly diastereoselective sequential Michael addition reactions to construct the bicyclo[2.2.2]octane core with the simultaneous generation of two quaternary carbon centers, a one‐pot SmI2‐mediated intramolecular ketyl–enoate cyclization/ketone reduction to generate the key oxabicyclo[3.3.1]nonane moiety, and an acid‐mediated deprotection/oxa‐Michael addition/β‐hydroxy elimination cascade sequence to assemble the tetracyclic pallamolide skeleton. Kinetic resolution of ketone 14 through Corey–Bakshi–Shibata reduction enabled the asymmetric synthesis of pallamolides A−E. [ABSTRACT FROM AUTHOR]

All provinces of China respond to the central government, predict future carbon dioxide emissions, and formulate action plans detailing how the province intends to fulfill its target of carbon emission peaking before 2030. Based on the bottom‐up energy consumption prediction and top‐down goal verification, this paper constructs a set of regional carbon dioxide emission prediction methods. Compared to the traditional bottom‐up prediction method, this method could simplify the parameters while improving the prediction accuracy. This model is used to predict and analyze the process of carbon dioxide emission peaking in Zhejiang. The results show that the mean absolute percentage error of the retrospective prediction value is only 1.56%. Zhejiang will reach carbon dioxide emission peaking around 2029–2030, and the peak value will be 569.7 million tons. Different factors have different effects on the process of carbon dioxide emission peaking. There is a strong correlation between the peak time of carbon dioxide emission and the production time of major energy‐consuming projects in Zhejiang. Meanwhile, if the 16 nuclear reactors are not put into operation, Zhejiang will not be able to achieve the goal of carbon dioxide emission peaking. Besides, the basic data used in this model is mainly from the local statistical departments of the region. Thus, it can be applied to other provinces and regions conveniently. [ABSTRACT FROM AUTHOR]

Photocatalytic degradation combined with adsorption removal of contaminants is one of the most effective methods of removing TCH P-(CM-β-CD/HPCS/KHA)@AC/TiO2 composite material was prepared by etheration modification of β-Cyclodextrin (β-CD) and combination of activated carbon (AC) and TiO2, the adsorption/photocatalytic degradation behavior of tetracycline hydrochloride (TCH) was studied, the P-(CM-β-CD/HPCS/KHA)@AC/TiO2 composites were successfully prepared by FTIR, SEM, XRD and XPS Characterisation tests. At 298 K and pH 4, the removal rate of TCH can reach 98% in 2 h. The adsorption of the composites follows the quasi-second-order kinetic model, which is highly consistent with the Langmuir model, an endothermic and spontaneous adsorption process is formed through intermolecular forces and coordination. Photocatalytic degradation follows the quasi-first order model, the photocatalytic performance was verified in conjunction with TOC testing, and the process was known to be a detoxification process through toxicity testing. Finally, after 10 cycles of treatment, the composite material removed up to 70% of TCH. [ABSTRACT FROM AUTHOR]

In our recent study, we explored the efficacy of three-dimensional (3D) measurement of tumor volume in predicting the improvement of quality of life (QoL) in patients suffering from renal cell cancer (RCC), who were treated with axitinib and anti-PD-L1 antibodies. This study encompassed 18 RCC patients, including 10 men and 8 women, with an average age of 56.83 ± 9.94 years. By utilizing 3D Slicer software, we analyzed pre- and post-treatment CT scans to assess changes in tumor volume. Patients' QoL was evaluated through the FKSI–DRS questionnaire. Our findings revealed that 3D models for all patients were successfully created, and there was a moderate agreement between treatment response classifications based on RECIST 1.1 criteria and volumetric analysis (kappa = 0.556, p = 0.001). Notably, nine patients reported a clinically meaningful improvement in QoL following the treatment. Interestingly, the change in tumor volume as indicated by the 3D model showed a higher area under the curve in predicting QoL improvement compared to the change in diameter measured by CT, although this difference was not statistically significant (z = 0.593, p = 0.553). Furthermore, a multivariable analysis identified the change in tumor volume based on the 3D model as an independent predictor of QoL improvement (odds ratio = 1.073, 95% CI 1.002–1.149, p = 0.045).In conclusion, our study suggests that the change in tumor volume measured by a 3D model may be a more effective predictor of symptom improvement in RCC patients than traditional CT-based diameter measurements. This offers a novel approach for assessing treatment response and patient well-being, presenting a significant advancement in the field of RCC treatment. [ABSTRACT FROM AUTHOR]

Usually, the traditional acrylate polymer latex, which is used as the binder of the coatings, is a linear polymer and properties of the latex film cannot meet with the demand of the high-grade coatings. Presently, there are few reports on the polyacrylate latex modified by diallyl malate, i.e. butanedioic acid,2-hydroxy-, 1,4-di-2-propen-1-yl ester (BAHD) and long fluorocarbon acrylate monomer such as dodecafluoroheptyl methacrylate (DFMA) in the open literatures. The purpose of this work is that the cross-linked acrylate latex is prepared which DFMA and BAHD are used as the functional monomer and as a cross-linking monomer, respectively. The cross-linked acrylate latex is prepared which methyl methacrylate (MMA) and butyl acrylate (BA) is used as the main monomers and the non-ionic emulsifier isomeric alcohol polyoxyethylene ether (X-407) and the anionic emulsifier sodium dodecyl sulfonate (SDS) are used as emulsifiers. DFMA and BAHD are used as the functional monomer and as a cross-linking monomer, respectively. Factors which have an influence on the properties of the resultant latex and the emulsion polymerization are investigated in detail. The optimal recipe of preparing the latex is obtained as follows: the amount of mixed emulsifiers is 6% and mass ratio of X-470 to SDS is 2:1. When the amount of BAHD is 4.47%, the water absorption rate is reduced greatly. The glass transition temperature is 10 °C. In compassion with the conventional latex, the thermal decomposition temperature is increased by 10 °C. The resultant latex has good stability and small particle size. The latex film exhibits hydrophobicity and the water contact angle is more than 90°. [ABSTRACT FROM AUTHOR]

Background and aims: Problematic pornography use (PPU) is a common manifestation of the newly introduced Compulsive Sexual Behavior Disorder diagnosis in the 11th edition of the International Statistical Classification of Diseases and Related Health Problems. Although cultural, gender‐ and sexual orientation‐related differences in sexual behaviors are well documented, there is a relative absence of data on PPU outside Western countries and among women as well as gender‐ and sexually‐diverse individuals. We addressed these gaps by (a) validating the long and short versions of the Problematic Pornography Consumption Scale (PPCS and PPCS‐6, respectively) and the Brief Pornography Screen (BPS) and (b) measuring PPU risk across diverse populations. Methods: Using data from the pre‐registered International Sex Survey [n = 82 243; mean age (Mage) = 32.4 years, standard deviation = 12.5], a study across 42 countries from five continents, we evaluated the psychometric properties (i.e. factor structure, measurement invariance, and reliability) of the PPCS, PPCS‐6, and BPS and examined their associations with relevant correlates (e.g. treatment‐seeking). We also compared PPU risk among diverse groups (e.g. three genders). Results: The PPCS, PPCS‐6, and BPS demonstrated excellent psychometric properties [for example, comparative fit index = 0.985, Tucker–Lewis Index = 0.981, root mean square error of approximation = 0.060 (90% confidence interval = 0.059–0.060)] in the confirmatory factor analysis, with all PPCS' inter‐factor correlations positive and strong (rs = 0.72–0.96). A total of 3.2% of participants were at risk of experiencing PPU (PPU+) based on the PPCS, with significant country‐ and gender‐based differences (e.g. men reported the highest levels of PPU). No sexual orientation‐based differences were observed. Only 4–10% of individuals in the PPU+ group had ever sought treatment for PPU, while an additional 21–37% wanted to, but did not do so for specific reasons (e.g. unaffordability). Conclusions: This study validated three measures to assess the severity of problematic pornography use across languages, countries, genders, and sexual orientations in 26 languages: the Problematic Pornography Consumption Scale (PPCS, and PPCS‐6, respectively), and the Brief Pornography Screen (BPS). The problematic pornography use risk is estimated to be 3.2–16.6% of the population of 42 countries, and varies among different groups (e.g. genders) and based on the measure used. [ABSTRACT FROM AUTHOR]

Left ventricular hypertrophy (LVH) is a common clinical manifestation associated with cardiovascular adverse events. Relying solely on the subjective judgment, it is challenging to promptly and accurately diagnose mild LVH. Quantitatively measuring the interventricular septum and left ventricular posterior wall to diagnose mild LVH is a time‐consuming and labor‐intensive process that is prone to errors. To propose a novel method for rapid and automatic end‐to‐end diagnosis of mild LVH. We propose a novel end‐to‐end automated method for detecting mild LVH. This method achieves rapid end‐to‐end detection of mild LVH in echocardiographic videos without the need for quantitative measurements. Initially, representative frames are extracted from echocardiographic videos, and these frames are then automatically diagnosed by the proposed network to detect LVH. The network architecture primarily consists of three key components: a feature extractor, bidirectional LSTM, and attention module. The Vit‐b model achieved 88% video classification accuracy in the experiment where 32 frames are extracted, and the ViT‐l model achieves 92% video classification accuracy in the experiment where 16 frames are extracted. It is shown experimentally that extracting fewer video frames can diagnose LVH more accurately. The experiments illustrate the superior performance and competitiveness of this method compared to other approaches, potentially applicable to the clinic. [ABSTRACT FROM AUTHOR]

Background: Mucosal-associated invariant T (MAIT) cells have been reported to regulate tumor immunity. However, the immune characteristics of MAIT cells in non-small cell lung cancer (NSCLC) and their correlation with the treatment efficacy of immune checkpoint inhibitors (ICIs) remain unclear. Patients and methods: In this study, we performed single-cell RNA sequencing (scRNA-seq), flow cytometry, and multiplex immunofluorescence assays to determine the proportion and characteristics of CD8+MAIT cells in patients with metastatic NSCLC who did and did not respond to anti-PD-1 therapy. Survival analyses were employed to determine the effects of MAIT proportion and C-X-C chemokine receptor 6 (CXCR6) expression on the prognosis of patients with advanced NSCLC. Results: The proportion of activated and proliferating CD8+MAIT cells were significantly higher in responders-derived peripheral blood mononuclear cells (PBMCs) and lung tissues before anti-PD-1 therapy, with enhanced expression of cytotoxicity-related genes including CCL4, KLRG1, PRF1, NCR3, NKG7, GZMB, and KLRK1. The responders' peripheral and tumor-infiltrating CD8+MAIT cells showed an upregulated CXCR6 expression. Similarly, CXCR6+CD8+MAIT cells from responders showed higher expression of cytotoxicity-related genes, such as CST7, GNLY, KLRG1, NKG7, and PRF1. Patients with ≥15.1% CD8+MAIT cells to CD8+T cells ratio and ≥35.9% CXCR6+CD8+MAIT cells to CD8+MAIT cells ratio in peripheral blood showed better progression-free survival (PFS) after immunotherapy. The role of CD8+MAIT cells in lung cancer immunotherapy was potentially mediated by classical/non-classical monocytes through the CXCL16-CXCR6 axis. Conclusion: CD8+MAIT cells are a potential predictive biomarker for patients with NSCLC responding to anti-PD-1 therapy. The correlation between CD8+MAIT cells and immunotherapy sensitivity may be ascribed to high CXCR6 expression. [ABSTRACT FROM AUTHOR]

Background: Zygotic genome activation (ZGA) is an important event in the early embryo development, and human embryo developmental arrest has been highly correlated with ZGA failure in clinical studies. Although a few studies have linked maternal factors to mammalian ZGA, more studies are needed to fully elucidate the maternal factors that are involved in ZGA. Methods and results: In this study, we utilized published single-cell RNA sequencing data from a Dux-mediated mouse embryonic stem cell to induce a 2-cell-like transition state and selected potential drivers for the transition according to an RNA velocity analysis. Conclusions: An overlap of potential candidate markers of 2-cell-like-cells identified in this research with markers generated by various data sets suggests that Trim75 is a potential driver of minor ZGA and may recruit EP300 and establish H3K27ac in the gene body of minor ZGA genes, thereby contributing to mammalian preimplantation embryo development. [ABSTRACT FROM AUTHOR]

Background: Neoadjuvant therapy followed by surgery has become the standard of care for locally advanced esophageal squamous cell carcinoma (ESCC) and accurate pathological response assessment is critical to assess the therapeutic efficacy. However, it can be laborious and inconsistency between different observers may occur. Hence, we aim to develop an interpretable deep-learning model for efficient pathological response assessment following neoadjuvant therapy in ESCC. Methods: This retrospective study analyzed 337 ESCC resection specimens from 2020–2021 at the Pudong-Branch (Cohort 1) and 114 from 2021–2022 at the Puxi-Branch (External Cohort 2) of Fudan University Shanghai Cancer Center. Whole slide images (WSIs) from these two cohorts were generated using different scanning machines to test the ability of the model in handling color variations. Four pathologists independently assessed the pathological response. The senior pathologists annotated tumor beds and residual tumor percentages on WSIs to determine consensus labels. Furthermore, 1850 image patches were randomly extracted from Cohort 1 WSIs and binarily classified for tumor viability. A deep-learning model employing knowledge distillation was developed to automatically classify positive patches for each WSI and estimate the viable residual tumor percentages. Spatial heatmaps were output for model explanations and visualizations. Results: The approach achieved high concordance with pathologist consensus, with an R^2 of 0.8437, a RAcc_0.1 of 0.7586, a RAcc_0.3 of 0.9885, which were comparable to two senior pathologists (R^2 of 0.9202/0.9619, RAcc_0.1 of 8506/0.9425, RAcc_0.3 of 1.000/1.000) and surpassing two junior pathologists (R^2 of 0.5592/0.5474, RAcc_0.1 of 0.5287/0.5287, RAcc_0.3 of 0.9080/0.9310). Visualizations enabled the localization of residual viable tumor to augment microscopic assessment. Conclusion: This work illustrates deep learning's potential for assisting pathological response assessment. Spatial heatmaps and patch examples provide intuitive explanations of model predictions, engendering clinical trust and adoption (Code and data will be available at https://github.com/WinnieLaugh/ESCC%5fPercentage once the paper has been conditionally accepted). Integrating interpretable computational pathology could help enhance the efficiency and consistency of tumor response assessment and empower precise oncology treatment decisions. [ABSTRACT FROM AUTHOR]

TiAl alloy is a new kind of lightweight high temperature resistant structural material. Its density is only about half of that of nickel-based superalloy. It is an excellent substitute material for nickel-based superalloy. TiAl alloy is a brittle material that needs to be processed in the plastic domain on the nanoscale. Due to the influence of humidity, a thin water film will inevitably condenses on the processed surface. Therefore, it is necessary to consider the role of humidity in nanofabrication. The results show that when the water layer thickness is 0, 4 Å and 8 Å, the maximum tangential grinding force is 165 nN, 266 nN and 386 nN, and the maximum normal grinding force is 517 nN, 521 nN and 528 nN, respectively. Compared with the normal grinding force, the stress value of tangential grinding force changes more obviously. The variation of the peak value of radial distribution function (RDF) around Al atoms before and after grinding is smaller than that of Ti. From the second peak to the sixth peak, with the increasing of the water layer thickness, the peak of the wave crest gradually decreases. When the grinding wheel is rotating forward, the maximum tangential grinding force is 266 nN and the maximum normal grinding force is 521 nN, when the wheel is rotating backward, the maximum tangential grinding force is 497 nN and the maximum normal grinding force is 451 nN. [ABSTRACT FROM AUTHOR]

After the excavation and unloading of deep-buried soft rock tunnels, support structures often experience deformation-related disasters such as concrete cracking, steel frame bending and twisting, and primary support instability under different forms of load. Accurately calculating the load borne by the primary support structure is the key to ensuring design rationality and construction safety. Especially in layered soft surrounding rock formations, the magnitude and distribution of the loads are different from those of conventional rock and soil masses, resulting in limited applicability of existing load calculation methods to similar formations. Therefore, based on the measured deformation of the tunnel structure, while considering the different geometric forms of the primary support structure during partial excavation, this paper proposes a deformation-structure (D-S) load calculation method. By comparing the calculation results of this method and a large number of sample data for typical deep-buried layered soft rock tunnels, the reliability of the D-S load calculation method is verified. In addition, the variation law of the loads during the tunnel construction period is enunciated, and the magnitude and distribution of the loads acting on the primary support are clarified. The D-S load calculation method provides a theoretical basis for load calculation in deep-buried layered soft rock tunnels. [ABSTRACT FROM AUTHOR]

Two natural adsorbent materials, potassium humate (KHA) and montmorillonite (MMT), were successfully prepared by embedding them in sodium alginate (SA) gel spheres through physical cross-linking with CaCl2. And CaCO3 was used as a porogenic agent to prepare the porous composites, KHA/SA/MMT. The materials were characterized by using XRD, TGA, SEM, and N2 adsorption/desorption equipment. The results showed that MMT and KHA were successfully embedded in the SA gel; the introduction of MMT increased the thermal stability of the composites and the embedding of MMT, and the porogenic effect of CaCO3 increased the specific surface area of the composites substantially, which provided favorable conditions for adsorption and treatment of pollutants. In addition, a one-way exploratory experiment yielded a higher removal rate of Rhodamine B (RhB) at D = 0.6 g/L, pH = 5, C0 = 100 mg/L, and t = 360 min. The adsorption kinetics and adsorption isotherm conformed to the secondary kinetic model and Langmuir model, respectively, and the maximum adsorption of RhB by KHA/SA/MMT could reach up to 884.96 mg/g at 303 K. The adsorption mechanism for RhB was shown by FT-IR and XPS analyses to be possibly bound by non-covalent bonding forces. After seven consecutive adsorption–desorption cycles, the adsorption of RhB by KHA/SA/MMT still reached 80.75%. Therefore, the prepared gel spheres have the advantages of easy regeneration and efficient reuse and great potential for application in purifying RhB from wastewater. [ABSTRACT FROM AUTHOR]

This study investigated the comprehension and production of long passives (i.e. bei-constructions with an overt agent) in Mandarin-speaking children with developmental language disorder (DLD). Seventeen preschool children with DLD (1 female; mean age: 61 months old) and 23 typically developing (TD) children (6 females; mean age: 62 months old) participated in a sentence-picture matching task (for comprehension) and an elicited production task. Their nonverbal working memory (NVWM) was measured with the fourth edition of the Wechsler Preschool and Primary Scale of Intelligence. Results showed that children with DLD were less accurate and more likely to choose the picture with reversed thematic roles than their TD peers on passives in the sentence-picture matching task; in the elicited production task, they produced fewer target responses than TD children in passives. For NVWM, although that of the DLD group was lower than that of TD children, most children in the DLD group were within the average range. Furthermore, their performance on passives in the comprehension and production tasks was significantly correlated with their NVWM, which adds to the body of work suggesting links between complex syntax and working memory. However, the fact that NVWM could be preserved in the face of difficulties with passives suggests that this link may be due to NVWM enhancing performance during tasks with a high visual component, while it may not be underlyingly responsible for syntactic impairments in children with DLD. [ABSTRACT FROM AUTHOR]

Benzimidazole fungicides are a class of highly effective, low-toxicity, systemic broad-spectrum fungicides developed in the 1960s and 1970s, based on the fungicidal activity of the benzimidazole ring structure. They exhibit biological activities including anticancer, antibacterial, and antiparasitic effects. Due to their particularly outstanding antibacterial properties, they are widely used in agriculture to prevent and control various plant diseases caused by fungi. The main products of benzimidazole fungicides include benomyl, carbendazim, thiabendazole, albendazole, thiophanate, thiophanate-methyl, fuberidazole, methyl (1-{[(5-cyanopentyl)amino]carbonyl}-1H-benzimidazol-2-yl) carbamate, and carbendazim salicylate. This article mainly reviews the physicochemical properties, toxicological properties, disease control efficacy, and pesticide residue and detection technologies of the aforementioned nine benzimidazole fungicides and their main metabolite (2-aminobenzimidazole). On this basis, a brief outlook on the future research directions of benzimidazole fungicides is presented. [ABSTRACT FROM AUTHOR]

In this paper, PVA/BDA/ADH gels with good mechanical properties and self-healing properties were prepared using polyvinyl alcohol (PVA), 4,4-biphenyldicarboxaldehyde (BDA), and adipic dihydrazide (ADH) as raw materials. The hydrogel network achieves chemical-physical double cross-linking through acylhydrazone bonds and hydrogen bonds. The as-prepared PVA/BDA/ADH gels have good mechanical properties (the tensile stress of PVA/BDA/ADH gels is about 2 times that of pure PVA hydrogel) due to chemical and physical double cross-linking. It also has good self-healing properties under external conditions. Compared with pure PVA hydrogel, PVA/BDA/ADH gels have more stable self-healing properties. [ABSTRACT FROM AUTHOR]

Purpose: Self-crosslinked long fluorocarbon acrylate polymer latex has good hydrophobic and oleophobicity, weather resistance, aging resistance, stability and other excellent properties, which make the polymer be widely used in coatings, dyes, adhesives and other products. The purpose of this study is to prepare self-crosslinked long fluorocarbon acrylate polymer latex via semi-continuous seeded emulsion technology and carry out comparative study on two different cross-linked monomers. Design/methodology/approach: Methyl methacrylate (MMA) and butyl acrylate (BA) were used as the main monomers, dodecafluoroheptyl methacrylate (DFMA) as the fluoromonomer, hydroxypropyl methacrylate (HPMA) and N-methylol acrylamide (NMA) as cross-linked monomers, and 1-allyloxy-3–(4-nonylphenol)-2-propanol polyoxyethylene (10) ether (ANPEO10) and 1-allyloxy-3–(4-nonylphenol)-2-propanol polyoxyethylene (10) ether ammonium sulfate (DNS-86) as compound emulsifiers via the semicontinuous-seeded emulsion polymerization. Findings: The properties of the polymer emulsions, which are prepared with two different cross-linked monomers, are compared and discussed, and it is concluded that HPMA is more suitable for the preparation of self-crosslinked polymer emulsions. The formula of the polymer latex is ANPEO10: DNS-86 = 1:1, and the mass ratio of the monomers used in the polymer is MMA: BA: DFMA: HPMA = 14.40:14.40:0.60:0.60. Practical implications: Self-crosslinked long fluorocarbon acrylate polymer latex can be used in many fields such as coatings, dyes, adhesives and other products. Originality/value: The self-crosslinked long fluorocarbon acrylate polymer latex is prepared by mixing the nonionic emulsifier ANPEO10 and the anionic emulsifier DNS-86 when potassium persulfate is used as the thermal decomposition initiator and the semicontinuous-seeded emulsion technology is adopted and the comparative study on two different cross-linked monomer is carried out, which is not reported in the open literatures. [ABSTRACT FROM AUTHOR]

High-precision and real-time global geographic information data are fundamental and strategic resources in various fields such as safeguarding global strategic interests, studying global environmental changes, and planning for sustainable development. However, due to challenges related to ground control and obtaining reference information, the development of global geographic information resources faces significant hurdles in terms of geometric positioning, information extraction, and data mining. This paper starts with the characteristics of domestically produced remote sensing images and proposes a comprehensive technical framework centered around "uncontrolled geometric positioning, intelligent interpretation of typical elements, mining of multi-source data from abroad, and intelligent hybrid collection and compilation of Digital Elevation Models (DEMs)." The paper elaborates on the key technical challenges that need to be overcome and their corresponding solutions. It also outlines the development of relevant data products and production technical specifications. Multiple production-oriented software tools were developed, leading to the creation of a variety of data products in multiple types and scales, including global 30-meter land cover data, DEM data, core vector data, and more. [ABSTRACT FROM AUTHOR]

In China, grid workers have increasingly become an indispensable and important force in basic social governance. They not only undertake several tasks, such as gaining publicity, collecting information, resolving conflicts, and assisting in management, but they also actively serve the grid residents enthusiastically and engage in proactive service behaviors. In order to better cultivate this important force, we hope to have a better understanding of the factors contributing to the behavioral performance of grid workers, especially the impact of organizational and personal factors. In this study, we sought to establish what factors influence the proactive service behaviors of grid workers. Based on a theoretical consideration of factors such as public service motivation, occupational identity, and organizational climate, a multi-factor influence hypothesis model was constructed to explain the proactive service behaviors of these workers. By analyzing data based on 348 paired survey samples received in two stages in eastern China, these hypotheses were then tested. The results reflect that grid workers' public service motivation can stimulate proactive service behaviors. Furthermore, occupational identity plays a mediating role, while organizational support and organizational service climate play a positive moderating role between public service motivation and occupational identity. This finding clarifies the important influencing factors of proactive service behaviors among grassroots workers, such as grid workers, and has important implications for how to effectively motivate these groups to provide more proactive services, promoting their sustainable development and improve the effectiveness of grassroots governance. [ABSTRACT FROM AUTHOR]

β-lactoglobulin (β-LG) is an important natural active nutrient and one of the main allergens in bovine milk. β-lactoglobulin is about 50% of the total whey protein, is the major whey protein in bovine milk, has strong heat sensitivity and allergenicity, and plays a key role in the high-quality dairy industry, not only as an evaluation index of heat treatment intensity of milk, but also as the marker protein of milk allergens in food. Therefore, it is very important to effectively identify and detect bovine β-lactoglobulin. Thirteen variants of bovine β-lactoglobulin have been reported, of which A and B are the common variants whose content are the highest. According to different detection principles, the article briefly describes three kinds of detection methods of milk β-lactoglobulin variants in recent years, and summarizes the principles, advantages, disadvantages and some application examples of electrophoresis, chromatography and immunoassay. The two quantitative methods of liquid chromatography and capillary electrophoresis were introduced emphatically, and the future development direction of bovine β-lactoglobulin was prospected. [ABSTRACT FROM AUTHOR]

Human immunodeficiency virus (HIV) is a virus that causes defects in the human immune system. HIV can abnormally activate immune cells, greatly reduce CD4 +T lymphocytes in the intestine, weaken the defense against pathogenic bacteria, make intestinal immune dysfunction, imbalance of intestinal flora, and cause other system abnormalities. In clinical practice, anti retroviral therapy (ART) is accompanied by diarrhea, nausea, allergy and other adverse reactions. In recent years, studies have found that the combination of probiotics and ART treatment can regulate intestinal flora, inhibit bacterial translocation, and reduce the inflammatory coefficient of HIV infected people. This article mainly summarizes the efficacy and mechanism of adjuvant treatment of HIV patients by supplementing a variety of probiotics after the intestinal microecological changes caused by HIV. It shows that dietary adjuvant treatment of HIV infection with probiotics has a positive effect and is an economic and feasible treatment method. [ABSTRACT FROM AUTHOR]

Drilling and blasting method used for excavation causes damage to surrounding rock mass, and frequent blasting often leads to cumulative damage effects. Thus, understanding the distribution of Blast-Induced Damage (BID) zone is critical to assess the slope stability of open-pit mines. Herein, this study aims to investigate the cumulative damage effects and safety control criteria on the final wall of the open-pit slope under blasting. The cumulative damage zone was defined using a continuous damage model coupled with tensile damage and Drucker–Prager yield criteria embedded in the finite difference method. The simulation results were validated against field data collected from the Wushan open-pit mine in Inner Mongolia, China. The results demonstrate that the cumulative damage of the final wall exhibited a non-linear decreasing trend from the bench face to the interior of the slope, successfully reproducing the spatial distribution of the BID obtained from the in situ test, and revealing that the maximum cumulative damage depth occurred at the slope crest. Additionally, a safety control criterion for the critical damage zone of open-pit final slope was proposed based on the investigation of the effects of dynamic loading rate and stemming length on excessive overbreak. The results highlight how important it is to account for cumulative damage effects when assessing the final slope stability of an open pit and optimizing the mining design. Highlights: The cumulative damage effects on the final wall of the open-pit under blasting are investigated. A model coupled with tensile damage and Drucker-Prager yield criteria is established and incorporated into finite difference method to simulate the blast-induced damage zone. The subsurface damage depth is obtained using the digital drilling images technology. The dynamic loading rate and stemming length could significantly affect the excessive overbreak along the crest. [ABSTRACT FROM AUTHOR]

Objective: We analyzed adult ADHD symptoms in a cross-cultural context, including investigating the occurrence and potential correlates of adult ADHD and psychometric examination of the Adult ADHD Self-Report Scale (ASRS) Screener. Method: Our analysis is based on a large-scale research project involving 42 countries (International Sex Survey, N =72,627, 57% women, Mage =32.84; SDage =12.57). Results: The ASRS Screener demonstrated good reliability and validity, along with partial invariance across different languages, countries, and genders. The occurrence of being at risk for adult ADHD was relatively high (21.4% for women, 18.1% for men). The highest scores were obtained in the US, Canada, and other English-speaking Western countries, with significantly lower scores among East Asian and non-English-speaking European countries. Moreover, ADHD symptom severity and occurrence were especially high among gender-diverse individuals. Significant associations between adult ADHD symptoms and age, mental and sexual health, and socioeconomic status were observed. Conclusions: Present results show significant cross-cultural variability in adult ADHD occurrence as well as highlight important factors related to adult ADHD. Moreover, the importance of further research on adult ADHD in previously understudied populations (non-Western countries) and minority groups (gender-diverse individuals) is stressed. Lastly, the present analysis is consistent with previous evidence showing low specificity of adult ADHD screening instruments and contributes to the current discussion on accurate adult ADHD screening and diagnosis. [ABSTRACT FROM AUTHOR]

Two terminal passive devices are regarded as one of the promising candidates to solve the processor‐memory bottleneck in the Von Neumann computing architectures. Many different materials are used to fabricate memory devices, which have the potential to act as synapses in future neuromorphic electronics. Metal halide perovskites are attractive for memory devices as they display high density of defects with a low migration barrier. However, to become promising for a future neuromorphic technology, attention should be paid on non‐toxic materials and scalable deposition processes. Herein, it is reported for the first time the successful fabrication of resistive memory devices using quasi‐2D tin–lead perovskite of composition (BA)2MA4(Pb0.5Sn0.5)5I16 by blade coating. The devices show typical memory characteristics with excellent endurance (2000 cycles), retention (105 s), and storage stability (3 months). Importantly, the memory devices successfully emulate synaptic behaviors such as spike‐timing‐dependent plasticity, paired‐pulse facilitation, short‐term potentiation, and long‐term potentiation. A mix of slow (ionic) transport and fast (electronic) transport (charge trapping and de‐trapping) is proven to be responsible for the observed resistive switching behavior. [ABSTRACT FROM AUTHOR]

A field experiment was conducted in northeast China to examine the response of nitrogen cycling enzymes, that is, protease, N‐acetyl‐β‐D‐glucosaminidase (NAG), amidase, urease, and peptidase, as well soil organic nitrogen (SON) fractions and their relationships to RT (no maize residue application), NT (no tillage with maize residues placed on the surface), TT (plow maize residues into the soil at 0–35 cm depth in the first year, 0–20 cm in the second year, and 0–15 cm in the third year), and PT (plow maize residues into soil at 0–35 cm depth). The results have shown that NT significantly enhanced the activities of protease and NAG at 0–10 cm soil depth in comparison with other treatments. NT and TT significantly enhanced the activities of protease compared to RT and PT at 10–20 cm soil depth. TT significantly enhanced the activities of NAG in comparison with RT at 10–20 cm soil depth. TT and PT significantly enhanced the activities of NAG and peptidase compared to RT and NT at 20–35 cm soil depth. PT significantly increased the activities of protease in comparison with RT at 20–35 cm soil depth. NT, TT, and PT significantly enhanced the activities of peptidase compared to RT at 10–20 cm soil depth. NT significantly increased the concentration of hydrolyzable NH4+‐N$$ {\mathrm{NH}}_4^{+}\hbox{-} \mathrm{N} $$ in comparison with other treatments at 0–10 cm soil depth. PT significantly enhanced the concentration of hydrolyzable NH4+‐N$$ {\mathrm{NH}}_4^{+}\hbox{-} \mathrm{N} $$ and amino acid N compared to other treatments at 20–35 cm soil depth. Redundancy analysis showed that protease played a crucial role in the cycling of SON under RT and NT, whereas peptidase and NAG played a significant role in the cycling of SON under TT and PT, respectively. This study provided a comprehensive understanding of crop residue return methods for regulating soil N cycling. [ABSTRACT FROM AUTHOR]

Modified latex is prepared via the soap-free emulsion polymerization of ethyl acetate (VAc) and vinyl versatate (VeoVa10). DFHMA is used as modified monomers. The composite surfactants of SR-10 and ANPEO-10 are used as the composite emulsifiers. The polymerization is initiated by potassium sulfate (KPS). The structure of latex film was characterized by Fourier transform infrared spectroscopy (FTIR). The latex films were tested by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and contact angle (CA) determinator. The particle size of the latex emulsion particle size is determined by the Zetatrac dynamic light scatter. Results show that the optimum condition of preparing the modified latex can be obtained, i.e. the amount of emulsifier is 4.0%; the mass ratio of SR-10 to ANPEO-10 is 1:1; the amount of initiator is 0.5%; the mass ratio ofVAc to VeoVa10 is 1:1; the amount of DFHMA is 5.0%. The appearance of the latex is blue and translucent with a small particle size. The conversion rate is more than 98%. Compared with the conventional latex, the hydrophobicity and heat resistance of the film have been improved. Moreover, the latex has good chemical stability and mechanical stability. [ABSTRACT FROM AUTHOR]

Background: Omics characterization of pancreatic adenocarcinoma tissue is complicated by the highly heterogeneous and mixed populations of cells. We evaluate the feasibility and potential benefit of using a coring method to enrich specific regions from bulk tissue and then perform proteogenomic analyses. Methods: We used the Biopsy Trifecta Extraction (BioTExt) technique to isolate cores of epithelial-enriched and stroma-enriched tissue from pancreatic tumor and adjacent tissue blocks. Histology was assessed at multiple depths throughout each core. DNA sequencing, RNA sequencing, and proteomics were performed on the cored and bulk tissue samples. Supervised and unsupervised analyses were performed based on integrated molecular and histology data. Results: Tissue cores had mixed cell composition at varying depths throughout. Average cell type percentages assessed by histology throughout the core were better associated with KRAS variant allele frequencies than standard histology assessment of the cut surface. Clustering based on serial histology data separated the cores into three groups with enrichment of neoplastic epithelium, stroma, and acinar cells, respectively. Using this classification, tumor overexpressed proteins identified in bulk tissue analysis were assigned into epithelial- or stroma-specific categories, which revealed novel epithelial-specific tumor overexpressed proteins. Conclusions: Our study demonstrates the feasibility of multi-omics data generation from tissue cores, the necessity of interval H&E stains in serial histology sections, and the utility of coring to improve analysis over bulk tissue data. [ABSTRACT FROM AUTHOR]

When interacting with strangers, people tend to draw inferences pertaining to the strangers' personality traits based on their facial information, which leads to differential feelings of trust for the strangers. This study explored whether the weightage which individuals' provide to facial warmth and competence changes with social situations when they have to make decisions based on trust. In experiment 1, a donation context was set, and the participants tended to select a stranger volunteer with feminine face as the recipient of a higher donation amount. In experiment 2, an investment context was set, and while interacting with male trustees, the participants tended to select masculine male faces as recipients of a higher investment amount. However, a contradictory result was obtained when the participants interacted with the female trustees. Participants' perceptions of the trustworthiness of the four kinds of faces (feminine or masculine male faces, feminine or masculine female faces) predicted the corresponding donation and investment amounts. The results indicated that feminine faces (both male and female) were preferred as recipients of donation, and the warmth in the faces was given more weightage in the donation context (warmth perception). In the investment context (competence perception), participants tended to choose masculine faces as recipients of investment amount among the male faces but showed a preference for feminine faces among female faces. The research provides empirical support for a better understanding of the mechanisms behind highly flexible and complex social interactions among humans. [ABSTRACT FROM AUTHOR]

Bacteria and fungi are core microorganisms in diverse ecosystems, and their cross‐kingdom interactions are considered key determinants of microbiome structure and ecosystem functioning. However, how bacterial‐fungal interactions mediate soil organic carbon (SOC) dynamics remains largely unexplored in the context of artificial forest ecosystems.Here, we characterised soil bacterial and fungal communities in four successive planting of Eucalyptus and compared them to a neighbouring evergreen broadleaf forest. Carbon (C) mineralisation combined with five C‐degrading enzymatic activities was investigated to determine the effects of successive planting of Eucalyptus on SOC dynamics.Our results indicated that successive planting of Eucalyptus significantly altered the diversity and structure of soil bacterial and fungal communities and increased the negative bacterial‐fungal associations. The bacterial diversity significantly decreased in all Eucalyptus plantations compared to the evergreen forest, while the fungal diversity showed the opposite trend. The ratio of negative bacterial‐fungal associations increased with successive planting of Eucalyptus due to the decrease in SOC, ammonia nitrogen (NH4+‐N), nitrate nitrogen (NO3−‐N) and available phosphorus (AP). Structural equation modelling indicated that the potential cross‐kingdom competition, based on the ratio of negative bacterial‐fungal correlations, was significantly negatively associated with the diversity of total bacteria and keystone bacteria, thereby increasing C‐degrading enzymatic activities and C mineralisation.Synthesis and applications: Our results highlight the regulatory role of the negative bacterial‐fungal association in enhancing the correlation between bacterial diversity and C mineralisation. This suggests that promoting short‐term successive planting in the management of Eucalyptus plantations can mitigate the impact of this association on SOC decomposition. Taken together, our study advances the understanding of bacterial‐fungal negative associations to mediate carbon mineralisation in Eucalyptus plantations, giving us a new insight into SOC cycling dynamics in artificial forests. [ABSTRACT FROM AUTHOR]

To achieve environmental protection, high removal rates, reusability, and degradability, a carboxymethyl-functionalized porous hydrogel P-(CM-β-CD/HPCS/KHA/AC) was synthesized with carboxymethyl cyclodextrin (CM-β-CD), hydroxypropyl chitosan (HPCS), potassium humate (KHA), and activated carbon (AC) using polyacrylic acid (PAA) as the carrier. The gel materials before and after adsorption were characterized via FTIR, TG, XRD, and XPS. Results showed high adsorption capacity for antibiotics such as tetracycline hydrochloride (TCH). P-(CM-β-CD/HPCS/KHA/AC) hydrogel exhibits optimal TCH adsorption at 298 K with 0.8 g/L of the adsorbent at pH 4, resulting in the highest adsorption capacity of up to 108.81 mg/g, a removal rate of 69%, and an adsorption equilibrium time of 150 min. The maximum swelling ratio is 100.39 times at pH 7. The theoretical values of the TCH adsorption capacity obtained using the quasi-second-order kinetic equation at 298 K, 308 K, and 318 K are 114.8106, 98.4552, and 90.4159 mg/g, respectively, corresponding to the experimental values. The adsorption behavior follows a quasi-second-order kinetic equation, which is in accordance with the Langmuir model. It is driven by electrostatic interactions, π–π conjugation reactions, hydrogen bond interactions, entropy increase, and heat absorption, resulting in a spontaneous process. The regeneration and degradability of the P-(CM-β-CD/HPCS/KHA/AC) hydrogel were tested. After five cycles of adsorption–desorption experiments, the removal rate was 50.57%. After degradation for 6 months, the weight loss rates of the P-(CM-β-CD/HPCS/KHA/AC) hydrogel in acid, water, and alkali were 45.29%, 24.90%, and 29.50%, respectively, indicating the environment-friendly nature and repeated recyclability of the hydrogel. [ABSTRACT FROM AUTHOR]