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Cervical cancer is still the leading cause of cancer mortality worldwide even after introduction of vaccine against Human papillomavirus (HPV), due to low vaccine coverage, especially in the developing world. Cervical cancer is primarily treated by Chemo/Radiotherapy, depending on the disease stage, with Carboplatin/Cisplatin-based drug regime. These drugs being non-specific, target rapidly dividing cells, including normal cells, so safer options are needed for lower off-target toxicity. Natural products offer an attractive option compared to synthetic drugs due to their well-established safety profile and capacity to target multiple oncogenic hallmarks of cancer like inflammation, angiogenesis, etc. In the current study, we investigated the effect of Bergenin (C-glycoside of 4-O-methylgallic acid), a natural polyphenol compound that is isolated from medicinal plants such as Bergenia crassifolia, Caesalpinia digyna, and Flueggea leucopyrus. Bergenin has been shown to have anti-inflammatory, anti-ulcerogenic, and wound healing properties but its anticancer potential has been realized only recently. We performed a proteomic analysis of cervical carcinoma cells treated with bergenin and found it to influence multiple hallmarks of cancers, including apoptosis, angiogenesis, and tumor suppressor proteins. It was also involved in many different cellular processes unrelated to cancer, as shown by our proteomic analysis. Further analysis showed bergenin to be a potent-angiogenic agent by reducing key angiogenic proteins like Galectin 3 and MMP-9 (Matrix Metalloprotease 9) in cervical carcinoma cells. Further understanding of this interaction was carried out using molecular docking analysis, which indicated MMP-9 has more affinity for bergenin as compared to Galectin-3. Cumulatively, our data provide novel insight into the anti-angiogenic mechanism of bergenin in cervical carcinoma cells by modulation of multiple angiogenic proteins like Galectin-3 and MMP-9 which warrant its further development as an anticancer agent in cervical cancer. [ABSTRACT FROM AUTHOR]

This exploration of paper presents an investigation of the Forest Region Inclusion Dataset that gives data on the backwoods inclusion of different nations overall from 1990 to 2020. The dataset contains country-wise information on population, population density, population development rate, total population rate, and forest region inclusion. We examined this dataset to decide the patterns in woodland region inclusion across various nations and mainlands, as well as the connection among populace and backwoods region inclusion. Our discoveries show that while certain nations have essentially expanded their forest region inclusion, others have encountered a decline. Besides, we found that population density and development rate are adversely related with forest area coverage. Authors have implemented four machine learning algorithms that are Linear Regression, Decision Tree, Random Forest and Support Vector Machine on the dataset. [ABSTRACT FROM AUTHOR]

Cancer has emerged as an immedicable and fatal disease all around the world. It ranks as the second most common cause of death worldwide. Cancer is estimated by the WHO to be the cause of 1 in 6 deaths. Many modern cancer treatment methods like chemotherapy, photodynamic therapy, catalytic therapy and radiotherapy have been developed, albeit these are restricted, noncurative and generate certain side effects. Therefore, naturopathic medicines are used along with standard treatment procedures as an adjunct to treat cancerous cells without producing any deleterious effects. Due to several bioactive components, Crocus sativus L. (saffron) has been utilized in traditional herbal therapy since ancient times. Anticancer activities of saffron and its ingredients-crocin, crocetin, and safranal are established by several workers in various animal models. This review article has focused on the cancer-preventive and curative properties of saffron and its ingredients in different types of cancers, along with pharmaceutical importance and toxicity. [ABSTRACT FROM AUTHOR]

Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize and attack tumor cells. T-cells are isolated from patients and modified to target tumor-associated antigens. CAR-T therapy has achieved FDA approval for treating blood cancers like B-cell acute lymphoblastic leukemia, large B-cell lymphoma, and multiple myeloma by targeting CD-19 and B-cell maturation antigens. Bi-specific chimeric antigen receptors may contribute to mitigating tumor antigen escape, but their efficacy could be limited in cases where certain tumor cells do not express the targeted antigens. Despite success in blood cancers, CAR-T technology faces challenges in solid tumors, including lack of reliable tumor-associated antigens, hypoxic cores, immunosuppressive tumor environments, enhanced reactive oxygen species, and decreased T-cell infiltration. To overcome these challenges, current research aims to identify reliable tumor-associated antigens and develop cost-effective, tumor microenvironment-specific CAR-T cells. This review covers the evolution of CAR-T therapy against various tumors, including hematological and solid tumors, highlights challenges faced by CAR-T cell therapy, and suggests strategies to overcome these obstacles, such as utilizing single-cell RNA sequencing and artificial intelligence to optimize clinical-grade CAR-T cells. [ABSTRACT FROM AUTHOR]

Purpose: Comparative study of intraoperative and postoperative complications, visual outcomes, and cost-effectiveness between conventional and 4-mm manual small-incision cataract surgery with MVR blade.Methods: In total, 600 patients having nuclear sclerosis grade I-IV were operated under peribulbar anesthesia and were divided into two groups of 300 each. In group A (300), conventional small-incision cataract surgery was done, whereas in group B (300), 4-mm manual small-incision cataract surgery was performed through a 4-mm sclerocorneal tunnel. A wire vectis was passed through the 4-mm incision below the nucleus to stabilize it, and a 20-G MVR blade was introduced from 11o'clock limbus and nucleus was bisected into two halves, which were removed through main incision. Cortical wash was given, and foldable IOL was implanted. Intraoperative and postoperative complications between the two groups were compared. Postoperative visual outcome and surgically induced astigmatism between the two groups was studied.Results: The most common intraoperative complication was hyphema (11.33%) and irido-dialysis (8.00%), whereas postoperatively, striate keratopathy (36.33%) and hyphema (19.33%) were common. Short-term complications such as striate keratopathy, hyphema, and irido-dialysis were significantly more in group B, and long-term results in terms of visual outcome and surgically induced astigmatism were significantly less in group B.Conclusion: Although intraoperative and short-term postoperative complications were observed more in 4-mm manual small-incision cataract surgery, it was found to be more effective in terms of surgically induced astigmatism and final visual outcome. In addition, it is cost-effective as compared to phacoemulsification. [ABSTRACT FROM AUTHOR]

Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize and attack tumor cells. T-cells are isolated from patients and modified to target tumor-associated antigens. CAR-T therapy has achieved FDA approval for treating blood cancers like B-cell acute lymphoblastic leukemia, large B-cell lymphoma, and multiple myeloma by targeting CD-19 and B-cell maturation antigens. Bi-specific chimeric antigen receptors may contribute to mitigating tumor antigen escape, but their efficacy could be limited in cases where certain tumor cells do not express the targeted antigens. Despite success in blood cancers, CAR-T technology faces challenges in solid tumors, including lack of reliable tumor-associated antigens, hypoxic cores, immunosuppressive tumor environments, enhanced reactive oxygen species, and decreased T-cell infiltration. To overcome these challenges, current research aims to identify reliable tumor-associated antigens and develop cost-effective, tumor microenvironment-specific CAR-T cells. This review covers the evolution of CAR-T therapy against various tumors, including hematological and solid tumors, highlights challenges faced by CAR-T cell therapy, and suggests strategies to overcome these obstacles, such as utilizing single-cell RNA sequencing and artificial intelligence to optimize clinical-grade CAR-T cells. [ABSTRACT FROM AUTHOR]

Objective: To investigate the epidemiology and clinical profile of glaucoma patients in a population-based sample. Methods: This cross-sectional study recruited 111 participants from a population-based sample. Demographic data, chief complaints, comorbidities, refractive errors, and intraocular pressure were recorded. Types of glaucoma were classified as primary or secondary and open angle or angle closure. Results: The mean age of participants was 59.6 years (SD 10.7), with the majority belonging to the 55-64 years age group (40.5%). Diminished vision was the most common chief complaint (91.8%), with myopia being the most common refractive error (39.6%). Hypertension (41.4%) was the most prevalent comorbidity, and primary open-angle glaucoma (63.1%) was the most common type of glaucoma. Myopia was significantly more prevalent in patients with primary open-angle glaucoma than in those with primary angle closure glaucoma (p<0.05). Conclusion: Glaucoma patients in the study population were predominantly middle-aged with diminished vision as the most common complaint. Hypertension was the most prevalent comorbidity, and primary open-angle glaucoma was the most common type of glaucoma. Myopia was significantly associated with primary open-angle glaucoma. [ABSTRACT FROM AUTHOR]

INTRODUCTION: Senile cataract has been documented to be the most significant cause of bilateral blindness in India. Cataract Extraction constitutes the largest workload in ophthalmic units in India. Cataract is responsible for 62.4% of blindness in India and the prevalence of blindness due to cataract is 5.3% [1]. Such a high prevalence of cataract is due to absence of effective eye health care delivery system, COVID outbreaks resulting in cessation of non-emergency surgeries and relatively poor surgical care. METHODOLOGY: Detailed history including demographics, ocular disease, past medical and surgical history, drug history and personal history and examination was done for all the study participants. An informed written consent was taken from all the patients. The need for the investigations and the procedure to be done was explained to all in detail. The patients have given wilful consent to be a part of the study. RESULTS: The comparison between both groups postoperatively, showed statistically insignificant alteration in cell density of endothelial cells in cornea post operatively. (p value 0.4). The comparison between both groups postoperatively, showed statistically insignificant alteration in Central Corneal Thickness of cornea post operatively. (p value 0.39). CONCLUSION: The results in our study show that manual SICS is as safe for the corneal endothelium as phacoemulsification, is almost as effective, and is much more economical. These factors indicate that SICS can be an alternative to phacoemulsification in areas in which surgeons proficient in phacoemulsification and phaco machines are not available. [ABSTRACT FROM AUTHOR]

Background: Osteosarcoma is a type of bone cancer that predominantly affects young individuals, including children and adolescents. The disease progresses through heterogeneous genetic alterations, and patients often develop pulmonary metastases even after the primary tumors have been surgically removed. Ubiquitin-specific peptidases (USPs) regulate several critical cellular processes, such as cell cycle progression, transcriptional activation, and signal transduction. Various studies have revealed the significance of USP37 in the regulation of replication stress and oncogenesis. Methods: In this study, the Cancer Genome Atlas (TCGA) database was analyzed to investigate USP37 expression. RNA sequencing was utilized to assess the impact of USP37 overexpression and depletion on gene expression in osteosarcoma cells. Various molecular assays, including colony formation, immunofluorescence, immunoprecipitation, and DNA replication restart, were employed to examine the physical interaction between USP37 and PCNA, as well as its physiological effects in osteosarcoma cells. Additionally, molecular docking studies were conducted to gain insight into the nature of the interaction between USP37 and PCNA. Furthermore, immunohistochemistry was performed on archived tissue blocks from osteosarcoma patients to establish a correlation between USP37 and PCNA expression. Results: Analysis of the TCGA database revealed that increased expression of USP37 was linked to decreased progression-free survival (PFS) in osteosarcoma patients. Next-generation sequencing analysis of osteosarcoma cells demonstrated that overexpression or knockdown of USP37 led to the expression of different sets of genes. USP37 overexpression provided a survival advantage, while its depletion heightened sensitivity to replication stress in osteosarcoma cells. USP37 was found to physically interact with PCNA, and molecular docking studies indicated that the interaction occurs through unique residues. In response to genotoxic stress, cells that overexpressed USP37 resolved DNA damage foci more quickly than control cells or cells in which USP37 was depleted. The expression of USP37 varied in archived osteosarcoma tissues, with intermediate expression seen in 52% of cases in the cohort examined. Conclusion: The results of this investigation propose that USP37 plays a vital role in promoting replication stress tolerance in osteosarcoma cells. The interaction between USP37 and PCNA is involved in the regulation of replication stress, and disrupting it could potentially trigger synthetic lethality in osteosarcoma. This study has expanded our knowledge of the mechanism through which USP37 regulates replication stress, and its potential as a therapeutic target in osteosarcoma merits additional exploration. [ABSTRACT FROM AUTHOR]

Objective: The objective of this study was to compare the outcomes of pterygium excision with conjunctival autograft using sutures versus a sutureless technique. Methods: This was a prospective, interventional, hospital-based study conducted at a tertiary care center from November 2020 to November 2022. The sample size was 74 participants, divided into two groups by simple random sampling. Group 1 underwent conjunctival autografting with sutures, while group 2 underwent sutureless conjunctival autografting with autologous blood. Data was collected through case record forms and analyzed using statistical methods. Results: The majority of participants (52.7%) had a history of UV light exposure, and most of the pterygiums were grade 2 (86.5%). At week two post-operatively, all patients in the suture group (100%) and 5 patients (13.5%) in the non-suture group experienced foreign body sensation. Severe foreign body sensation was observed in 7 patients in the suture group and none in the non-suture group. The recurrence rate was 5.4% in the suture group and 8.1% in the non-suture group, which was not statistically significant. Conclusion: The sutureless technique for conjunctival autografting in pterygium excision results in less post-operative discomfort and fewer complications compared to the sutured technique. However, there was no significant difference in recurrence rates between the two techniques. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings. [ABSTRACT FROM AUTHOR]

Gene editing has great potential in treating diseases caused by well-characterized molecular alterations. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)-based gene-editing tools has substantially improved the precision and efficiency of gene editing. The CRISPR/Cas9 system offers several advantages over the existing gene-editing approaches, such as its ability to target practically any genomic sequence, enabling the rapid development and deployment of novel CRISPR-mediated knock-out/knock-in methods. CRISPR/Cas9 has been widely used to develop cancer models, validate essential genes as druggable targets, study drug-resistance mechanisms, explore gene non-coding areas, and develop biomarkers. CRISPR gene editing can create more-effective chimeric antigen receptor (CAR)-T cells that are durable, cost-effective, and more readily available. However, further research is needed to define the CRISPR/Cas9 system's pros and cons, establish best practices, and determine social and ethical implications. This review summarizes recent CRISPR/Cas9 developments, particularly in cancer research and immunotherapy, and the potential of CRISPR/Cas9-based screening in developing cancer precision medicine and engineering models for targeted cancer therapy, highlighting the existing challenges and future directions. Lastly, we highlight the role of artificial intelligence in refining the CRISPR system's on-target and off-target effects, a critical factor for the broader application in cancer therapeutics. [ABSTRACT FROM AUTHOR]

Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like chemotherapy, radiotherapy, and surgery offer limited efficacy and poor clinical outcome with a less than 25% 5-year survival rate. The poor prognosis of EC persists despite the growth in the development of diagnostic and therapeutic modalities to treat EC. This underlines the need to elucidate the complex molecular mechanisms that drive esophageal oncogenesis. Apart from the role of the tumor microenvironment and its structural and cellular components in tumorigenesis, mounting evidence points towards the involvement of the esophageal microbiome, inflammation, and their cross-talk in promoting esophageal cancer. The current review summarizes recent research that delineates the underlying molecular mechanisms by which the microbiota and inflammation promote the pathophysiology of esophageal cancer, thus unraveling targets for potential therapeutic intervention. [ABSTRACT FROM AUTHOR]

Background: Development of cerebral infarcts following clipping of ruptured intracranial aneurysm is one of the major determinants of functional outcome in patients with subarachnoid hemorrhage (SAH). The aim of this study is to evaluate the factors affecting development of postoperative infarcts, its incidence, pattern, and functional outcome.Material and Methods: This study includes 118 patients of spontaneous SAH because of ruptured anterior communicating artery aneurysm, who underwent clipping. Relevant points in history, preoperative and intraoperative findings, and postoperative outcome are evaluated.Results: 29 of 118 (24.5%) patients developed postoperative radiological infarcts. Approximately 37.9%, 17.2%, and 3.4% patients developed isolated infarcts, respectively, in anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA) territory. About 20.7% patients developed infarcts in deep perforator territory. Nine of 29 (31.3%) patients developed multiple-vessel territory infarcts. Patients with poor preoperative neurologic status, prior history of seizure, and history of intraoperative rupture had higher chances of development of infarcts. Development of infarct was irrespective of temporary clipping (TC), duration of clipping, and elective versus rescue clipping. Development of infarcts adversely affected the outcome in significant proportions. Among patients with infarcts, unilateral ACA territory infarcts showed best prognosis, whereas all patients with multiple territory infarcts and PCA territory infarcts died. Age or sex of the patients did not affect the functional outcome. Timing of development of infarcts has no influence on functional recovery.Conclusion: Development of symptomatic infarct is the sole important predictor of functional outcome. A crowded neurovascular neighborhood and complex variations in local angioarchitecture make anterior communication (ACOM) territory predisposed to operative insults. Elective TC and aggressive management of cerebral vasospasm are recommended to prevent development of infarcts. [ABSTRACT FROM AUTHOR]

Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ubiquitination process may lead to tumorigenesis. Ubiquitin-specific peptidases are attractive therapeutic targets in different cancers and are being evaluated for clinical development. Ubiquitin-specific peptidase 37 (USP37) is one of the least studied members of the USP family. USP37 controls numerous aspects of oncogenesis, including stabilizing many different oncoproteins. Recent work highlights the role of USP37 in stimulating the epithelial-mesenchymal transition and metastasis in lung and breast cancer by stabilizing SNAI1 and stimulating the sonic hedgehog pathway, respectively. Several aspects of USP37 biology in cancer cells are yet unclear and are an active area of research. This review emphasizes the importance of USP37 in cancer and how identifying its molecular targets and signalling networks in various cancer types can help advance cancer therapeutics. [ABSTRACT FROM AUTHOR]

Background: The high-density silicone oil (Densiron), a mixture of F6H8 with silicone oil, has been used in the management of retinal detachment (RD) complicated by the presence of proliferative vitreoretinopathy (PVR) with varying rate of anatomical success and visual outcomes. Methods: We conducted a prospective interventional case series of 22 eyes in 22 children less than 18 years diagnosed with complicated retinal detachment complicated by the presence of PVR in inferior quadrant. Results: The mean age of the patients was 8.45 ± 3.36 years. There were 14 male and 8 female children. Five patients presented with total RD, 5 had subtotal RD and remaining 10 with inferior retinal detachment. There were 8 children with PVR C1, 13 with PVR C2, 3 with PVR C3. All patient's had macula off RD at presentation. The anatomical success in the form of attached retina was achieved in 21 (95.45%) eyes. Standard three-port pars plana vitrectomy without scleral buckling under general anesthesia was surgical technique employed in all cases. Conclusion: Densiron can be an important tamponade agent in pediatric retinal detachment complicated by PVR with increased success rate of retinal re-attachment. [ABSTRACT FROM AUTHOR]

Reference 1 Dagar G, Gupta A, Masoodi T, Nisar S, Merhi M, Hashem S, Chauhan R, Dagar M, Mirza S, Bagga P, Kumar R. Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments. Correction: Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments Tariq Masoodi, Sabah Nisar and Maysaloun Merhi have contributed equally. [Extracted from the article]

A total of 57 tissue samples of domestic pigs (Sus scrofa) were collected from the meat outlets of five north Indian states and examined for sarcocystosis by histological and molecular methods. The genomic DNA extracted from five representative positive isolates was subjected to PCR amplification of the partial 18S rRNA gene followed by cloning and sequencing. Sequence analysis of the newly generated Indian isolates recorded 96.9–100.0% identity with published sequences of Sarcocystis suihominis. Two new haplotypes that have not been previously described manifested 99.5–100.0% nucleotide homology within themselves. In the phylogenetic analysis, Indian isolates of S. suihominis grouped together with S. suihominis originating from Italy, and they collectively formed a sister clade with Sarcocystis miescheriana within a clade containing various Sarcocystis spp. of ruminants having felids as final hosts. At the same time, this clade separated from a sister clade containing Sarcocystis spp. of bovid or cervid ruminants using canids as known or surmised definitive host. The current study established the phylogenetic relationship of Indian isolates of S. suihominis with various Sarcocystis spp. as well as with other taxa of Sarcocystidae family based on 18S rRNA gene for the first time. [ABSTRACT FROM AUTHOR]

The DNA and protein complex known as chromatin is subject to posttranslational modifications (PTMs) that regulate cellular functions such that PTM dysregulation can lead to disease, including cancer. One critical PTM is acetylation/deacetylation, which is being investigated as a means to develop targeted cancer therapies. The histone acetyltransferase (HAT) family of proteins performs histone acetylation. In humans, MOF (hMOF), a member of the MYST family of HATs, acetylates histone H4 at lysine 16 (H4K16ac). MOF-mediated acetylation plays a critical role in the DNA damage response (DDR) and embryonic stem cell development. Functionally, MOF is found in two distinct complexes: NSL (nonspecific lethal) in humans and MSL (male-specific lethal) in flies. The NSL complex is also able to acetylate additional histone H4 sites. Dysregulation of MOF activity occurs in multiple cancers, including ovarian cancer, medulloblastoma, breast cancer, colorectal cancer, and lung cancer. Bioinformatics analysis of KAT8, the gene encoding hMOF, indicated that it is highly overexpressed in kidney tumors as part of a concerted gene coexpression program that can support high levels of chromosome segregation and cell proliferation. The linkage between MOF and tumor proliferation suggests that there are additional functions of MOF that remain to be discovered. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the parameters that affect primary stability of dental implants, to determine how primary stability influences posthealing stability, and to ascertain the effect of primary stability and insertion parameters on marginal bone loss. Materials and Methods: A total of 940 immediately loaded implants were considered. Using resonance frequency analysis, primary stability (primary implant stability quotient [pISQ]) and stability after 4 months (tISQ) were recorded. When the differences between pISQ and tISQ exceeded 5 units, marginal bone loss was measured. The implants were placed into three groups based on their primary stability: high (pISQ > 72), moderate, and low (pISQ < 68). Changes in stability after 4 months of loading were evaluated. The relationships between pISQ, insertion parameters, DISQ (ie, tISQ - pISQ), and marginal bone loss were analyzed. The Student t test, one-way analysis of variance, and Spearman nonparametric correlation coefficient were employed for statistical evaluation. Results: Of the 940 implants, tISQ was recorded in 526 implants and marginal bone loss was measured in 76 implants. There was no statistical relationship between pISQ and insertion torque. Primary stability was influenced by implant diameter but not by implant length. There was a significant relationship between implant insertion torque and bone type. The low primary stability group showed a significant increase in stability during healing. However, high primary stability implants demonstrated a significant reduction in their stability. The linear regression analysis demonstrated that at a pISQ of 69.2, tISQ value would equal pISQ value. Correlations between marginal bone loss and final insertion torque and between marginal bone loss and DISQ values were observed. Conclusions: Stability of immediately loaded implants with high pISQ decreased significantly during the initial 4 months of healing. However, stability of implants with low primary stability increased significantly. DISQ and insertion torque showed correlation with marginal bone loss. Int J Oral Maxillofac Implants 2010;25:1085-1092. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the parameters that affect primary stability of dental implants, to determine how primary stability influences posthealing stability, and to ascertain the effect of primary stability and insertion parameters on marginal bone loss. Materials and Methods: A total of 940 immediately loaded implants were considered. Using resonance frequency analysis, primary stability (primary implant stability quotient [pISQ]) and stability after 4 months (tISQ) were recorded. When the differences between pISQ and tISQ exceeded 5 units, marginal bone loss was measured. The implants were placed into three groups based on their primary stability: high (pISQ > 72), moderate, and low (pISQ < 68). Changes in stability after 4 months of loading were evaluated. The relationships between pISQ, insertion parameters, ΔISQ (ie, tISQ - pISQ), and marginal bone loss were analyzed. The Student t test, one-way analysis of variance, and Spearman nonparametric correlation coefficient were employed for statistical evaluation. Results: Of the 940 implants, tISQ was recorded in 526 implants and marginal bone loss was measured in 76 implants. There was no statistical relationship between pISQ and insertion torque. Primary stability was influenced by implant diameter but not by implant length. There was a significant relationship between implant insertion torque and bone type. The low primary stability group showed a significant increase in stability during healing. However, high primary stability implants demonstrated a significant reduction in their stability. The linear regression analysis demonstrated that at a pISQ of 69.2, tISQ value would equal pISQ value. Correlations between marginal bone loss and final insertion torque and between marginal bone loss and ΔISQ values were observed. Conclusions: Stability of immediately loaded implants with high pISQ decreased significantly during the initial 4 months of healing. However, stability of implants with low primary stability increased significantly. ΔISQ and insertion torque showed correlation with marginal bone loss. [ABSTRACT FROM AUTHOR]

Terrorist attacks are increasing each year as are the number of deaths associated with them. Recent incidents have seen a shift in tactics with the use of multiple terrorists across multiple locations with firearms or knives, referred to as the marauding terrorist attack. These methods are becoming more prevalent alongside the use of vehicles deliberately aimed at pedestrians. Management of these incidents can be challenging. Not only it involves a large number of casualties but also the management of a dynamic scene in terms of both location and threat from attack. In order to improve response, and potentially outcomes, a system or response needs to have preplanned and practised procedures in place. This article reviews major incident management for those unfamiliar with current prehospital practice and details some of the findings from recent marauding terrorist firearm attacks, in particular the evolution of newer scene management tools such as 3 Echo and THREAT. It highlights the importance of haemorrhage control and the public initiatives focusing on actions during a terrorist incident. [ABSTRACT FROM AUTHOR]

"Green Revolution" has been one of the most touted achievements in Indian agriculture. The term refers to a phenomenal rise in productivity experienced by the major food grain-crops, such as wheat, rice and maize. However, the revolution has left us with a legacy of declining biodiversity and stagnant rural income. Even as we celebrate our self-sufficiency in foodgrains production, we need to understand that Indian agriculture is dependent on a basket of around 30 crops, accounting for more than 80per cent of our agricultural output. Not only is this limited basket a drag on our environment but also on our input resources. It is time to recognise the fact that India is home to many useful plant species with superior nutritional and medicinal properties, and they should be developed in terms of market size to achieve economic growth. Currently, the agricultural system is lopsided in terms of cultivation and research; focusing on a few crops, this needs to change in the near future. Aggressive breeding programmes using advanced biotechnological tools such as tissue culture, micropropagation, genomics and bioinformatics are the need of the hour. While the Indian Council of Agricultural Research (ICAR) has put into place some resources to look at the future potential crops, more needs to be done. This study looks at these issues and proposes a multi-faceted policy approach to tackle them. If the proposed changes can be brought about to the agricultural system, we may be able to achieve an increase in biodiversity along with the growth in rural income. [ABSTRACT FROM AUTHOR]

Study Design: Cross-sectional study. Purpose: To evaluate the prevalence and various risk factors for low back pain (LBP) in young adults in India. Overview of Literature: LBP is an emerging problem in adolescents, with an incidence that is the highest in the third decade of life worldwide. Various risk factors such as obesity, smoking, family history, stress, and exercise have been described in the literature. This study was conducted because of paucity of data in the Indian literature. Methods: A total of 1,355 (741 males and 641 females) young Indian Administrative Service aspirants and medical postgraduate aspirants aged 18-35 years were enrolled in the study. The subjects completed a detailed, semi-structured questionnaire that gathered data regarding their sociodemographic profile and factors considered to be risk factors for LBP. Anthropometric measurements, including height and weight, were measured and body mass index was calculated. Results: Most subjects (90.6%) were aged 20-29 years (mean, 24.49; range, 18-35 years). Results indicated that the following factors were associated with LBP in young adults: marital status, previous history of spine problems, strenuous exercise, job satisfaction, monotony, stress, daily number of studying hours, and family history of spine problems (p <0.05). However, age, sex, smoking, alcoholism, coffee intake, mode and duration of travel, diet, frequency of weightlifting, wearing heels, studying posture, and frequency and type of sports activities were not associated with LBP. Conclusions: The study identified various modifiable and non-modifiable risk factors that precipitated LBP in young adult Indians. Identifying these risk factors at an early stage will prevent LBP progression to a chronic disease state, thereby improving an individual's quality of life and increasing productivity. [ABSTRACT FROM AUTHOR]

The article offers information about peri-implantitis. Topics covered include the causes of the biological complication involving dental implants, clinical characteristics of peri-implantitis including bleeding and the loss of bone around a dental implant, and the surgical and non-surgical strategies for managing peri-implantitis.

Basic research continues to unravel the molecular complexity of normal and abnormal biologic processes. The development of means to affect the expression level of genes that promote or contribute to cellular transformation, invasion, and metastasis has spawned the concept of gene therapy. This relatively new field seeks to reverse or suspend the pathologic progression of a variety of diseases including the malignant transformation of prostatic epithelial cells. Initial clinical trials for prostate cancer have thus far shown gene therapy to be relatively safe, although definitive evidence of durable therapeutic efficacy remains to be demonstrated. In this article, recent preclinical research, current therapeutic strategies, and recent results of gene therapy clinical trials for the treatment of prostate cancer are reviewed. [ABSTRACT FROM AUTHOR]

Basic research continues to unravel the molecular complexity of normal and abnormal biologic processes. The development of means to affect the expression level of genes that promote or contribute to cellular transformation, invasion, and metastasis has spawned the concept of gene therapy. This relatively new field seeks to reverse or suspend the pathologic progression of a variety of diseases including the malignant transfor-mation of prostatic epithelial cells. Initial clinical trials for prostate cancer have thus far shown gene therapy to be relatively safe, although definitive evidence of durable therapeutic efficacy remains to be demonstrated. In this article, recent preclinical research, current therapeutic strategies, and recent results of gene therapy clinical trials for the treatment of prostate cancer are reviewed. [ABSTRACT FROM AUTHOR]

The author discusses the article "Cavity lining after excavating caries lesions: Meta-analysis and trial sequential analysis of randomized clinical trials" by F. Schwendicke and colleagues. He outlines the results of the said study which evaluates the risk of failure with or without the use of a cavity liner following the removal of primary carious lesions after at least one-year.

The article presents an abstract of the article "Longevity of posterior resin composite restorations in adults-A systematic review" by J. Dagerhamn and colleagues and offers comments on the study. The author discusses the lack of evidence about the efficacy of composite resins against amalgams for dental restorations. He recommends further studies on the long-term survival of posterior composite resin restorations, but he thinks that their outcomes may prove obsolete.