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The thermal behavior of the anticancer drug-irinotecan was measured by Thermogravimetry-Differential thermal analysis (TG-DTA) to explore the application of TG-DTA in nanomedicine firstly. The TG-DTA result showed that the irinotecan was oxidized completely before 700 °C. When irinotecan was loaded onto nanosized mesoporous silica spheres, the loading capacity for irinotecan measured by TG-DTA was about 9.11% in the irinotecan/mesoporous SiO composite, similar to the typical UV-Vis spectra results (10.5%), which showed that TG-DTA characterization provided an alternative method to determine the drug loading amount on inorganic carriers. Secondly, Thermogravimetry-Differential scanning calorimetry-Mass Spectrometry coupling techniques (TG-DSC-MS) were used to characterize the hydrogen adsorption temperature and capacity of TiCr (V-Fe) alloy. The MS result showed that the released region of hydrogen was 250-500 °C, which was consistent with the TG-DSC results. Lastly, TA-MS combined with pulse thermal analysis (PulseTA) were used for a simultaneous characterizing study in the changes of mass, determination and quantitative calibration of the evolved nitrogen formed during the thermal decomposition of the InN powder. The results showed that relative error of this method between measured value and theoretical value was 2.67% for the quantitative calibration of evolved N. It shows that TA-MS combined with PulseTA techniques offer a good tool for the quantification of the evolved nitrogen in the InN powder. [ABSTRACT FROM AUTHOR]