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2. Structure of S35C flavodoxin mutant from Desulfovibrio vulgaris in the semiquinone state.

Author

Artali, R., Marchini, N., Meneghetti, F., Cavazzini, D., Cassetta, A., and Sassone, C.

Subjects
DESULFOVIBRIO, ANAEROBIC bacteria, GRAM-negative bacteria, GENETIC mutation, CYSTEINE proteinases
Abstract

The crystallographic structure of an engineered flavodoxin mutant from Desulfovihrio vulgaris has been analysed. Site-directed mutagenesis was used to substitute serine 35 with a cysteine to provide a possible covalent linkage. The crystal structure of the semiquinone form of this mutant is similar to the corresponding oxidation state of the wild-type flavodoxin. Analysis of the structural changes reveals the interaction between N(5)H of the flavin and the carhonyl 0 atom of G1y61 to he critical for modulation of the electrochemical properties of the protein. [ABSTRACT FROM AUTHOR]

Published
2005
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