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A constitutive model of unsaturated soils is developed by incorporating the concept of intergranular stress into the framework of the modified Cam–Clay model. Within this context, the degree of saturation is viewed as an internal state variable, so that the soil–water retention function appears naturally as an evolution equation for the volume fraction of water. The new model not only has a neat structure but also includes fewer material parameters compared to the other models. A new volumetric-hardening law is proposed by taking into account the effect of wetting-induced pore collapse. It is shown that the collapsing void ratio (the current void ratio minus the void ratio at full saturation under the same effective stress) is dominated by the degree of pore air saturation (one minus the degree of water saturation) and practically independent of intergranular pulling forces, highlighting the important effect of soil fabric on the wetting-induced pore collapse. The proposed model is applied to simulate different types of experiments on unsaturated soils subjected to various combined hydraulic and mechanical loadings, showing its capability and diversity in modeling the hydraulic and mechanical behavior of unsaturated soils. [ABSTRACT FROM AUTHOR]

Pore water chemistry can exert significant controls over the chemo-mechanical behavior of chemically active soils, which has not been characterized by using the traditional Terzaghi's effective stress to a satisfactory extent. In this paper, based on the concept of intergranular stress, a generalized effective stress for saturated active soils is reconceptualized and incorporated into the framework of the modified Cam–Clay (MCC) model to describe the mechanical response of soils upon complex chemical and mechanical loadings. The proposed model is capable of capturing very well the diverse features of the chemo-behavior of saturated active soils, while inheriting all the advantages of the MCC model, by introducing only one additional parameter. Within this context, a simple equation is derived to predict the development of swelling pressure with the variation of pore water chemistry. It is shown that the proposed swelling-pressure equation predicts very well the development of swelling pressure for expansive soils with a dilute pore solution, though discrepancy appears at high concentration. Because the double layer of clay particles is severely suppressed at high salt concentration, the microfabric of soil can be significantly changed, pointing to the importance of taking into account the effect of soil fabric in the constitutive modeling of active soils with high pore water concentration. [ABSTRACT FROM AUTHOR]

There are relatively few experimental studies on the hydromechanical and critical state behaviours of unsaturated silty sand. In this paper, suction-controlled, consolidated, drained triaxial shear tests were conducted on silty sand under saturated (net confining pressures of 100, 200, 300 and 400 kPa) and unsaturated (suctions of 30, 100 and 200 kPa and net confining pressures of 100, 200 and 300 kPa) conditions. For unsaturated silty sand, the effects of dry density, matric suction and net confining pressure on the hydromechanical and critical state behaviour were investigated, and the critical state parameters were obtained. The main findings for unsaturated silty sand included shear shrinkage at low dry density (1·6 g/cm3) and dilatancy at higher density (1·96 g/cm3). The peak shear strength was positively correlated with dry density, matric suction and net confining pressure. The critical state volumetric strain and critical state degree of saturation were negatively correlated with dry density and matric suction but positively correlated with net confining pressure. A new dilatancy equation that includes the state parameter for unsaturated silty sand was established. A unique critical state line passes through the origin in the effective stress p ∗ –deviator q plane, and its slope is the saturated critical state stress ratio M s . In the lnp*–v plane ( v is the specific volume), the critical state lines corresponding to different matric suctions are parallel. [ABSTRACT FROM AUTHOR]

The volume change behaviour of an unsaturated compacted loess under thermo-hydro-mechanical loads is comprehensively investigated in this experimental research. A new temperature/suction-controlled triaxial apparatus with triple cells was developed. Temperature- and suction-controlled isotropic tests, heating–cooling tests with isotropic net stress and suction control and drying–wetting tests with isotropic net stress and temperature control were conducted on an unsaturated compacted loess from Shaanxi, China. Experimental results show that compressibility indices remain unchanged at various temperatures, but show different variation trends with changes in suction. Both suction hardening and thermal softening were observed. Irreversible volumetric contraction is induced in the compacted loess upon heating–cooling path and becomes more significant at higher isotropic net stresses and higher suctions. Lower over-consolidation ratio prior to heating results in greater irreversible contraction in loess samples. Water-holding capacity of loess samples decreases upon heating, but it is independent of the stress level. The hydraulic hysteresis of samples has no significant change with temperature changes. Slight shrinkage occurs during drying process in loess samples, and collapse can be observed in wetting process. Heating has limited effect on the drying shrinkage of loess samples but induces more distinctive wetting collapse. [ABSTRACT FROM AUTHOR]

Loess is usually compacted as building filler in geotechnical engineering construction and the wetting-induced deformation characteristics of compacted loess are closely related to engineering safety. The influence of hydromechanical paths on compacted loess wetting-induced deformation characteristics has been rarely addressed in the literature, especially for compacted sandy loess. In this study, the scanning electron microscopy (SEM) and soil–water retention curve (SWRC) tests are performed to investigate the microstructure and water retention characteristics of compacted sandy loess. Single-oedometer triaxial wetting tests with three complex hydromechanical paths (consolidation-wetting under isotropic stress state, consolidation-loading-wetting-loading and consolidation-unloading-wetting-unloading under deviator stress) are carried out on unsaturated compacted sandy loess. Results indicate that: (1) As the dry density increases, the large inter-aggregate pores inside the compacted sandy loess turned into medium inter-aggregate pores and small inter-aggregate pores; the air entry value increases and the water retention capacity is enhanced. (2) Within a certain range of confining pressure (no more than 400 kPa), the wetting volumetric strain increases with the increase in confining pressure and dry density under isotropic stress condition; the loading paths wetting-induced deformation is greater than unloading paths wetting-induced deformation under deviator stress condition. (3) At a lower stress ratio, compacted sandy loess undergoes significant wetting-induced dilatancy; the wetting-induced deformation under the unloading path appears significant, compared with that under the loading path. [ABSTRACT FROM AUTHOR]

Focusing mainly on the compressive-shear (C-S) stress, the existing soil strength theories fail to well describe the soil strength under tenso–shear (T-S) stress and are not suitable for analyzing the tensile strength and T-S coupling strength. Taking the T-S strength into account, a three-dimensional nonlinear strength model of soil is established. The failure function on the π plane is a Lade Lade-curved triangle in principal stress space, which reasonably reflects the effect of medium principal stress. The failure function on the triaxial compression meridian plane is divided into the T-S and C-S zones, in which the two failure functions are smoothly connected at the closed stress point. To easily combine it with the specific elastoplastic constitutive theory, the proposed strength model is transformed into the D-P criterion in transformed stress space using the transformation stress method, which provides a theoretical foundation for numerical calculations. Compared with the true triaxial test results and numerical slope examples, the proposed model gives a good description of the nonlinear soil strength under complex stresses and the instability failure mechanism of the slope. [ABSTRACT FROM AUTHOR]

This paper proposes a detailed parametric design method for a round-pin inner-outer compound meshing silent-chain plate structure. A meshing design method for parameter harmonization among a silent chain, a sprocket hob, and an involute sprocket is proposed. To analyze the influence of extended arc parameters on the meshing process and impact, the extended arc parameter extension δ and height HY are considered as variables to formulate the motion-analysis model of the chain-drive system. The results reveal that the extended arc parameters δ and HY have a significant effect on the meshing process and the meshing impact. When δ and HY are optimal, the inner-outer compound meshing process of the chain-drive system can be smoothly realized; furthermore, the meshing impact force is minimal as it is reduced by more than 25 % compared to when only the outer meshing process occurs. Thus, the chain-plate structure is optimized. [ABSTRACT FROM AUTHOR]

In this study, a refined three-dimensional stratigraphic–structural model is established based on ABAQUS finite element software, and the basis for determining pneumatic and vibration loads is explained in detail. From this, the force characteristics of the segment and bolts with and without a cavity behind the lining under the action of multi-field coupling were analyzed, and the force law and corresponding safety of the segment structure and high-strength bolts were determined. The results show that the peak value of the maximum principal stress on the segment structure caused by the surrounding rock pressure was 92.7 times greater than the variation in the peak value of the maximum principal stress caused by additional loads (pneumatic and vibration loads). Despite this, the safety factor of the segment structure satisfied the code requirements. Compared to the situation with no cavity behind the lining, when the cavity behind the lining was small the stresses of the segment structure were large and concentrated, which increased the possibility of crack development in the segment structure. The nodal stresses and strains on the straight and bending bolts exhibited an approximately "W"-shaped distribution with a cavity behind the lining. In addition to the effect of the preload near the nut, the stress and strain at the central measurement point of the bolt rod at the joint face were larger owing to the coupling effect of multiple fields. The high-strength bolt remained in an elastic state and did not yield with damage. [ABSTRACT FROM AUTHOR]

Cell migration is a pivotal step in metastatic process, which requires cancer cells to navigate a complex spatially‐confined environment, including tracks within blood vessels and in the vasculature of target organs. Here it is shown that during spatially‐confined migration, the expression of insulin‐like growth factor‐binding protein 1 (IGFBP1) is upregulated in tumor cells. Secreted IGFBP1 inhibits AKT1‐mediated phosphorylation of mitochondrial superoxide dismutase (SOD2) serine (S) 27 and enhances SOD2 activity. Enhanced SOD2 attenuates mitochondrial reactive oxygen species (ROS) accumulation in confined cells, which supports tumor cell survival in blood vessels of lung tissues, thereby accelerating tumor metastasis in mice. The levels of blood IGFBP1 correlate with metastatic recurrence of lung cancer patients. This finding reveals a unique mechanism by which IGFBP1 sustains cell survival during confined migration by enhancing mitochondrial ROS detoxification, thereby promoting tumor metastasis. [ABSTRACT FROM AUTHOR]

The combined effect of stress and seepage is an important reason of engineering geological problems such as landslides, dam failures, and tunnel collapse. However, due to the limitations of the test apparatus, the existing studies rarely consider the stress effect in the seepage process. In this study, a soil column apparatus based on the wetting front advancing method was developed to explore the permeability properties of intensely weathered sandstone in a wide range of suction (10∼106 kPa). The results suggest that the wetting front advancing velocity decreased as the vertical stress increased during infiltration, which indicates that the stress changes the infiltration channel and affects the infiltration rate. On the other hand, due to the water sensitivity of intensely weathered sandstone, the soil column deformation before and after wetting is significantly different, indicating that water infiltration further exacerbates the deformation. When vertical stress is applied to the soil column, the permeability coefficient–suction curves at different sections are paralleled in general, which is affected by the variation in dry density and the non-uniform distribution of stresses inside the soil column. Moreover, as the initial dry density increases, the influence of the vertical stress on the permeability coefficient gradually decreases. [ABSTRACT FROM AUTHOR]

Contaminated soil management and renovation is one of the major environmental geotechnical issues in China. Due to their special strength and stiffness properties, contaminated soil has attracted extensive attention in foundation and slope stability design. For the differentiated influence of acidic/alkaline contamination on the geotechnical physical and mechanical characteristics of soil, this study mainly introduced a remodeled silty clay sample contaminated by acidic and alkaline solutions in the laboratory and conducted research into its basic physical properties, compressive properties, shear strength, and microstructure. It was shown that when the hydrochloric acid concentration increased from 1% to 7%, the density and specific gravity decreased by 7.07% and 3.11%, respectively. The void ratio showed a descending trend with increasing concentration of acid. The acidic solution concentration was negatively correlated with the cohesion of the soil, but the internal friction angle remained constant with a concentration of 1–5%. Alternatively, when the sodium hydroxide concentration increased from 1% to 7%, the density and specific gravity increased by 1.88% and 2.67%, respectively. The void ratio decreased linearly with the increase in consolidation pressure. Alkaline concentration could affect the internal friction angle and cohesion in a positive correlation. Through the observation of microstructure, the surface of acidified soil particles was smooth and flat, while the surface of alkalized soil particles was rough and uneven. The results can provide reference for the evaluation of the mechanical properties of soil contaminated by acid and alkali. [ABSTRACT FROM AUTHOR]

The microstructure can have an important impact on the hydraulic and mechanical behaviors of unsaturated soil; therefore, it must be considered in constitutive models to enable accurate predictions of soil behavior. This paper focused on the constitutive modeling of soils that exhibited a dual porosity structure. Based on the assumption that macro and micropores contained in the double porosity structure had different influences on the mechanical and hydraulic behaviors, the effective degree of saturation (Se) was selected as a microstructural index. This microstructural index was implemented within Bishop's effective stress-based approach and the Glasgow coupled (GCM) and modified Cam-Clay models (MCC) were adopted as the basic framework for the development of a constitutive model. Typical samples of low expansive, nonexpansive, and collapsible soils with dual porosity were selected to validate the model's performance, and the model performed well when compared with experimental data for isotropic compression, triaxial shear, and wetting tests. [ABSTRACT FROM AUTHOR]

A temperature-dependent water retention curve (WRC) model is necessary in numerous geotechnical engineering cases such as the disposal and storage of nuclear waste, buried high-voltage cables, heat dissipation embankments and geothermal structures. A series of pioneering models attempting to consider the mechanisms of temperature effect have been proposed. Nevertheless, it should be noted that very limited research can be found in the literature to consider temperature effects on both capillarity and adsorption. Thus, a temperature-dependent WRC model for both adsorption and capillarity is developed in this study. An adsorption equation is first proposed by integrating Kelvin equation, Clausius–Clapeyron equation and the adsorption enthalpy equation. Then, the proposed adsorption equation and an existing capillary equation are incorporated into Peters–Durner–Iden (PDI) model to establish the temperature-dependent WRC model. Sixteen series of non-isothermal WRC data are employed to illustrate the application and performances of the proposed model. The proposed WRC model provides good agreement between the predicted and measured temperature-dependent WRCs. Moreover, the main differences between different types of soils are temperature effects on adsorption. The value of parameter α gradually increases from sandy soils to bentonite, representing an increasingly strong soil–water interaction and increasingly significant temperature effects on adsorption. By comparing with three existing models, the proposed model is found as the most suitable for describing the observed data. [ABSTRACT FROM AUTHOR]

In this paper, the discrete element method is used to simulate triaxial tests of unsaturated soil under a tension–shear state. A relationship between water content and uniaxial tensile strength with different void ratios is obtained, which is applied to uniaxial tensile discrete element simulations to establish a relationship between grain-scale parameters and water content from back analysis. A group of triaxial simulations for unsaturated soil under a tension–shear state is then conducted. The discrete element method is used to obtain the relationship between deviatoric stress and axial displacement with different water contents, and also to reveal the effects of water content on peak strength and dilatancy phenomena with different confining pressures. The displacement fields of numerical specimen are analyzed qualitatively, and the mechanism and process of failure are discussed from the prospective of energy and dissipation. [ABSTRACT FROM AUTHOR]

Shear strength (τ) analysis has received considerable attention, because of its importance when designing various geotechnical structures, such as tunnels, retaining walls, shallow foundations, and slopes. Predicting the unsaturated τ from water retention curves (WRCs) is an existing method. The validity of this method for the prediction of unsaturated τ over a wide suction (ψ) range has been discussed by several researchers. However, the existing method ignores the influence of void ratio (e), which plays a strong part in the water holding capacity and the τ analysis of unsaturated soils. Therefore, according to an existing WRC equation that distinguishes capillary water and adsorbed water, a new WRC equation was proposed to consider the effect of e on the water holding capacity. In addition, using the e dependent WRC, a new method that predicted the τ of unsaturated silts or silty clays at various e over a wide ψ range (that included the residual zone) was proposed. The prediction of τ by the proposed method produced better predictions for experimental data than that of the existing method. [ABSTRACT FROM AUTHOR]

Pore ice content is crucial in evaluating the mechanical properties of frozen soils. Existing strength criterion models are usually empirical and ignore the influence of pore ice content. By assuming that the critical state shear stress ratio of soil is a function of the stress level, a critical state line of frozen soil is proposed to consider pore ice content. By combining the Mohr–Coulomb (M–C) and Drucker–Prager strength criteria to describe the failure shape characteristics on the deviatoric plane, a new strength criterion is established for complex stress conditions. The proposed model is validated against existing models and measured data in the literature. In addition, the proposed model can uniformly describe the CSL of different types of geotechnical materials and has a clear physical meaning, which may provide a theoretical basis for constitutive models. [ABSTRACT FROM AUTHOR]

North China Plain is the largest agricultural production center in China and wheat-maize rotation is a widespread cultivation practice in this area. As gross primary production (GPP) is a proxy of land productivity, research on its spatial-temporal dynamics helps understand the variation of grain production in wheat-maize rotation. Here, Moderate Resolution Imaging Spectroradiometer (MODIS) data and ground observation data were combined to drive Vegetation Photosynthesis Model (VPM) in GPP estimation over wheat-maize rotation area during 2000–2015. Annual GPP has increased by 540.95 g C m−2 year−1 from 2000 to 2015, while total annual GPP has grown ∼150% than that of 2000. Moreover, annual GPP showed an increasing trend in the consecutively wheat-maize rotation area between 2000 and 2015. A strong linear relationship between GPP estimates and grain production demonstrated the potential of using VPM model to evaluate grain production in wheat-maize rotation area of Henan province, China. [ABSTRACT FROM AUTHOR]

Based on previous research results and the three-dimensional strength characteristics of different soil types, a three-dimensional nonlinear strength model of soil considering tenso-shear (T-S) coupling strength and compressive-shear (C-S) strength is established. The proposed model can better describe the influences of intermediate principal stress and T-S coupling stress in soil. The secondary development of user material subroutine (UMAT) is conducted in ABAQUS. The UMAT procedure is programmed using an implicit backward Euler integral algorithm, and numerical experiments verify its accuracy. This procedure is then applied to the analysis of slope stability. Using the strength reduction method, the stability of the saturated slope and unsaturated slope are analyzed. The numerical results show that when the slope approaches instability, the T-S coupling plastic zone and T-S coupling failure surface develop downward from the top surface of the slope. The critical slip surface is a composite slip surface composed of a C-S slip surface and a T-S coupling failure surface. Compared with the M-C strength model, the three-dimensional nonlinear strength model can describe the failure mechanism of the slope more clearly and reasonably and can provide an accurate stability evaluation. [ABSTRACT FROM AUTHOR]

To construct urban metro stations, the concrete diaphragm walls are widely used as the support of deep foundation. During the installation of concrete diaphragm wall, the global instability of slurry trench may occur due to the insufficient internal support. The instability originates at a shallow depth blow ground surface and propagates to the ground surface. This paper develops a three-dimensional mechanism for analysing the trench global instability. In the mechanism, the instability is initiated by the movement of a rigid block with conical discontinuity surfaces. The trench stability is analysed using the kinematic approach of limit analysis and the upper bound solution of the safety factor is obtained. The optimal mechanism is achieved through minimising the safety factor. The critical depth of instability and the influence zone on the ground surface are identified. With the higher frictional angle, the critical failure depth becomes smaller and the volume of the failure zone decreases. The drop of slurry level significantly increases the risk of trench instability especially for cohesionless soils. The mechanism is validated through analysing the slurry trench instability during the construction of a subway station in Suzhou, China. The analysis result shows a close agreement with the field measurements. [ABSTRACT FROM AUTHOR]

In the past, the capillary effect is rarely considered for microcontact models when two adjacent particles are separated by a certain distance. In this paper, a liquid-bridge contact model of unsaturated particles is presented, which is applied to the discrete-element software PFC. Based on this, simulations of uniaxial tensile for unsaturated soils under (2D) situation are carried out, and influence of a water retention angle on uniaxial tensile strength are studied. The simulation results show that the uniaxial tensile strength of unsaturated soil decreases gradually with the increase of the water retention angle, obvious cracks generate at both ends of the soil samples, and the soil sample possesses a residual strength. According to the particle displacement field, velocity field, and contact force chain, the failure forms of samples with different water retention angles are determined. Based on the rose diagram of normal contact force, the changes of its direction and value during failure process are observed directly, so as to analyze the evolution law of contact force for unsaturated soils. [ABSTRACT FROM AUTHOR]

To study the phenomenon of convection diffusion and solute migration in porous media, the smoothed particle hydrodynamics method is used to solve the N–S equation describing pore water flow and the linear homogeneous second-order differential equation describing the solute diffusion process. The accuracy of the simulation method is verified by solving the one-dimensional definite solution of the convection diffusion equation at a low Peclet (Pe) number. Under the condition of a high Pe number, the simulation experiment of solute breakthrough porous media at the pore scale is simulated. Through the analysis of the velocity distribution of fluid particles in pore channels of porous media and the mechanical dispersion process of solutes in porous media, it is found that the flow velocity presents a parabolic distribution in the pore channel, and the particles with high velocity are mainly concentrated in the middle of the pore channel between the solid particles. The solute dispersion is obvious in porous media, and some fluid particles containing solutes penetrate porous media earlier along fast-flowing pore channels. Finally, the solute breakthrough curve and the motion path length of the particle are obtained through the simulation experiment. The calculation methods of the dispersion degree and tortuosity of porous media are further given, and the dispersion degree of porous media in this paper is 0.000 95 m. [ABSTRACT FROM AUTHOR]

An unsaturated soil constitutive model considering the influence of microscopic pore structure can more accurately describe the hydraulic–mechanical behavior of unsaturated soil, but its numerical implementation is more complicated. Based on the fully implicit Euler backward integration algorithm, the ABAQUS software is used to develop the established hydro-mechanical coupling constitutive model for unsaturated soil, considering the influence of micro-pore structure, and a new User-defined Material Mechanical Behavior (UMAT) subroutine is established to realize the numerical application of the proposed model. The developed numerical program is used to simulate the drying/wetting cycle process of the standard triaxial specimen. The simulation results are basically consistent with those calculated by the Fortran program, which verifies the rationality of the developed numerical program. [ABSTRACT FROM AUTHOR]

With the development of power electronics technology, power modules delivery considerably greater power density, which makes junction temperature an important parameter for reliable operation. Existing thermal models often ignore the influence of the thermal boundary conditions on the thermal parameter and cannot accurately predict junction temperature in various operating conditions. This article proposes a three-dimensional compact thermal network model that considers the thermal boundary conditions and can be obtained by the finite-element method (FEM). A novel two-step method for thermal parameter extraction is presented and the effects of boundary conditions on thermal network parameters are discussed in detail. The experimental results and FEM simulation show that the proposed thermal network model can accurately estimate the junction temperature in different thermal boundary conditions. [ABSTRACT FROM AUTHOR]

Most soil mechanics theories are limited to strain hardening and shrinkage under high compressive stresses, and there are some shortcomings in the selection of suction or degree of saturation as the water content state varies in the constitutive models of unsaturated soil. Based on the triaxial shear tests of unsaturated compacted soil (a silt of high plasticity) with different water content and confining pressure (low-confining), a shear dilatancy model of unsaturated soil based on the mass water content is proposed in this paper. The influence of the water content on the shear deformation characteristics of the unsaturated soil is analysed. The stress–dilatancy relationship and the prediction equation of the minimum dilatancy rate of the unsaturated soil under different water content and different confining pressure are provided. Selecting the mass water content as the state variable, a constitutive model suitable for the dilatancy of unsaturated soil is established. The method of determining model parameters based on the mass water content is analysed. The applicability of the model is verified by comparisons between the predicted and experimental results. [ABSTRACT FROM AUTHOR]

The interparticle bonding effect due to water menisci plays an important role in the hydromechanical coupling properties of unsaturated soils. This paper presents an unsaturated hydromechanical coupling model that considers the influence of matric suction, degree of saturation, and microscopic pore structure on the interparticle bonding effect. The enhanced effective stress and bonding variable are selected as constitutive variables. The bonding variable is correlated with the ratio between unsaturated void ratio and saturated void ratio. The deformation characteristics of unsaturated soils are described based on the bounding surface plasticity theory. A soil–water characteristic model that considers deformation and hydraulic hysteresis is integrated into the constitutive model to achieve hydromechanical coupling. The proposed model can effectively describe the hydromechanical coupling characteristics and the meniscus bonding force of unsaturated bimodal structure soils; the model parameters can be easily obtained through routine experiments. The experimental results of unsaturated isotropic compression, the wetting/drying cycle, and unsaturated triaxial shear tests are used to validate the capability of the proposed model. [ABSTRACT FROM AUTHOR]

In this paper, the law of ice-rich permafrost embankment thaw consolidation is studied based on three-dimensional nonlinear large strain thaw consolidation theory. To avoid problems associated with numerical simulation efficiency and stability when a nonlinear stress-strain relationship is employed, a segment interpolation function is used to implement the nonlinear relationship between the compression modulus and the void ratio, and the corresponding simulation strategy is proposed. Through a comparison of the monitoring and calculated results, it is indicated that the calculation accuracy on ice-rich embankment thaw settlement can be notably improved after nonlinear theory is implemented with the proposed numerical simulation method. A further analysis of the calculated results indicates that the interactive effects between the thermal and mechanical fields can be more reasonably described by nonlinear theory than by linear theory. It is also determined that the postthaw pore water in the shallow embankment dissipates in the early operation period, while in the following long operation period, the development of the permafrost embankment thaw settlement is mainly due to the dissipation of newly postthaw pore water at the thaw depth or the permafrost table. This is one of the main differences in the law of permafrost embankment thaw settlement compared with that of unfrozen embankments. [ABSTRACT FROM AUTHOR]

This paper presents an experimental investigation of the soil water retention curve (SWRC) and volume change curve over a large suction range (0–286.7 MPa), and microstructure evolution of Guilin lateritic soil under drying and wetting processes. The scanning electron microscopy results show that the reconstituted and compacted samples have very different microstructures. The soil samples compacted at optimum water content features flocculation of the colloids showing a low degree of particle orientation, while the reconstituted samples prepared from slurry produce dispersed arrangement of particles showing a high degree of particle orientation. The pore size distribution curves of reconstituted and compacted samples show the unimodal and bimodal distributions, leading to S-shaped and double S-shaped SWRCs, respectively. At the same initial density, the soils with a low degree of particle orientation (like compacted samples) exhibit less shrinkage than those with a high degree of particle orientation (like reconstituted samples). The mercury intrusion porosimetry test results show that the drying and wetting processes and initial density clearly affect the macropores of the compacted samples, while the micropores remain almost unchanged. For the reconstituted samples, the drying and wetting processes and initial density primarily affect the micropores. [ABSTRACT FROM AUTHOR]

There is an urgent need to understand the characteristics of both precipitation and drought in arid regions of China. Different indexes may provide differing results in terms of the detection and estimation of the temporal and spatial extent of droughts. In this study, the temporal and spatial characteristics of rainfall and drought at 53 meteorological stations from 1960 to 2016 across the Xinjiang region of China were analyzed. Four precipitation-related indexes (precipitation concentration degree (PCD), precipitation concentration period (PCP), standardized precipitation index (SPI), and long-cycle drought–flood abrupt alternation index (LDFAI)) were used to investigate the spatial and temporal patterns of drought and flood. In addition, the Bayesian method and Pettitt test were used as detection tools to identify changing points in precipitation time series. The study indicated the following: (1) a wetting tendency was evident in recent years and was supported by the upward trend in SPI and inter-decadal variation in summer precipitation; (2) the spatial patterns and tendencies of PCD, PCP, and SPI were markedly different in southern and northern Xinjiang; (3) compared with the Pettitt test, use of the Bayesian method provided data closer to the real drought events; (4) it is suggested that multiple indices be used for detecting precipitation and drought characteristics as use of the SPI may lead to other indexes related to flood and drought risks being ignored. [ABSTRACT FROM AUTHOR]

At present, there is no clear understanding of the influence of differences in soil mineral composition, particle size grading, and hydraulic paths on the shear strength of unsaturated soil, and the related strength models are not applicable. The shear strength characteristics of different saturation specimens under different hydraulic paths were studied on two granite weathered soils. The experimental results show that the shear strength index of the prepared specimen is "arched" with the increase of saturation, and the dehydration specimen decreases linearly with the saturation. As considering the cementation of free oxides in soils and the interaction among soil particles at different saturations, it is assumed that there are three different contact modes among soil particles: direct contact, meniscus contact, and cement contact. The difference in contact modes will reflect the different laws of shear strength. A shear strength model capable of distinguishing between the capillary effect and the adsorptive effect was established. The model predicted and verified the shear strength data of granite weathered soil under different hydraulic paths well, and then theoretically explained the evolution law of the shear strength of granite weathering soil under the change of saturation. [ABSTRACT FROM AUTHOR]

An ABAQUS UMAT subroutine was used for the secondary development of the established coupled hydromechanical constitutive model of unsaturated soil considering the effect of the microscopic pore structure. Combined with Euler's backward implicit integration algorithm, a numerical program was established for simulating the proposed model. The developed numerical program was used to simulate the rainfall infiltration process of an actual slope engineering example, and the effects of rainfall intensity and rainfall duration on the pore pressure, fluid velocity, and displacement of the unsaturated soil slope were analyzed. The results show that the developed numerical program can reasonably analyze the changes in the seepage field and displacement field of unsaturated soil slopes under rainfall infiltration. [ABSTRACT FROM AUTHOR]

This paper describes the development of a direct tension apparatus and its application to test the tensile strength of unsaturated fine sands. The apparatus consists of two halves of wedge-shaped specimen molds. A criterion is developed for designing the inclination angle of the inner sidewall of the specimen molds as a function of soil–wall interface frictional angle and soil dilatancy angle. Tensile strength of unsaturated fine sands is measured over a range of dry density and water content. Results show that tensile strength generally increases with the increase in dry density. For relatively dense sand, tensile strength follows a non-monotonic double-peak pattern with increasing water content. The first peak occurs in the pendular regime and is attributed to peak occurrence of interparticle stress contributed by pendular water bridges. The second peak occurs in the capillary regime and is attributed to the capillary component of interparticle stress arising from negative pore pressure. [ABSTRACT FROM AUTHOR]

This study presents a rate-independent constitutive model for granular materials which is based on the analysis of discrete element modelling (DEM) results. We examine the elastic and plastic strain rate at any state of shear, and explore how the plastic strain rate and the stress rate are related to some state variables (e.g. stress, void ratio, etc.). The elastic and plastic strain rate are evaluated by assuming that the rate of conservative energy defined in term of elastic strain rate equals the energy rate from work–energy analysis of granular assemblies. The verification of the theoretical work–energy analysis and the acquire of data regarding the mechanical rates at contacts between grains are done through DEM. It is shown that for a representative element volume of granular materials, the external work rate equals the sum of an elastic energy rate and a dissipation rate at contacts. The work rate is either the product of stress and strain rate or the sum of discrete work rate of external forces. Equations regarding the dilatancy, plastic deviatoric strain rate and stress rate are proposed. In the model, a yield surface is not explicitly defined and the deviatoric stress rate is related to not only the elastic deviatoric strain rate, but also a rate of dilatancy. Simulations show that the predictions match both virtual and Toyoura sand satisfactorily in various shear tests within a board range of densities. Additionally, the calibration of parameters is extremely simple. The treatment of cyclic loading condition is also presented. [ABSTRACT FROM AUTHOR]

This paper presents a study of the tensile strength of unsaturated soil by a DEM model in a novel uniaxial tensile test device. For validation and comparison, traditional triaxial shear test of unsaturated soil are also conducted. In the DEM model, the capillary effects and some other cementation effects are modelled by a bond, whose strength is a function of the moisture content and void ratio in uniaxial tensile tests and also the confining pressure in triaxial tests. To compare the DEM simulations with experiments, the bond strength function is calibrated through a quantity measurable in both laboratory and DEM simulations such as the shear strength in triaxial tests or the uniaxial tensile strength in uniaxial tensile tests. The comparison shows that the proposed model is able to capture the phenomena observed in experiments. Most importantly, through investigation of the grain-scale data such as the motion, force chains and development of fractures, it is possible to explain some macroscopic observations such as the form of shear bands in the sample, the influence of the moisture content on the shear and tensile strength, etc. [ABSTRACT FROM AUTHOR]

Summary: This study uses an incompressible smoothed‐particle hydrodynamics model to investigate the interaction between dry granular material flows and rigid barriers. The primary aim is to summarise some practical guidelines for the design of debris‐resisting barriers. The granular materials are modelled as a rigid‐perfectly plastic material where the plastic flow corresponds to the critical state. The coupled continuity equation and momentum equation are solved by a semi‐implicit algorithm. Compared with flows in controlled flume experiments, the model adequately reproduces both the kinetic of the flows and the impact force under various conditions. Then the numerical simulations are used to study the detailed interaction process. It is illustrated quantitatively that the interaction force consists of two parts, ie, the earth pressure force caused by the weight of the soil and a dynamic force caused by the internal deformation (flowing mass on top of a dead zone). For the estimation of impact load, this study suggests that an increased earth pressure coefficient depending on the Froude number should be incorporated into the hydrostatic model. [ABSTRACT FROM AUTHOR]

Polycystic ovary syndrome (PCOS) is a complex, heterogeneous endocrine and metabolic disorder affecting 5% to 10% of reproductive-age women. A high rate of granulosa cell (GC) proliferation contributes to the abnormal folliculogenesis in patients with PCOS. Evidence has proved that dysregulation of microRNAs is involved in the pathogenesis of PCOS. In this study, we investigated the effect of miR-145 on cell proliferation and the underlying mechanism of miR-145 in isolated human GCs from the aspirated follicular fluid in women with PCOS. Our findings showed that miR-145 is downregulated in human GCs from PCOS. The miR-145 mimics suppress cell proliferation and promoted cell apoptosis in human GCs from PCOS. However, miR-145 inhibitor promotes cell proliferation and inhibited cell apoptosis. Moreover, using a dual-luciferase reporter assay, we confirmed that the insulin receptor substrate 1 (IRS1) gene is a direct target of miR-145. The miR-145 mimics inhibited messenger RNA and protein IRS1 expression levels, and silencing of IRS1 by small interfering RNA inhibits human GC proliferation, but IRS1 overexpression abrogates the suppressive effect of miR-145 mimics. Furthermore, miR-145 mimics can inhibit the activation of p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal-regulated kinase (ERK). The IRS1 overexpression abrogates the suppressive effect of miR-145 mimics on MAPK/ERK signaling pathways. Together, miR-145 mimics suppress cell proliferation by targeting and inhibiting IRS1 expression to inhibit MAPK/ERK signaling pathways. Our study further found that high concentrations of insulin decreases the miR-145 expression, upregulates IRS1, and promotes cell proliferation. These observations showed that miR-145 is a novel and promising molecular target for improving the dysfunction of GCs in PCOS. [ABSTRACT FROM AUTHOR]

Paclitaxel resistance becomes common in patients with aggressive ovarian cancer and results in recurrence after conventional therapy. Galectin-3 is a multifunctional lectin associated with cell migration, cell proliferation, cell adhesion, and cell-cell interaction in tumor cells. Whether circulating galectin-3 is involved in paclitaxel resistance in ovarian cancer remains unknown. The current study investigated the effect of galectin-3 on toll-like receptor 4 (TLR4) signaling and thus paclitaxel resistance. With blood and cancer tissue samples obtained from 102 patients, we identified associations between serum galectin-3 level or TLR4 expression and paclitaxel resistance phenotype. In vitro, treatment with exogenous galectin-3 restored cell survival and migration of SKOV-3 and ES-2 cells was decreased by galectin-3 silencing and paclitaxel treatment. Furthermore, exogenous galectin-3 boosted expression of TLR4, MyD88, and p-p65, as well as interleukin (IL)-6, IL-8, and vascular endothelial growth factor (VEGF) release induced by paclitaxel. Moreover, galectin-3 inhibited the interaction between TLR4 and caveolin-1 (Cav-1) in SKOV-3 and ES-2 cells. In addition, overexpression of Cav-1 dampened the expression of MyD88 and p-p65 stimulated by galectin-3 and enhanced apoptosis in SKOV-3 cells under paclitaxel exposure. In summary, our study elucidated that exogenous galectin-3 might induce paclitaxel resistance through TLR4 signaling activation by inhibiting TLR4-Cav-1 interaction, revealing a novel insight into paclitaxel resistance induction. [ABSTRACT FROM AUTHOR]

Cocaine- and amphetamine-regulated transcript (CART) peptide is implicated in the control of avian energy balance, however, the structure and expression of CART gene(s) remains largely unknown in birds. Here, we cloned and characterized two CART genes (named cCART1 and cCART2) in chickens. The cloned cCART1 is predicted to generate two bioactive peptides, cCART1(42-89) and cCART1(49-89), which share high amino acid sequence identity (94-98%) with their mammalian counterparts, while the novel cCART2 may produce a bioactive peptide cCART2(51-91) with 59% identity to cCART1. Interestingly, quantitative RT-PCR revealed that cCART1 is predominantly expressed in the anterior pituitary and less abundantly in the hypothalamus. In accordance with this finding, cCART1 peptide was easily detected in the anterior pituitary by Western blot, and its secretion from chick pituitaries incubated in vitro was enhanced by ionomycin and forskolin treatment, indicating that cCART1 is a novel peptide hormone produced by the anterior pituitary. Moreover, cCART1 mRNA expression in both the pituitary and hypothalamus is down-regulated by 48-h fasting, suggesting its expression is affected by energy status. Unlike cCART1, cCART2 is only weakly expressed in most tissues examined by RT-PCR, implying a less significant role of cCART2 in chickens. As in chickens, 2 or more CART genes, likely generated by gene and genome duplication event(s), were also identified in other non-mammalian vertebrate species including coelacanth. Collectively, the identification and characterization of CART genes in birds helps to uncover the roles of CART peptide(s) in vertebrates and provides clues to the evolutionary history of vertebrate CART genes. [ABSTRACT FROM AUTHOR]

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Solid-fluid interactions in unsaturated expansive clays can be divided into capillarity and adsorption effects based on their physical mechanisms. Most constitutive models for unsaturated soils are proposed on the basis of the capillarity mechanism, ignoring the contributions of the adsorption effect to mechanical and hydraulic behaviors. For expansive clays, however, the adsorption effect which leads to more complex behavioral characteristics than that in low plasticity clays cannot be ignored. In the light of this, a new binary-medium model for unsaturated expansive clays is proposed, involving a consideration of the solid-fluid interactions stemming from the capillary and the adsorption mechanisms at the same time. Firstly, we assume that expansive clay is a mixture of two ideal parts, i.e. the ideal capillarity part and the ideal adsorption part, and then an ideal capillarity model and an ideal adsorption model, each of which is available for the corresponding ideal part, are established. Furthermore, a participation function is used to reflect the degrees of capillarity effect and adsorption effect. Finally, predictions are performed on the results of the consolidation tests and the cyclical controlled-suction tests published in literature. After comparing predicted results with test results, it is illustrated that the established model can quantitatively predict mechanical and hydraulic behaviors in expansive clays. [ABSTRACT FROM AUTHOR]

In this paper, based on the porous media theory, the specific expressions of the total stress and the input work of unsaturated expansive soils with double porosity are proposed, and then the energy-conjugate variables are further derived. We make distinctions between the effects of capillary water and adsorbed water on the soil behaviour, as well as between the deformations of micro- and macrostructure. According to the derived input work expression and the work-energy-dissipation relations for an open multiphase thermodynamic system, we establish a thermodynamics-based modelling framework for unsaturated expansive soils with double porosity. [ABSTRACT FROM AUTHOR]

With the development of modern geotechnical engineering practices such as the construction of high level radioactive waste repositories, exploitation and utilization of geothermal resources, energy-saving buildings and underground storage of CO, research into the influence of temperature on the basic mechanical properties of unsaturated soils has become an important issue internationally. By using the work expression and considering the influence of temperature on the basic properties of unsaturated soils, the average soil skeleton stress, modified suction and temperature were selected as state variables of generalized forces in thermodynamics and the soil skeleton strain, saturation and entropy were chosen as state variables of generalized flows conjugate to the variables of generalized forces. Based on the nonlinear multi-field coupled model and by using existing experimental results, an elastic-plastic constitutive model of unsaturated soils under non-isothermal conditions was developed to analyze the influence of temperature on the deformation properties of unsaturated soils. The model was used to predict and analyze the influence of suction and temperature on the deformation properties of unsaturated soils under isotropic conditions, and was successfully verified using experimental results. [ABSTRACT FROM AUTHOR]

The influence of gases on unsaturated soils is discussed in the paper. First, the selection of stress state variables is discussed. It is shown that gas pressure as well as generalized effective stress and modified suction are required to construct a constitutive model of an unsaturated soil. The deformation mechanisms of solid, liquid and gas phases in soils are then investigated. It is realized that the deformation of gas phase interacts with the deformations of the other two phases in soils. Gas laws are used to describe the gas behavior. Similar to the other two phases in soil, the change of gas volume can be divided into an elastic part and a plastic part, and the latter part is then introduced to the soil hardening equation to reflect the impact of the gas on the soil. Then, a simple elasto-plastic model considering the gas effect for isotropic states is developed. Finally, the model predictions are given and compared with existing experimental data. A good agreement between them is found. Comparisons of the predictions between our model and Wheeler's model are also performed. [ABSTRACT FROM AUTHOR]

nonlinear multi-field coupled model for multi-constituent three-phase soils is derived by using the hybrid mixture theory. The balance equations with three levels (constituents, phases and the whole mixture soil) are set up under the assumption that soil is composed of multi-constituent elastic-plastic solid skeleton (which is different from the linearization method) and viscous liquid and ideal gas. With reasonable constitutive assumptions in such restrictive conditions as the principles of determinism, equipresence, material frame-indifference and the compatible principle in continuum mechanics, a theoretical framework of constitutive relations modeling three-phase soil in both non-equilibrium and equilibrium states is established, thus the closed field equations are formed. In the theoretical framework, the concept of effective generalized thermodynamic forces is introduced, and the nonlinear coupling constitutive relations between generalized dissipation forces and generalized flows within the system at nonequilibrium state are also presented. On such a basis, four special coupling relations, i.e., solid thermal elastic-plastic constitutive relation, liquid visco-elastic-plastic constitutive relation, the generalized Fourier's law, and the generalized Darcy's law are put forward. The generalized or nonlinear results mentioned above can degenerate into the linear coupling results given by Bennethum and Singh. Based on a specific dissipation function, the concrete form of generalized Darcy's law is deduced, which may degenerate into the traditional form of Darcy's law by neglecting the influence of skeleton deformation and temperature. Without considering temperature and other coupling effects, the nonlinear coupled model in this paper can degenerate into a soil elastic-plastic constitutive model. [ABSTRACT FROM AUTHOR]