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BACKGROUND: Statins have anti-inflammatory actions which in theory are potentially beneficial in asthma. Small trials have failed to show a significant benefit, but a systematic study to evaluate the steroid-sparing effect of statin treatment has not been carried out. METHODS: A randomised, placebo-controlled, crossover trial was conducted of simvastatin 40 mg at night with simultaneous stepwise reduction of fluticasone propionate dose until loss of control occurred, followed by an increase until regain of control (‘minimum’ dose required) in 51 patients with asthma and sputum eosinophils (steroid-free) ≥2%. RESULTS: 43 patients completed the study. There was no significant difference in ‘minimum’ inhaled corticosteroid (ICS) dose requirement between simvastatin and placebo: (median (IQR) 50 µg daily (0–250) vs 100 µg daily (0–250), p=0.931). ‘Minimum’ dose distribution was similar (p=0.269). The fluticasone dose at which loss of control occurred did not differ significantly between simvastatin and placebo (p=0.404). In patients with loss of control in both treatment arms, fluticasone dose at loss of control was similar with simvastatin and placebo (median (IQR) 50 µg daily (0–100) for both, p=0.620). In those patients who reached 0 µg/day (n=18), Astma Control Questionnaire (ACQ) was lower (p=0.037), forced expiratory volume in 1 s (FEV1) higher (p<0.01) and sputum eosinophils lower with simvastatin compared with placebo (9.5% compared with 25.4%, p=0.033). CONCLUSIONS: Simvastatin does not have clinically important steroid-sparing effects in patients with eosinophilic asthma. In the absence of steroid, simvastatin is associated with minor improvements in symptoms and lung function, and a reduction in sputum eosinophils. CLINICAL TRIAL NUMBER: ACTRN12606000531516. [ABSTRACT FROM AUTHOR]

Purpose - This paper sets out to provide a consensus position on the potential for the inclusion of small businesses in electronic platforms in the food industry. Design/methodology/approach - The consensus was derived through a Delphi-type series of questions in an open forum of academics and industrialists across Europe. Findings - The consensus reached was of the proven benefits of electronic platforms for small businesses and the need for further research to assess how small businesses can incorporate electronic traceability and supply chain management systems into their existing operations. Practical implications - Electronic platforms are spreading rapidly in the food industry. However, there is some concern that small businesses are not aware of the potential for electronic supply chains such as the potential that electronic traceability offers smaller networks to supply highly demanded food quality attributes such as organic production and regional foods. Originality/value - The paper addresses the highly topical issue of food origin with a new approach to the supply technologies behind the product. [ABSTRACT FROM AUTHOR]

In an attempt to mitigate the effects of the atmosphere on the coherence of an optical (laser) beam, interest has recently been shown in changing the beam shape to determine if a different power distribution at the transmitter will reduce the effects of random fluctuations in the refractive index. Here, a model is developed for the field of a flattened Gaussian beam as it propagates through atmospheric turbulence, and the resulting effects on the scintillation of the beam and beam wander are determined. A comparison of these results is made with the like effects on a standard TEM00 Gaussian beam. The theoretical results are verified by comparison with a computer simulation model for the flattened Gaussian beam (FGB). Further, a determination of the probability of fade and of mean fade time under weak fluctuation conditions is determined using the widely accepted lognormal model. Although this model has been shown to be somewhat optimistic when compared to results obtained in field tests, it has value here in allowing us to compare the effects of atmospheric conditions on the fade statistics of the FGB with those of the lowest order Gaussian beam. [ABSTRACT FROM AUTHOR]