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A procedure is presented for finding the shortest network connecting three given undirected points, subject to a curvature constraint on both the path joining two of the points and the path that connects to the third point. The problem is a generalisation of the Fermat–Torricelli problem and is related to a shortest curvature-constrained path problem that was solved by Dubins. The procedure has the potential to be applied to the optimal design of decline networks in underground mines. [ABSTRACT FROM AUTHOR]

Renewable multifunctional materials are crucial for advancing industries such as electronics and packaging. This study investigates the potential of graphene nanoplatelet (GNP) and multi-wall carbon nanotube (MWCNT) reinforcement in poly(lactic acid) (PLA)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blends for multifunctional packaging. Employing solvent-free techniques, we conducted a comprehensive analysis of morphological, thermal, mechanical, antimicrobial, and biodegradable properties. High-resolution scanning electron microscopy (FEG-SEM) was applied to evaluate the nanofiller morphologies and the immiscibility between PLA and PHBV, while differential scanning calorimetry (DSC) confirmed crystallinity changes induced by carbon nanomaterials. Mechanical tests demonstrated remarkable enhancements, notably a 30% increase in elastic modulus and 195% in ultimate tensile strength. Antimicrobial assays revealed exceptional effectiveness, especially in GNP-containing nanocomposites. Crucially, biodegradation tests highlighted compatibility with the blend. A Life Cycle Assessment (LCA) underscored significant eco-efficiency, minimizing harmful emissions. These findings emphasize the potential of MWCNT, GNP-reinforced PLA/PHBV nanocomposites for diverse applications and as eco-friendly alternatives to conventional plastics. [ABSTRACT FROM AUTHOR]

Background: The academic development and widespread adoption of meditation practices for well-being and therapy have predominantly focused on secularised adaptations of Buddhist and Hindu techniques. This study aims to expand the field by investigating Christian and Islamic meditation that emphasize the spiritual significance of the heart through elements of visualisation and recitation. It compares the effects of spiritual heart-centred meditation with mindfulness meditation and a waitlist control, focusing on dimensions of social functioning, psychophysiology, cognition, and mental health. Method: This study employs a stratified 3-arm randomised controlled method with mixed-method repeated measures across three assessment time points: before intervention (T1), after an 8-week intervention (T2), and at a 3-month follow up (T3). The three conditions include spiritual meditation (either Christian or Islamic), mindfulness meditation (Mindfulness-Based Stress Reduction – MBSR), and a waitlist. Participants will be stratified into Christian and Muslim samples and randomly allocated to the spiritual meditation, MBSR, or waitlist control conditions. Importantly, participants assigned to the spiritual meditation condition will be matched to the spiritual meditation program corresponding to their religion. The intervention will be administered through a mobile phone app with daily 20-minute guided meditation sessions for eight weeks. Primary outcomes pertain to the domain of interpersonal functioning, focusing on prosociality, forgiveness, empathy, and perspective taking. Secondary outcomes include physiology: pain tolerance, pain intensity, stress reactivity assessed via heart rate (HR) and heart rate variability (HRV), psychophysiological reactivity associated with a forgiveness task as measured through HR and HRV, attention (alerting, orienting, and executive attention networks), and mental health (stress, depression, anxiety, subjective well-being, positive and negative affect). Discussion: This trial aims to test the effects of an app-based Christian and Islamic meditation, compared to secular mindfulness and a waitlist, using a randomised controlled trial. If the results yield positive outcomes, this study will support the efficacy of these contemplations, offering practitioners a way to enhance their well-being within their religious framework. Trial registration: ClinicalTrials.gov, NCT06136676. Registered on 18 November 2023. https://clinicaltrials.gov/study/NCT06136676. [ABSTRACT FROM AUTHOR]

Large-scale evaluation permeates the UK university system, but some countries are rejecting harsh judgements and emphasizing strategic development. [ABSTRACT FROM AUTHOR]

To explore school nurses' roles globally through their own perceptions of what they do and how they do it and to compare the realities for the role its representation in professional literature. A comprehensive narrative literature review, using ENTREQ guidelines, with "qualitizing" of the quantitative literature, and athematic analysis was carried out. Findings were reviewed in relation toestablished theory. CINAHL, Medline, Cochrane Library, and Embase were systematically searched from 2000–2021. Included studies focused on school nurses'perceptions of their own practice. Five themes: direct care, health promotion, collaboration,support from school and health authorities and promoting the school nurses'role were found. These themes were closely aligned to the National Associationfor School Nurses' framework for 21st century practice. However, the schoolnurses signposted areas where they need support in carrying out their job tothe highest standard. School nurses are important to support thehealth needs of students while at school. They also, particularly in areas likethe United Arab Emirates where resources are being invested in the role, have a unique role to play in health promotion, leading to improved health literacy,as positive health behaviors tend to be learned young. However, worldwide, thepotential for the school nursing role needs to be recognized and supported by healthand education providers, by families and within the schools for its fullpotential to be achieved. [ABSTRACT FROM AUTHOR]

Most studies examining empathy in psychopathy and autism agree that different components of empathy are implicated in each condition. Most of these studies, however, have relied on a two-component model of empathy (emotional and cognitive). Our study examines how psychopathic and autistic traits may be associated with the components of a more differentiated model of empathy that includes affective (i.e., feeling what others feel), cognitive (i.e., knowing what others feel), and motivational/sympathetic components (i.e., caring what others feel). The study included 884 college students who completed self-report measures of psychopathic and autistic traits as well as the three components of empathy. Using path modeling, we found that of the three components of empathy, sympathetic empathy was uniquely negatively associated with psychopathic traits and each of its dimensions whereas cognitive empathy was uniquely negatively associated with autistic traits and each of its dimensions. Affective empathy was not uniquely associated with either psychopathic or autistic traits. Our findings suggest that sympathetic aspects of empathy are uniquely implicated in psychopathy and cognitive aspects of empathy are uniquely implicated in autism, but neither condition may have core problems with affective empathy. We suggest that etiological models and treatment approaches might consider the implications of a three-component model of empathy for psychopathy and autism. [ABSTRACT FROM AUTHOR]

This paper investigates the deep-sea morphology and sedimentary processes within the Santa Catarina Plateau and the Vema Channel, prominent features crucial for influencing bottom circulation in the western South Atlantic and regulating the exchange of deep and bottom waters between the Argentine and Brazil basins. The study leverages a unique dataset comprising multibeam data for generating detailed digital terrain models and sub-bottom profiling records, alongside numerical modeling of bottom current velocities (GLORYS12V1 reanalysis). Numerous sediment waves, predominantly cresting mudwaves and mass-wasting deposits associated with steeper sea floor gradients, were identified in the region, aligning with findings from the Argentinian and South Brazilian slopes. The investigation of these features contributes not only to the identification of contourites but also to the enhancement of understanding regarding deep-water circulation within the 3,500-to-4,500-meter range. This depth range serves as a critical transition zone between the Argentine and Brazil basins and plays a pivotal role in elucidating the northward distribution of Antarctic Bottom Water (AABW), an integral component of the Atlantic meridional circulation. In contrast to prior studies that focused on specific regions of the plateau, this research offers a comprehensive overview of the region's morphology and sedimentary processes, thereby advancing comprehension of deep-water circulation dynamics between the Argentinian and Brazilian basins. [ABSTRACT FROM AUTHOR]

Background: Sicariidae is a small family of cryptic and recluse spiders, with 178 species grouped into three genera: Hexophtalma, Loxosceles and Sicarius. Only the last two occur in Brazil, where 29 species are recorded, with a greater number of records in the Southeast and South regions. To date, there is no regionalized study of the distribution of these spiders in the Northeast of Brazil. We presented more than four decades of data on the distribution of sicariid spiders in the state of Bahia. Our research aimed to identify and evaluate the distribution of sicariid species in this region, characterizing them in their biomes and phytophysiognomies. Methods: Data covers a period from 1983 to 2024, obtained from articles describing species recorded in Bahia and from three scientific collections from Brazilian institutions: Universidade Federal da Bahia (MHNBA); Instituto Butantan (IBSP); Universidade Federal de Minas Gerais (UFMG). Maps were produced using the QGIS 3.34.1 software, based on geographic coordinates obtained from the original literature, when provided. Species without information on geographic coordinates were georeferenced using the SpeciesLink (geoLoc tool) for the municipalities. Biomes were consulted on the georeference Brazilian institute website and the phytophysiognomies were ignored when not specified in the data of collections or original literature. Results: We confirmed 14 species of sicariid spiders in the state of Bahia, eight from the genus Loxosceles (i) and six from Sicarius. The species were recorded in 48 municipalities, located mainly in the Caatinga biome. We recorded a distribution expansion of seven species: Loxosceles amazonica, L. chapadensis, L. karstica, L. similis, Sicarius cariri, S. ornatus and S. tropicus. There is a difference in species composition in the two regions separated by the São Francisco River, an important geographic barrier especially for small invertebrates. More than 75% of the species were registered in the east side and about 20% exclusively in the west side: L. boqueirao, L. cardosoi, L. carinhanha. This suggests the need for future studies to evaluate additional variables that determine community structure, especially considering their low vagility and reclusive behavior. Although Sicarius are found almost exclusively in the Caatinga, there are isolated records from Restinga and dry forest enclaves in the Cerrado domain and Atlantic Forest areas. This reinforces the possibility of them being able to adapt to slightly wetter environments erase colonize and survive in seasonally dry rainforest areas. Unlike Sicarius (i), Loxosceles (i) occupy a wide variety of habitats in natural, urban and domiciliary situations. Many of the records here such as for Loxosceles boqueirao, L. cardosoi, L. carinhanha, L. chapadensis, L. karstica and L. troglobia were obtained at caves or nearby areas, which appear to be attractive habitats for these nocturnal spiders. [ABSTRACT FROM AUTHOR]

Azole antifungals inhibit the sterol C14-demethylase (CYP51/Erg11) of the ergosterol biosynthesis pathway. Here we show that the azole-induced synthesis of fungicidal cell wall carbohydrate patches in the pathogenic mold Aspergillus fumigatus strictly correlates with the accumulation of the CYP51 substrate eburicol. A lack of other essential ergosterol biosynthesis enzymes, such as sterol C24-methyltransferase (Erg6A), squalene synthase (Erg9) or squalene epoxidase (Erg1) does not trigger comparable cell wall alterations. Partial repression of Erg6A, which converts lanosterol into eburicol, increases azole resistance. The sterol C5-desaturase (ERG3)-dependent conversion of eburicol into 14-methylergosta-8,24(28)-dien-3β,6α-diol, the "toxic diol" responsible for the fungistatic activity against yeasts, is not required for the fungicidal effects in A. fumigatus. While ERG3-lacking yeasts are azole resistant, ERG3-lacking A. fumigatus becomes more susceptible. Mutants lacking mitochondrial complex III functionality, which are much less effectively killed, but strongly inhibited in growth by azoles, convert eburicol more efficiently into the supposedly "toxic diol". We propose that the mode of action of azoles against A. fumigatus relies on accumulation of eburicol which exerts fungicidal effects by triggering cell wall carbohydrate patch formation. Azole antifungals inhibit the ergosterol biosynthesis enzyme CYP51, but their effects on fungal viability and growth vary greatly among fungal species. Here, the authors provide evidence that the mode of action of azoles against Aspergillus fumigatus relies on accumulation of the CYP51 substrate eburicol, which exerts fungicidal effects by triggering cell-wall carbohydrate patch formation. [ABSTRACT FROM AUTHOR]

This work aimed at optimizing the preparation of activated carbon (AC) from Kraft lignin for the adsorption of methylene blue (MB) and amoxicillin (AMX) from water. A full factorial design of three factors (precursor:activating agent (H3PO4) ratio, pyrolysis temperature, and residence time) at two levels was used to optimize the AC production. Eight AC products were obtained and evaluated considering the following responses: product yield, specific surface area (SBET), energy consumption, and adsorptive removal of the contaminants under study. The produced AC presented satisfactory SBET, ranging between 750 and 1335 m2 g−1, and efficient adsorption of MB and AMX from water, achieving up to 99% removal under the studied experimental conditions (100 mg L−1 of MB and AMX solution and material dose of 1 g L−1). Statistical analysis showed that product yield and energy consumption for AC production were influenced by temperature and residence time. The determination of a desirability function indicated a precursor/H3PO4 ratio of 1:2, pyrolysis at 700 °C, and residence time of 60 min as the optimal production conditions. The optimized AC presented SBET 1335 m2 g−1 and maximum adsorption capacity of 210 and 280 mg g−1 for MB and AMX, respectively. [ABSTRACT FROM AUTHOR]

Objective Physical activity is recommended for recipients of a kidney transplant. However, ADHERE BRAZIL study found a high prevalence (69%) of physical inactivity in Brazilian recipients of a kidney transplant. To tackle this behavior, a broad analysis of barriers is needed. This study aimed to identify factors (patient and transplant center levels) associated with physical inactivity among recipients of a kidney transplant. Methods This was a subproject of the ADHERE BRAZIL study, a cross-sectional, multicenter study of 1105 recipients of a kidney transplant from 20 kidney transplant centers. Using a multistage sampling method, patients were proportionally and randomly selected. Applying the Brief Physical Activity Assessment questionnaire, patients were classified as physically active (≥150 min/wk) or physically inactive (<150 min/wk). On the basis of an ecological model, 34 factors associated with physical inactivity were analyzed by sequential logistic regression. Results At the patient level, physical inactivity was associated with smoking (odds ratio = 2.43; 95% CI = 0.97–6.06), obesity (odds ratio = 1.79; 95% CI = 1.26–2.55), peripheral vascular disease (odds ratio = 3.18; 95% CI = 1.20–8.42), >3 posttransplant hospitalizations (odds ratio = 1.58; 95% CI = 1.17–2.13), family income of >1 reference salary ($248.28 per month; odds ratio = 0.66; 95% CI = 0.48–0.90), and student status (odds ratio = 0.58; 95% CI = 0.37–0.92). At the center level, the correlates were having exercise physiologists in the clinical team (odds ratio = 0.54; 95% CI = 0.46–0.64) and being monitored in a teaching hospital (undergraduate students) (odds ratio = 1.47; 95% CI = 1.01–2.13). Conclusions This study identified factors associated with physical inactivity after kidney transplantation that may guide future multilevel behavioral change interventions for physical activity. Impact In a multicenter sample of recipients of a kidney transplant with a prevalence of physical inactivity of 69%, we found associations between this behavior and patient- and center-level factors. At the patient level, the chance of physical inactivity was positively associated with smoking, obesity, and patient morbidity (peripheral vascular disease and hospitalization events after kidney transplantation). Conversely, a high family income and a student status negatively correlated with physical inactivity. At the center level, the presence of a dedicated professional to motivate physical activity resulted in a reduced chance of physical inactivity. A broad knowledge of barriers associated with physical inactivity can allow us to identify patients at a high risk of not adhering to the recommended levels of physical activity. [ABSTRACT FROM AUTHOR]

Sauroleishmania spp. comprises one of the four Leishmania subgenera, which has been historically considered a non-pathogenic protozoan of reptiles. However, some strains appear to be transiently infective to mammals, and recent findings have detected these parasites in dogs and humans in areas where leishmaniasis is endemic. Herein, the digestion pattern of PCR–RFLP of the 234 bp-hsp70 fragment was evaluated as a simpler and cheaper tool to distinguish the Sauroleishmania species from the other Leishmania subgenera. As a result, the digestion of the 234 bp-hsp70 fragments with HaeIII produced a banding pattern specific to the four Sauroleishmania strains assessed. This technique could contribute to the identification of Leishmania parasites isolated from sandflies, reptiles, or even mammals in fieldworks as an alternative to the use of laborious and expensive methodologies. [ABSTRACT FROM AUTHOR]

Background: The sand fly Nyssomyia neivai is one of the most abundant species in Southern Brazil. It is frequently found in areas that are foci of visceral leishmaniasis in the state of Santa Catarina, caused by Leishmania infantum. In this region, the main vector of L. infantum, Lutzomyia longipalpis, has not been detected. In the absence of L. longipalpis, this study aimed to identify the sand fly fauna and diagnose any potential Leishmania spp. infection in sand flies and in dogs in a region of Southern Brazil that experienced a recent canine visceral leishmaniasis outbreak. Methods: This report includes a survey of the sand fly fauna at the Zoonosis Control Center of the Municipality of Tubarão (Santa Catarina, Brazil). Molecular tests were conducted to investigate Leishmania spp. natural infection in sand flies using polymerase chain reaction (PCR). In positive females, in addition to morphological identification, molecular analysis through DNA barcoding was performed to determine the sand fly species. Additionally, the dogs were tested for the presence of Leishmania spp. using a non-invasive technique for the collection of biological material, to be assessed by PCR. Results: A total of 3419 sand flies, belonging to five genera, were collected. Nyssomyia neivai was the most abundant species (85.8%), followed by Migonemyia migonei (13.3%), Pintomyia fischeri (0.8%), Evandromyia edwardsi (< 0.1%), and species of the genus Brumptomyia. (0.1%). Out of the 509 non-engorged females analyzed by PCR, two (0.4%) carried L. infantum DNA. The naturally infected females were identified as Ny. neivai, in both morphological and molecular analysis. In addition, two out of 47 conjunctival swabs from dogs tested positive for L. infantum, yielding an infection rate of 4.2%. Conclusions: These results confirm the presence of Ny. neivai naturally infected with L. infantum in an area where dogs were also infected by the parasite, suggesting its potential role as a vector in Southern Brazil. [ABSTRACT FROM AUTHOR]

Pterocaulon polystachyum is a species of pharmacological interest for providing volatile and non-volatile extracts with antifungal and amebicidal properties. The biological activities of non-volatile extracts may be related to the presence of coumarins, a promising group of secondary metabolites. In the present study, leaves and inflorescences previously used for the extraction of essential oils instead of being disposed of were subjected to extraction with supercritical CO2 after pretreatment with microwaves. An experimental design was followed to seek the best extraction condition with the objective function being the maximum total extract. Pressure and temperature were statistically significant factors, and the optimal extraction condition was 240 bar, 60 °C, and pretreatment at 30 °C. The applied mathematical models showed good adherence to the experimental data. The extracts obtained by supercritical CO2 were analyzed and the presence of coumarins was confirmed. The extract investigated for cytotoxicity against bladder tumor cells (T24) exhibited significant reduction in cell viability at concentrations between 6 and 12 μg/mL. The introduction of green technology, supercritical extraction, in the exploration of P. polystachyum as a source of coumarins represents a paradigm shift with regard to previous studies carried out with this species, which used organic solvents. Furthermore, the concept of circular bioeconomy was applied, i.e., the raw material used was the residue of a steam-distillation process. Therefore, the approach used here is in line with the sustainable exploitation of native plants to obtain extracts rich in coumarins with cytotoxic potential against cancer cells. [ABSTRACT FROM AUTHOR]

Purpose: To investigate a possible association between the risk of obstructive sleep apnoea (OSA) and disability in individuals with cardiovascular or cerebrovascular diseases. Methods: Cross-sectional study was conducted with 373 individuals (313 with cardiovascular or cerebrovascular diseases and 60 healthy). Disability was assessed by the 12-item World Health Organization Disability Assessment Schedule (WHODAS), and the risk of OSA was assessed by STOP-BANG. Anxiety and depression symptoms, daytime sleepiness, and cognition were assessed by the Hospital Anxiety and Depression Scale (HADS), Epworth Sleepiness Scale (ESS), and Mini Mental State Examination (MMSE). Results: Greater disability was found in individuals with intermediate or high risk of OSA, considering healthy individuals (p=0.03), or individuals diagnosed with arrhythmia (p<0.01) or coronary artery disease (p=0.04). A high risk of OSA and higher WHODAS scores was significant among women as well as between OSA risk categories (p<0.01). Cognitive deficit and level of education also showed differences between OSA risk categories. Age, depression, and sleepiness were also associated with the subjects' disability (p<0.01). Gamma regression model showed higher WHODAS scores in female, in those with intermediate and high risk of OSA, and in those with depressive symptoms and cognitive deficit. Age also showed a correlation with higher WHODAS scores. The presence of all investigated cardio and cerebrovascular diseases showed an increase in the WHODAS score, implying a greater disability compared to healthy individuals. Conclusion: Moderate and high risk of OSA is associated with disability, as well as gender, age, depressive symptoms, cognitive deficit, and cardiovascular diseases. [ABSTRACT FROM AUTHOR]

Background and Objectives The inability of individuals in the advanced stage of dementia to communicate about preferences in care at the end-of-life poses a challenge for healthcare professionals and family carers. The proven effective Family Carer Decision Support intervention has been designed to inform family carers about end-of-life care options available to a person living with advanced dementia. The objectives of the mySupport study were to adapt the application of the intervention for use in different countries, assess impact on family satisfaction and decision-making, and identify costs and supportive conditions for the implementation of the intervention. Research Design and Methods A multiple-case study design was chosen where the nursing home was the case. Nursing homes were enrolled from six countries: Canada, Czech Republic, Italy, Netherlands, Republic of Ireland, and United Kingdom. Results Seventeen cases (nursing homes) participated, with a total of 296 interviews completed including family carers, nursing home staff, and health providers. Five themes relevant to the implementation of the intervention were identified: supportive relationships; committed staff; perceived value of the intervention; the influence of external factors on the nursing home; and resource impact of delivery. Discussion and Implications There is a commonality of facilitators and barriers across countries when introducing practice innovation. A key learning point was the importance of implementation being accompanied by committed and supported nursing home leadership. The nursing home context is dynamic and multiple factors influence implementation at different points of time. [ABSTRACT FROM AUTHOR]

Virtual Reality (VR) technology has the potential to support the aging population and improve testing of daily abilities to detect functional decline. In multiple research studies, VR performance of participants has been assessed by measuring time to complete test, but the effect of learning how to use the VR system and differences between real and virtual environments have been understudied, especially for fine motor tasks. In this study, 20 older adults ages 65–84 performed a task that required fine motor skills in real-life and then in a VR replica of the same task. All participants completed the task in each setting with no difficulties. A clear learning effect was observed in VR, which was attributed to learning how to use the device itself. Still, participants could not reach the same level of performance (time) in VR as in real-life. Participants rated the VR task more mentally and physically demanding than in real-life, as well as more stressful, but with an overall low cognitive demand. In an exploratory cluster analysis, participants with an average age of 69 years old had more technological devices, found the VR system more usable and realistic than participants in the group with an average of 76 years old. This study demonstrated that VR influences time to complete a fine motor task, and that learning effects related to the system could be confounded with actual task performance if not properly considered in VR studies with older adults. [ABSTRACT FROM AUTHOR]

Background: Parkinson's disease (PD) is the second most common neurodegenerative illness and has the highest increase rate in recent years. There is growing evidence to suggest that PD is linked to higher osteoporosis rates and risk of fractures. Objective: This study aims to estimate the prevalence and factors associated with osteoporosis as defined by the National Osteoporosis Foundation (NOF) and World Health Organization in patients with mild to moderate PD. Methods: We performed a cross-sectional study at a tertiary public hospital in Fortaleza, Brazil, dating from May 2021 until April 2022. The study sample was comprised of patients with mild to moderate PD who were at least 40 years old and who had the ability to walk and stand unassisted. Bone Mineral Density (BMD) of both the hip (neck of the femur) and the lumbar spine were obtained via properly calibrated Dual Energy X-ray Absorptiometry (DXA) scanning. The FRAX (Fracture Risk Assessment Tool) score was used to determine a person's 10-year risk of major osteoporotic fracture. The Revised European Working Group on Sarcopenia in Older People (EWGSOP 2) was used as a basis to confirm a sarcopenia diagnosis with the following parameters: low muscle strength gauged by handgrip strength and low muscle quantity by DXA. Physical performance was carefully evaluated by using the Short Physical Performance Battery test. Osteoporosis and osteopenia were diagnosed following the NOF guidelines and WHO recommendations. Results: We evaluated 107 patients in total, of whom 45 (42%) were women. The group's mean age was 68 ± 9 years, and the mean disease time span was 9.9 ± 6.0 years and mean motor UPDRS was 43 ± 15. We found that 42.1% and 34.6% of the sample had osteopenia and osteoporosis following NOF criteria, respectively, and 43% and 33.6% following the WHO recommendations. Lower lean appendicular mass was associated to osteopenia and osteoporosis in multinomial logistic regression analysis in both diagnostic criteria. Conclusion: Our findings provide additional evidence for the protective role of lean mass against osteoporosis in patients with PD. [ABSTRACT FROM AUTHOR]

Resting eggs are commonly produced by zooplankton inhabiting permanent and temporary lakes. Although resting eggs are acknowledged to survive varying harsh conditions, the effects of desiccation on the viability and hatching patterns of resting eggs are not fully understood and might be context‐dependent.This study simulated one long‐term (1 year) dry‐out episode in wet sediments originating from permanent and temporary lakes and compared hatching patterns through ex situ experiments.The abundance and species richness of hatchlings decreased in dry sediments compared to wet sediments. Hatchling composition differed between wet and dry sediments of each lake category, whereas community variability did not differ between wet and dry sediments of temporary lakes.Overall, there was no difference in the ability of rotifers and crustaceans to cope with desiccation, since all species decreased hatchling numbers after desiccation. Artemia was the only taxon that benefited from drying sediments.Long‐term desiccation may affect the contribution of resting egg banks to future active populations in the water column, even in temporary habitats which presumably select for drought‐resistant resting eggs. The ecological roles played by resting egg banks may be weakening because droughts are becoming more common worldwide, even in former permanent aquatic habitats. [ABSTRACT FROM AUTHOR]

This article reports on an exploration of social workers' perspectives on the social policy and agency processes that shape their experiences of working in child protection services. A qualitative constructivist grounded theory methodology was employed, and 17 qualified social workers and managers were recruited. Social workers described working within an oppressive system, balancing unrealistic demands placed on them, and struggling to restore balance and hope. They shared how this filtered into the work they do with families and the role that relationality and peer support has in surviving the work. [ABSTRACT FROM AUTHOR]

Should offenders with psychopathy or those exhibiting extreme forms of antisocial behaviour be considered criminally responsible? The current debate seems to have reached a stalemate. Several scholars have argued that neuropsychological data on individuals with psychopathy might be relevant for determining their criminal responsibility. However, relying on such data has not produced a consensus among legal scholars and philosophers on whether individuals with psychopathy should be excused from responsibility. We offer a diagnosis about why this debate has reached a standoff. We argue that part of the problem is that psychopathy, being a syndrome-based category, is too heterogeneous and thus offers low prospects for being integrated with neuropsychological data that might support significant conclusions about the criminal responsibility of individuals with psychopathy. Moreover, the construct of psychopathy was not originally devised to discriminate criminally accountable from unaccountable antisocial individuals. To overcome these difficulties and advance the debate, we extend a currently less discussed theoretical framework for bridging biopsychology and the law that focuses on neuropsychological constructs, domains, and processes that directly measure capacities of offenders that are relevant for criminal responsibility, without necessarily relying on mediating syndrome-based constructs. The novelty of our contribution is that the biopsychological bases of exculpation can be further developed and used for determining more fine-grained categorisations of antisocial personality types. We show how this framework provides guidelines for interdisciplinary research that can significantly advance our understanding of the preconditions for criminal responsibility and help the legal practice of ascribing or withholding it. [ABSTRACT FROM AUTHOR]

Coumarins are benzopyrones found in several plant genera, including Pterocaulon (Asteraceae). These compounds represent an important source of new treatments, especially as antimicrobial and antifungal agents. In this study, two coumarin-rich extracts from Pterocaulon balansae using green technologies were obtained through aqueous maceration (AE) and supercritical fluid extraction (SFE). Such extracts were incorporated into nanoemulsions (NAE and NSFE) composed of a medium-chain triglyceride oil core stabilized by phospholipids. The nanoemulsions exhibited droplet sizes between 127 and 162 nm, pH above 5.0, and viscosity of approximately 1.0 cP, properties compatible with the topical route. The coumarins permeation/retention from formulations through ear porcine skin using Franz-type diffusion cells were evaluated. Whatever the extract, coumarins were distributed in skin layers, especially in the dermis in both intact and impaired (tape stripping) skin. In addition, a significant increase in coumarins that reached up to the receptor fluid was observed for impaired skin, with increases of approximately threefold for NAE and fourfold for NSFE. Finally, antifungal activity of nanoemulsions was evaluated according to minimum inhibitory concentrations, and the values were 250 µg/mL for all strains tested. The overall results demonstrated the feasibility of incorporating P. balansae extracts into nanoemulsions and showed a potential alternative for the treatment of sporotrichosis. [ABSTRACT FROM AUTHOR]

Background Tuberculosis (TB) treatment–related adverse drug reactions (TB-ADRs) can negatively affect adherence and treatment success rates. Methods We developed prediction models for TB-ADRs, considering participants with drug-susceptible pulmonary TB who initiated standard TB therapy. TB-ADRs were determined by the physician attending the participant, assessing causality to TB drugs, the affected organ system, and grade. Potential baseline predictors of TB-ADR included concomitant medication (CM) use, human immunodeficiency virus (HIV) status, glycated hemoglobin (HbA1c), age, body mass index (BMI), sex, substance use, and TB drug metabolism variables (NAT2 acetylator profiles). The models were developed through bootstrapped backward selection. Cox regression was used to evaluate TB-ADR risk. Results There were 156 TB-ADRs among 102 of the 945 (11%) participants included. Most TB-ADRs were hepatic (n = 82 [53%]), of moderate severity (grade 2; n = 121 [78%]), and occurred in NAT2 slow acetylators (n = 62 [61%]). The main prediction model included CM use, HbA1c, alcohol use, HIV seropositivity, BMI, and age, with robust performance (c-statistic = 0.79 [95% confidence interval {CI},.74–.83) and fit (optimism-corrected slope and intercept of −0.09 and 0.94, respectively). An alternative model replacing BMI with NAT2 had similar performance. HIV seropositivity (hazard ratio [HR], 2.68 [95% CI, 1.75–4.09]) and CM use (HR, 5.26 [95% CI, 2.63–10.52]) increased TB-ADR risk. Conclusions The models, with clinical variables and with NAT2 , were highly predictive of TB-ADRs. [ABSTRACT FROM AUTHOR]

Sandflies are known vectors of leishmaniasis. In the Old World, sandflies are also vectors of viruses while little is known about the capacity of New World insects to transmit viruses to humans. Here, we relate the identification of RNA sequences with homology to rhabdovirus nucleocapsids (NcPs) genes, initially in the Lutzomyia longipalpis LL5 cell lineage, named NcP1.1 and NcP2. The Rhabdoviridae family never retrotranscribes its RNA genome to DNA. The sequences here described were identified in cDNA and DNA from LL-5 cells and in adult insects indicating that they are transcribed endogenous viral elements (EVEs). The presence of NcP1.1 and NcP2 in the L. longipalpis genome was confirmed in silico. In addition to showing the genomic location of NcP1.1 and NcP2, we identified another rhabdoviral insertion named NcP1.2. Analysis of small RNA molecules derived from these sequences showed that NcP1.1 and NcP1.2 present a profile consistent with elements targeted by primary piRNAs, while NcP2 was restricted to the degradation profile. The presence of NcP1.1 and NcP2 was investigated in sandfly populations from South America and the Old World. These EVEs are shared by different sandfly populations in South America while none of the Old World species studied presented the insertions. [ABSTRACT FROM AUTHOR]

Considering that epoxy composites filled with Fe-based materials can be an alternative for the processing of microwave absorbing materials (MAMs) and electromagnetic shielding materials, this work presents a comparative study with three different Fe-based materials, two with magnetic characteristics: manganese zinc ferrite–MZ and carbonyl iron–CI and a non-magnetic one: ferric oxide–FO. This study compares the main structural and morphological characteristics of fillers with the electromagnetic interference shielding effectiveness (EMI SE) and the reflection loss (RL) behaviors of epoxy composites, prepared with 30, 50, and 70 wt% of fillers by mechanical mixing. The results show that the intrinsic magnetic properties of MZ and CI had a significant influence on the EM properties, as expected, and also on the electrical conductivity. Notably, a higher content of magnetic particles (MZ and CI) increased the EMI SE. Epoxy/MZ-70 achieved 30 dB of EMI SE, with a predominant shielding mechanism by absorption. The 2.1 mm thick epoxy/CI-70 presented the most effective RL result (− 20 dB at 10.4 GHz). The epoxy/FO composite showed less significant results because this filler does not have magnetic and electrical characteristics. The experimental and simulated RL curves were close, with a slight shift in frequency. Simulated curves allowed exploring the behavior of MAMs at different thicknesses. This work clearly shows the influence of the different magnetic natures of Fe-based fillers on the EMI SE and RL behaviors of epoxy composites, emphasizing the EM behavior of materials processed with magnetic and non-magnetic Fe-based fillers. [ABSTRACT FROM AUTHOR]

Passion episodes such as the Buffeting are known for the powerful acts of compassion they occasioned within audiences through their performance of violence on the person of Jesus. Few critics, however, have considered that these episodes depend on antisemitic, Islamophobic, and anti-Black depictions of antagonists when engendering such emotional dispositions. By investigating the dynamics of mockery through a deeper look into the composite identities of Jesus's antagonists, this study reveals that these plays and the communities that produced them rely on a disingenuous stance of victimhood for their effectiveness. This 'victim play'—the collaborative community effort to claim the status of victim while simultaneously participating in the victimization of others—obscures that those who are attributed cruel acts of mockery are actually its targets. The powerful rhetorical strategies of the premodern English episodes are thus unearthed in this study. [ABSTRACT FROM AUTHOR]

Alzheimer's disease is characterized by a decline in episodic memory and executive functioning, hampering learning ability. Insight into outcome‐based learning capacity may be relevant for optimizing the learning potential of these patients. To date, mixed results have been found in studies in which cognitively impaired participants have to learn based on positive and negative outcomes. In this study, we investigated the role of negative and positive feedback on memory performance and participants' ability to adjust their behaviour accordingly in a sample of 23 early‐stage AD patients and 23 matched healthy controls. We administered a novel computerized object‐location memory task, in which participants were instructed to learn and memorize the locations of different everyday objects following errorless learning (EL) and trial‐and‐error learning (TEL). A separate probabilistic TEL task was employed in which participants had to learn how to adjust their behaviour based on positive and negative feedback. EL had a beneficial general effect on memory performance for object locations. However, this effect was not larger in early‐stage AD patients compared to controls and error frequency during acquisition of object locations was unrelated to later recall performance. No group differences were found on the probabilistic learning task with respect to learning performance over time and based on positive and negative feedback. Although the error monitoring system seems intact in patients with early‐stage AD, errors during learning are likely acting as a source of interference causing difficulty in storage or retrieval of object locations. [ABSTRACT FROM AUTHOR]

Glassy carbon (GC) and graphene nanoplatelets (GNP) were used as fillers for the preparation of antistatic and biodegradable composites based on poly (lactic acid)/poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PLA/PHBV) blend. In this work, PLA/PHBV (80/20) blends with the addition of different GC contents (0.1, 0.3, and 0.5 wt%) were prepared by melt mixing using a twin‐screw extruder, and specimens were injection molded. Furthermore, hybrid composites were prepared with the addition of 5 wt% of GNP and different GC contents (0.1, 0.3, and 0.5 wt%) using the same processing. The effect of the addition of GC and GNP on the mechanical, electrical, and electromagnetic properties and its effect on the biodegradability of the PLA/PHVB blend was evaluated. The simultaneous addition of GC (0.3 and 0.5 wt%) and GNP (5 wt%) significantly increases the elastic modulus and decreases the electrical resistivity, becoming suitable for electrostatic discharge protection packaging applications. The hybrid composite GC0.5/GNP5 reached a maximum value of total attenuation (4.5 dB), which corresponds to 60% EMI shielding. The degree of crystallinity affects biodegradability more than the type or presence of carbon material. After 110 days of anaerobic biodegradation, the hybrid composite exhibited 10% biodegradability due to the high degree of crystallinity that hinders the biodegradability process. The hybrid composites with the addition of GC and GNP are very promising for use in antistatic packaging. [ABSTRACT FROM AUTHOR]

We evaluated the effects of supplementation with catalase (CAT) and superoxide dismutase (SOD) antioxidants, isolated or combined, on the freezability of collared peccary sperm. Semen aliquots from ten individuals were diluted in Tris‐yolk with or without the presence of antioxidants CAT (200 or 400 IU/mL) and SOD (150 or 300 IU/mL) alone or in combination (CAT: 200 IU/mL + SOD: 150 IU/mL), and then cryopreserved in liquid nitrogen (−196°C). After 1 week, samples were thawed and evaluated for kinetic parameters, membrane functionality and integrity, mitochondrial activity, chromatin integrity, sperm morphology, sperm cell binding capacity and intracellular oxidative levels. Regardless of the use of antioxidants, the treatments did not differ in any of the evaluated parameters, except for the treatment with 300 IU/mL SOD, which showed the highest percentage of static cells (69.1 ± 4.4%) when compared to the group without antioxidant (51.6 ± 3.3%). In general, all samples maintained around 50% of functional membranes, 40% of intact membranes with mitochondrial activity, more than 99% of cells with condensed chromatin, as well as more than 70% of morphologically normal cells. Regarding the binding capacity, the minimum and maximum values found ranged from 33.8 to 194 spermatozoa bound to the perivitelline membrane. Finally, regardless of the presence of antioxidants, all thawed groups showed similar levels of reactive oxygen species (ROS). In conclusion, supplementation with CAT or SOD antioxidants, at the tested concentrations, does not bring benefits to freezability, and the increase in SOD concentration resulted in negative effects on sperm motility in collared peccary semen. [ABSTRACT FROM AUTHOR]

Background: Patient and public involvement (PPI) is a critical priority in research, policy, academia and advocacy organizations. PPI in dementia research is gaining momentum. However, these efforts are missing in international projects aimed at those living with advanced dementia in long‐term care (LTC) homes. Additional complexities can arise in enacting PPI within the context of integration of a palliative approach to care and experiences around end‐of‐life in (EOL) dementia. The mySupport study involved implementing the Family Carer Decision Support (FCDS) intervention for care partners of those living with advanced dementia in LTC in six countries. Research Design and Objective: An interpretive description study was conducted to explore the perspectives of international researchers from six countries on engaging people with lived experiences of dementia and EOL care in research processes. The findings from this study informed the development of a PPI strategy and a subsequent toolkit for the FCDS intervention. Findings: Thirty‐eight interviews were completed with project researchers: 12 from the United Kingdom, 8 from Canada, 7 from Ireland, 4 each from Italy and The Netherlands and 3 from the Czech Republic. Four broad themes describe international researchers' perspectives on advancing methods of engagement for people with lived experiences of dementia and EOL in international PPI activities: (1) Groundwork to engage in research; (2) planning for research activities is key; (3) focus on meaningful engagement and (4) having foresight for practical issues shaping PPI. Discussion and Implications: International projects that involve PPI can present many sources of challenges. The findings in this study highlight important considerations for foundational work for incorporating PPI in international projects. Learning from world leaders and those with lived experiences in various regions can be insightful and help share tools and resources. Patient or Public Contribution: PPI was envisioned as a critical part of conducting the mySupport study. The findings from this study informed the development of a PPI strategy and an international Strategic Guiding Council that included family carers of those living with advanced dementia in LTC homes in six countries. This manuscript focused on the perspectives of researchers on their engagement with people with lived experiences of dementia and EOL. The perspectives of persons with lived experiences on engaging in the mySupport research study will be reported in a forthcoming manuscript. [ABSTRACT FROM AUTHOR]

The correct destination of this post-used of carbon fiber (CF) reinforced epoxy composites, is considered noble since their manufacturing process involves high costs and advanced technologies. This work aimed to study the feasibility of mechanical recycling of CF/epoxy composites for nobler applications, such as non-structural internal components, antistatic packaging, or electronics housings. The CF/epoxy residues (CFRPres.) were collected from parts of the aerospace industry, selected, and ground, followed by granulometric separation. Then, the CFRPres. particles were incorporated as filler and/or partial reinforcement in a polypropylene (PP) matrix to obtain a new thermoplastic composite using double-screw extrusion processing, followed by hot compression molding to obtain standardized specimens. The quality of the composites obtained was evaluated through mechanical tests (tensile test, Izod impact strength, and Shore D hardness), thermal (differential scanning calorimetry), electric (impedance spectroscopy, electromagnetic), and morphological characterization (scanning electron microscopy). The addition of 30 wt% of CFRPres. in the PP matrix increases the electrical conductivity by seven orders of magnitude and exhibits semiconductor behavior, and increases 168% in the elastic modulus. As for the electromagnetic properties, increasing the content of residues in the composites also occurs a substantial increase in the relative permittivity. In addition, the development of composites from the incorporation of residues from the aerospace sector proved viable in applications where the impact strength, rigidity, and hardness are crucial, even for the high content of residues aggregate. Graphical Abstract [ABSTRACT FROM AUTHOR]

Research shows psychopathic traits in adults are associated with perpetrating intimate partner violence (IPV). Less research, however, has examined this association in adolescents' relationships. Our study examines whether adolescent psychopathic traits are associated with different forms of IPV and whether early adverse experiences of abuse and/or interparental violence might be implicated in this relationship. A mixed sample of 156 justice-involved and at-risk adolescents were assessed with the PCL:YV, participated in an early adversity interview assessing abuse and interparental violence, and completed IPV measures of physical and psychological aggressive acts. Psychopathic traits were associated with each IPV measure over and above early adversity. Psychopathic traits continued to be associated with psychological but not physical IPV after accounting for sample type. Furthermore, psychopathic traits indirectly linked interparental violence with psychological IPV, suggesting that psychopathic traits may play a role in the intergenerational perpetration of partner violence. [ABSTRACT FROM AUTHOR]

Efficient and low-cost production of activated carbon (AC) is a challenge due to environmental and economic concerns. The combination of microwave pyrolysis and the use of lignocellulosic waste is a promising alternative to reduce the AC production costs in a sustainable way. In the present study, the adaptation performed in a domestic microwave oven is described, with no radiation leak, being a safe, simple, and fast method for AC production. Activated carbon samples from coffee grounds (CG), olive stones (OS), and Kraft lignin (KL) were produced by chemical activation (H3PO4 as activating agent), resulting in surface areas of 550, 1125, and 1170 m2g−1 and yields of 19, 21, and 23%, respectively. Phosphoric acid favored the microwave absorption by the lignocellulosic material (CG, OS, and KL), making the AC production viable for all tested raw materials. This result was confirmed by FTIR and XRD analyses, showing, respectively, the reduction of functional groups and the presence of characteristic carbon bands at 24° and 44° in the treated samples. Scanning electron microscopy analyses confirmed that the morphology of ACs is strongly influenced by the nature of the precursors. The maximum adsorption capacity of methylene blue dye (MB) was of 80, 90, and 85 mgg−1, i.e., 82, 95, and 92% for the ACCG, ACOS, and ACKL samples, respectively. The obtained results allow concluding that the microwave-assisted pyrolysis is a process with great potential for rapid and low-cost AC production. [ABSTRACT FROM AUTHOR]

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Individual specialization (IS) refers to intrapopulation variation in resource use unrelated to ontogeny, sexual dimorphism, or discrete morphological variation. A broad niche increases individual specialization because individuals might segregate in niche space. If trophic position influences niche breadth, it would indirectly constrain the degree of individual specialization. Intermediate trophic levels, usually associated with omnivory, might display fewer constraints on their trophic niche, leading to high levels of individual specialization. We investigate the degree of individual specialization and its relationship to the trophic position in 121 fish populations belonging to 32 species from the upper Tocantins River, Central Brazil. We calculated IS using the index V based on the stomach contents of individuals, whereas values close to 1 indicate strong IS. IS ranged from 0 to 0.87 and greatly varied among species. We showed that niche breadth positively affects a population's individual specialization regardless of its trophic position. Populations occupying intermediate and high trophic positions displayed the highest degrees of individual specialization. Omnivory has no significant effect over individual specialization values. We argue that the intricate relationship among individual specialization, trophic position, and niche breadth relates to the great ecological opportunity and trophic plasticity in tropical fishes. [ABSTRACT FROM AUTHOR]

Background The high burden of drug-resistant tuberculosis (TB) is a problem to achieve the goals of the End TB Strategy by 2035. Whether isoniazid monoresistance (Hr) affects anti-TB treatment (ATT) outcomes remains unknown in high-burden countries. Methods We evaluated determinants of ATT outcome among pulmonary TB cases reported to the National Notifiable Disease Information System (SINAN) between June 2015 and June 2019, according to drug sensitivity testing (DST) results. Binomial logistic regression models were employed to evaluate whether Hr was associated with an unfavorable ATT outcome: death or failure, compared to cure or treatment completion. Results Among 60 804 TB cases reported in SINAN, 21 197 (34.9%) were included in the study. In this database, the frequency of unfavorable outcomes was significantly higher in those with Hr in contrast to isoniazid-sensitive persons with pulmonary TB (9.1% vs 3.05%; P <.001). Using a binomial logistic regression model, Hr was independently associated with unfavorable outcomes (odds ratio, 3.34 [95% confidence interval, 2.06–5.40]; P <.001). Conclusions Hr detected prior to ATT was predictive of unfavorable outcomes at the national level in Brazil. Our data reinforce the need for high-TB-burden countries to prioritize DST to detect Hr. Effective treatment regimens for Hr-TB are needed to improve outcomes. [ABSTRACT FROM AUTHOR]

GREMLIN1 (GREM1) is member of a family of structurally and functionally related secreted cysteine knot proteins, which act to sequester and inhibit the action of multifunctional bone morphogenetic proteins (BMPs). GREM1 binds directly to BMP dimers, thereby preventing BMP-mediated activation of BMP type I and type II receptors. Multiple reports identify the overexpression of GREM1 as a contributing factor in a broad range of cancers. Additionally, the GREM1 gene is amplified in a rare autosomal dominant inherited form of colorectal cancer. The inhibitory effects of GREM1 on BMP signaling have been linked to these tumor-promoting effects, including facilitating cancer cell stemness and the activation of cancer-associated fibroblasts. Moreover, GREM1 has been described to bind and signal to vascular endothelial growth factor receptor (VEGFR) and stimulate angiogenesis, as well as epidermal and fibroblast growth factor receptor (EGFR and FGFR) to elicit tumor-promoting effects in breast and prostate cancer, respectively. In contrast, a 2022 report revealed that GREM1 can promote an epithelial state in pancreatic cancers, thereby inhibiting pancreatic tumor growth and metastasis. In this commentary, we will review these disparate findings and attempt to provide clarity around the role of GREM1 signaling in cancer. [ABSTRACT FROM AUTHOR]