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We propose a major upgrade to the existing PandaX-4T experiment at the China Jinping Underground Laboratory. The new experiment, PandaX-xT, will be a multi-ten-tonne liquid xenon, ultra-low background, and general-purpose observatory. The full-scaled PandaX-xT contains a 43-t liquid xenon active target. Such an experiment will significantly advance our fundamental understanding of particle physics and astrophysics. The sensitivity of dark matter direct detection will be improved by nearly two orders of magnitude compared to the current best limits, approaching the so-called “neutrino floor” for a dark matter mass above 10 GeV/c2, providing a key test to the Weakly Interacting Massive Particle paradigm. By searching for the neutrinoless double beta decay of 136Xe isotope in the detector, the effective Majorana neutrino mass can be measured to a 10–41 meV/c2 sensitivity, providing a key test to the Dirac/Majorana nature of neutrinos. Astrophysical neutrinos and other ultra-rare interactions can also be measured and searched for with an unprecedented background level, opening up new windows of discovery. Depending on the findings, PandaX-xT will seek the next stage upgrade utilizing isotopic separation of natural xenon. [ABSTRACT FROM AUTHOR]

Lung cancer remains the most commonly diagnosed cancer and the leading cause of death from cancer. Recent research shows that the human eye can provide useful information about one's health status, but few studies have revealed that the eye's features are associated with the risk of cancer. The aims of this paper are to explore the association between scleral features and lung neoplasms and develop a non-invasive artificial intelligence (AI) method for detecting lung neoplasms based on scleral images. A novel instrument was specially developed to take the reflection-free scleral images. Then, various algorithms and different strategies were applied to find the most effective deep learning algorithm. Ultimately, the detection method based on scleral images and the multi-instance learning (MIL) model was developed to predict benign or malignant lung neoplasms. From March 2017 to January 2019, 3923 subjects were recruited for the experiment. Using the pathological diagnosis of bronchoscopy as the gold standard, 95 participants were enrolled to take scleral image screens, and 950 scleral images were fed to AI analysis. Our non-invasive AI method had an AUC of 0.897 ± 0.041(95% CI), a sensitivity of 0.836 ± 0.048 (95% CI), and a specificity of 0.828 ± 0.095 (95% CI) for distinguishing between benign and malignant lung nodules. This study suggested that scleral features such as blood vessels may be associated with lung cancer, and the non-invasive AI method based on scleral images can assist in lung neoplasm detection. This technique may hold promise for evaluating the risk of lung cancer in an asymptomatic population in areas with a shortage of medical resources and as a cost-effective adjunctive tool for LDCT screening at hospitals. [ABSTRACT FROM AUTHOR]

PandaX-4T is a ton-scale dark matter direct detection experiment using a dual-phase TPC technique at the China Jinping Underground Laboratory. Various ultra-low background technologies have been developed and applied to material screening for PandaX-4T, including HPGe gamma spectroscopy, ICP-MS, NAA, radon emanation measurement system, krypton assay station, and alpha detection system. Low background materials were selected to assemble the detector. Surface treatment procedures were investigated to further suppress radioactive background. Combining measured results and Monte Carlo simulation, the total material background rates of PandaX-4T in the energy region of 1–25 keVee are estimated to be (9.9 ± 1.9) × 10−3 mDRU for electron recoil and (2.8 ± 0.6) × 10−4 mDRU for nuclear recoil. In addition, natKr in the detector is estimated to be < 8 ppt. [ABSTRACT FROM AUTHOR]