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Some ideologies, such as liberalism, conservatism, and socialism, are complex symbolic structures. Mastering them requires specialization, and because we are all amateurs in almost all symbolically rich domains, most people are not ideologically sophisticated. Instead, they reason about politics in a maturationally natural way, via friend-foe representations and inferences based on those representations (for example, friends of foes are foes). However, even complex ideologies are much simpler than the political, economic, and social systems that they are supposed to represent. Hence, all ideologies are inaccurate to varying degrees. More subtly, all are incomplete in various ways; in particular, they fail to anticipate some crucial events (for example, global warming), which leads to unanticipated value trade-offs and strategic conundrums. Ideologists sometimes adapt to incompleteness via recombinant innovation, producing hybrid ideologies (for example, ecosocialism). In turn, this tends to produce inconsistencies between new and old parts of an ideology. Thus, inaccuracy, incompleteness, and inconsistency are not pathologies of political belief systems. They are the inevitable result of ideologists grappling with a reality that is far more complex than their symbolic constructions can be. Therefore, evaluations of ideologies that identify errors, incompleteness, or inconsistency at a single point in time are often unenlightening. Following Imre Lakatos, evaluations should focus on how a sequence of ideologies—an ideological tradition—evolves. [ABSTRACT FROM AUTHOR]

This essay considers the meaning of criticality in design futures education. It identifies three such meanings - criticality as an indication of importance, as a style of reasoning, and as attentiveness to power - and argues that the latter is most suitable for seeding transformative change. By drawing connections between critical pedagogy and critical futures studies, we aim to chart a path through which design futures education can potentially grapple with the political, contentious aspects of future-making. [ABSTRACT FROM AUTHOR]

Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and specifically activated by selective agonists, are appealing methods to constrain overactive neuronal activity. We developed BARNI (Bradanicline- and Acetylcholine-activated Receptor for Neuronal Inhibition), an engineered channel comprised of the α7 nicotinic acetylcholine receptor ligand-binding domain coupled to an α1 glycine receptor anion pore domain. Here we demonstrate that BARNI activation by the clinical stage α7 nicotinic acetylcholine receptor-selective agonist bradanicline effectively suppressed targeted neuronal activity, and controlled both acute and chronic seizures in male mice. Our results provide evidence for the use of an inhibitory acetylcholine-based engineered channel activatable by both exogenous and endogenous agonists as a potential therapeutic approach to treating epilepsy.Traditional systematic anti-seizure treatments alter brain-wide activity and often carry significant side effects. The authors engineered an inhibitory, acetylcholine receptor-based, chemogenetic tool to suppress targeted neurons, enabling control of chronic seizures in mice. [ABSTRACT FROM AUTHOR]

Limiting housing and infrastructure in flood-prone places has long been recognized as critical to managing long-term risk. However, due to the difficulty of tracking development at small spatial scales, little empirical research has been conducted to explain differences between communities' floodplain development patterns. We analyzed new construction across 5 million parcels in the state of North Carolina to develop standardized measures of floodplain development and evaluated the relationships between flood risk management effort and development outcomes. Statewide, for every property removed through buyouts from 1996 to 2017, more than 10 new residences were built in floodplains. At the community level, indicators of flood risk management effort (participation in the Community Rating System and use of buyouts) did not consistently align with floodplain development outcomes. Based on a sample of urban and suburban counties, we found more than 75,000 acres of vacant floodplain land currently zoned for development. Although we did not capture the full range of flood risk mitigation practices, results indicate that local development policies often run counter to efforts to limit long-term risk. Land use planning and floodplain management have the potential to play a larger role in flood risk mitigation. Modifying federal programs to more strongly disincentivize floodplain development could enhance local regulation and minimize future flood exposure. Given extensive undeveloped floodplain land and projected climate change, additional effort to manage development is needed to limit increases in flood risk. [ABSTRACT FROM AUTHOR]

Federal, state, and local government funding helps stimulate urban development, with growth machine politics playing an important role in determining where subsidies are allocated. The U.S. Coastal Barrier Resources Act (CBRA) was enacted to curb the role of federal subsidies in fostering development along hazardous coastal barriers, providing an opportunity to explore how local growth politics are influenced by the removal of one source of government funding. In this study, we used a series of interview-based case studies to investigate why certain areas in the CBRA developed while most did not. In most cases, the CBRA obstructed local growth coalitions, isolating landowners from the resources necessary to improve the growth potential of their land interests. However, in cases where development occurred within the CBRA, we often found evidence that powerful growth machines were able to acquire replacement subsidies from state and local governments, suggesting these actions are a key driver in overcoming the financial barriers posed by the CBRA. This study revealed how growth machines could be hampered by removing access to the financial resources of one level of government, despite the potential to be undermined by intervention at other levels. In an era of increasing coastal risks, subsidy removal can be an effective tool for managing coastal growth, even when authority over land use decisions is limited. [ABSTRACT FROM AUTHOR]

During sleep, recent memories are replayed by the hippocampus, leading to their consolidation, with a higher priority given to salient experiences. To examine the role of replay in the selective strengthening of memories, we recorded large ensembles of hippocampal place cells while male rats ran repeated spatial trajectories on two linear tracks, differing in either their familiarity or number of laps run. We observed that during sleep, the rate of replay events for a given track increased proportionally with the number of spatial trajectories run by the animal. In contrast, the rate of sleep replay events decreased if the animal was more familiar with the track. Furthermore, we find that the cumulative number of awake replay events occurring during behavior, influenced by both the novelty and duration of an experience, predicts which memories are prioritized for sleep replay, providing a more parsimonious neural correlate for the selective strengthening of memories. While memory consolidation involves repeated reactivation of past memory traces, it is not fully understood how the brain prioritizes memories for long-term storage during sleep. Here the authors recorded from hippocampal place cells in rats, and find that a novel experience with a longer duration is prioritized for consolidation. [ABSTRACT FROM AUTHOR]

For several decades, the USA has increasingly relied on government-administered floodplain buyout programs to reduce flood risk and remove flood-damaged dwellings from floodplains. However, high transaction costs and long administrative timelines dramatically hamper buyout program efficiency. A growing literature describes significant barriers governments face in ensuring positive financial (and social) outcomes for displaced property owners. Some of these barriers may be the result of cost-sharing and other requirements placed on local and tribal governments. Under what conditions, financing mechanisms, and market structures could private sector involvement offer a meaningful strategy for improving buyout program performance and reducing costs? In this paper, we derive financial efficiency thresholds suggesting situational advantages to both private- and government-run buyout programs. We also evaluate alternative institutional structures for implementing buyouts and novel mechanisms for financing buyouts. For these alternatives, we note a variety of equity impacts, as they relate to community- and household-buyout selection processes, social and economic impacts, and cost-share requirements. We also describe ideas for incentivizing privately financed buyout markets, and identify areas of uncertainty with respect to potential changes to buyout policy structures. We show that, by distributing investment risks outside the public sector, certain privatization schemes could re-structure programs in a manner that achieves hazard mitigation objectives and aligns stakeholder interests. We couch these ideas within a discussion of legislative changes necessary to leverage private financing in implementing buyouts, noting legal and social equity challenges to these policy changes. [ABSTRACT FROM AUTHOR]

Interest has focused on quantifying the size and scope of environmental markets, particularly those that offset ecosystem impacts or restore natural infrastructure to improve habitat or promote clean air and water. In this paper, we focus on the US wetland and stream compensatory mitigation market, asking: what types of firms make up the mitigation "industry"? What are the economic impacts–i.e., the "size"–of the mitigation industry? How has this industry changed over time? We present the results of a national survey of mitigation firms and construct an input-output model of the industry's economic impacts and employment. We also develop a comparative, 2014 model of the industry using data from a previous study of the broader, ecological restoration economy. Our findings suggest that the (2019, pre-COVID) mitigation industry collects annual revenues (direct economic impacts) in excess of $3.5 billion, which, along with additional indirect (supply chain) and induced (spillover) economic impacts, combine to over $9.6 billion in total output and support over 53,000 total jobs. We estimate 2014–2019 growth of ~35.2 percent in revenues, ~32.6 percent in total economic impacts, and a compound annual growth rate (CAGR) of 5.25%. This places the mitigation industry within the range of other, well-established industries within the technical services sector. We suggest establishing North American Industry Classification System (NAICS) codes specifically for ecological restoration and mitigation firms, an essential step in generating accurate and consistent employment estimates in the future, particularly at sub-national geographic scales. [ABSTRACT FROM AUTHOR]

Our brain's capacity for memory storage may be vast but is still finite. Given that we cannot remember the entirety of our experiences, how does our brain select what to remember and what to forget? Much like the triage of a hospital's emergency room, where urgent cases are prioritized and less critical patients receive delayed or even no care, the brain is believed to go through a similar process of memory triage. Recent salient memories are prioritized for consolidation, which helps create stable, long-term representations in the brain; less salient memories receive a lower priority, and are eventually forgotten if not sufficiently consolidated (Stickgold and Walker in Nat Neurosci 16(2):139–145, 2013). While rodents are a primary model for studying memory consolidation, common behavioral tests typically rely on a limited number of items or contexts, well within the memory capacity of the subject. A memory test allowing us to exceed an animal's memory capacity is key to investigating how memories are selectively strengthened or forgotten. Here we report a new serial novel object recognition task designed to measure memory capacity and prioritization, which we test and validate using female mice. [ABSTRACT FROM AUTHOR]

Importance: The increased incidence of adolescent obesity over recent decades may be associated with lower cognitive performance than the expected potential. Objective: We aimed to assess the association between adolescent body mass index (BMI) and cognitive function. Design: A nationwide, cross-sectional, population-based study. Setting: Pre-recruitment evaluation for military service during 1967-2018. Participants: All Israeli-born adolescents, 1 459 522 males and 1 027 953 females aged 16 to ≤20 years. Exposures: Weight and height were measured to calculate BMI. Main outcome: Cognitive performance was assessed by using a validated intelligence-quotient-equivalent test and was standardized to the year- and sex-Z-score. For 445 385 persons, parental cognitive scores could be identified. Multinomial logistic regression models were applied. Results: Among male adolescents with severe obesity, 29.4% achieved a cognitive score below the 25th percentile, compared with 17.7% among their normal-weight (50th-84th percentile) counterparts. A J-shaped relation was observed between BMI and the odds ratio (OR) for a low cognitive score among male adolescents: underweight, 1.45 (1.43-1.48); overweight, 1.13 (1.12-1.15); mild obesity, 1.36 (1.33-1.39); and severe obesity, 1.58 (1.52-1.64). Similar findings were observed in females. For both sexes, point estimates were overall consistent in models adjusted for sociodemographic confounders, coexisting morbidities, and parental cognitive scores. Examinees with abnormal BMI had higher ORs for a lower-than-expected cognitive score, based on their parents' data as adolescents, in a manner that depends on obesity severity. Conclusion and relevance: Abnormal BMI, and especially obesity, is associated with increased odds for a lower cognitive performance, and the inability to fully achieve cognitive potential, regardless of sociodemographic background. [ABSTRACT FROM AUTHOR]

Copyright of Social Science Information is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The US federal government has implemented a variety of policies and subsidies that help coastal development remain viable, including investments in risk reduction measures, subsidized flood insurance, and post‐disaster assistance. In this study, we explored how the removal of federal subsidies impacts coastal development patterns by measuring the causal effect of the US Coastal Barrier Resources Act (CBRA) on building activity. Implemented in 1982, CBRA withdrew eligibility for federal funding for infrastructure, post‐disaster assistance, and subsidized flood insurance along designated sections of coastal barriers ("CBRA units"). Using a novel built‐structures dataset, we employed a spatial regression discontinuity design to compare development rates within and outside of CBRA units in 1980 and 2016. We found that enactment of the CBRA has resulted in significant reductions in development activity: indeed, development rates were reduced by more than 75% in CBRA areas as compared to non‐CBRA areas. Our findings suggest that policies like CBRA can be effective at slowing development in other sensitive or hazardous areas, and could help to preserve natural environments for habitat conservation and climate adaptation purposes. [ABSTRACT FROM AUTHOR]

Theta oscillations are a hallmark of hippocampal activity across mammals and play a critical role in many hippocampal models of memory and spatial navigation. To reconcile the cross-species differences observed in the presence and properties of theta, we recorded hippocampal local field potentials in rats and ferrets during auditory and visual localisation tasks designed to vary locomotion and sensory attention. Here, we show that theta oscillations occur during locomotion in both ferrets and rats, however during periods of immobility, theta oscillations persist in the ferret, contrasting starkly with the switch to large irregular activity (LIA) in the rat. Theta during immobility in the ferret is identified as analogous to Type 2 theta that has been observed in rodents due to its sensitivity to atropine, and is modulated by behavioural state with the strongest theta observed during reward epochs. These results demonstrate that even under similar behavioural conditions, differences exist between species in the relationship between theta and behavioural state. Cross-species research is key to fully understanding brain function. Here, the authors present the ferret as a species for hippocampal research and show that, in stark contrast to rats, ferrets have robust theta oscillations during immobility. [ABSTRACT FROM AUTHOR]

Transfer of development rights (TDR) programs shift development intensity between land parcels. Jurisdictions, most commonly local municipal or county governments, employ TDR to protect resources such as farmland or historical properties and to encourage infill and redevelopment where deemed appropriate. However, while championed by economists and others seeking to reduce conflicts between land development and preservation, TDR program adoption has varied widely across the US. What demographic, economic, or environmental factors are associated with TDR program establishment? This paper describes a census of 375 TDR programs in the United States, documenting primary program attributes and adoption year and categorizing their functions and typology. Using logistic regression, we analyze program spatial patterns and factors predicting program implementation. We find that areas that are coastal, more liberal, have higher home values, in home-rule states, and in states with state-wide growth management programs, are all significantly more likely to implement TDR programs. [ABSTRACT FROM AUTHOR]

Drone use in the United States has taken off in recent years, bolstered by rapid technological innovations, business needs, and societal changes. It may soon be common to see small, unmanned aircrafts flying above city streets, local fields, and residential and commercial properties across the country. With the capability to deliver packages and transport goods more efficiently and quickly than ever before, drone delivery services have the potential to revolutionize our everyday way of life. Legislators, landowners, and businesses are beginning to explore their future roles in the commercialization of low-altitude airspace. But few, if any, theories of airspace rights and economic regulation have generated a viable legal and regulatory framework that balances the often-competing business imperatives of a robust drone economy, property rights of landowners, and interests of federal, state, and local governments. This Article seeks to remedy that gap. Under existing law, we argue, landowners exclusively own and control the "superadjacent," low-altitude airspace directly above their land, and they are free to commercialize and sell access to, or to prohibit drones from entering, their private airspace. It remains unsettled whether the Federal Aviation Administration (FAA) has the statutory authority to regulate low- altitude airspace and whether the federal government can do so without committing a "taking" of property that, under the Fifth Amendment, requires compensating landowners. Likewise, the boundaries of privately owned low- altitude airspace and the legal status of the area between it and public, high-altitude 'navigable airspace" remain entirely unclear. Essentially, the questions this Article seeks to answer are: who owns the sky and who should? This Article proposes a legal and regulatory framework to fill in the information gaps surrounding the commercialization of airspace and offers a viable solution for controlling and using low-altitude airspace in the age of drones . We predict the emergence of a marketplace for parties to buy, sell, and lease valuable airspace to accommodate drone delivery, such that companies like Amazon or Walmart will compensate landowners, or even governments that own city streets and highways, for the airspace where drones will one day fly. To effectuate that marketplace, we argue that the FAA must redefine the public 'navigable airspace" for it to lawfully regulate drone flight paths under 500 feet. We also advocate for the division of airspace into four distinct regions, with different rights and responsibilities for those operating in each domain. Our proposal constitutes one of the first comprehensive efforts to establish a framework that balances the rights of federal, state, and local governments, landowners, and drone operators to ensure the safety and full potential of the emerging airspace economy. [ABSTRACT FROM AUTHOR]

Objective: Gestational hyperglycemia is associated with deleterious neonatal outcomes, but long-term risks for offspring obesity are less clear. We estimated the odds for offspring adolescent overweight and obesity among mothers with gestational glucose intolerance.Research Design and Methods: In a mother-offspring historical cohort, the Israel military conscription data set was linked to a large health maintenance organization. Included were women who were evaluated at adolescence and underwent two-step gestational diabetes screening (mean age, 31 years) with a 50-g glucose challenge test (GCT), followed by a 100-g oral glucose tolerance test (OGTT) if the result was abnormal. Glucose tolerance categories included gestational normoglycemia, abnormal GCT with normal OGTT, impaired glucose tolerance (IGT; one abnormal OGTT value), and gestational diabetes. The primary outcome was offspring overweight/obesity (BMI ≥85th percentile) at adolescence, measured prior to military conscription. Logistic regression models were applied.Results: Of 33,482 mother-offspring pairs, overweight and obesity were observed in 6,516 offspring. Across increasing categories of pregnancy glycemia, the proportions of offspring with adolescent overweight/obesity increased: normoglycemia, 19%; abnormal GCT with normal OGTT, 22%; gestational IGT, 24%; and gestational diabetes, 25% (P < 0.0001). Corresponding odds ratios after adjustment for the mother's late adolescent characteristics (sociodemographic confounders and BMI) and pregnancy age were 1.2 (95% CI 1.1-1.4), 1.3 (1.2-1.5), and 1.4 (1.3-1.6), respectively. Further adjustment for offspring birth weight percentile and sociodemographic variables did not materially change results. Associations were more pronounced with increasing obesity severity.Conclusions: Gestational glucose intolerance, including categories not meeting the gestational diabetes threshold, was associated with increased odds for offspring overweight/obesity at late adolescence. [ABSTRACT FROM AUTHOR]

The Article suggests that broad standing rights in Israel not only have contributed to the development of constitutional and administrative law, but also encourage the establishment of public interest organizations whose activities focus on filing petitions in those areas. Many of these petitions deal with issues that have significant political implications. This Article presents the broad standing rights in Israel, indicates the role of broad compliance in the development of Israeli constitutional and administrative law, describes the contribution of the broad standing in Israel to the establishment of public interest organizations and civic groups, and offers explanations of the dominance of these organizations and groups in filing petitions on issues which do not involve claims of violation of human rights or of individual interests. [ABSTRACT FROM AUTHOR]

Introduction: Severe obesity among children and adolescents has emerged as a public health concern in multiple places around the world. Methods: We searched the Medline database for articles on severe obesity rates in children published between January 1960 and January 2020. For studies with available prevalence rates for an early and a more recent time period, the relative increase in prevalence was imputed. Results: In total, 874 publications were identified, of which 38 contained relevant epidemiological data. Rates of severe obesity varied significantly according to age, gender, geographic area, and the definition of severe obesity. The highest rates of class II and III obesity in the USA according to the Centers of Disease Control cut-off were 9.5% and 4.5%, respectively. Seventeen studies reported prevalence rates in at least two time periods. Data for 9,190,718 individuals showed a 1.71 (95% CI, 1.53–1.90) greater odds for severe obesity in 2006–2017 (N = 5,029,584) versus 1967–2007 (N = 4,161,134). In an analysis limited to studies from 1980s with a minimum follow-up of 20 years, a 9.16 (95% CI, 7.76–10.80) greater odds for severe obesity in recent versus earlier time was found. An analysis limited to studies from 2000, with a follow-up of 5–15 years, a 1.09 (95% CI, 0.99–1.20) greater odds was noted when comparing (2011–2017; N = 4,991,831) versus (2000–2011; N = 4,134,340). Conclusion: Severe pediatric obesity is escalating with a marked increase from the 1980s and a slower rate from 2000. [ABSTRACT FROM AUTHOR]

Addressing "wicked" problems like urban stormwater management necessitates building shared understanding among diverse stakeholders with the influence to enact solutions cooperatively. Fuzzy cognitive maps (FCMs) are participatory modeling tools that enable diverse stakeholders to articulate the components of a socio-environmental system (SES) and describe their interactions. However, the spatial scale of an FCM is rarely explicitly considered, despite the influence of spatial scale on SES. We developed a technique to couple FCMs with spatially explicit survey data to connect stakeholder conceptualization of urban stormwater management at a regional scale with specific stormwater problems they identified. We used geospatial data and flooding simulation models to quantitatively evaluate stakeholders' descriptions of location-specific problems. We found that stakeholders used a wide variety of language to describe variables in their FCMs and that government and academic stakeholders used significantly different suites of variables. We also found that regional FCM did not downscale well to concerns at finer spatial scales; variables and causal relationships important at location-specific scales were often different or missing from the regional FCM. This study demonstrates the spatial framing of stormwater problems influences the perceived range of possible problems, barriers, and solutions through spatial cognitive filtering of the system's boundaries. [ABSTRACT FROM AUTHOR]

The study of voter competence has made significant contributions to our understanding of politics, but at this point there are diminishing returns to the endeavor. Voter competence is unlikely to improve dramatically enough to make much of a difference to our politics. By contrast, the competence of officials can and does vary substantially over short periods of time. To understand variations in government performance, therefore, we would do better to focus on the abilities and performance of officials, not ordinary citizens. We elaborate on this argument, emphasizing the "incompetence multiplier": the way that the properties of hierarchies can amplify the incompetence of those in powerful positions. We illustrate our argument with an extended discussion of the U.S. response to the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Context: Thyroid hormones play a key role in systemic metabolism, yet the relationship between thyroid dysfunction and risk for type 2 diabetes is unclear.Objective: To assess type 2 diabetes risk in adulthood among adolescents with thyroid disorders.Design and Setting: A nationwide, population-based study of Israeli adolescents who were examined before military recruitment during 1988 to 2007 and were followed until December 31, 2016.Participants: 1 382 560 adolescents (mean age 17.3 years).Interventions: The diagnosis of thyroid disorders was based on recent thyroid function tests. Data were linked to the Israeli National Diabetes Registry. Cox proportional hazard models were applied.Main Outcome Measures: Type 2 diabetes incidence.Results: During a mean follow-up of 18.5 years, 1.12% (69 of 6,152) of adolescents with thyroid disorders were diagnosed with type 2 diabetes vs 0.77% of adolescents without thyroid disorders. The hazard ratio (HR) for type 2 diabetes was 2.3 (95% CI, 1.8-2.9) among those with thyroid disorders, after adjustment for sex, birth-year, body mass index, and sociodemographic confounders. The increased diabetes risk was observed in both men and women, with the presence or absence of obesity, and in the absence of other health conditions and was associated with different types of thyroid disorders. It was also similar when the outcome was defined as type 2 diabetes diagnosed at or before the age of 30 years (HR 2.3, 95% CI, 1.5-3.5).Conclusions: Thyroid disorders diagnosed in adolescence are a risk factor for early-onset type 2 diabetes in both men and women. [ABSTRACT FROM AUTHOR]

Given projected increases in flood damages, managed retreat strategies are likely to become more widespread. Voluntary buyouts, where governments acquire flood-damaged properties and return the sites to open space, have been the primary form of federally funded retreat in the USA to date. However, little attention has been paid to the cost structure of buyout projects. Using a transaction cost framework, we analyze the costs of activities that comprise floodplain buyouts. Federal data do not distinguish transaction costs, but they do suggest that the cost of purchasing properties often accounts for 80% or less of total project costs. Through a systematic review (n = 1103 publications) and an analysis of government budgets (across n = 859 jurisdiction-years), we find limited sources with relevant cost information, none of which reports transaction costs. The absence of activity-level cost data inhibits more targeted policy reform to support community-driven and efficient buyout programs. Better data collection and reporting can inform more impactful and equitable buyout policy. [ABSTRACT FROM AUTHOR]

The growing cost of climate-driven coastal impacts requires an improved understanding of how coastal populations engage with adaptation decisions. While many studies explore factors driving coastal adaptation, generally, few evaluate how residents consider relationships between in situ, protective adaption vs. retreat from at-risk areas. What is the relationship between residents’ exposure, perceptions of climate trends, and concerns about the future? How do these factors influence openness to different adaption strategies? Are these strategies considered to be progressive—where protection is indexed to minor threats and retreat occurs when protection measures fail—or are these dichotomous choices? We apply structural equation modeling to evaluate these decision pathways using a 2017 household survey in North Carolina’s (USA) Albemarle-Pamlico Peninsula (n = 147). Our results reveal that residents commonly view protection and retreat as mutually exclusive, rather than progressive, methods for reducing risk, and that their preferences are correlated with different understandings of climate threats. [ABSTRACT FROM AUTHOR]

The p53 pathway is a universal tumor suppressor mechanism that limits tumor progression by triggering apoptosis or permanent cell cycle arrest, called senescence. In recent years, efforts to reactivate p53 function in cancer have proven to be a successful therapeutic strategy in murine models and have gained traction with the development of a range of smallmolecules targetingmutant p53. However, knowledge of the downstream mediators of p53 reactivation in different oncogenic contexts has been limited. Here, we utilized a panel of murine cancer cell lines from three distinct tumor types susceptible to alternative outcomes following p53 restoration to define unique and shared p53 transcriptional signatures. While we found that the majority of p53-bound sites and p53-responsive transcripts are tumor-type specific, analysis of shared targets identified a core signature of genes activated by p53 across all contexts. Furthermore, we identified repression of E2F and Myc target genes as a key feature of senescence. Characterization of p53-induced transcripts revealed core and senescence-specific long noncoding RNAs (lncRNAs) that are predominantly chromatin associated and whose production is coupled to cis-regulatory activities. Functional investigation of the contributions of p53-induced lncRNAs to p53-dependent outcomes highlighted Pvt1b, the p53-dependent isoform of Pvt1, as a mediator of p53-dependent senescence via Myc repression. Inhibition of Pvt1b led to decreased activation of senescencemarkers and increased levels of markers of proliferation. These findings shed light on the core and outcome-specific p53 restoration signatures across different oncogenic contexts and underscore the key role of the p53-Pvt1b-Myc regulatory axis in mediating proliferative arrest. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Planning Education & Research is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Context: The long-term risk of type 2 diabetes in adolescents with nonalcoholic fatty liver disease (NAFLD) is unclear.Objective: To assess type 2 diabetes risk among adolescents with NAFLD.Design and Setting: A nationwide, population-based study of Israeli adolescents who were examined before military service during 1997-2011 and were followed until December 31, 2016.Participants: A total of 1 025 796 normoglycemic adolescents were included.Interventions: Biopsy or radiographic tests were prerequisite for NAFLD diagnosis. Data were linked to the Israeli National Diabetes Registry.Main Outcome Measures: Type 2 diabetes incidence.Results: During a mean follow-up of 13.3 years, 12 of 633 adolescents with NAFLD (1.9%; all with high body mass index [BMI] at baseline) were diagnosed with type 2 diabetes compared with 2917 (0.3%) adolescents without NAFLD. The hazard ratio (HR) for type 2 diabetes was 2.59 (95% confidence interval [CI], 1.47-4.58) for the NAFLD vs. the non-NAFLD group after adjustment for BMI and sociodemographic confounders. The elevated risk persisted in several sensitivity analyses. These included an analysis of persons without other metabolic comorbidities (adjusted HR, 2.75 [95% CI, 1.48-5.14]) and of persons with high BMI; and an analysis whose outcome was type 2 diabetes by age 30 years (adjusted HR, 2.14 [95% CI, 1.02-4.52]). The results remained significant when a sex-, birth year-, and BMI-matched control group was the reference (adjusted HR, 2.98 [95% CI, 1.54-5.74]).Conclusions: Among normoglycemic adolescents, NAFLD was associated with an increased adjusted risk for type 2 diabetes, which may be apparent before age 30 years. [ABSTRACT FROM AUTHOR]

Mission is shaped by the life and experience of the church, both past and present, and this in turn is the function of both the work of the Spirit of God and the interaction of the people of God with their contexts. In line with this position, we examine the impact of Covid-19, highlighting some elements of the global context of mission, trends in world Christianity and mission. We then explore how global mission is in a process of realignment that has the potential to be enhanced through embracing the conditions Covid-19 has imposed on us. Finally, we consider the need for deep reflection on our identity if we are to take the opportunity to bear faithful witness in this moment. [ABSTRACT FROM AUTHOR]

The article argues that over the years a series of gradual developments has taken place in the judicial review policies of Israel's Supreme Court, whereby the Court expanded its ad hoc discretion in determining the constitutional limits that apply to primary legislation. Israeli constitutionalism has become judiciary-centered. The article suggests that judicial discretion that the Israeli Supreme Court tends to exercise in constitutional matters is of two types: substantive judicial discretion, which concerns the interpretation or application of the law; and adjudicative discretion, which includes both the discretion to deny in limine petitions in which the Court does not deem it necessary to grant relief according to considerations such as standing or delay; and the Court's discretion in the manner of the hearing. The article suggests three illuminations of Israeli judiciary-centered constitutionalism: expenditure of the justices' awareness of their discretion; the decline of the rules structuring judicial discretion; and a re-rise of the justices' recognition of legitimacy of adjudicative discretion due to the expansion of substantive judicial discretion. [ABSTRACT FROM AUTHOR]

Objective: Type 2 diabetes (T2D) is increasingly diagnosed at younger ages. We investigated the association of adolescent obesity with incident T2D at early adulthood.Research Design and Methods: A nationwide, population-based study evaluated 1,462,362 adolescents (59% men, mean age 17.4 years) during 1996-2016. Data were linked to the Israeli National Diabetes Registry. Weight and height were measured at study entry. Cox proportional models were applied.Results: During 15,810,751 person-years, 2,177 people (69% men) developed T2D (mean age at diagnosis 27 years). There was an interaction among BMI, sex, and incident T2D (Pinteraction = 0.023). In a model adjusted for sociodemographic variables, the hazard ratios for diabetes diagnosis were 1.7 (95% CI 1.4-2.0), 2.8 (2.3-3.5), 5.8 (4.9-6.9), 13.4 (11.5-15.7), and 25.8 (21.0-31.6) among men in the 50th-74th percentile, 75th-84th percentile, overweight, mild obesity, and severe obesity groups, respectively, and 2.2 (1.6-2.9), 3.4 (2.5-4.6), 10.6 (8.3-13.6), 21.1 (16.0-27.8), and 44.7 (32.4-61.5), respectively, in women. An inverse graded relationship was observed between baseline BMI and mean age of T2D diagnosis: 27.8 and 25.9 years among men and women with severe obesity, respectively, and 29.5 and 28.5 years among low-normal BMI (5th-49th percentile; reference), respectively. The projected fractions of adult-onset T2D that were attributed to high BMI (≥85th percentile) at adolescence were 56.9% (53.8-59.9%) and 61.1% (56.8-65.2%) in men and women, respectively.Conclusions: Severe obesity significantly increases the risk for incidence of T2D in early adulthood in both sexes. The rise in adolescent severe obesity is likely to increase diabetes incidence in young adults in coming decades. [ABSTRACT FROM AUTHOR]

Urban development relies on many factors to remain viable, including infrastructure, services, and government provisions and subsidies. However, in situations involving federal or state level policy, development responds not just to one regulatory signal, but also to multiple signals from overlapping and competing jurisdictions. The 1982 U.S. Coastal Barrier Resources Act (CoBRA) offers an opportunity to study when and how development restrictions and economic disincentives protect natural resources by stopping or slowing urban development in management regimes with distributed authority and responsibility. CoBRA prohibits federal financial assistance for infrastructure, post-storm disaster relief, and flood insurance in designated sections (CoBRA units) of coastal barriers. How has CoBRA's removal of these subsidies affected rates and types of urban development? Using building footprint and real estate data (n = 1,385,552 parcels), we compare density of built structures, land use types, residential house size, and land values within and outside of CoBRA units in eight Southeast and Gulf Coast states. We show that CoBRA is associated with reduced development rates in designated coastal barriers. We also demonstrate how local responses may counteract withdrawal of federal subsidies. As attention increases towards improving urban resilience in high hazard areas, this work contributes to understanding how limitations on infrastructure and insurance subsidies can affect outcomes where overlapping jurisdictions have competing goals. [ABSTRACT FROM AUTHOR]

Introduction: Pituitary gigantism is a rare but significant paediatric condition with complexities surrounding diagnosis and management. Transsphenoidal surgery (TSS) is the treatment of choice; however, medical treatment is often considered as adjuvant therapy.Case: A 10½ -year-old boy presented with tall stature and a height velocity of 11 cm/year. His height was 178.7 cm (+5.8 SD above mean) and insulin-like growth factor-1 (IGF-1) was elevated. An oral glucose tolerance test demonstrated non-suppression of growth hormone (GH). Initial contrast MRI was inconclusive, but C-11 methionine functional positron emission tomography CT identified a 6 mm pituitary microadenoma. A multidisciplinary team clinic held with the family allowed discussion about medical and surgical treatment options. Due to a number of factors including the patient's young age, prepubertal status, a wish to allow him to settle into his new high school and his desire to reach a final height taller than his father's height, it was decided to try medical therapy first with a somatostatin analogue. Pubertal induction was also commenced and bilateral epiphysiodesis surgery performed. Initial response to octreotide was positive; however, 4 months into therapy his IGF-1 was climbing and a repeat GH profile was not fully suppressed. The patient therefore proceeded to have successful TSS excision of the adenoma.Conclusion: Rare cases such as this require sharing of knowledge and expertise, so the best possible care is offered. It is often necessary to work across sites and disciplines. Each case requires an individual approach tailored to the patient and their family. [ABSTRACT FROM AUTHOR]