Search

A domino catalytic reaction between terminal alkynes, isocyanates, and malonates has been developed. Copper acetylides attack on isocyanates to form a propargylic amide species which further reacted with malonates by the action of t-BuOLi to form dihydropyridine-3-carboxylates. The regioselectivity of the reaction has been examined with unsymmetrical malonate. The procedure is easy to implement, has a broad scope and allows the construction of the scaffolds by creating three covalent bonds in one pot. [ABSTRACT FROM AUTHOR]

In situ generated copper acetylides react with isocyanates and oxiranes to form a decent range of morpholine derivatives. The reactions proceeded with acceptable yields and excellent regioselectivity. The presence of oxygen and moisture completely inhibited the reaction. The scope of the reaction is wide and the reactions involve consecutive C–C, C–N, and C–O bond formations. [ABSTRACT FROM AUTHOR]