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The angiotensin II receptor, losartan, has been found to inhibit platelet aggregability to some extent in in vitro experiments. There have been conflicting results about the in vivo effects of losartan. We sought to clarify the in vivo effect of losartan on platelet aggregation. Forty patients with grade I essential hypertension were treated with losartan for 3 weeks. Platelet aggregation tests with adenosine diphosphate (ADP) and ristocetin were analyzed and compared before and at the end of the study. Losartan effectively decreased systolic (SBP) and diastolic (DBP) blood pressure. Mean SBP before and after treatment was 159.6 ± 12.8 and 149.2 ± 17.3 mmHg, respectively. Mean DBP decreased from 93.7 ± 8.2 to 87.7 ± 10.3 mmHg after treatment. The results of the platelet aggregation tests with ADP and ristocetin were not significantly different when both rate and amplitude of maximal aggregation were included. Peak platelet aggregation with ADP regarding the lowest light transmission in the aggregometer was 59.8% ± 24.3% before and 58.3% ± 18.1% after the treatment. The same variables with ristocetin were 66.8% ± 21.6% and 60.8% ± 23.3%, respectively. In vivo effects of losartan on platelet aggregation with ADP and ristocetin were insignificant. [ABSTRACT FROM AUTHOR]

Sclerosing lipogranuloma of the male genitalia is a rather uncommon condition presenting with subcutaneous masses of the penis and the scrotum. The masses are composed of granulomatous tissue formed around an either exogenous or endogenous lipomatous substance. In case of incomplete resection the masses show a rapid recurrence, thus mimicking a neoplastic lesion. On the basis of a case report a review of this entity in the literature is presented here. [ABSTRACT FROM AUTHOR]

Directional gamma-gamma correlations of the strong 208.4-112.9 keV and of the weak 71.6-249.7 keV cascade transitions in the decay ofLu have been measured. The correlation coefficients A=−0.208±0.012 of the strong and A=−0.105±0.005 of the weak cascade have been determined. The mixing ratio E2/ M1 of −3.7±0.3 for the 112.9 keV transition and the M2/ E1 of −0.0173±0.0065 for the 71.6 keV transition have been obtained. The deduced M2 admixture in the 71.6 keV transition is in good agreement with the theoretical estimates of Weisskopf and of Nilsson. [ABSTRACT FROM AUTHOR]