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There is increasing interest in the link between early linguistic skills and later language development. In a longitudinal study, we investigated infants’ (a) ability to use speech sound categories to guide word learning in the habituation-based minimal pair switch task, and (b) early productive vocabulary, related to their concurrent and later language task performance. The participants at Phase 1 were 64 infants aged 16–24 months (25 with familial risk of language/speech impairment), followed up at 27 months (Phase 2) and at 3 years (Phase 3). Phase 1 productive vocabulary was correlated with Phase 2 productive vocabulary, and with concurrent and later (Phase 3) tests of language production and comprehension scores (standardized tool), and phonology. Phase 1 switch task performance was correlated with concurrent productive vocabulary and language production scores, but not by Phase 3. However, a combination of early low vocabulary score and a preference for looking at an already-habituated word–object combination in the switch task may show some promise as an identifier for early speech–language intervention. We discuss how these relations can help us better understand the foundations of word learning. [ABSTRACT FROM PUBLISHER]

Background Arabic, a Semitic language of the Afro-Asiatic variety, has a rich consonant inventory. Previous studies on Arabic phonological acquisition have focused primarily on dialects in Jordan and Egypt. Because Arabic varies considerably across regions, information is also needed for other dialects. Aims To determine acquisition benchmarks for singleton consonants for Kuwaiti Arabic-speaking 4-year-olds. Methods & Procedures Participants were 80 monolingual Kuwaiti Arabic-speaking children divided into two age groups: 46-54 and 55-62 months. Post-hoc, eight children were identified as possibly at risk for protracted phonological development. A native Kuwaiti Arabic speaker audio-recorded and transcribed single-word speech samples (88 words) that tested consonants across word positions within a variety of word lengths and structures. Transcription reliability (point-to-point) was 95% amongst the authors, and 87% with an external consultant. Three acquisition levels were designated that indicated the proportion of children with no mismatches ('errors') for a given consonant: 90%+ of children, 75-89%, fewer than 75%. Mismatch patterns were described in terms of a phonological feature framework previously described in the literature. Outcomes & Results The Kuwaiti 4-year-olds produced many singleton consonants accurately, including pharyngeals and uvulars. Although the older age group had fewer manner and laryngeal mismatches than the younger age group, consonants still developing at age 5 included coronal fricatives and affricates, trilled /r/ and some uvularized consonants ('emphatics'). The possible at-risk group showed mastery of fewer consonants than the other children. By feature category, place mismatches were the most common, primarily de-emphasis and lack of contrast for [coronal, grooved] (distinguishing alveolar from interdental fricatives). Manner mismatches were next most common: the most frequent substitutions were [+lateral] [l] or other rhotics for /r/, and stops for fricatives. Laryngeal mismatches were few, and involved partial or full devoicing. Group differences generally reflected proportions of mismatches rather than types. Conclusions & Implications Compared with studies for Jordanian and Egyptian Arabic, Kuwaiti 4-year-olds showed a somewhat more advanced consonant inventory than same age peers, especially with respect to uvulars, pharyngeals and uvularized (emphatic) consonants. Similar to the other studies, consonant categories yet to master were: [+trilled] /r/, coronal fricative feature [grooved], [+voiced] fricatives /ʕ, z/ and the affricate /d͡͡ʒ/ and some emphatics. Common mismatch patterns generally accorded with previous studies. This study provides criterion reference benchmarks for Kuwaiti Arabic consonant singleton acquisition in 4-year-olds. [ABSTRACT FROM AUTHOR]

Information and assessment tools concerning Tagalog phonological development are minimally available. The current study thus sets out to develop elicitation and analysis tools for Tagalog. A picture elicitation task was designed with a warm-up, screener and two extension lists, one with more complex and one with simpler words. A nonlinear phonological analysis form was adapted from English (Bernhardt & Stemberger, 2000) to capture key characteristics of Tagalog. The tools were piloted on a primarily Tagalog-speaking 4-year-old boy living in a Canadian-English-speaking environment. The data provided initial guidance for revision of the elicitation tool (available at phonodevelopment.sites.olt.ubc.ca). The analysis provides preliminary observations about possible expectations for primarily Tagalog-speaking 4-year-olds in English-speaking environments: Lack of mastery for tap/trill ‘r’, and minor mismatches for vowels, /l/, /h/ and word stress. Further research is required in order to develop the tool into a norm-referenced instrument for Tagalog in both monolingual and multilingual environments. [ABSTRACT FROM PUBLISHER]

Purpose: This clinical focus article describes an exploratory case study addressing reduction of vocal loudness in a young adult with a history of autism spectrum disorder and developmental delay. The need for a short-term pullout individual intervention arose from his participation in the Advancing Language and Literacy group, a program that provides support for enhancement of speech, language, and literacy skills for young adults with developmental disabilities. Method: The participant attended individual treatment sessions weekly for 9 sessions, all of which were digitally audio-recorded. Client awareness of different loudness levels was first established using nonspeech sounds and speech samples. Loudness in spontaneous speech was monitored with support of verbal and visual feedback in the individual sessions and tracked in individual sessions as well as sessions of the Advancing Language and Literacy group, which served as a generalization context. Results: In the individual sessions, the participant’s spontaneous production of acceptable volume improved from 42% to 92% of utterances. Observation of group participation indicated generalization, with the majority of utterances produced posttreatment at an acceptable volume. Conclusions: This clinical focus article emphasizes suprasegmental aspects as a dimension of communicative competence and highlights the need for continued intervention research and services for young adults with developmental disabilities. [ABSTRACT FROM AUTHOR]

Currently, there is no theoretically justified, evidence-based metric for evaluating segmental and prosodic components of multisyllabic words (MSWs). A pilot study evaluated a MSW metric embedded in non-linear phonological- and language-processing frameworks. Six MSWs were analyzed in 10 Canadian English-speaking 5-year-olds with typically developing speech, and eight French-speaking children, ages 3–4 years, with protracted phonological development (PPD). Mismatches were tallied (with and without vowels), with totals ranked by word and participant, then compared with ranks from Phonological Mean Length of Utterance (PMLU) and Percent Consonants Correct (PCC) tallies. For both groups, the number of different ranks was significant in comparisons of MSW metrics with PMLU and PCC. Rank orderings were systematically higher for English-speaking children using the MSW metric, with/without vowels, and for French-speaking children using the MSW metric with vowels. Overall, the MSW metric was particularly suitable for fine-grained differentiation of phonological accuracy in MSW production. [ABSTRACT FROM PUBLISHER]

Few studies have directly compared fricative development across languages. The current study examined voiceless fricative production in Icelandic- versus English-speaking preschoolers with protracted phonological development (PPD). Expected were: a low fricative match (with age effect), highest match levels for /f/ and non-word-initial fricatives, developmentally early mismatch (error) patterns including deletion, multiple feature category mismatches or stops, and developmentally later patterns affecting only one feature category. Crosslinguistic differences in phonetic inventories were predicted to provide different options for mismatch patterns, e.g. affricates in English, [+spread glottis] segments in Icelandic. For each language, native speakers audio-recorded and transcribed single-word speech samples for thirteen 3-year-olds and ten 4-year-olds. Predictions regarding mismatches were generally confirmed. Accuracy data were partially confirmed, /f/ having a lower match than /s/ overall for the Icelandic children. Other results reflected language or group differences. The data provide confirmation that phonological acquisition reflects crosslinguistic, language-specific and child-specific influences. [ABSTRACT FROM AUTHOR]

Two 6-year-old male fraternal twins each received 8 weeks of morphosyntactic and phonological intervention in counterbalanced order. Progress occurred for most targets and measures, with each child making greater progress for either phonology or morphosyntax during the corresponding unitary-domain block. Gains were maintained during the subsequent alternate treatment block. Possible indirect changes in the non-treated domain were also observed in global measures. The data suggest that at least some school-aged children with concomitant difficulties in morphosyntax and phonology, perhaps those with significant constraints in each domain, can benefit from sequences of unitary-domain intervention. This study invites further research concerning many unresolved clinical issues for school-aged children with protracted development in both phonology and morphosyntax. [ABSTRACT FROM PUBLISHER]

An adolescent with a persistent frontal lisp participated in a two-part 11-session intervention case study. The first phase used ultrasound imagery and acoustic, phonetic and voice education to provide information about articulatory setting (AS) and general awareness of the speech production process. The second phase used traditional articulation therapy, online visual-acoustic biofeedback and fluency strategies to target the frontal lisp directly (specifically /s/, /z/, /ʃ/ and /ʧ/). Trained listener evaluations of pre-intervention, post-phase 1 and post-phase 2 assessments showed no improvement after phase 1, but notable improvement in all treatment targets immediately after phase 2. These improvements were substantially maintained at assessment 4 months post-intervention. The outcomes suggest that direct training was more effective than the AS approach; however, the client's ability to self-monitor in phase 2, rapid acquisition of the targets and maintenance at 4 months post-intervention possibly reflected the knowledge gained in phase 1 about AS. [ABSTRACT FROM AUTHOR]

An overview of Kuwaiti Arabic is presented, with very preliminary data from two typically developing brothers (ages 2;4 and 5;2) and a 6-year-old with a severe sensorineural hearing impairment. The siblings show early mastery of many aspects of the complex Arabic phonological system, with universally expected later mastery of coronal fricatives and /r/. The 6-year-old shows patterns typical of children with hearing impairments, e.g. hypernasality, a prevalence of ‘visible’ segments, particularly labials, and simplified syllable structure. Her accurate use of /l/, /r/, and some gutturals, however, raise questions about the enhanced perceptibility and functionality of these segments in Arabic. [ABSTRACT FROM AUTHOR]

The article presents a descriptive profile of early communication of a 4-year-old child with Rubinstein-Taybi syndrome (RTS), a rare genetic developmental disorder that often shows associated language delay. Physical and facial features of children diagnosed with RTS are cited. Intentional communication appear toward the end of the first year of life, in terms of typically developing infants. Background information about the child is provided. The results of the child's video-recorded interactions with familiar conversational partners are analyzed.

Insulin-like growth factors (IGFs) are thought to promote tumour progression and metastasis in part by stimulating cell migration. Insulin receptor substrate-1 (IRS-1) and IRS-2 are multisite docking proteins positioned immediately downstream from the type I IGF and insulin receptors. IRS-2 but not IRS-1 has been reported to be involved in the migratory response of breast cancer cells to IGFs. The purpose of this investigation was to determine if IRS-1 is involved in, and to assess the contributions of IRS-1 and IRS-2 to, the migratory response of breast cancer cells to IGFs. The expression of IRS-1 and IRS-2 varied considerably between ten breast cancer cell lines. Oestrogen increases expression of the type I IGF receptor, IRS-1 and IRS-2 in MCF-7 and ZR-75 cells. Oestrogens may control the sensitivity of breast cancer cells to IGFs by regulating the expression of components of the IGF signal transduction pathway. The migratory response to a range of IGF-1 concentrations was measured in MCF-7 and MDA-MB-231 breast cancer cells in which IRS-1 and IRS-2 levels were modulated using a doxycycline-inducible expression system. Induction of both IRS-1 and IRS-2 expression increased the sensitivity of the migratory response to IGF-1 but did not increase the magnitude of the response stimulated at higher concentrations of IGF-1. Knockdown of IRS-1, IRS-2 and the type I IGF receptor in MCF-7 and MDA-MB-2231 cells decreased sensitivity to IGF-1. We conclude that both IRS-1 and IRS-2 control the migratory response of breast cancer cells to IGF-1 and may, therefore, be key molecules in determining breast cancer spread. [ABSTRACT FROM AUTHOR]

The current study reports preliminary information gathered about First Nations English dialects in Canada and considers implications for speech-language pathology practice. Information was gathered from literature searches and forums of First Nations and non-First Nations speech-language pathologists, developmentalists, and linguists. The exploratory findings suggest that First Nations English dialects are shaped both by transference of features from the ancestral languages and by cultural patterns of communication. The dialects likely represent late stages of depidginization and decreolization. Examples of phonological and syntactic dialectal features illustrate the importance of recognizing non-standard varieties of English when assessing speakers of First Nations communities and setting up goals and strategies for treatment. Research is urgently needed to identify features of First Nations English dialects both for linguistic documentation and to help speech-language pathologists and other educators to distinguish between language impairments and dialect differences and to develop culturally relevant assessment and intervention practices. [ABSTRACT FROM AUTHOR]

Background: Ultrasound has shown promise as visual feedback in remediation of /ɹ/. Aims: To compare treatment for /ɹ/ with and without ultrasound. Methods & Procedures: A Canadian English-speaking adolescent participated in a case study with a no treatment baseline, alternating treatment blocks with and without ultrasound and a final no treatment period. Outcomes & Results: Formant values and trained listener ratings of speech samples indicated improvement in /ɹ/ production, particularly after the introduction of ultrasound. Conclusions: Ultrasound appeared to facilitate the acquisition of /ɹ/ for the participant. Large-scale studies are needed to evaluate ultrasound further. [ABSTRACT FROM AUTHOR]

Abstract The objective of this research was to study the meiotic stability of a subset of chicken telomere arrays, which are the largest reported for any vertebrate species. Inheritance of these ultra-long telomere arrays (200 kb to 3 mb) was studied in a highly homozygous inbred line, UCD 003 (F ≥ 99.9). Analysis of array transmission in four families indicated unexpected heterogeneity and non-Mendelian segregation including high-frequency-generation of novel arrays. Additionally, the largest array detected (2.8 Mb) was female-specific and correlated to the most intense telomeric DNA signal on the W-sex chromosome by fluorescence in situ hybridization (FISH). These results are discussed in regard to the potential functions of the ultra-long telomere arrays in the chicken genome including generation of genetic variation through enhanced recombination, protection against erosion by providing a buffer for gene-dense regions, and sex-chromosome organization. [ABSTRACT FROM AUTHOR]

Zusammenfassung Post-mortem-Untersuchungen bestätigten, dass glutamaterge NMDA-, AMPA- und Kainatrezeptoren an der Pathophysiologie der Schizophrenie beteiligt sind. Ob die veränderten Rezeptorzahlen dabei krankheits- oder medikamentenbedingt sind, ist bislang unklar. Im Tiermodell wurde deshalb der Einfluss von antipsychotischer Medikation nach bis zu 6-monatiger Behandlung untersucht und hier zusammengefasst. Übereinstimmend ergab sich eine erhöhte NMDA-Rezeptor-Bindung nach Haloperidol im Striatum und Nucleus accumbens, nach Clozapin nur im Nucleus accumbens. Die AMPA-Rezeptorzahl war nach Haloperidol im Gyrus cinguli, Striatum, insulären Kortex sowie Nucleus accumbens, nach Clozapin im anterioren Gyrus cinguli und infralimbischen Kortex erhöht. Die Kainatrezeptorbindung wurde im Hippokampus von beiden Antipsychotika erhöht, jedoch in größerem Ausmaß von Clozapin. Die Ergebnisse zeigen einen differenziellen Effekt zwischen dem Neuroleptikum Haloperidol und dem Atypikum Clozapin. Ein Teil der post-mortem erhobenen Befunde im glutamatergen System bei Patienten mit langjähriger Schizophrenie lassen sich auf auf Medikamenteneffekte zurückführen und sind Ausdruck plastischer Veränderungen durch die Langzeitmedikation mit Antipsychotika. [ABSTRACT FROM AUTHOR]

This communication describes a method of preparing crystalline Aerobacter aerogenes pullulanase free from α-amylase. The preparation is suitable for structural studies of starch and glycogen. Two forms of pullulanase have been observed, differing in molecular weight the proportions varying according to the conditions of growth of the organism. The crystalline enzyme is that of lower molecular weight, concentration-dependent values of 108000 to 145000 being found. The action of the enzyme on polysaccharide substrates has been compared. The rate of action on branched substrates is most rapid when the outer chains have been shortened by α- or Β-amylase. Under comparable conditions, action on rabbit liver glycogen is almost negligible. [ABSTRACT FROM AUTHOR]

The trefoil protein TFF1 is expressed principally in the superficial cells of the gastric mucosa. It is a small protein and forms homo- and hetero-dimers via a disulphide bond through Cys58 which is located three amino acids from the C terminus. TFF1 is co-expressed with the secreted mucin MUC5AC in superficial cells of the gastric mucosa suggesting that it could be involved in the packaging or function of gastric mucus. We have previously shown that TFF1 co-sediments with mucin glycoproteins on caesium chloride gradients. To extend this observation we have now used gel filtration under physiological conditions, immunoprecipitation and Western transfer analysis to characterise the interaction of TFF1 with gastric mucin glycoproteins. We show that TFF1 co-elutes with MUC5AC but not MUC6 on gel filtration and that immunoprecipitation and Western transfer analysis confirms that TFF1 interacts with MUC5AC. We also demonstrate that the TFF1 dimer is the predominant molecular form bound to MUC5AC. Salt and chelators of divalent cations such as EDTA and EGTA disrupted the TFF1- MUC5AC interaction and increased the degradation of MUC5AC, whereas calcium increased the amount of TFF1 bound to MUC5AC. These data support the contention that TFF1 is pivotal in the packaging and function of human gastric mucusa. [ABSTRACT FROM AUTHOR]