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The objective of this study was to investigate whether serum high-sensitivity C-reactive protein (hs-CRP) concentration varies with dietary fatty acid intake in Iranian adults free of any history of cardiovascular disease (CVD). This cross-sectional study involved 8105 adults (3142 men) aged 35-65 years. Dietary intake was assessed using 24-h dietary recalls. The relationship between anthropometric, cardiometabolic risk factors and dietary data and serum hs-CRP was assessed using SPSS software. Median crude dietary saturated fat decreased across hs-CRP quarters (P =0.009 for linear trend), whereas energy-adjusted total fat (P =0.017), trans-fat (P =0.016), monounsaturated fatty acids (P =0.030) and cholesterol (P =0.005) monotonically increased, with some evidence of statistical interactions by gender. In conclusion, serum hs-CRP concentrations were associated with some components of dietary fatty acid intake in our population of individuals without CVD, suggesting that dietary fat intake could be associated with subclinical inflammation. [ABSTRACT FROM AUTHOR]

Background/objectives: Metabolic syndrome (MetS) is characterized by abdominal obesity, dyslipidemia, hypertension and glucose intolerance, and is associated with an increased risk of developing cardiovascular disease (CVD), diabetes mellitus and related diseases. Circulating levels of inflammatory markers such as C-reactive-protein (CRP) have reported to be associated with CVD. Against this background, the prevalence of MetS is increasing globally, and thus predictive biomarkers are required for identification of MetS patients at an increased risk. Here we explored the value of CRP as a biomarker in 7284 subjects and also investigated which features of MetS have the greatest association with the hs-CRP level.Subjects/methods: The subjects were recruited from the Mashhad stroke and heart atherosclerotic disorder study. Anthropometric factors and biochemical parameters (for example, high-sensitivity CRP (hs-CRP), high-density lipoprotein/low-density lipoprotein, triglycerides (TGs) and fasting blood glucose (FBG)) were determined. Univariate and multivariate analyses were conducted to evaluate the association of hs-CRP and MetS.Results: Our results illustrated that the concentration of serum hs-CRP increased progressively with the number of MetS components, and subjects who fulfilled the criteria of MetS for waist circumference, TGs, blood pressure and FBG were found to have hs-CRP of 0.53, 0.38, 0.34 and 0.71 mg/l, respectively, higher than matched-subjects. Importantly, FBG had the greatest association with hs-CRP concentration.Conclusions: Our data demonstrate the significant association between MetS components with hs-CRP, indicating that this association was cumulative by increasing the number of the defining features of MetS, supporting further studies to explore the value of emerging marker as a novel method for detecting individuals at high risk of developing MetS. [ABSTRACT FROM AUTHOR]

The goal of this study was to investigate the prevalence of adiposity in a sample of 35-65 years old individuals from Mashhad in North Eastern Iran, and to ascertain the socioeconomic factors contributing to obesity. The MASHAD study was initiated in 2010 and is a longitudinal cohort study of 9765 individuals aged 35-65 years old. It used a stratified cluster randomized sampling design. Anthropometric measurements [height, weight and waist circumference (WC)] were measured by standard methods. The criteria for under-weight, normal-weight, overweight, and obesity were a BMI of 18.5>, 18.5 to 24.9, 25 to 29.9, 30< (kg/m2), respectively. Abdominal obesity was defined as WC ⩾102 cm in men and WC ⩾88 cm in women and obesity was defined as BMI ⩾30. Logistic regression analysis was used to determine the adjusted odds ratio (OR) and chi-square tests were used to determine whether different categories of demographic and lifestyle variables were associated with different degrees of adiposity. The overall prevalence of obesity and overweight were 30.9% and 42.8% respectively. The overall prevalence of central obesity was 46.7%. The prevalence of obesity in women was higher than in men (P < 0.0001). There was an inverse relationship between the risk of obesity and increasing socioeconomic status (P < 0.0001). Adiposity is prevalent in Mashhad, and appears to be particularly common in women. This may be due to the high levels of physical inactivity in the population as a whole and among women in particular. [ABSTRACT FROM AUTHOR]