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Background: The use of potentially inappropriate medications (PIM) by the elderly is commonly studied, but studies evaluating the use of PIM by frail elderly covered by prepaid health plans are still lacking. Objective: To identify the prevalence of use and the factors associated with the use of PIM by the elderly patients with high and moderate risk of clinical-functional vulnerability, according to the Beers criteria 2019. Methods: A cross-sectional study was developed with elderly people from a private health plan in Vitória-ES, Brazil. Socioeconomic, demographic and clinical data were collected through a digital platform and a structured questionnaire through an interview, from October 2018 to June 2019. The association between the use of PIM and independent variables was verified by univariate logistic regression with their respective confidence intervals (CI) 95%. The Multiple Model included the variables with P ≤.20. Results: 332 elderly patients were interviewed (mean age 81.5 years, gender 237 female, 95 male). A 65% prevalence of PIM use was identified. In the multiple logistic regression model, the variables associated with the use of PIM were self-medication (P =.004), high risk of clinical-functional vulnerability (P =.022), use of psychotropic medications (P =.000001), musculoskeletal medications (P =.04) and alimentary tract medications (P =.03). Physical exercises were considered a protection factor (P =.02). Conclusion: The high prevalence of PIM use indicates the need for improvement in elderly private health care, to increase pharmacotherapy safety for this population. [ABSTRACT FROM AUTHOR]

Chronic myeloid leukaemia ( CML) is a myeloproliferative disorder characterized by the presence of Philadelphia chromosome and by BCR- ABL1, which encodes the BCR- ABL oncoprotein. Although imatinib mesylate ( IM) is effective for CML treatment, patients in accelerated and blastic phases of the disease are often refractory to this therapy, and there are also cases of IM resistance in patients in the chronic phase. Therefore, potential new drugs are being investigated to improve the efficiency of the therapy of CML such as snake venoms and their compounds. In this investigation, Bothrops pirajai L-amino acid oxidase (Bpir LAAO-I) effect on normal peripheral blood mononuclear cells ( PBMC) and on BCR- ABL+ cell line was assessed to explore its potential against leukaemic cells. MTT viability assay, lymphocyte subsets quantification and cell activation markers expression were performed to evaluate Bpir LAAO-I effect on normal PBMC. The effect of Bpir LAAO-I on HL-60 and HL-60. BCR- ABL cell lines was assessed by apoptosis detection. Bpir LAAO-I was able to induce apoptosis in HL-60 and HL-60. BCR- ABL cell lines in a dose-dependent manner, promoted caspases 3, 8 and 9 activation and enhanced IM effect while not affecting the viability of normal cells. In addition, Bpir LAAO-I promoted immune cells activation and lymphocytes subsets changes on normal PBMC. The results indicate that Bpir LAAO-I induces apoptosis and potentiates IM effect on BCR- ABL+ cells. [ABSTRACT FROM AUTHOR]