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5 results on '"Avasthi, P S"'

4. EXPERIMENTAL GLOMERULONEPHRITIS IN THE MOUSE II. EFFECT OF ANTITHYMOCYTE GLOBULIN.

Author

Avasthi, P. S., Avasthi, Pushpa, Tokuda, Sei, Anderson, R. E., and Williams, Jr, R. C.

Subjects
GLOMERULONEPHRITIS, IMMUNE complex diseases, IMMUNIZATION, LABORATORY rats, IMMUNITY, LABORATORY animals
Abstract

Experimental glomerulonephritis induced by heterologous GBM immunization in mice is temporarily prevented and reduced in severity when ATG is administered prior to or in conjunction with GBM. Once the disease is well established, ATG does not appear to significantly alter glomerular damage. [ABSTRACT FROM AUTHOR]

Published
1972

5. EXPERIMENTAL GLOMERULONEPHRITIS IN THE MOUSE.

Author

Avasthi, P. S., Avasthi, Pushpa, Tokuda, Sei, Anderson, R. E., and Williams Jr., R. C.

Subjects
PRECANCEROUS conditions, CELLS, IMMUNOGLOBULINS, KIDNEYS, CANCER, BIOLOGY
Abstract

Mice immunized with dog glomerular basement membrane in Fruend's complete adjuvant uniformly developed severe renal lesions. A prominent event in many animals appeared to be mononuclear cell accumulation around small renal blood vessels. Glomerular lesions characterized by hypercellularity, thickening of basement membrane, necrosis, and well marked crescent formation were noted. Immunofluoresecnt and antibody elution studies from the kidneys of animals immunized with dog GBM demonstrated the presence of specific anti-GBM antibody which could be detected in mouse glomeruli 4 weeks after initial immunization. [ABSTRACT FROM AUTHOR]

Published
1971

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