Lewandoski, Lizie Tanani, Grymuza de Souza, Vanessa, Cannan Kiekiss, Gabriella, Soares, Franciele, Buzanello, Márcia Rosangela, and Bertolini, Gladson Ricardo Flor
Objective: The aim of this study was to systematically review the preclinical studies that have applied the static magnetic field to wound healing. Methods: The search strategy was performed in databases: PubMed, Embase, Scopus, Web of Science, LILACS, CINAHL and Cochrane Database, and in gray literature. The inclusion criteria were: Pre-clinical studies, either with a separate control/sham parallel-group or cross-over design in rodents that used magnets to treat skin injuries anywhere on the body. The risk of bias tool was the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE). Results: Eight randomized clinical trials were included. Wound rate area DM experimental vs DM sham [MD = 2.19, 95% CI, (−0.61, 4.99), I2 25%, p = 0.13] and wound rate area – DM experimental vs non-DM control [MD = 3.33, 95% CI, (−1.86, 8.55), I2 63%, p = 0.21] were not statistically significant. A significant improvement in gross healing time in the experimental group DM compared to the DM sham [MD = -4.48, IC 95%, (−7.88, −1.07), I2 38%, p = 0.010]. The same way tensile strength – DM and non DM subgroup analysis showed improved tensile strength in both the non-diabetic and diabetic experiment groups [SMD = 1.36, 95% CI, (0.60, 2.12), I2 0%, p = 0.0005]. Conclusions: Although not statistically significant, the static magnetic field had a positive effect on wound healing in rodents compared to the sham or control group. There was a significant improvement in the assessment of healing time and skin tensile strength. Plain-language Summary: The magnetic field is a natural and physical modality and can be used as a form of therapy in cases of injuries to a wide variety of tissues, such as bones, muscles and skin. It has been found to be responsible for increasing the synthesis of collagen, an essential protein as a foundation for different organs. This review analyzed the available literature on the effects of magnetic fields on experimental skin lesions in rodents. The form of the study was characterized as a systematic review, with well-established inclusion/exclusion criteria, a broad search, no restriction on period or language, analysis of the risk of bias of the studies included and meta-analysis of the data relating to skin lesions. It was observed that there are positive results indicating a reduction in the time taken to close the lesion, with clinical evidence also favorable to the closure of the lesion area. [ABSTRACT FROM AUTHOR]