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Cities are increasingly acknowledged as crucial when facing climate change—and the environmental crisis more in general—, offering challenges and opportunities in terms of both mitigation and adaptation. Climate change‐sensitive urban governance requires proactive, integrated, and contextualized approaches, making room for the complex, multilayered, multiscalar, and dynamic processes constituting a city. The notion of "resilience" has been acquiring growing recognition as a flexible and powerful concept to respond to these challenges. Resilience itself, however, is also a polysemic notion, often treated as little more than a catchword or a wishful aim or superimposed with other climate‐related terms, such as risk, vulnerability, or adaptation. To promote a stronger integration among different problem‐settings and epistemic communities, this paper advances six analytical distinctions aiming to provide structure and articulation to existing definitions of the concept of "resilience." Likewise, it offers an integrated analytical framework and methodological pipeline to streamline resilience analysis in the context of urban climate risk assessment. The framework is specially defined to link up with the definition of climate risk provided by the Intergovernmental Panel on Climate Change (IPCC) latest Assessment Reports and is illustrated through examples derived from the recent experience of the Chilean Climate Risk Atlas. Plain Language Summary: This paper offers an integrated terminology, analytical framework, and procedure to measure and predict a city's resilience in the face of climate threats. Based on a thorough review and discussion of the literature on the topic, the proposal is designed to articulate existing approaches, usages, and interpretations of the concept. It aims to guide scholars, practitioners, and policymakers to employ resilience as a tool for urban planning and governance. Key Points: We advance six analytical distinctions and a methodological pipeline to streamline resilience in urban climate risk assessmentOur framework promotes integrated and interdisciplinary efforts toward climate‐sensitive urban risk assessment and planningPolycentric governance is required to balance autonomy and coherence across the systems constituting urban Systems‐of‐Systems [ABSTRACT FROM AUTHOR]

Introduction: Glucocorticoids are widely used in the treatment of immune-mediated diseases. Despite their widespread use, details on dosing, effectiveness and adverse effects are yet to be determined. Objective: To know the current use of methylprednisolone (MTP) in the management of immune-mediated conditions, evaluating the relationship among doses, therapeutic response and adverse effects. Methodology: A multicenter retrospective cohort study was designed, including patients who received intravenous pulses of MTP between 1 January 2013 and 12 December 2015 in three different hospitals in Uruguay. The patients included received MTP to treat systemic autoimmune diseases (SADs), hematological, nephrological and neurologic diseases and others. The following variables were analyzed: age, gender, MTP cumulative dose, duration of treatment, clinical response (complete, partial and no response) and adverse effects. Results: In total, 164 cases were identified, of which 118 (72%) were female. The median age was 48.4 (SD: 18) years. The indications for MTP included: neuroimmune- mediated 92 (56.1%), SADs 29 (17.5%), hematological 15 (9.1%), nephrological 12 (7.3%) and others 16 (9.9%). The median dose to achieve complete response was 3.2 g (SD: 1.5); the median dose to accomplish a partial response was 3.5 g (SD: 1.25); the median dose for non-responders was 3.3 g (SD 1.2) (p>0.05). The median dose in those patients with adverse effects was 3.4 g (SD 1.5) and the median dose for those who did not experience adverse effects was 3.3 g (SD: 1.3) (p>0.05). The most frequent adverse effects were infectious (22/164, 13.4%). Diabetics were found to have the highest incidence of adverse effects (13/16, 81%) in comparison to non-diabetics, p<0.05. Discussion: Our study suggests a wide range of doses and duration of treatments with MTP. No major associations were found between clinical response and the use of high MTP doses, but the latter was associated with a large proportion of severe infections. No severe infections were identified with MTP doses lower than 1.5 g. The diabetic population is known to be at risk of experiencing varied adverse effects to MTP. These observations reinforce the need for protocolized use of MTP in order to achieve a better relationship among doses, effectiveness and safety profile. [ABSTRACT FROM AUTHOR]

Microbiological analysis is an integral part of food quality control, as well as of the management of food chain safety. Microbiological testing of foodstuffs complements the preventive approach to food safety activities based mainly on implementation and application of the concept of Hazard Analysis and Critical Control Points (HACCP). Traditional microbiological methods are powerful but lengthy and cumbersome and therefore not fully compatible with current requirements. Even more, pathogens exist that are fastidious to cultivate or uncultivable at all. Besides immunological tests, molecular methods, specifically those based on polymerase chain reaction (PCR), are available options to meet industry and enforcement needs. The clear advantage of PCR over all other rapid methods is the striking analytical principle that is based on amplification of DNA, a molecule being present in every cell prone to multiply. Just by changing primers and probes, different genomes such as bacteria, viruses or parasites can be detected. A second advantage is the ability to both detect and quantify a biotic contaminant. Some previously identified obstacles of implementation of molecular methods have already been overcome. Technical measures became available that improved robustness of molecular methods, and equipment and biochemicals became much more affordable. Unfortunately, molecular methods suffer from certain drawbacks that hamper their full integration to food safety control. Those encompass a suitable sample pre-treatment especially for a quantitative extraction of bacteria and viruses from solid foods, limited availability of appropriate controls to evaluate the effectiveness of the analytical procedure, the current inability of molecular methods to distinguish DNA from viable cells and DNA from dead or non-cultivable cells, and the slow progress of international harmonisation and standardisation, which limit full acceptance of PCR-based methods in food control. The aim of this review is to describe the context and the prospects of PCR-based methods, as well as trends in research and development aimed at solving the next decade challenges in order to achieve full integration of molecular methods in food safety control. [ABSTRACT FROM AUTHOR]