Search

Pseudomonas aeruginosa is a multidrug-resistant opportunistic human pathogen that utilizes two-component systems (TCSs) to sense pathophysiological signals and coordinate virulence. P. aeruginosa contains 64 sensor histidine kinases (HKs) and 72 response regulators (RRs) that play important roles in metabolism, bacterial physiology, and virulence. However, the role of some TCSs in virulence remains uncharacterized. In this study, we evaluated the virulence potential of some uncharacterized sensor HK and RR knockouts in P. aeruginosa using a Galleria mellonella infection model. Furthermore, we demonstrated that KdpD and AauS HKs regulate virulence by affecting P. aeruginosa biofilm formation and motility. Both DkdpD and DaauS showed reduced biofilm and motility which were confirmed by restored phenotypes upon complementation. Moreover, DkdpD and DaauS exhibited increased survival of HeLa cells and G. mellonella during in vivo infection. Altered expression of the transcriptional regulators anR and lasR, along with the virulence genes lasA, pelA, cupA, pqsA, pqsB, pqsC, and pqsD in the mutant strains elucidated the mechanism by which DkdpD and DaauS affect virulence. These findings confirm that kdpD and aauS play important roles in P. aeruginosa pathogenesis by regulating biofilm formation and motility. [ABSTRACT FROM AUTHOR]

Background: The ethnic diversity of India provides a unique opportunity to study the history of the origin of mutations of genetic disorders. Spinocerebellar ataxia type 27B (SCA27B), a recently identified dominantly inherited cerebellar disorder is caused by GAA-repeat expansions in intron 1 of Fibroblast Growth Factor 14 (FGF14). Predominantly reported in the European population, we aimed to screen this mutation and study the founder haplotype of SCA27B in Indian ataxia patients. Methods: We have undertaken screening of GAA repeats in a large Indian cohort of ~ 1400 uncharacterised ataxia patients and kindreds and long-read sequencing-based GAA repeat length assessment. High throughput genotyping-based haplotype analysis was also performed. We utilized ~ 1000 Indian genomes to study the GAA at-risk expansion alleles. Findings: We report a high frequency of 1.83% (n = 23) of SCA27B in the uncharacterized Indian ataxia cohort. We observed several biallelic GAA expansion mutations (n = 5) with younger disease onset. We observed a risk haplotype (AATCCGTGG) flanking the FGF14-GAA locus over a 74 kb region in linkage disequilibrium. We further studied the frequency of this risk haplotype across diverse geographical population groups. The highest prevalence of the risk haplotype was observed in the European population (29.9%) followed by Indians (21.5%). The observed risk haplotype has existed through ~ 1100 generations (~ 22,000 years), assuming a correlated genealogy. Interpretation: This study provides valuable insights into SCA27B and its Upper Paleolithic origin in the Indian subcontinent. The high occurrence of biallelic expansion is probably relevant to the endogamous nature of the Indian population. [ABSTRACT FROM AUTHOR]

This study introduces an environment‐friendly perovskite photodetector (PPD) utilizing the inorganic–organic perovskite CH3NH3SnI3 as the light‐absorbing layer. Perovskite materials, known for their exceptional optoelectronic properties, hold significant promise in photodetector fabrication. The proposed device architecture strategically employs NiO and TiO2 layers to facilitate efficient hole and electron transport. The CH3NH3SnI3‐based PPD demonstrates outstanding quantum efficiency across the visible spectrum, extending into infrared regions. It exhibits a responsivity of 0.68 A W−1 and a detectivity of 3.81 × 1013 Jones. Comprehensive defect and temperature analyses are performed to understand the behavior of the proposed device. These results underscore the potential of less toxic perovskite alternatives for high‐performance photodetectors. All simulations are conducted using the SCAPS‐1D simulator to ensure the validity of the findings. [ABSTRACT FROM AUTHOR]

Introduction: Coronoid process of mandible is seldom fractured during maxillofacial trauma. Majority of the cases of coronoid fracture are treated conservatively, but some lead to complications which are often overlooked. At present, the literature on coronoid fractures is inadequate for meta-analysis. Also, there exists no standardized classification in the literature. Hence, the purpose of this study was to analyze the incidence and establish a novel 'tripartite' classification. Material and Methods: In this study carried out at level 1 trauma center, all patients with coronoid fracture with or without associated maxillofacial fractures were included. Relevant data were noted from Hospital records and CT scans (computer tomographic scans). These cases were classified according to 'tripartite' classification and treated. Data feed was given to IBM® SPSS® statistics (version 21) for analysis. Results: Among 33 coronoid fracture patients, majority (57.57% cases) were from age group of 21–40 years with 82.85% cases attributed to road traffic accidents. 11.43% cases were bilateral, and the rest unilateral cases revealed right-side predilection. Conclusion: Novel tripartite classification allows us to easily categorize and visualize the coronoid fractures. Horizontal types 1 to 3 and vertical types 4 to 6 are in increasing order of incidence, which makes it easy for communication, treatment approach and record maintenance. [ABSTRACT FROM AUTHOR]

Sprinting ability is important for successful performance in sports. The aim of this study was to examine the correlation between force-velocity-power relationship of a whole-body movement and sprint performance. Twelve male participants performed maximal squat jumps with additional loads ranging from 0% to 100% body weight to obtain force-velocity profiles. The mean force and velocity were calculated during the push-off phase for each jump, which resulted in a force-velocity curve. The theoretical maximal force (F0), theoretical maximal velocity (V0) and theoretical maximum power (P0) were computed via extrapolation of the force and velocity data. In the second session, participants performed two 60 m sprints and the time to cover 20 m (t20), time to cover 60 m (t60), and maximum sprint velocity (Vmax) were calculated from the best 60 m trial. Correlation analyses revealed strong and significant correlations between V0 and t20 (r = −0.60), V0 and t60 (r = −0.60), P0 and t20 (r = −0.75) and P0 and t60 (r = −0.78). Multiple linear regression indicated that P0 explained 56%, 61% and 60% of the variability in t20, t60 and Vmax, respectively. Our results emphasise the importance of developing power production capabilities to improve sprint performance. [ABSTRACT FROM AUTHOR]

The growing challenge of food waste management presents a critical opportunity for advancing the circular bioeconomy, aiming to transform waste into valuable resources. This paper explores innovative strategies for converting food wastes into renewable food resources, emphasizing the integration of sustainable technologies and zero-waste principles. The main objective is to demonstrate how these approaches can contribute to a more sustainable food system by reducing environmental impacts and enhancing resource efficiency. Novel contributions of this study include the development of bioproducts from various food waste streams, highlighting the potential of underutilized resources like bread and jackfruit waste. Through case studies and experimental findings, the paper illustrates the successful application of green techniques, such as microbial fermentation and bioprocessing, in valorizing food wastes. The implications of this research extend to policy frameworks, encouraging the adoption of circular bioeconomy models that not only address waste management challenges but also foster economic growth and sustainability. These findings underscore the potential for food waste to serve as a cornerstone in the transition to a circular, regenerative economy. [ABSTRACT FROM AUTHOR]

This study details the design and optimization of a high-performance, stable perovskite solar cell utilizing the nontoxic Sn-based perovskite MASnI3 as the absorber layer. To address the critical challenge of Sn oxidation, oxygen-free electron transport layers (ETLs) and hole transport layers (HTLs) are employed. Comprehensive simulations of 56 ETL/HTL combinations revealed 12 high-performing configurations, with SnS2, WSSe, and ZnSe as notable ETLs and CuSbS2, Sb2S3, Sb2Se3, and Zn3P2 as effective HTLs. Further optimization pinpoints the FTO/SnS2/MASnI3/CuSbS2/Ni configuration as the most promising, achieving a short-circuit current density of 34.81 mA/cm2, open-circuit voltage of 0.89 V, fill factor of 82.19%, and a power conversion efficiency of 25.40%, along with 97% quantum efficiency in the visible spectrum. These findings underscore the potential of oxygen-free charge transport layers to mitigate the internal oxidation of Sn, which is crucial for enhancing the stability of the cell. A comprehensive study has been conducted to highlight the role of numerical methods, particularly using the Solar Cell Capacitance Simulator, a one-dimensional tool, in reducing the trial-and-error process and accelerating fabrication. [ABSTRACT FROM AUTHOR]

This review focuses on the sustainable use of waste plastic by converting it into waste plastic oil (WPO) through catalytic pyrolysis. The primary objective is to explore the potential of WPO, derived from used polyethylene terephthalate bottles, as an alternative fuel for diesel engines. This review also evaluates WPO's physical and chemical properties, revealing that it possesses fuel attributes similar to those of petroleum-based fuels. Catalytic pyrolysis is employed on a laboratory scale, using catalysts such as silica, Zeolite Socony Mobil-5 (ZSM-5), alumina, and kaolin to extract WPO from mixed waste plastics. However, direct use of WPO in diesel engines has shown drawbacks, including significant combustion delays and increased emissions. To address these issues, this review suggests blending WPO with diesel fuel rather than using it as a standalone fuel. Furthermore, the review explores hydrogen enrichment in WPO blends to improve combustion efficiency. Hydrogen enrichment enhances thermal efficiency and reduces environmental emissions, showing potential for improved performance and lower brake-specific fuel consumption. This review presents a comparative analysis of various WPO blends with hydrogen enrichment, highlighting the benefits of incorporating hydrogen to boost combustion and performance. Although promising, further research is needed to ensure the sustainability and effectiveness of WPO blends as a long-term energy source. [ABSTRACT FROM AUTHOR]

The study primarily seeks to investigate the behavioral attribution of distraction in pedestrian road crossing. A distraction-themed questionnaire survey was conducted across Kolkata city, India, to understand the contribution of distraction to near-misses and injuries. The survey response showed that among all reported respondents, 13.7% (61) encountered at least one near-miss and 4.5% (20) experienced at least one accident in the past. The video-based observational field study of 2,360 pedestrians revealed that 28.7% of the pedestrians were distracted while crossing the road. Pedestrians who text walked relatively slowly and 7.9% more likely to violate signal. Additionally, mobile phone talkers were observed to be 4.5% more likely to nearly hit/bump into another oncoming pedestrian. The present study constitutes vital information for planners and policymakers and plays a pivotal role in identifying critical intersections and developing countermeasures to minimize the impact or occurrence of pedestrian distraction and unsafe behavior. [ABSTRACT FROM AUTHOR]

The interaction between two Airy pulses propagating at different wavelengths is numerically investigated. The periodically varying peak intensity of the soliton that emerges from stronger Airy pulse (pump pulse) leads to the formation of periodic temporal boundary. The relatively weaker Airy pulse (probe pulse) on interaction with this boundary gets partially reflected as well as transmitted. As a result, the probe pulse spectrum splits into two parts‐ the reflected pulse spectrum undergoes redshift while transmitted pulse exhibits blueshift. The probe pulse witnesses maximum reflection when point of interaction lies on the intensity maxima of the emergent soliton from pump Airy pulse. On the other hand, maximum transmission occurs when probe Airy pulse interacts at the intensity minima of the soliton. The reflection and transmission processes can be manipulated by tuning the time delay between pump and probe Airy pulses. In the case of a sufficiently intense pump pulse, the temporal boundary mimics the artificial optical event horizon, and the weak probe Airy pulse is completely reflected. This phenomenon is equivalent to the temporal version of total internal reflection. The results of the study hold potential applications in optical manipulation and temporal waveguiding. [ABSTRACT FROM AUTHOR]

γ‐Polyglutamic acid (γ‐PGA) microgel, produced by Bacillus spp., represents a promising biomaterial with diverse industrial applications due to its biodegradability, biocompatibility, and nontoxic nature. This review explores the current methodologies in the industrial production of γ‐PGA microgel, emphasizing the optimization of fermentation conditions, genetic engineering of Bacillus strains, and advances in downstream processing techniques. Key applications in pharmaceuticals, agriculture, and environmental management are discussed, highlighting its role in drug delivery systems, as a biocontrol agent, and in wastewater treatment. Future perspectives include enhancing production efficiency through synthetic biology, expanding its application scope, and addressing economic and regulatory challenges to facilitate broader adoption. The integration of innovative technologies and multidisciplinary approaches is crucial for the sustainable development and commercial success of γ‐PGA microgel. [ABSTRACT FROM AUTHOR]

Here, we assess the effect of silica and modifier ions on the biological performance of quaternary 81S bio-glass (81SiO2–16CaO–2P2O5–1Na2O mol%) against ternary 85S bio-glass (85SiO2–10CaO–5P2O5 mol%) synthesized via Stober’s method. The in vitro simulated body fluid (SBF) assay confirms the deposition of a hydroxyapatite layer on 81S and 85S bio-glasses, verified by XRD, FTIR and HRSEM analyses. However, a notable difference emerges in the pH study, where a slower degradation rate has been observed in the case of 85S compared to that of 81S bio-glass, which can be attributed to the presence of high silica content. In the MTT assay, 81S bio-glass exhibits significantly higher cell viability of 130%, surpassing that of 85S bio-glass, where 114% of cell viability is detected. While both bio-glasses exhibit antibacterial properties, 81S shows a higher efficacy in inhibiting the growth of E. coli by 47% and S. aureus by 51%, whereas 85S demonstrates comparatively lower inhibition, restraining E. coli by 16% and S. aureus by 35%. The substantial difference in antibacterial activity can be attributed to a slower dissolution rate of 85S bio-glass, which results in a very small change in pH of the surrounding environment. In conclusion, 81S bio-glass demonstrates superior bioactivity, cell proliferation and antimicrobial efficacy, making it a promising candidate for biomedical applications. [ABSTRACT FROM AUTHOR]

Researchers are focusing on the development of bio-fillers through different approaches for dental purposes. The present work reports a relatively simple and faster chemical approach for synthesising composites using silica from waste rice husk along with PEGMA, PNIPAm, HEMA, APS, and MBA. The synthesis includes no harmful chemical reagents and focuses on the effective management of waste. The X-ray diffraction revealed the crystalline nature of composite and with an average crystallite size of 35 nm for the silica particles. The average particle size for silica was found in the range 200–230 nm from dynamic light scattering having a stable structure with −18.23 ± 0.5 mV as the zeta potential. The porosity was analysed using scanning electron microscopy and the stoichiometric composition by energy-dispersive spectroscopy with the pore size from 95–350 nm. Fourier transform infrared spectroscopy revealed the presence of different functional groups. The thermal stability of silica was analysed through Thermogravimetric analysis. The antibacterial activity of the composite against E.coli and S. aureus demonstrated its efficacy against bacterial growth inhibition. The porous composite can be effectively used as a filler material in potential biomedical applications including dental composite for sustained drug loading and release. [ABSTRACT FROM AUTHOR]

This study delved into the intricate relationship between tunnel geometry and the stability of shallow foundations. It investigated the influence of various tunnel geometries on the behavior of a strip footing (width, B) subjected to uniform loading positioned above a single/dual-tunnel system. The analysis encompassed three different tunnel geometries, namely, circular, square, and horseshoe, for both single- and dual-tunnel configurations. The primary focus of the study was quantifying the stability number, Nv, as a measure of tunnel's impact on footing stability using finite-element analysis. For the single-tunnel configuration, the study examined the vertical depth between the footing base and the tunnel crest (Z) and the horizontal distance between the central vertical axis of the footing and the center of the tunnel (X). Additionally, in the case of the dual-tunnel configuration, the influence of horizontal spacing between the two tunnels (S) on Nv and also the impact of asymmetrical shapes of tunnels with three different cases, i.e., Case I (circular and square-shaped tunnels), Case II (circular and horseshoe-shaped tunnels), and Case III (square- and horseshoe-shaped tunnels), were studied. The findings of this study emphasize that tunnel geometries have a substantial impact on Nv, especially when the Z/B ratio is less than 3 for both tunnel configurations. However, when Z/B exceeds 3, the influence of tunnel geometries on Nv becomes negligible. Furthermore, in the case of asymmetrical tunnel configurations, Case II consistently exhibits the highest stability number (Nv), followed by Case I and Case III, across all combinations of S/B and Z/B values. Additionally, the study identifies zones of plastic stress deformation associated with different tunnel geometries. It underscores the importance of implementing supplementary support systems in cases where these deformations are prominent, ensuring the overall stability of the footing–tunnel system. Practical Applications: In the dynamic realm of underground space utilization, ensuring the safety of structures above and below ground is paramount. With the increasing construction of tunnels near existing buildings, it is crucial to prioritize their protection and assess their suitability for use. In response to contemporary challenges, this study investigated the impact of nearby tunnels on load-bearing capacity of structures. It delved into how the shape of tunnels influences the behavior of surrounding structures, taking into account the regions of the rock mass affected by such interactions. Additionally, the study provided insights into the practical implications of planning and constructing asymmetrical tunnels—a common scenario where new tunnels with varying shapes are built near pre-existing ones. The findings of this research offer practical applications in determining the load-carrying capacity of shallow foundations in the vicinity of tunnels with diverse configurations, shapes, and locations from the foundation. The special significance of this research lies in its ability to guide the design of surrounding structures and identify specific zones around tunnels that require attention, ultimately contributing valuable insights for establishing suitable support systems. [ABSTRACT FROM AUTHOR]

Purpose: This study aims to re-examine the relationship between financial accessibility and performance of micro, small and medium enterprises (MSMEs) in developing countries using a large database. Design/methodology/approach: This study uses cross-sectional firm-level data from the World Bank Enterprises Survey database collected under Wave II from 2006 to 2019. Controlled for firm level and country level factors, OLS and instrumental variable regressions have been used for analysis. Firm performance has been measured in terms of labour productivity. Findings: The study observes a positive association between access to finance and MSME performance measured in terms of sales and value-added per worker. Along with firm characteristics (like size, age and managerial experience), country's development level, institutional quality (i.e. corruption and regulations) and economic openness also impact MSMEs' productivity. Practical implications: Strengthening the financial system to allow the financial sector to meet the requirements of MSME finance is very important. Better access to external finance will enable MSMEs to invest in upgrading technology and expanding operations, thus improves their labour productivity. As the MSME sector is vulnerable to economic shocks, policies facilitating their access to formal credit during crises could strengthen resilience. Social implications: Credit constraint to MSMEs is a multi-stakeholder problem. It requires a coordinated approach from MSME owners, financial institutions and policymakers to address it and enhance the credit flow to the MSME sector. Timely research inputs from academia, research institutions and think tanks may help assess MSMEs promotion policies and their revision if needed. Originality/value: To the best of the authors' knowledge, this is the first study that examines the effect of access to finance on the labour productivity of MSMEs in developing countries. Given the mixed results in the recent past between access to finance and firm performance, it highlights the critical role of financial accessibility in improving their labour productivity and thus enabling MSMEs to realise their full potential in developing countries. [ABSTRACT FROM AUTHOR]

Present study is a comparative evaluation of the financial impact on choice of flap, clinical results as well as post resection quality of life assessment of cancer patients reconstructed with anterolateral thigh(ALT) flap and pectoralis major myo-cutaneous(PMMC) flap. Ethical clearance was obtained from institutional ethical committee. In this non-randomised, prospective study design among 49 oral squamous cell carcinoma cases, 39 cases were reconstructed using PMMC flap and 10 using ALT flap from year 2020 to 2022. These 2 flaps were compared in terms of parameters like time utilised for reconstruction, hospital stay, overall survival and Washington University Quality of Life index(UW-QOL) for head and neck cancer. Patients were followed regularly for post-operative complications. The University of Washington Quality of Life score (UW-QOL) questionnaire, version 4, was completed at six months post-operatively. Obtained data was statistically analysed using IBM® SPSSⓇ. Washington University Quality of Life index scores and esthetics are better with Antero-lateral thigh flap, with less overall post-operative complications. On the other hand Pectoralis myocutaneous flap has less surgical time and more salvage potential. Despite of Antero-lateral thigh flap having Good Washington University Quality of Life index scores, lesser post-operative complications and better esthetics; scale of developing nations is still tipping towards economical, less time consuming and less technique sensitive Pectoralis major myocutaneous flap. [ABSTRACT FROM AUTHOR]

Melt blending is a reliable and well‐demonstrated strategy for improving the mechanical, thermal, rheological, and surface properties of biopolymers. Poly(hydroxy‐3‐butyrate‐co‐3‐hydroxyvalerate) (PHBV) and poly(butylene adipate‐co‐terephthalate) (PBAT) are the two popular choices for blending polymers due to their diverse properties and complementary soil biodegradable behaviour. Due to their immiscibility, however, blending with the help of processing additives is necessary to reap the most significant benefits from this process and to avoid immiscibility issues. This study utilized the additives (peroxides and epoxy‐based chain extender) to compatibilize the biodegradable polymers PHBV and PBAT in a 60:40 blending ratio. The tensile strength and Young's modulus of the PHBV/PBAT(60/40) blend were improved by 32% and 64%, respectively, after adding a combination of peroxide (0.02 phr) and chain extender (0.3 phr) due to the formation of a complex network structure with increased chain length. The positive effect of an additive addition was also reflected by a 30°C increment in heat deflection temperature of biodegradable blend due to its high modulus value as supported by mechanical properties. The combined action of a peroxide and chain extender demonstrated a significantly higher complex viscosity of the PHBV/PBAT(60/40) blend due to the formation of a crosslinked polymer network as analyzed by rheological analysis. Our research demonstrated the effect of additives and their combined impact on analytical properties of PHBV/PBAT(60/40) blend to guide future work in improving their candidature to serve as a drop‐in solution in replacing non‐biodegradable petro‐based plastic products. [ABSTRACT FROM AUTHOR]

Drilling precise micro-holes in glass material has brought a new challenge, primarily due to its application in microfluidic devices. It is required to reduce machining time and simultaneously achieve repeatability of the process. The machined hole should have minimum overcut to get desired hole diameter. Maximum hole circularity and minimum heat-affected zone are the essential hole characteristics to achieve controlled machining. The multi-criteria decision-making (MCDM) method is quite effective in selection of best possible combination of outputs from several alternative solutions. The experimental data from the previously published paper is used in the current study. As input parameters, the experiment data include voltage, tool feed rate, and machining time. The radial overcut (ROC), circularity of the machined hole and heat-affected zone (HAZ) were calculated as output responses. The experiments were conducted using copper and nickel-coated copper tools in previous study and response data were used in current work. The present study uses the methods which include hybrid grey relational analysis (GRA), technique for order performance by similarity to ideal solution (TOPSIS), and VIšekriterijumsko KOmpromisno Rangiranje (VIKOR) methods for the selection of the best combination of process parameters in drilling to obtain the optimal geometric characteristic of a hole, i.e. optimal values of ROC, circularity and HAZ, in glass using electrochemical discharge machining (ECDM). In this study, weight calculation for MCDM was proposed using entropy and analytic hierarchy process (AHP) methods and combined to get final weights using the fuzzy logic tool, which determines the importance of AHP and entropy weights using the expert opinion. The final weights were used to calculate the ranks from each MCDM method and determine optimal process parameter selection in ECDM hole drilling with copper and nickel-coated copper tools. The fuzzy logic method determined that the weight contribution from AHP is 0.586 in the present study. Genetic algorithm-based multi-objective optimization was conducted, and a non-dominated Pareto front was generated. The Spearman correlation method was used to determine the relationship between different MCDM methods. The current study will be helpful in selecting the best combination of process parameters in drilling holes during ECDM machining using MCDM methods. [ABSTRACT FROM AUTHOR]

As a dietary strategy, methionine restriction has been reported to promote longevity and regulate metabolic disorders. However, the role and possible regulatory mechanisms underlying methionine in neurodegenerative diseases such as Alzheimer's disease (AD), remain unexplored. This study utilized the data from BXD recombinant inbred (RI) mice to establish a correlation between the AD phenotype inmice andmethionine level. Gene enrichment analysis indicated that the genes associated with the concentration of methionine in the midbrain are involved in the dopaminergic synaptic signaling pathway. Protein interaction network analysis revealed that glycogen synthase kinase 3 beta (GSK-3b) was a key regulator of the dopaminergic synaptic pathway and its expression level was significantly correlated with the AD phenotype. Finally, in vitro experiments demonstrated that methionine deprivation could reduce the expression of Ab and phosphorylated Tau, suggesting that lowering methionine levels in humans may be a preventive or therapeutic strategy for AD. In conclusion, our findings support that methionine is a high risk factor for AD. These findings predict potential regulatory network, theoretically supporting methionine restriction to prevent AD. [ABSTRACT FROM AUTHOR]

This study aimed to assess the inclusion of antioxidant diphenylamine (DPA) to a Jatropha biodiesel (B30) blend to affects engine performance and exhaust emissions. In this research, three fuel blends has been utilized: diesel, B30, and 100 ppm of antioxidant diphenylamine is added to the B30 blend referred to as B30 + DPA100. A Response Surface Methodology (RSM) has been employed to analyze experimental data, resulting in the development of a regression equation. Additionally, an Adaptive Neuro-Fuzzy Inference System (ANFIS) has been employed to assess and verify the consistency of the developed model. The results from the experiments revealed that the inclusion of the antioxidant had a notable impact on reducing NOx emissions with only a slight effect on brake thermal efficiency (BTHE). Specifically, B30 + DPA100 showed a 7.48 and 15.53% decrease in average NOx emissions, while the average BTHE experienced a modest 0.78% decrease and a 2.67% increase compared to diesel and B30 biodiesel blend, respectively. The Brake Mean Effective Pressure (BMEP) of B30 + DPA100 has been found to be 3.91% and 1.3% higher than diesel and B30, respectively. The Brake Specific Fuel Consumption (BSFC) was 8.68% lower than B30 but 1.49% higher than diesel. Overall, these findings suggest that B30 + DPA100 can be used in diesel engines without modification, offering reduced NOx emissions. [ABSTRACT FROM AUTHOR]

Neurological disease is one of the most common types of dementia that predominantly concerns the elderly. In clinical approaches, identifying its premature stages is complicated, and no biomarker is comprehended to be thorough in witnessing neurological disorders in their earlier stages. Deep learning approaches have attracted much attention in the scientific community using scanned images. They differ from simple machine learning (ML) algorithms in that they study the most favorable depiction of untreated images. Deep learning is helpful in the neuroimaging analysis of neurological diseases with subtle and dispersed changes because it can discover abstract and complicated patterns. The current study discusses a vital part of deep learning and looks at past work that has been used to switch between different ML algorithms that can predict neurological diseases. Convolution Neural Networks, Generative Adversarial Network, Recurrent Neural Network, Deep Belief Network, Auto Encoder, and other algorithms for Alzheimer's illness prediction have been considered. Many publications on preprocessing methods, such as scaling, correction, stripping, and normalizing, have been evaluated. [ABSTRACT FROM AUTHOR]

The emergence of resistance against the last-resort antibiotic vancomycin in staphylococcal infections is a serious concern for human health. Although various drug-resistant pathogens of diverse genetic backgrounds show higher virulence potential, the underlying mechanism behind this is not yet clear due to variability in their genetic dispositions. In this study, we investigated the correlation between resistance and virulence in adaptively evolved isogenic strains. The vancomycin-susceptible Staphylococcus aureus USA300 was exposed to various concentrations of vancomycin repeatedly as a mimic of the clinical regimen to obtain mutation(s)-accrued-clonally-selected (MACS) strains. The phenotypic analyses followed by expression of the representative genes responsible for virulence and resistance of MACS strains were investigated. MACS strains obtained under 2 and 8 µg/ml vancomycin, named Van2 and Van8, respectively; showed enhanced vancomycin minimal inhibitory concentrations (MIC) to 4 and 16 µg/ml, respectively. The cell adhesion and invasion of MACS strains increased in proportion to their MICs. The correlation between resistance and virulence potential was partially explained by the differential expression of genes known to be involved in both virulence and resistance in MACS strains compared to parent S. aureus USA300. Repeated treatment of vancomycin against vancomycin-susceptible S. aureus (VSSA) leads to the emergence of vancomycin-resistant strains with variable levels of enhanced virulence potentials. [ABSTRACT FROM AUTHOR]

Background: About 10% of Indians have common mental disorders (CMDs) which include depression and anxiety. These disorders are common in women, which not only impacts on their quality of life but also their family members. The objective of the study was to estimate the prevalence of CMDs, and factors associated with them among women residing in coastal Karnataka. Methods: A cross-sectional study was carried out among 980 women aged between 18 and 60 years from 2019 to 2021. Women were administered a baseline questionnaire along with Patient Health Questionnaire-9 (PHQ-9), Generalised Anxiety Disorder questionnaire-7 (GAD-7) and Cohen's Perceived Stress Scale-4 (PSS-4). Data were collected using Epi-info and were analysed using SPSS version 15.0. Association between CMDs and socio-demographic, reproductive health and behavioural factors were expressed as crude and adjusted odds ratio (OR) with 95% confidence intervals (CI). Results: The prevalence of CMDs among women was 5.7%, with 4.6% having depression and 3.37% with anxiety disorders. Multivariate logistic regression analysis showed that residing in urban areas (OR = 2.15; 95% CI:1.10–4.17), having a chronic illness (OR = 2.38; 95% CI:1.14–4.97), history of recent bereavement in the family (OR = 2.20; 95% CI:1.02–4.75), early marriage (OR = 2.63; 95% CI:1.09–6.33), history of abortion (OR = 2.89; 95% CI:1.42–5.92), and exposure to domestic violence (OR = 3.08; 95% CI:1.14–8.33) were significantly correlated with CMDs in this sample. Conclusions: The study revealed that CMDs were prevalent among the surveyed women, which calls for routine screening of women for CMDs in primary care settings for early identification and appropriate interventions. [ABSTRACT FROM AUTHOR]

In this study, the role of solvent viscosity ratio (β) on the creeping flow characteristics of Oldroyd-B fluid over a channel-confined circular cylinder has been explored numerically. The flow governing equations have been solved by RheoTool, an open-source toolbox based on OpenFOAM, employing the finite volume method for extensive ranges of Deborah number (D e = 0.025 – 1.5) and solvent viscosity ratio (β = 0.1 – 0.9) at a fixed wall blockage (B = 0.5). The present investigation has undergone extensive validation, with available literature under specific limited conditions, before obtaining detailed results for the relevant flow phenomena, such as stream function, pressure and stress contour profiles, pressure coefficient (Cp), wall shear stress (τw), normal stress (τxx), first normal stress difference (N1), and drag coefficient ( C D ). The flow profiles have exhibited a distinctive behavior characterized by a loss of symmetry in the presence of pronounced viscoelastic effects. The results for low De notably align closely with those for Newtonian fluids, and the drag coefficient (CD) remains relatively constant regardless of β, as the viscoelastic influence is somewhat subdued. These observations indicate that at high De and low β, viscoelasticity causes asymmetry in creeping flow around a circular cylinder. With an increase in De, the maximum velocity in gap between cylinder and channel walls increases; however, the cylinder experiences significantly less drag force. Within this parameter range, the prevailing force governing the flow is the pressure drag force. [ABSTRACT FROM AUTHOR]

Self-powered biosensors are innovative devices that can detect and analyze biological or chemical substances without the need for an external power source. These biosensors can convert energy from the surrounding environment or the analyte itself into electrical signals for sensing and data transmission. The self-powered nature of these biosensors offers several advantages, such as portability, autonomy, and reduced waste generation from disposable batteries. They find applications in various fields, including healthcare, environmental monitoring, food safety, and wearable devices. While self-powered biosensors are a promising technology, there are still challenges to address, such as improving energy efficiency, sensitivity, and stability to make them more practical and widely adopted. This review article focuses on exploring the evolving trends in self-powered biosensor design, outlining potential advantages and limitations. With a focal point on enzymatic biofuel cell power generation, this article describes various sensing mechanisms that employ the analyte as substrate or fuel for the biocatalyst's ability to generate current. Technical aspects of biofuel cells are also examined. Research and development in the field of self-powered biosensors is ongoing, and this review describes promising areas for further exploration within the field, identifying underexplored areas that could benefit from further investigation. [ABSTRACT FROM AUTHOR]

In two-stage electric vehicle (EV) battery chargers, ac-dc conversion stage contributes significantly in determining the power quality. At this stage, multilevel rectifiers (MLRs) featuring switches with lower voltage rating and better input voltage waveform quality can be adopted. However, balancing capacitor voltage in MLR is an important challenge. In this paper, a single-phase five-level power factor correction (PFC) rectifier with self-balancing capacitor is implemented for EV battery charging. The complimentary switching scheme adopted for rectifier reduces number of gate driver circuits and ensures capacitor voltage balancing. The rectifier shows added benefit of reduced voltage stress across switches and not requiring an external filter at the dc side as the load is parallelly connected with one of the capacitors. The operating principle, control strategy, modulation technique and design features of the implemented five-level rectifier is discussed in detail. The implemented control scheme enhances rectifier performance by establishing precise output voltage regulation during load fluctuations while maintaining unity power factor at input side. The five-level rectifier is validated experimentally and compared with other existing multilevel and non-multilevel rectifier topologies. The peak efficiency of 93.8% is achieved at 2 kW of output power. [ABSTRACT FROM AUTHOR]

A material that composed a components either nanoscale or nano-sized and have improved dielectric characteristics is called a nanocomposite material for dielectric applications. Dielectric materials can sustain an electric field with little energy loss since they are non-conductive. This study examined in detail the optical, morphological, and structural characteristics of materials made of tin dioxide/graphene oxide (SnO2/GO), with an emphasis on the potential uses of these materials as dielectrics. The crystalline nature of the materials was revealed by using X-ray diffraction (XRD) to clarify the structural properties of the produced nanocomposites. This was done in a systematic manner. For the purpose of enhancing dielectric characteristics, morphological investigations using scanning electron microscopy (SEM) reveal a well-dispersed and linked structure. A significant defect density is discovered in the composite, and the energy dispersive X-ray spectroscopy (EDX) spectrum's exclusive Tin (Sn), carbon (C), and oxygen (O) content confirms the originality of the sample. The optical properties of the nanocomposites were studied using photoluminescence (PL) measurements, and ultraviolet-visible spectroscopy (UV-Vis) of the nanocomposite revealed a 3.7 eV energy of the band gap that is consistent with SnO. The tiny high fault density and grain size are in charge of the dielectric constant's observable increase. The synthesized SnO2/GO nanocomposite shows promising properties use in dielectric applications. [ABSTRACT FROM AUTHOR]

Background: Female athletes are four to six times more likely to sustain an anterior cruciate ligament (ACL) injury than male athletes. Jump-landing biomechanics are influenced by maturation, with post-pubertal female athletes at a heightened risk of ACL injuries. Objective: The aim of our systematic review was to identify and summarise the current evidence regarding the changes in kinematic and kinetic risk factors associated with ACL injuries during jump-landing tasks in female athletes at various stages of maturity. Methods: A systematic search was conducted in PubMed, CINAHL, Web of Science, SPORTDiscus, EMBASE and Scopus. Articles were included if they: (1) conducted the research on uninjured female athletes with no restriction on playing level/experience; (2) provided information regarding the stage of the maturity and the scale used for estimating the maturity status of the participants; and (3) reported a biomechanical risk factor associated with ACL injuries during jump-landing tasks across at least two different maturity groups (e.g. pre-pubertal vs post-pubertal). Results: Sixteen articles involving 2323 female athletes were included in our review. A total of 12 kinematic and 8 kinetic variables were identified across these studies. Of the 12 kinematic variables reported in our review, we found strong evidence for higher peak knee abduction angle in post-pubertal female individuals compared with pre-pubertal girls (p < 0.05). With regard to the 8 kinetic variables, we found strong evidence for lower relative peak vertical ground reaction force, higher external knee abduction moment and internal rotation moment in post-pubertal compared with pre-pubertal athletes. The strength of evidence for the remaining kinematic and kinetic variables ranged from conflicting to moderate and, in some instances, could not be determined. Conclusions: Our study provides an overview of the changes in biomechanical risk factors in female athletes during jump-landing tasks at various stages of maturity. We found moderate-to-limited evidence for most kinematic and kinetic variables, highlighting the need for further research. [ABSTRACT FROM AUTHOR]

The striatum plays a central role in directing many complex behaviors ranging from motor control to action choice and reward learning. In our study, we used 55 male CFW mice with rapid decay linkage disequilibrium to systematically mine the striatumrelated behavioral functional genes by analyzing their striatal transcriptomes and 79 measured behavioral phenotypic data. By constructing a gene coexpression network, we clustered the genes into 13 modules, with most of them being positively correlated with motor traits. Based on functional annotations as well as Fisher’s exact and hypergeometric distribution tests, brown and magenta modules were identified as core modules. They were significantly enriched for striatal-related functional genes. Subsequent Mendelian randomization analysis verified the causal relationship between the core modules and dyskinesia. Through the intramodular gene connectivity analysis, Adcy5 and Kcnma1 were identified as brown and magenta module hub genes, respectively. Knock outs of both Adcy5 and Kcnma1 lead to motor dysfunction in mice, and KCNMA1 acts as a risk gene for schizophrenia and smoking addiction in humans. We also evaluated the cellular composition of each module and identified oligodendrocytes in the striatum to have a positive role in motor regulation. [ABSTRACT FROM AUTHOR]

Materials that lead to devices with tunable responses to the morphology are a potential opportunity. Tellurium, a growing material class possessing higher electronic conductivity, has recently been seen to exhibit the same in transition-metal-based complexes when combined toward wider energy applications. However, it has rarely been engineered and implemented for morphology-dependent low-dimensional (LD) structures for catalytic reactions. Herein, for the first time, we provide a novel approach for designing dimension variable nano nickel tellurate (NTO), such as nanorods (NRs), through pH assisted anisotropic transformation from the zero-dimensional amorphous counterpart. The resulting NRs have an average width of 5–30 nm and lengths in micrometers. Mechanistic studies show that the morphology of the final product is determined by the pH value used. In line with structural phase analysis, average core-level spectroscopic and local spectro-microscopic determinations confirm the formation of Ni2+- and Te4+/Te6+-based NTO NRs via electronic structure investigation and covalency. Our study not only provides a fresh approach to achieve varied NTO NRs but also offers insights into the growth reaction mechanisms of anisotropic transformation. The proposed facile design scheme can be optimized to synthesize any nanotellurates with morphological purity to promote the catalytic reactions through low-dimensional activity. As an example, these samples were tested for the oxygen evolution reaction. [ABSTRACT FROM AUTHOR]

This research article delves into the synthesis and characterization of Li(1‐x)Sm(x/3)NbO3 ceramic, employing a high‐energy ball milling process. The investigation explores the incorporation of Sm3+ at the Li+1 site across a range of compositions (x = 0, 0.01, 0.02, 0.03, 0.04, 0.05). Structural analysis, using x‐ray diffraction (XRD) and Rietveld structural refinement, establishes that within the investigated composition range, no significant changes in the crystal structure are evident. The x‐ray photoelectron spectroscopy revealed the presence of oxygen vacancies as well as the stable oxidation state of different elements like O2−, Nb5+, Sm3+, and Li1+. At sintering temperature 1050°C, the average grain sizes vary approximately from 1.5 to 3.8 μm for different compositions with regular grain morphology. The UV‐Vis analysis reveals a noteworthy reduction in the band gap to 3.09 eV for the x = 0.01 composition. Photoluminescence studies exhibit distinct green, orange, and red bands, with the highest intensity observed for x = 0.01, showcasing promising optical properties. The dielectric permittivity of Sm‐substituted compositions surpasses the response of pure LiNbO3, demonstrating an increasing trend with temperature in the frequency range 100 Hz‐1 MHz intriguingly, no Curie temperature is observed up to 500°C for any composition. The polarization vs electric field hysteresis loop response highlights better polarization characteristics at the room temperature and maximum polarization is 0.66 μC/cm2 for the composition x = 0.05. The energy storage response of the developed compositions is investigated, which reveals a maximum efficiency of 46.64% for x = 0.04 in Li(1‐x)Sm(x/3)NbO3. The tunable optical properties, enhanced dielectric response, and notable energy efficiency of these high TC ceramics suggest their utility across diverse applications. These findings not only contribute to the understanding of functional ceramic materials but also pave the way for their optimized utilization in advanced technological applications, particularly in energy storage devices under nonambient conditions at high temperatures. [ABSTRACT FROM AUTHOR]

Unlike lane-based traffic where each driver has a distinct leader, the subject driver in disorderly traffic may interact with multiple vehicles in-front. The existence of lateral interactions among the vehicles in-front adds even more complexity to modeling the human-driving process. Utilizing trajectory data extracted from an instrumented vehicle study, this research attempts to propose a gated recurrent unit neural network model to predict responses of vehicles interacting with two leading vehicles simultaneously. The recurrent neural network model can illustrate realistic human-like following behavior of drivers, much better than the classical optimal velocity-based models in terms of trajectory reproducing accuracy. The model can also explain the closing-in, shying-away behavior and local stability properties. Results of the study provide insights into the driving behavioral phenomena of disorderly traffic flows and can contribute to the development of a realistic microsimulation model, smarter autonomous systems, and in-traffic safety evaluation as well. [ABSTRACT FROM AUTHOR]

Hydrogen, a form of energy that is both clean and renewable, is now being researched and developed as a potential source of alternative energy. There are many different kinds of microbial systems that have the potential to be utilised in the manufacturing of biohydrogen. Thermophiles are found as potential producers of hydrogen, at a high rate, in adverse operating conditions. Temperature, pH, and concentration of substrates play a crucial role in affecting the metabolism of these microorganisms. Sustainable production of hydrogen is feasible when organic waste is employed as a potential feedstock. The overall yield of hydrogen production procedures demands improvements, to turn them into commercial applications. The integration of two-stage processes may contribute to an overall increase in energy output. As examples of second-stage processes, biomethanation, microbial electrolysis cells, photo-fermentation, and microbial fuel cells have been the subject of extensive research. This article provides an overview of the photocatalytic method for producing biohydrogen, including its fundamentals and underlying mechanisms, as well as other biological methods of hydrogen production. This process exhibits reduced energy consumption and demonstrates environmental friendliness by potentially utilising waste material as a substrate. [ABSTRACT FROM AUTHOR]

A patient presenting with a history of restricted mouth opening and deflection of the mandible after a prolonged dental procedure raises a suspicion of temporomandibular joint disorder (TMD) due to its estimated high prevalence of 29%. Muscle relaxants and routine active physiotherapy established normal range of movement and pain reduction was achieved through TENS therapy and analgesics. However, the non-subsidence of deflection prompted an initial suspicion of TMD which was overturned by MRI. The MRI evaluation revealed left side medial pterygoid abscess. It is imperative to understand that despite strong history and relevant clinical features, for the definitive diagnosis radiographic evaluation is highly contributory. Misdiagnosing TMD due to its similar presentation can have significant implications for the patient's well-being and quality of life. The clinical features of medial pterygoid abscess including restricted mouth opening and pain can be similar to that of TMD. These abscesses are most commonly caused by odontogenic infections but can also occur as a result of septic inferior alveolar nerve block techniques. Limited literature reports of pterygoid space abscess have been described, but intramuscular and medial pterygoid abscess is an absolute rarity. Causal relationship to septic inferior alveolar nerve block further makes this case report an interesting read. [ABSTRACT FROM AUTHOR]

Two species of lichenicolous fungi viz. Didymocyrtis cladoniicola (Diederich, Kocourk. and Etayo) Ertz and Diederich, and Epicladonia simplex D. Hawksw., inhabiting Cladonia species are discovered as new records for India, besides four species known earlier from India. Cladonia, a dimorphic genus is one of the most suitable hosts for the fungal spores to colonize easily for the growth of lichenicolous fungi. The brief taxonomic descriptions of species, distribution and illustrations are provided to facilitate their identification. [ABSTRACT FROM AUTHOR]

Subtilisin-like serine proteases (SBT), a serine proteolytic enzymes play an important role in plant growth function and during different stresses responses. The systematic analysis of the SBT gene family in Musa acuminate (MaSBT) has been done and their responses to abiotic stresses in banana variety cv. G-9 were also analyzed. Total of 67 MaSBT genes were identified and based on phylogeny these were grouped into five districted subgroups. Cis-acting element analysis indicated that almost all MaSBT promoters contain regulatory elementary related to growth and development, hormonal regulation, and stress responses. The gene structure and domain analysis showed a maximum of seventeen exons and four functional domains in MaSBT. The 42 orthologous genes, 07 MaSBT paralogous genes were also identified through synteny analysis. The Ka/Ks study indicated that four MaSBT paralogous gene pairs were tandemly duplicated, while the other three were segmental duplications. Further, the expression pattern via RNA-seq data revealed that MaSBTs exhibited differential expression specifically in response to the abiotic stress of low nitrogen. and also during the flowering time. The MaSBT-1.7 gene was found involved in the response to salt stress and flowering. These findings establish a cornerstone for future research on banana's salt stress mechanism. The study offers valuable insights into SBT encoding genes, shedding light on their roles in growth, development, and abiotic stress responses. [ABSTRACT FROM AUTHOR]

Globally, large quantity of animal byproducts is generated from the slaughter of food animals, but there is lack of research articles related to drying of these byproducts and its use as pet food. Therefore, this study was conducted with the aim of utilization of intact whole buffalo liver by drying for pet treat, evaluating its shelf life and palatability. The intact liver surface was superficially sliced, and the surface was pierced. Thereafter, the livers were pretreated in 3% sugar and 4% salt solution (1 : 3 w / v) for 3 h followed by microwaving for 4 min and hot air drying at 60°C for 40 h (designated as T2L). The livers which were dried the same as T2L except surface piercing were referred as T1L, whereas the livers dried only using hot air oven were referred as control (CL). The moisture and protein contents of the dried CL and T2L were found to be 28.46% and 14.29% and 43.85% and 52.76%, respectively. Sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS-PAGE) image of T2L revealed the presence of few low as well as high molecular weight protein bands which were absent in CL and T1L indicating a comparatively lower level of protein degradation in T2L. The shelf life of T1L and T2L samples based on microbiological and lipid oxidation analyses was found to be more than 60 days at 25 and 4°C. Palatability studies using dogs showed that all dried samples were highly palatable. Thus, it could be concluded that intact buffalo liver could be dried using surface slicing, with/without piercing followed by salt and sugar pretreatment, 4 min microwaving, and hot air drying at 60°C for 40 h. Future study should focus on the sensory properties such as aroma, texture, and flavor and sensory analysis of the dried liver by human. [ABSTRACT FROM AUTHOR]

In this study, we investigated dense BaTi1−xNbxO3 ceramics prepared by the conventional solid-state reaction technique which shows energy storage properties and anomalous photovoltaic effect. Structural analysis of BaTi1−xNbxO3 compositions has been performed by fitting the XRD patterns with Rietveld method and all samples show coexisting tetragonal (P4 mm) and cubic (Pm-3 m) structures. Composition (x = 0.04) shows minimum band gap (2.4 eV), smaller than pure BaTiO3 ceramics which can be attributed to lattice distortion and oxygen vacancies. The improved breakdown strength and energy storage density is achieved for BaTi0.93Nb0.07O3 composition. This ferroelectric ceramic shows energy storage of 278.7 mJ/cm2 and high energy conversion efficiency (90.4%). The composition (x = 0.07) exhibit a very high photovoltage (26 V) under visible light wavelength. These findings provide a fresh approach to create high-performance functional ferroelectric materials for energy applications. [ABSTRACT FROM AUTHOR]