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A hybrid trapped field magnet lens (HTFML) is a promising device that is able to concentrate a magnetic field higher than the applied field continuously, even after removing an external field, which was conceptually proposed by the authors in 2018. In this study, we propose a new additional advantage of the HTFML, which could be applicable for magnetic levitation and separation. The HTFML device consisting of a GdBaCuO bulk cylinder and a GdBaCuO magnetic lens, after the magnetization process from an applied field, Bapp = 10 T, can generate a maximum trapped field, Bc = 11.4 T, as well as an ultra-high magnetic field gradient product, Bz⋅dBz/dz, over ±3000 T2/m at Ts = 20 K, which is higher than that of existing superconducting magnets and large-scale hybrid magnets. Through detailed numerical simulations, the HTFML device is considered for the magnetic separation of a mixture of precious metal particles (Pt, Au, Ag, and Cu) dispersed in pure water, by exploiting the magneto-Archimedes effect. The HTFML can be realized as a compact and mobile desktop-type superconducting bulk magnet system, and there are a wide range of potential industrial applications, such as in the food and medical industries. [ABSTRACT FROM AUTHOR]

Bulk high-temperature superconducting materials can trap magnetic fields up to an order of magnitude larger than conventional permanent magnets. Recent advances in pulsed field magnetization (PFM) techniques now provide a fast and cost-effective method to magnetize bulk superconductors to fields of up to 5 T. We have developed a portable, desktop bulk high-temperature superconducting magnet system by combining advanced PFM techniques with state-of-the-art cryocooler technology and single-grain, REâ€"Baâ€"Cuâ€"O [(RE)BCO, where RE is a rare-earth element or yttrium] bulk superconducting materials. The base temperature of the system is 41 K and it takes about 1 h for the system to cool down to 50 K from room temperature. A capacitor bank, combined with easily-interchangeable, solenoid- or split-type copper magnetizing coils and an insulated bipolar gate transistor acting as a high-speed switch, allows magnetic pulses to be generated with different pulse profiles. The system is capable of trapping magnetic fields of up to ∼3 T. In this work, we report the results of the magnetization of a range of single-grain Yâ€"Baâ€"Cuâ€"O, Euâ€"Baâ€"Cuâ€"O and Gdâ€"Baâ€"Cuâ€"O (GdBCO), bulk superconducting discs using this system. A higher trapped field was recorded using a split coil incorporating iron yokes at temperatures of 65 K and above, whereas at lower temperatures, a higher trapped field was obtained using the solenoid coil. The GdBCO sample achieved the highest trapped field for both single-pulse (SP) and two-stage-multi-pulse (TSMP) methods using the solenoid coil. Maximum trapped fields of 2.26 T at 55 K and 2.85 T at 49 K were recorded at the centre of the top surface of the GdBCO sample for the SP and TSMP methods, respectively. The PFM process is substantially an adiabatic process so, therefore, the thermal contact between the sample and sample holder is of critical importance for cooling the bulk sample during application of the pulse. The design of the sample holder can be modified easily to enhance the thermal stability of the sample in order to achieve a higher trapped field. [ABSTRACT FROM AUTHOR]

MgB2 in bulk form shows great promise as an inexpensive, lightweight alternative to bulk (RE)-Ba-Cu-O materials to act as trapped field magnets (TFMs), which can replace permanent magnets in applications such as desktop high-field magnet systems and rotating machines. In this paper, we investigate the thickness dependence of the trapped magnetic field in bulk MgB2 superconductors. Two bulk MgB2 samples, 20 mm in diameter and 10 mm in thickness, were fabricated using the powder-in-closed-tube (PICT) technique. The trapped field was then measured after field-cooled magnetisation for thicknesses of approximately 20 mm (both bulks stacked), 10 mm (single bulk), and then 7.5, 5, 4, 3, 2, 1.5 and 1 mm, for which the sample was machined down to the designated thickness using an automated-wet-polishing technique. A 2D axisymmetric finite-element model based on the H-formulation is used to simulate the experimental results and explain the observed thickness dependence of the trapped field. The numerical results assume a Jc(B) dependence based on the measured characteristics of small specimens taken from the bulk before and after machining. The Jc(B) measurements suggested a degradation of Jc occurred as the bulk was machined thinner and thinner: a decrease in Jc(0 T) of ∼35% was observed between the pre- and post-machining specimens. Taking this into account in the models, by assuming a linear reduction in Jc with each machining process, reproduced the experimental results with very good agreement. Consistent trapped field measurements on the top and bottom surfaces suggest this degradation occurred globally, rather than local to the machined surface. [ABSTRACT FROM AUTHOR]

Bulk superconductors can act as trapped-field magnets with the potential to be used for many applications such as portable medical magnet systems and rotating machines. Maximising the trapped field, particularly for practical magnetisation techniques such as pulsed field magnetisation (PFM), still remains a challenge. PFM is a dynamic process in which the magnetic field is driven into a superconducting bulk over milliseconds. This flux motion causes heating and a complex interplay between the magnetic and thermal properties. In this work, the local flux density during PFM in a MgB2 bulk superconductor has been studied. We find that improving the cooling architecture increases the flux trapping capabilities and alters the flux motion during PFM. These improvements lead to the largest trapped field (0.95 T) for a single MgB2 bulk sample magnetised by a solenoidal pulsed field magnet. The findings illustrate the fundamental role bulk cooling plays during PFM. [ABSTRACT FROM AUTHOR]

In the critical state model, the critical current, , of a superconductor defines the upper limit of dissipation-free current flow. However conventional transport measurements of practical superconductors rely on the detection of a voltage drop along the length of the conductor. This requires that the superconductor has entered the dissipative regime, and hence inherently over-estimates the current at which geometric saturation occurs. Nonetheless, the convenience of the 1 µV cm−1 criterion means that it has become the widely adopted definition of transport. Here, we present an alternative definition for the transport critical current of a superconducting tape under self-field conditions, which is based on the concept of geometric current saturation across the full cross-sectional area. This saturation threshold can be experimentally determined through simple Hall sensor measurements of the evolving perpendicular magnetic field at the tape surface. The surface field exhibits a signature transition when the transport current increases beyond the current-saturation threshold. We present an analytical model which describes this effect and defines the critical saturated current as a function of. This definition is first validated using finite element (FE) modelling, and then experimentally demonstrated through measurements on a variety of commercial REBCO and Bi-2223 tapes of differing widths. It is found that the 1 µV cm−1 criterion consistently leads to an overestimation of the saturated critical current by ∼15% in REBCO tapes, and up to 30% in a Bi-2223 tape. FE modelling indicates that this overestimate is most prominent in superconductors exhibiting a low n-value (i.e. n ≲ 20). A key advantage of the measurement approach presented here is that it allows the unambiguous measurement of a transport value to be completed at lower currents, without entering the dissipative region in which sample damage can occur. There are also implications as to the correct choice of value which should be employed within the well-known Norris and Brandt equations for AC loss. [ABSTRACT FROM AUTHOR]

Modern active sonar systems can (almost) continuously transmit and receive sound, which can lead to more masking of important sounds for marine mammals than conventional pulsed sonar systems transmitting at a much lower duty cycle. This study investigated the potential of 1–2 kHz active sonar to mask echolocation-based foraging of sperm whales by modeling their echolocation detection process. Continuous masking for an echolocating sperm whale facing a sonar was predicted for sonar sound pressure levels of 160 dB re 1 μPa2, with intermittent masking at levels of 120 dB re 1 μPa2, but model predictions strongly depended on the animal orientation, harmonic content of the sonar, click source level, and target strength of the prey. The masking model predicted lower masking potential of buzz clicks compared to regular clicks, even though the energy source level is much lower. For buzz clicks, the lower source level is compensated for by the reduced two-way propagation loss to nearby prey during buzzes. These results help to predict what types of behavioral changes could indicate masking in the wild. Several key knowledge gaps related to masking potential of sonar in echolocating odontocetes were identified that require further investigation to assess the significance of masking. [ABSTRACT FROM AUTHOR]

Limited understanding of seabird bycatch in purse seine fisheries has been highlighted as a key information gap in assessments of seabird bycatch in fisheries globally. This study documents the bycatch of breeding flesh-footed shearwaters (Ardenna carneipes) in a sardine purse seine fishery on the southern coast of Western Australia. Fishery-dependent bycatch records from 2009/2010 to 2017/2018 showed a strong peak in the mortality rate per fishing trip during March and April, closely associated with the final stage of chick rearing. Observers during those peak months in 2007, 2008, 2017, and 2018 recorded 171 mortalities during 222 trips at per trip rates (±95% confidence limits) ranging from 0.59 (0.25–1.17) in 2017 to 1.10 (0.56–1.96) in 2007. Zero mortalities were recorded on at least 70% of trips in any year, suggesting infrequent formation of net folds that can trap birds. Total annual mortalities estimated for 2016/2017 and 2017/2018 were 123 (52–251) and 172 (91–302), respectively. Although within a sustainable anthropogenic limit of 495 (369–660) estimated from conservative application of the potential biological removal method, the extent of other anthropogenic mortalities is unknown. Further research on the effect of distance of breeding colonies from fishing operations is required. [ABSTRACT FROM AUTHOR]

The no-insulation (NI) winding method is an effective technique for winding coils from high- superconductors (HTS). NI coils are electrically and thermally robust due to their ability to radially bypass current away from the fragile superconducting path when necessary. This avoids stored magnetic energy being entirely discharged on local defects in the HTS tape. However, the increased degrees of freedom for the current distribution makes finite-element modelling of these coils a complicated and multi-level problem. Here we present and validate a 2D axially symmetric model of an NI (or partially insulated) coil that captures all the inherent electromagnetic properties of these coils, including axial vs radial current flow and critical current suppression, and also reproduces the well-known charging and discharging characteristics. The model is validated against previously reported discharge measurements, and is shown to produce results consistent with the expected equivalent-circuit behaviour. Only by solving the NI coil problem with both axial and radial fidelity can the interplay of critical current anisotropy and turn-to-turn current be properly accounted for. The reported FE model will now enable coil designers to simulate key complex behaviours observed in NI coils, such as shielding currents, magnetic field inhomogeneity and remnant field effects. [ABSTRACT FROM AUTHOR]

The papers in this special issue focuses on the verification and validation of models for predicting the sound field radiated by air guns and air gun arrays. This issue aims to address the demand for increasingly precise assessments of environmental impacts, requiring accurate characterization of the air gun array sound field, including the interface between source signature models and sound propagation models. To address this need, a modeling workshop was held in July 2016. Participants in the 2016 workshop were asked to predict, for specified scenarios, the time series of sound pressure and sound particle acceleration at different positions relative to the source, as well as the sourcewaveform. Air gun modeling experts worldwide, including the 2016 workshop participants, were invited to contribute to this special issue. [ABSTRACT FROM AUTHOR]

Despite their proven ability to output DC currents of >100 A, the physical mechanism which underpins the operation of a high-Tc superconducting (HTS) dynamo is still debated widely. Here, we show that the experimentally observed open-circuit DC output voltage, Vdc, is due to the action of overcritical eddy currents within the stator wire. We demonstrate close agreement between experimental results and numerical calculations, and show that large over-critical currents flow within the high-Tc stator during certain parts of the dynamo cycle. These overcritical currents experience a non-linear local resistivity which alters the output voltage waveform obtained in the superconducting state. As a result, the full-cycle integral of this altered waveform outputs a non-zero time-averaged DC voltage. We further show that the only necessary requirement for a non-zero Vdc output from any dynamo is that the stator must possess a non-linear local resistivity. Here, this is provided by the flux-flow regime of an HTS coated conductor wire, where conduction is described by the E–J power law. We also show that increased values of Vdc can be obtained by employing stator wires which exhibit a strong in-field dependence of the critical current J c (B , θ). However, non-linear resistivity is the key requirement to realize a DC output, as linear magneto-resistance is not sufficient. Our results clarify this longstanding conundrum, and have direct implications for the optimization of future HTS dynamo devices. [ABSTRACT FROM AUTHOR]

To understand the consequences of underwater noise exposure for cetaceans, there is a need for assessments of behavioural responses over increased spatial and temporal scales. Bottom-moored acoustic recorders and satellite tags provide such long-term and large spatial coverage of behaviour compared to short-duration acoustic-recording tags. However, these tools result in a decreased resolution of data from which an animal response can be inferred, and no direct recording of the sound received at the animal. This study discusses the consequence of the decreased resolution of data from satellite tags and fixed acoustic recorders on the acoustic dose estimated by propagation modelling and presents a method for estimating the range of sound levels that animals observed with these methods have received. This problem is illustrated using experimental results obtained during controlled exposures of northern bottlenose whales (Hyperoodon ampullatus) exposed to naval sonar, carried out near Jan Mayen, Norway. It is shown that variability and uncertainties in the sound field, resulting from limited sampling of the acoustic environment, as well as decreased resolution in animal locations, can lead to quantifiable uncertainties in the estimated acoustic dose associated with the behavioural response (in this case avoidance and cessation of foraging). [ABSTRACT FROM AUTHOR]

Several case reports suggest that non-steroidal anti-inflammatory drug (NSAID) use is associated with development of thrombotic microangiopathy (TMA). We conducted a matched population-based case-control study using linked administrative healthcare data in Ontario, Canada to assess the relationship between TMA hospitalization and recent exposure to prescription NSAIDs versus acetaminophen (acetaminophen was chosen as the referent drug because it has no known association with TMA). Cases and controls were drawn from a source population of adults who filled a prescription for either NSAIDs or acetaminophen between 1991 and 2015 (restricted to adults with prescription drug benefits [n = 3.6 million]). We identified 44 eligible cases with a hospital admission for incident TMA and a recent prescription for NSAIDs or acetaminophen. We successfully matched 38 cases (1:4) to 152 controls without TMA on demographics, risk factors for TMA, and indications for NSAID use. Cases and controls were similar with respect to age (71 years) and sex (63% women); however, on average, cases had more comorbidities than controls (12 vs. 14; p<0.05) and more primary care visits in the year before the index date (19 vs. 12; p<0.05). Cases were significantly less likely than controls to have received a recent prescription for NSAIDs (19/38 [50%] vs. 115/152 [76%], respectively; adjusted odds ratio 0.37, 95% confidence interval: 0.16 to 0.84). Results were similar in several sensitivity analyses. Overall, the results of this study do not support a harmful association between NSAID use and the development of TMA. [ABSTRACT FROM AUTHOR]

GdBa2Cu3 O7-δ bulk superconductors are a route to higher magnetic fields in rotating machines. Here, we examine the resistance of pulse-field magnetized bulks to the demagnetization fields they may experience in such a system. The bulks were magnetized at 77 K, after which several thousand cycles of AC field were applied. Subsequently, the decay of the trapped field was characterized. We found that the decay per cycle decreases with frequency and is, normalized to the initial trapped field, largest at the edge of the bulk. At 77 K, the reduction in trapped field proved significant (25% in the center for 150 mT (peak) AC field at 6 Hz), however, reducing below 1% when lowering the temperature to 60 K.We explain this observation as being due to increased flux pinning strength at low temperatures. When applying an AC field, we found a temperature rise that increased with applied field amplitude and frequency. However, when applying an AC field of amplitude 45 mT with a frequency of 48 Hz, we found an increase of the bulk temperature of only 100 mK. Therefore, we conclude that the temperature rise within the analyzed AC field frequency and amplitude range does not contribute significantly to the decay of trapped field. [ABSTRACT FROM AUTHOR]

The Bulk Superconductivity Group at the University of Cambridge is currently investigating the use of high-temperature superconducting (HTS) materials in wire and bulk form in order to increase the electrical and magnetic loadings of an axial gap, trapped flux-type superconducting electric machine. As part of this research, accurate 2D axisymmetric and 3D finite element models of superconducting coils have been developed to investigate and simulate their electromagnetic behaviour. Some of the recent advances in analysing the performance of HTS coils are highlighted, including the simulation of in-field performance and increasing the computational speed and accuracy of 3D models. Experimental and simulation results on the DC characterisation of a test circular, epoxy-impregnated HTS coil are used to interpret the effects of degradation due to epoxy impregnation from the coil's ideal performance. With this numerical modelling framework, it is possible to simulate a variety of complex devices in both 2D and 3D over a broad range of electromagnetic situations with good accuracy. [ABSTRACT FROM AUTHOR]

Introduction: The Revised Cardiac Risk Index (RCRI) is a popular classification system to estimate patients' risk of postoperative cardiac complications based on preoperative risk factors. Renal impairment, defined as serum creatinine >2.0 mg/dL (177 µmol/L), is a component of the RCRI. The estimated glomerular filtration rate has become accepted as a more accurate indicator of renal function. We will externally validate the RCRI in a modern cohort of patients undergoing non-cardiac surgery and update its renal component. Methods and analysis: The Vascular Events in Non-cardiac Surgery Patients Cohort Evaluation (VISION) study is an international prospective cohort study. In this prespecified secondary analysis of VISION, we will test the risk estimation performance of the RCRI in ~34 000 participants who underwent elective non-cardiac surgery between 2007 and 2013 from 29 hospitals in 15 countries. Using data from the first 20 000 eligible participants (the derivation set), we will derive an optimal threshold for dichotomising preoperative renal function quantified using the Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) glomerular filtration rate estimating equation in a manner that preserves the original structure of the RCRI. We will also develop a continuous risk estimating equation integrating age and CKD-Epi with existing RCRI risk factors. In the remaining (approximately) 14 000 participants, we will compare the risk estimation for cardiac complications of the original RCRI to this modified version. Cardiac complications will include 30-day non-fatal myocardial infarction, non-fatal cardiac arrest and death due to cardiac causes. We have examined an early sample to estimate the number of events and the distribution of predictors and missing data, but have not seen the validation data at the time of writing. Ethics and dissemination: The research ethics board at each site approved the VISION protocol prior to recruitment. We will publish our results and make our models available online at http://www.perioperativerisk.com. Trial registration number: ClinicalTrials.gov NCT00512109. [ABSTRACT FROM AUTHOR]

Background We frequently fail to identify articles relevant to the subject of acute kidney injury (AKI) when searching the large bibliographic databases such as PubMed, Ovid Medline or Embase. To address this issue, we used computer automation to create information search filters to better identify articles relevant to AKI in these databases. Methods We first manually reviewed a sample of 22 992 full-text articles and used prespecified criteria to determine whether each article contained AKI content or not. In the development phase (two-thirds of the sample), we developed and tested the performance of >1.3-million unique filters. Filters with high sensitivity and high specificity for the identification of AKI articles were then retested in the validation phase (remaining third of the sample). Results We succeeded in developing and validating high-performance AKI search filters for each bibliographic database with sensitivities and specificities in excess of 90%. Filters optimized for sensitivity reached at least 97.2% sensitivity, and filters optimized for specificity reached at least 99.5% specificity. The filters were complex; for example one PubMed filter included >140 terms used in combination, including ‘acute kidney injury’, ‘tubular necrosis’, ‘azotemia’ and ‘ischemic injury’. In proof-of-concept searches, physicians found more articles relevant to topics in AKI with the use of the filters. Conclusions PubMed, Ovid Medline and Embase can be filtered for articles relevant to AKI in a reliable manner. These high-performance information filters are now available online and can be used to better identify AKI content in large bibliographic databases. [ABSTRACT FROM AUTHOR]

Purpose: To determine the relationship between indoor and outdoor mobility capacity in older adults with unilateral total knee arthroplasty (TKA) and, secondarily, to determine walking intensity in the same population and to compare all outcomes to a control group of older adults without knee pathology. Method: In this cross-sectional study, participants (TKA=16, mean 22.9 (SD 9.7) mo post TKA; control=22) completed indoor walking tests and a 580 m outdoor course that included varying terrain (e.g., curbs, grass, sidewalk) and frequent changes in direction. Walking capacity was assessed using stopwatches, global positioning system watches and accelerometers. Results: Outdoor walking time was moderately correlated (p<0.05) with the timed up-and-go (TUG) test (r=0.65), stair-climb test (SCT) (r=0.67 ascending, r=0.79 descending), 10 m walk test (10 mWT) (r=0.73), and 6-minute walk test (6 MWT) (r=-0.75). Based on activity counts, walking intensity levels for participants in both groups were moderate (outdoor walk and 6 MWT). There was no significant difference in walking capacity between groups (TUG, SCT, 10 mWT, 6 MWT, outdoor walk). Conclusions: Common clinical walking tests are moderately correlated with outdoor mobility. Mobility capacity of individuals post TKA was similar to controls in both indoor and outdoor environments, and participants in both groups achieved moderate physical activity levels with walking. [ABSTRACT FROM AUTHOR]

In order to design a High Temperature Superconducting (HTS) machine that is able to operate safely and reliably, studies on the characterization of Second Generation (2G) HTS tapes are of paramount importance. This paper presents an experimental setup to measure critical current of 2G HTS tapes in high DC magnetic fields (up to 5 Tesla) with an AC current ripple superimposed, as well as various temperatures ranging from 25 K to 77 K. The 2G tape measured is the SGS12050 coated conductor made by SuperPower. The critical current is measured by a flux vector with reference to the widest sample face from 0 to 90 degrees in 10 degree steps. Smaller steps are required close to 0^\circ. A Variable Temperature Insert (VTI) is utilized to control temperature change. [ABSTRACT FROM AUTHOR]

YBaCuO-coated conductors offer great potential in terms of performance and cost-saving for superconducting fault current limiter (SFCL). A resistive SFCL based on coated conductors can be made from several tapes connected in parallel or in series. Ideally, the current and voltage are shared uniformly by the tapes when quench occurs. However, due to the non-uniformity of property of the tapes and the relative positions of the tapes, the currents and the voltages of the tapes are different. In this paper, a numerical model is developed to investigate the current and voltage sharing problem for the resistive SFCL. This model is able to simulate the dynamic response of YBCO tapes in normal and quench conditions. Firstly, four tapes with different Jc's and n values in E\-J power law are connected in parallel to carry the fault current. The model demonstrates how the currents are distributed among the four tapes. These four tapes are then connected in series to withstand the line voltage. In this case, the model investigates the voltage sharing between the tapes. Several factors that would affect the process of quenches are discussed including the field dependency of Jc, the magnetic coupling between the tapes and the relative positions of the tapes. [ABSTRACT FROM AUTHOR]

This paper begins with introducing the winding techniques of two superconducting double-pancake coils wound using 2G coated conductors. These winding techniques are able to guarantee a good performance for the superconducting coils. Then the coil critical currents were measured and compared with a simulation model. The results were consistent. Finally the coil AC losses were measured using an experimental circuit including a compensation coil. The simulation results are close to the experiment results. [ABSTRACT FROM AUTHOR]

High-temperature superconductors have created the opportunity for a step change in the technology of power applications. Racetrack superconducting coils made from YBCO coated conductors have been used in several engineering applications including SMES, rotor or stator windings of electric machines. AC loss is one of the most important factors that determine the design and performance of superconducting devices. In this paper, a numerical model is developed to calculate the AC losses in superconducting racetrack coils in different magnetic conditions. This paper first discusses the AC losses of the coils in self-field or external field only. It then goes to investigate the AC losses of the coils being exposed to AC ripple field and a DC background field. Finally, the AC losses of the coils carrying DC current and being exposed to AC field are calculated. These two scenarios correspond to using superconducting coils as the rotor field winding of an electric machine. [ABSTRACT FROM AUTHOR]

This paper presents an SMES coil which has been designed and tested by University of Cambridge. The design gives the maximum stored energy in the coil which has been wound by a certain length of second-generation high-temperature superconductors (2G HTS). A numerical model has been developed to analyse the current density and magnetic field distribution and calculate the AC losses during the charge and discharge process of the coil. A cryostat has been designed and a test of the I-V curve measurement of the coil has been accomplished. In addition, the power electronics control of the SMES coil has been simulated. [ABSTRACT FROM AUTHOR]

Background: The lung is an important tertiary lymphoid organ and many lung diseases are associated with disordered lung immunity. Unlike the gut (alpha4beta7 binding to MAdCAM-1) and skin (CLA+ve T cells binding to E-selectin) where the adhesion receptors involved in organ specific homing of T cells have been identified, the molecular pathways controlling lymphocyte migration to the lung are unclear. Using a modified version of the Stamper-Woodruff assay we have investigated the receptors mediating adhesion of peripheral blood lymphocytes to airway endothelium.Methods: Longitudinal frozen sections of bronchus (8 micro m) obtained from lung resection specimens were incubated with T cell enriched peripheral blood mononuclear cells for 30 minutes under shaking conditions in the presence of a fluorescently labelled polyclonal anti-von Willebrand antibody to identify blood vessels. After fixation the percentage of blood vessels supporting adhesion was measured. Blocking monoclonal antibodies were used to determine the role of individual adhesion receptors in lymphocyte binding.Results: Specific cation dependent binding of lymphocytes to bronchial endothelium was observed which was significantly inhibited by antibodies against P-selectin, PSGL-1, L-selectin, LFA-1, ICAM-1 and ICAM-2 but not E-selectin, VLA-4, VCAM-1 or Mac-1. This was consistent with the pattern of endothelial expression of these receptors with strong expression of P-selectin and ICAM-1, but negligible expression of E-selectin on bronchial endothelium.Conclusion: This study suggests an important role for PSGL-1/P-selectin in T cell migration into the bronchi and provides further evidence for a pattern of recirculation for respiratory tract homing T cells distinct from the gut and skin. [ABSTRACT FROM AUTHOR]

An iterative matched field processing scheme is described for efficient inversion of geoacoustic parameters in shallow water using a vertical receiving array at three frequencies in the range 50500 Hz. The method relies on the assumption that the acoustic data are sensitive to different geoacoustic parameters at different frequencies. First an exhaustive 2D search is carried out at high frequency to determine initial estimates for density and sound speed. A second 2D search follows at an intermediate frequency to determine sediment attenuation and sound speed gradient. An iteration is carried out over these first two phases until these four parameters converge. In a third phase, the low frequency data are used to search for the remaining unknown parameters (primarily sediment thickness, substrate density and substrate sound speed) with a differential evolution algorithm. Finally all three phases are repeated iteratively, in principle until a complete converged solution (a self-consistent set of all inverted parameters) is found, although for practical reasons the search is terminated before convergence is demonstrated. Tests on synthetic data are reported demonstrating the accuracy and stability of the method. Initial results for measured data are also presented. [ABSTRACT FROM AUTHOR]

A two-stage approach to the geoacoustic inversion problems of selected Workshop '97 test cases is described. Initial parameters are deduced by inspection of transmission losses versus range, depth and frequency, and comparison with the calibration case. These provide a starting point for a conventional matched-field inversion applied to individual frequency data sets for a vertical array at 5-km range using the normal mode model SUPERSNAP and the standard Bartlett processor. Grid searches are carried out over pairs of parameters using: 500-Hz data to establish the sediment density and top sediment sound speed, 100-Hz data to estimate the sound speed gradient in the sediment layer and 25-Hz data for the remaining parameters. Results and error bounds are presented for two realizations of the SD workshop case. Partial results are presented for the SO case. Issues regarding SUPERSNAP/SAFARI mismatches are also discussed. [ABSTRACT FROM AUTHOR]

The article comments on managing blood pressure in patients having chronic kidney diseases. It is informed that a clinical practice guideline "Kidney Disease: Improving Global Outcomes" has been published to evaluate and manage chronic kidney disease. It is informed that the article "Effects of Intensive Blood Pressure Lowering on the Progression of Chronic Kidney Disease: A Systematic Review and Meta-Analysis" discusses results of clinical trials evaluating the issue.

The ability of large-grain (RE)Ba2Cu3O7−δ ((RE)BCO; RE = rare earth) bulk superconductors to trap magnetic fields is determined by their critical current. With high trapped fields, however, bulk samples are subject to a relatively large Lorentz force, and their performance is limited primarily by their tensile strength. Consequently, sample reinforcement is the key to performance improvement in these technologically important materials. In this work, we report a trapped field of 17.6 T, the largest reported to date, in a stack of two silver-doped GdBCO superconducting bulk samples, each 25 mm in diameter, fabricated by top-seeded melt growth and reinforced with shrink-fit stainless steel. This sample preparation technique has the advantage of being relatively straightforward and inexpensive to implement, and offers the prospect of easy access to portable, high magnetic fields without any requirement for a sustaining current source. [ABSTRACT FROM AUTHOR]

The ability to generate a permanent, stable magnetic field unsupported by an electromotive force is fundamental to a variety of engineering applications. Bulk high temperature superconducting (HTS) materials can trap magnetic fields of magnitude over ten times higher than the maximum field produced by conventional magnets, which is limited practically to rather less than 2 T. In this paper, two large c-axis oriented, single-grain YBCO and GdBCO bulk superconductors are magnetized by the pulsed field magnetization (PFM) technique at temperatures of 40 and 65 K and the characteristics of the resulting trapped field profile are investigated with a view of magnetizing such samples as trapped field magnets (TFMs) in situ inside a trapped flux-type superconducting electric machine. A comparison is made between the temperatures at which the pulsed magnetic field is applied and the results have strong implications for the optimum operating temperature for TFMs in trapped flux-type superconducting electric machines. The effects of inhomogeneities, which occur during the growth process of single-grain bulk superconductors, on the trapped field and maximum temperature rise in the sample are modelled numerically using a 3D finite-element model based on the H-formulation and implemented in Comsol Multiphysics 4.3a. The results agree qualitatively with the observed experimental results, in that inhomogeneities act to distort the trapped field profile and reduce the magnitude of the trapped field due to localized heating within the sample and preferential movement and pinning of flux lines around the growth section regions (GSRs) and growth sector boundaries (GSBs), respectively. The modelling framework will allow further investigation of various inhomogeneities that arise during the processing of (RE)BCO bulk superconductors, including inhomogeneous Jc distributions and the presence of current-limiting grain boundaries and cracks, and it can be used to assist optimization of processing and PFM techniques for practical bulk superconductor applications. [ABSTRACT FROM AUTHOR]