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The article investigates the role of transnational criminal groups in migration governance. Although this topic has attracted increasing global attention due to the intersection of migration management and crime, academic research remains limited. Most studies tend to view criminal groups merely as threats to migration governance or as peripheral actors. The article advocates for a significant paradigm shift in conventional debate on transnational governance. Rather than merely viewing criminal groups as global challenges for various actors to tackle, we should acknowledge them as pivotal actors influencing these challenges. Based on empirical research on migrant smuggling and human trafficking in the Greece and Libya, the article sheds more light on the complex relationships between these criminal actors, state actors and other key stakeholders in migration governance. It shows how criminal groups not only disrupt but also actively shape migration governance, and may even play a crucial role in the functioning and reproduction of its legal apparatus. In so doing, the article transcends both mainstream perspectives that view crime as a mere challenge to migration governance and critical studies that frame the role of crime in migration governance solely in terms of a state-driven process of 'criminalization'. [ABSTRACT FROM AUTHOR]

Background: The COVID-19 pandemic greatly impacted healthcare workers (HWs) around the world. Italy was the first Western country hit by the pandemic, and several studies have been published targeting the mental health burden held by Italian HWs. Notwithstanding, only a few studies focused on the impact of COVID-19 on HWs' levels of functioning. Methods: An online survey was distributed to HWs in Italy through physicians' and nurses' associations, social networks, and researchers' direct contacts, between 4 April and 13 May 2020. Participants provided sociodemographic, work-related, and pandemic-related data and filled out a set of psychometric questionnaires (Patient Health Questionnaire-9—PHQ-9, General Anxiety Disorder-7—GAD-7, Impact of Event Scale—Revised—IES-R, and Work and Social Adjustment Scale—WSAS). Results: The final sample included 1041 HWs (mean age 45.01 ± 11.62, 63.9% females). In total, 58.1% of the subjects screened positive on the GAD-7, 27.5% on the PHQ-9, and 25.9% on the IES-R. Furthermore, 67.4% showed a significant level of impairment in functioning according to the WSAS, while 35.8% reached scores of moderate or worse impairment. In the multiple linear regressions, screening positive on any of the psychometric scales and being exposed to unusual suffering significantly predicted worse scores in all WSAS domains (p < 0.05). Having a history of mental disorders significantly predicted worse scores in the WSAS domain of work ability (p = 0.002), while being the parent of children younger than 18 years significantly predicted worse WSAS family functioning scores (p < 0.001). Conclusions: Our results corroborate extant data about the impact of the COVID-19 pandemic on HWs' mental health and shed light on its detrimental effect on functioning. Tailored interventions should be designed in order to support HWs during times of crisis. [ABSTRACT FROM AUTHOR]

Introduction: Different protocols and procedures for sinus lift and implant placement are available, generally involving the use of grafts to increase the tissue volume and/or prevent the Schneiderian membrane from collapsing. Among xenografts, deproteinised bovine bone graft (DBBP) is frequently used in sinus lift procedures. Leaving an ungrafted space following membrane elevation has proven to have a bony regenerative potential as well. This study aimed to compare the clinical and histological features of sinus lift surgery performed with or without biomaterials. Methods: Patients with severe maxillary posterior atrophy (residual bone height 2–6 mm and residual crest thickness ≥4 mm), and in need of sinus lift surgery to allow the placement of three implants were enrolled and randomly divided into two groups. They underwent sinus lifts with DBBP (control) or with a graftless technique (test) and immediate placement of two implants (a mesial and distal one). After 6 months, a bone sample was retrieved from the area between the previously inserted fixtures, and a third, central implant was placed. The collected bone samples were analyzed morphologically and histomorphometrically. The patients were provided with prosthetic restorations after 6 months and followed up for 5–12 years. Results: Ten patients were enrolled in the test and nine in the control group. The 6‐month follow‐up showed in the control group an average augmentation of 10.31 mm (±2.12), while in the test group it was 8.5 mm (±1.41) and a success rate of 96.3% in the control and 86.7% in the test group (p > 0.05). The histological analysis evidenced the presence of new bone tissue surrounded by immature osteoid matrix in the test group, and a variable number of DBBP particles surrounded by an immature woven bone matrix in the control group. Conclusion: The results of the present trial indicate that, with residual bone height of 2–6 mm and residual crest thickness ≥4 mm, sinus lift surgery with or without biomaterials followed by implant restoration, produces similar clinical and histological outcomes. [ABSTRACT FROM AUTHOR]

Plain language summary: Expanded carrier screening (ECS) is a genetic screening test carried out by analysing a blood sample. This screen can be used to detect whether the individual unknowingly carries gene variants associated with common genetic conditions, such as cystic fibrosis, that may be passed on to their children. It is typically performed in reproductive medicine for those who are considering having a family either naturally or via fertility treatment. Many donor sperm and egg banks, particularly in the USA and Europe, also perform blanket ECS testing on all their prospective sperm and egg donors. ECS is not currently routine practice in the UK, but a growing number of patients are requesting it before treatment. All of us carry gene variants of some sort that may cause autosomal recessive disease in their children if their partner or donor also carry a variant in the same gene. An autosomal recessive disease means two copies of an abnormal gene must be present in order for the disease or trait (such as cystic fibrosis or sickle cell disease) to develop. One copy of the variant means the person is a carrier but does not have the condition. Two copies, i.e. from the mother and father, means the child has a 25% chance of having the genetic disease. Carrying a gene variant does not mean that the individual would necessarily have any symptoms of the disease or any features of the condition. Genetic tests for specific conditions are currently available either before or during pregnancy for prospective parents who have a family or personal history of a genetic condition, or for those from ethnic backgrounds where certain conditions – such as haemoglobinopathies (blood disorders) – are common, prompting referral to a clinical genetics department. Expanded carrier screens may test for more than 100 genetic conditions. The list of conditions screened for is called a panel. Common panels are 250 or 600 genes. Not all expanded carrier screens that are available analyse the same genes. Some may test for genes that do not cause serious disease, or cause diseases that occur in later life; others test for genes that cause severe conditions in childhood. There is no agreement as to which panel of genes should be tested for in an ECS. Understanding the screening that is being offered, and the meaning of any results, is complicated and requires support from appropriately trained professionals to best inform the prospective parent or parents. [ABSTRACT FROM AUTHOR]

Donkeys (Equus asinus) have been used extensively in agriculture and transportations since their domestication, ca. 5000–7000 years ago, but the increased mechanization of the last century has largely spoiled their role as burden animals, particularly in developed countries. Consequently, donkey breeds and population sizes have been declining for decades, and the diversity contributed by autochthonous gene pools has been eroded. Here, we examined coding-region data extracted from 164 complete mitogenomes and 1392 donkey mitochondrial DNA (mtDNA) control-region sequences to (i) assess worldwide diversity, (ii) evaluate geographical patterns of variation, and (iii) provide a new nomenclature of mtDNA haplogroups. The topology of the Maximum Parsimony tree confirmed the two previously identified major clades, i.e. Clades 1 and 2, but also highlighted the occurrence of a deep-diverging lineage within Clade 2 that left a marginal trace in modern donkeys. Thanks to the identification of stable and highly diagnostic coding-region mutational motifs, the two lineages were renamed as haplogroup A and haplogroup B, respectively, to harmonize clade nomenclature with the standard currently adopted for other livestock species. Control-region diversity and population expansion metrics varied considerably between geographical areas but confirmed North-eastern Africa as the likely domestication center. The patterns of geographical distribution of variation analyzed through phylogenetic networks and AMOVA confirmed the co-occurrence of both haplogroups in all sampled populations, while differences at the regional level point to the joint effects of demography, past human migrations and trade following the spread of donkeys out of the domestication center. Despite the strong decline that donkey populations have undergone for decades in many areas of the world, the sizeable mtDNA variability we scored, and the possible identification of a new early radiating lineage further stress the need for an extensive and large-scale characterization of donkey nuclear genome diversity to identify hotspots of variation and aid the conservation of local breeds worldwide. [ABSTRACT FROM AUTHOR]

In this article, I analyze instances of Ukrainian poetry written between Taras Ševčenko's death and the establishment of modernism that deal with the theme of the precarity of Ukrainian literature as a consequence of the lack of a Ukrainian nation in those times. On the basis of examples drawn from the works of Pantelejmon Kuliš, Lesja Ukrajinka, Mychajlo Staryc'kyj, Borys Hrinčenko, Volodymyr Samijlenko, Volodymyr Šaškevyč, and Ivan Franko, I aim to show how Ukrainian poets of the second half of the 19th century tended to imagine the Ukrainian community as belonging to the past and/or the future, while its presence and its agency in the present are made impossible by imperial subjugation, hence making communication, including literary, impossible or powerless. In the final part of my article, I also reflect on the complex nexus between aesthetic judgment and the re-evaluation of Ukrainian literary history. [ABSTRACT FROM AUTHOR]

The organic molecules adsorbed on antiferromagnetic surfaces can produce interesting interface states, characterized by charge transfer mechanisms, hybridization of molecular-substrate orbitals, as well as magnetic couplings. Here, we apply an ab initio approach to study the adsorption of Fe phthalocyanine on stoichiometric Cr2O3(0001). The molecule binds via a bidentate configuration forming bonds between two opposite imide N atoms and two protruding Cr ones, making this preferred over the various possible adsorption structures. In addition to the local modifications at these sites, the electronic structure of the molecule is weakly influenced. The magnetic structure of the surface Cr atoms shows a moderate influence of molecule adsorption, not limited to the atoms in the close proximity of the molecule. Upon optical excitation at the onset, electron density moves toward the molecule, enhancing the ground state charge transfer. We investigate this movement of charge as a mechanism at the base of light-induced modifications of the magnetic structure at the interface. [ABSTRACT FROM AUTHOR]

Purpose: This paper follows the call for more future-oriented practices within organisations, particularly in relation to how they respond to growing concerns about Earth's sustainability and life on the Planet. This study aims to explore how the data produced by major scientific projects in the Space sector can support future-oriented accountability practices by enabling both a projection and an imagination of a more or less distant future, thereby feeding into accountability practices. Design/methodology/approach: We rely upon a multiple interpretative case study analysis and interview-based data from three main organisations in the Earth observation (EO) value chain: an International Space Company, a Research Centre of Energy Transition and a European Private Equity Firm. Findings: We find that future-oriented accountability practices can be fed by a creative assemblage of scientific data provided by Space sector's programmes with different sources of knowledge and information. These data are embedded into a broader accountability system, connecting different actors through a "value chain": from the data providers, gathering data from Space, to the primary users, working on data modelling and analysis, to the end users, such as local authorities, public and private organisations. The predictive data and expertise exchanged throughout the value chain feed into future-oriented accountability efforts across different time-space contexts, as a projected and imagined, more or less distant, future informs the actions and accounts in the present. Originality/value: This research extends the literature on the time dimension of accountability. We show how a creative assemblage of scientific data with different sources of knowledge and information –such as those provided by Space sector's programmes and EO data – enable organisations to both project the present into (a more or less distant) future and imagine this future differently while taking responsibility, and accounting for, what could be done and desired in response to it. We also contribute to the limited literature on accountability in the Space sector by examining the intricate accountability dynamics underpinning the relationships among the different actors in the EO data value chain. [ABSTRACT FROM AUTHOR]

Epigenetics studies changes in gene activity without changes in the DNA sequence. Methylation is an epigenetic mechanism important in many pathways, such as biotic and abiotic stresses, cell division, and reproduction. Eragrostis curvula is a grass species reproducing by apomixis, a clonal reproduction by seeds. This work employed the MCSeEd technique to identify deferentially methylated positions, regions, and genes in the CG, CHG, and CHH contexts in E. curvula genotypes with similar genomic backgrounds but with different reproductive modes and ploidy levels. In this way, we focused the analysis on the cvs. Tanganyika INTA (4x, apomictic), Victoria (2x, sexual), and Bahiense (4x, apomictic). Victoria was obtained from the diploidization of Tanganyika INTA, while Bahiense was produced from the tetraploidization of Victoria. This study showed that polyploid/apomictic genotypes had more differentially methylated positions and regions than the diploid sexual ones. Interestingly, it was possible to observe fewer differentially methylated positions and regions in CG than in the other contexts, meaning CG methylation is conserved across the genotypes regardless of the ploidy level and reproductive mode. In the comparisons between sexual and apomictic genotypes, we identified differentially methylated genes involved in the reproductive pathways, specifically in meiosis, cell division, and fertilization. Another interesting observation was that several differentially methylated genes between the diploid and the original tetraploid genotype recovered their methylation status after tetraploidization, suggesting that methylation is an important mechanism involved in reproduction and ploidy changes. [ABSTRACT FROM AUTHOR]

Background: Rendena is a dual-purpose cattle breed, which is primarily found in the Italian Alps and the eastern areas of the Po valley, and recognized for its longevity, fertility, disease resistance and adaptability to steep Alpine pastures. It is categorized as 'vulnerable to extinction' with only 6057 registered animals in 2022, yet no comprehensive analyses of its molecular diversity have been performed to date. The aim of this study was to analyse the origin, genetic diversity, and genomic signatures of selection in Rendena cattle using data from samples collected in 2000 and 2018, and shed light on the breed's evolution and conservation needs. Results: Genetic analysis revealed that the Rendena breed shares genetic components with various Alpine and Po valley breeds, with a marked genetic proximity to the Original Braunvieh breed, reflecting historical restocking efforts across the region. The breed shows signatures of selection related to both milk and meat production, environmental adaptation and immune response, the latter being possibly the result of multiple rinderpest epidemics that swept across the Alps in the eighteenth century. An analysis of the Rendena cattle population spanning 18 years showed an increase in the mean level of inbreeding over time, which is confirmed by the mean number of runs of homozygosity per individual, which was larger in the 2018 sample. Conclusions: The Rendena breed, while sharing a common origin with Brown Swiss, has developed distinct traits that enable it to thrive in the Alpine environment and make it highly valued by local farmers. Preserving these adaptive features is essential, not only for maintaining genetic diversity and enhancing the ability of this traditional animal husbandry to adapt to changing environments, but also for guaranteeing the resilience and sustainability of both this livestock system and the livelihoods within the Rendena valley. [ABSTRACT FROM AUTHOR]

Artificial Intelligence (AI) and Machine Learning (ML) approaches that could learn from large data sources have been identified as useful tools to support clinicians in their decisional process; AI and ML implementations have had a rapid acceleration during the recent COVID-19 pandemic. However, many ML classifiers are "black box" to the final user, since their underlying reasoning process is often obscure. Additionally, the performance of such models suffers from poor generalization ability in the presence of dataset shifts. Here, we present a comparison between an explainable-by-design ("white box") model (Bayesian Network (BN)) versus a black box model (Random Forest), both studied with the aim of supporting clinicians of Policlinico San Matteo University Hospital in Pavia (Italy) during the triage of COVID-19 patients. Our aim is to evaluate whether the BN predictive performances are comparable with those of a widely used but less explainable ML model such as Random Forest and to test the generalization ability of the ML models across different waves of the pandemic. [ABSTRACT FROM AUTHOR]

This paper investigates the experiences of children associated with Boko Haram in Northeast Nigeria. The central argument posits that, within highly coercive environments, exploitation and agency are mutually constitutive. While acknowledging the prevalent exploitation of these children, it is crucial to recognise how such exploitation is intimately connected to their agency. As economic, social, and political pressures mount, children may perceive participation in Boko Haram (and self-exploitation) as the only viable means to achieve various goals—from protecting their families and communities to seeking self-significance. Consequently, exploitation—whether orchestrated by group leaders or members—may be consciously embraced by children as a means to create new horizons of possibilities. Simultaneously, by engaging in Boko Haram’s activities, children reproduce a system aimed to their own exploitation and vilification. Neglecting the complexities inherent in children’s associations with Boko Haram has potential implications for their reintegration and community healing processes. [ABSTRACT FROM AUTHOR]

Aim: Locally advanced rectal cancer (LARC) is commonly treated with neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME) to reduce local recurrence (LR) and improve survival. However, LR, particularly associated with lateral lymph node (LLN) involvement, remains a concern. The aim of this study was to investigate preoperative factors associated with LLN involvement and their impact on LR rates in LARC patients undergoing nCRT and curative surgery. Method: This multicentre retrospective study, including four academic high‐volume institutions, involved 301 consecutive adult LARC patients treated with nCRT and curative surgery between January 2014 and December 2019 who did not undergo lateral lymph node dissection (LLND). Baseline and restaging pelvic MRIs were evaluated for suspicious LLNs based on institutional criteria. Patients were divided into two groups: cLLN+ (positive nodes) and cLLN– (no suspicious nodes). Primary outcome measures were LR and lateral local recurrence (LLR) rates at 3 years. Results: Among the cohort, 15.9% had suspicious LLNs on baseline MRI, and 9.3% had abnormal LLNs on restaging MRI. At 3 years, LR and LLR rates were 4.0% and 1.0%, respectively. Ten out of 12 (83.3%) patients with LR showed no suspicious LLNs at the baseline MRI. Abnormal LLNs on MRI were not independent risk factors for LR, distant recurrence or disease‐free survival. Conclusion: Abnormal LLNs on baseline and restaging MRI assessment did not impact LR and LLR rates in this cohort of patients with LARC submitted to nCRT and curative TME surgery. [ABSTRACT FROM AUTHOR]

This paper summarises the results of an experimental campaign carried out at SIET on the ELSMOR facility built in 2022 to validate a decay heat removal system for the E-SMR. Based on the passive mechanisms of natural circulation, the system aims to dissipate the reactor decay heat to a water pool, using two heat exchangers: a plate-type one coupling the primary side to the secondary side, and a vertical tube one coupling the secondary side to the water pool. Such a system is considered to be the most effective passive system, capable of safely managing the SMR accident and accidental situations, and achieving long-term decay heat removal without the need for electricity or external inputs. A description of the primary and secondary loops of the plant is given, together with the installed instrumentation and data acquisition system. In addition, the paper summarises the tests performed in terms of test procedures, test type and associated objectives, test matrix, test results, achievements, and open issues. [ABSTRACT FROM AUTHOR]

In recent decades, extensive attention has been paid to the study and development of robotic devices specifically designed for hand rehabilitation. Accordingly, a many concepts concerning rigid, soft, and hybrid types have emerged in the literature, with significant ongoing activity being directed towards the development of new solutions. In this context, the paper focuses on the technical features of devices conceived for the robotic rehabilitation of the hand with reference to the three kinds of exoskeleton architecture and the clinical requirements demanded by the target impairment of the end-user. The work proposes a roadmap (i) for both the design and selection of exoskeletons for hand rehabilitation, (ii) to discriminate among the peculiarities of soft, rigid, and hybrid devices, and (iii) with an impairment-oriented rationale. The clinical requirements expected for an exoskeleton are identified by applying a PICO-inspired approach focused on the impairment analysis; the technical features are extracted from a proposed design process for exoskeletons combined with a narrative literature review. A cross-analysis between device families and features is presented to provide a supporting tool for both the design and selection of exoskeletons according to an impairment-oriented rationale. [ABSTRACT FROM AUTHOR]

Service-learning models serve as noteworthy curriculum paradigms that can help students engage with their communities while continuously learning. This article recounts the implementation of a servicelearning model within a student initiative aimed to help combat vaccine hesitancy and promote the uptake of vaccinations within the Rhode Island community. Through a collaborative effort between students, faculty, and the university, the student initiative was able to construct a credit-bearing course to help assess and alleviate vaccine hesitancy within Rhode Island. This article highlights the journey the organization took to develop a service-learning model within the course, the project details, and the impact of their project on the community. A detailed analysis of the service-learning model's impact on students as well as key takeaways of the project are also highlighted below. [ABSTRACT FROM AUTHOR]

Contemporary research shows that current migration policies and technologies produce criminality. It would be advantageous, then, to understand how migrants make sense of and respond to these criminalizing migration policies, technologies, and practices. This volume delves deeply into criminalization processes, focusing on how migrants perceive and react to the enactment and implementation of policy. The articles take a close look at the day-to-day experiences of criminalized migrants, advancing our understanding of some of the societal effects of migration policies and of the relationship between criminalization and migration. The collection of work presented in this volume seeks to inspire more critical scholarship, given that public narratives about migration tend to present narratives of tragedy and despair only. We argue that policy and public understanding of migration can improve if we understand more about how, exactly, migrants respond to their criminalization and how they manage to sustain their migratory projects and their lives. [ABSTRACT FROM AUTHOR]

A widespread narrative in policy and media circles is that criminal organizations' exploitation of migrants amounts to "modern slavery." The research presented here argues for a different understanding that includes migrant agency. I examine the interactions of migrants—specifically Syrian unaccompanied minors—within illicit economies in Lebanon. I use the notion of "markets of dispossession" to explain the intricate relationship binding migration policy, migrant agency, and crime formation. The term shows how, rather than stemming from extensive criminal enterprises, the "crime" associated with these economies often emerges from myriad micro-interactions, decisions, and acts of resilience by disenfranchised individuals, like unaccompanied minors, navigating restrictive policies and their subsequent criminalization. I go on to argue that acknowledging the agency of the minor migrants in criminalized systems underscores the importance of addressing the poverty, inequality, and social instability that compel their participation in these markets of dispossession. [ABSTRACT FROM AUTHOR]

Child migration has generated shock, the global public appalled by photos of corpses of children washed ashore or abandoned in deserts. However, despite the growing visibility of child migration there has been scant research into the practices and interactions often associated with the smuggling of minors. We still lack a clear understanding of the interactions between minors and smugglers that go beyond a stereotypical predator/victim frame. This paper is grounded in the conviction that any understanding of the complex interactions between minors and migrant smugglers requires an epistemic reversal in conventional learning and debate. Instead of investigating the systematic exploitation of vulnerable migrants at the hands of criminal rings, we need to focus on the capacity of minors to exert agency and craft new spheres of possibility in situations characterised (also) by exploitation and extreme dependence. The article does so by investigating the day-to-day interactions between facilitators and Syrian minors who left their country following the outbreak of the civil war in 2011. What will be shown is that minors' interactions with human smuggling provide them with new forms of action, while contending with exploitation, constraints or dependency. [ABSTRACT FROM AUTHOR]

This contribution reflects on the state of comparative studies devoted to East Slavic literatures in Italy. Between the end of the 20th and beginning of the 21st century, Italian scholars of Slavic studies and the editors of Italian journals have made a number of interesting proposals on the subject. However, hyper-specialization has often hampered efforts to put theory into practice. I foreground some of these important methodological contributions by Italian scholars on comparative Slavic studies and discuss them both in the international context and with reference to other methodologies and research fields, most notably postcolonial studies. After the full-scale invasion of Ukraine by the Russian Federation in February 2022, comparative studies at the crossroads of Belarusian, Russian, and Ukrainian cultures have become a thorny issue. Scholars should seek to strike a balance between a philological approach and the ethical need to respect the different cultural orientations of East Slavic nations. [ABSTRACT FROM AUTHOR]

Background: Despite its potential oncologic benefit, complete mesocolic excision (CME) has rarely been offered to elderly patients. The present study evaluated the effect of age on postoperative outcomes among patients undergoing laparoscopic right colectomies with CME for right-sided colon cancer (RCC). Methods: Data of patients undergoing laparoscopic right colectomies with CME for RCC between 2015 and 2018 were retrospectively analyzed. Selected patients were divided into two groups: the under-80 group and the over-80 group. Surgical, pathological, and oncological outcomes among the groups were compared. Results: A total of 130 patients were selected (95 in the under-80 group and 35 in the over-80 group). No difference was found between the groups in terms of postoperative outcomes, except for median length of stay and adjuvant chemotherapy received, which were in favor of the under-80 group (5 vs. 8 days, p < 0.001 and 26.3% vs. 2.9%, p = 0.003, respectively). No difference between the groups was found regarding overall survival and disease free survival. Using multivariate analysis, only the ASA score > 2 (p = 0.01) was an independent predictor of overall complications. Conclusions: laparoscopic right colectomy with CME for RCC was safely performed in elderly patients ensuring similar oncological outcomes compared to younger patients. [ABSTRACT FROM AUTHOR]

Post-traumatic growth (PTG) and specific traumatic events have been poorly explored in the literature focusing on post-traumatic stress disorder (PTSD) among healthcare workers (HWs) tackling the COVID-19 pandemic. In a large sample of Italian HWs, we investigated the kinds of traumatic events and whether PTG affects the risk of PTSD, along with its prevalence and features, during the first COVID-19 wave. COVID-19-related stressful events, Impact of Event Scale-Revised (IES-R) and PTG Inventory-Short Form (PTGI-SF) scores were collected through an online survey. Out of 930 HWs included in the final sample, 257 (27.6%) received a provisional PTSD diagnosis based on IES-R scores. Events referring to the overall pandemic (40%) and to a threat to a family member (31%) were reported as the most stressful events. Female sex, previous mental disorders, job seniority, unusual exposure to sufferance and experiencing a threat to one's family significantly increased the provisional PTSD diagnosis' risk, while being a physician, the availability of personal protective equipment and moderate/greater scores on the PTGI-SF spiritual change domain were found to be protective factors. [ABSTRACT FROM AUTHOR]

Impaired respiratory function reduces haemoglobin oxygen affinity in COVID-19 Keywords: COVID-19; haemoglobin-oxygen affinity; haemoglobin P50; oxyhaemoglobins; PaO2 to fraction of inspired oxygen ratio; SARS-CoV-2 EN COVID-19 haemoglobin-oxygen affinity haemoglobin P50 oxyhaemoglobins PaO2 to fraction of inspired oxygen ratio SARS-CoV-2 e44 e47 4 02/21/23 20230301 NES 230301 Using homology modelling and molecular docking algorithms, Liu and Li predicted the existence of interactions between SARS-Cov-2 and haemoglobin (Hb) and suggested that these interactions may change haemoglobin-oxygen (Hb-O SB 2 sb ) affinity.[1] Hb-O SB 2 sb affinity has been extensively studied in intensive care unit (ICU) patients with COVID-19 (usually intubated and mechanically ventilated) showing normal to increased affinity.[[2], [4]] Higher Hb-O SB 2 sb affinity facilitates Hb oxygenation in the lungs while reducing tissue O SB 2 sb unloading; a reduced Hb-O SB 2 sb affinity has the opposite effect. COVID-19, haemoglobin-oxygen affinity, haemoglobin P50, oxyhaemoglobins, PaO2 to fraction of inspired oxygen ratio, SARS-CoV-2. [Extracted from the article]

The introduction of a two-dimensional oxide layer at the interface between an organic semiconductor and a ferromagnetic metal (spinterface) can help in tailoring the formation of spin-polarized hybridized interface states. Here, we consider the case of a Cr 4 O 5 monolayer at the C 60 / Fe (001) interface, which is already known to feature the occurrence of spin-polarized states in the fullerene molecules. In this work, we employ scanning tunneling microscopy/spectroscopy and photoemission spectroscopy to show that the C 60 / Cr 4 O 5 / Fe (001) spinterface is characterized by the formation of a well-ordered fullerene monolayer and of strongly hybridized interface states. These experimental results are discussed in terms of state-of-the-art ab initio calculations of the structural, electronic, and magnetic properties at the interface. [ABSTRACT FROM AUTHOR]

Contemporary research increasingly recognizes the role of community archives in preserving evidence of the pasts of identity groups, validating their historical experience, and thus furthering the goals of social justice and equality. Such values underlie the Association of Ukrainians in Victoria (Australia) Archival Project, which the present article places into the broader context of Ukrainian community archival collections in the state of Victoria. Data obtained through interview have enabled a descriptive survey of such collections, which are found to be concentrated in a handful of "archival clusters" in suburban Melbourne and regional Victoria. The most typical contents of the collections--records of the proceedings and activities of community secular and religious organizations--reflect the dominant role in the community's life of organizations established by post-World War II immigrants. The collections constitute a rich resource for research into the part of the community encompassed by these organizations, even if, as a rule, at least at present, they are not well ordered or described. They are less revealing of the experience of immigrants who arrived later or were less inclined to join community organizations. Lack of resources, both human and material, confronts the mainly volunteer officeholders who are responsible for the organizations' archives. In consequence, collections are often inadequately and sometimes unsafely housed, and in general only informally organized; finding aids or descriptions of them are seldom available. Initiatives taken by some organizations suggest that there is growing awareness among community activists of the potential value of archives for showing and interpreting the community to itself and to others. [ABSTRACT FROM AUTHOR]

Teaching robotics requires interdisciplinary skills and a good creativity, providing instructions and hands-on experiences, exploiting different kinds of learning. Two kinds of learning methods are commonly used: the 'visual learning' and the 'auditory learning', recognizable by the preference of an approach for images, rather than for texts, or oral explanations. A third possible learning style is the 'kinesthetic learning', based on tactile activities, which is generally least exploited, both by teachers in the classroom and by students during individual study. In this perspective, the use of educational test rigs is a good practice and adds an opportunity to share a passion for robotics. The paper focuses on the realization and application of an educational test rig aimed at explaining how a differential mechanism works and how it can be applied to robotic underactuated soft grippers to move multiple robotic fingers independently of each other using just a single actuator. The differential test bench was realized by 3D printing and mounted with the help of students in high school seminaries oriented to encourage students towards robotic or mechatronic studies. This activity was very thrilling for the students and helped them to approach robotics in a natural way, exploiting kinesthetic learning as it is demonstrated by test results. [ABSTRACT FROM AUTHOR]

Sicily is one of the main islands of the Mediterranean Sea, and it is characterized by a variety of archaeological records, material culture and traditions, reflecting the history of migrations and populations' interaction since its first colonization, during the Paleolithic. These deep and complex demographic and cultural dynamics should have affected the genomic landscape of Sicily at different levels; however, the relative impact of these migrations on the genomic structure and differentiation within the island remains largely unknown. The available Sicilian modern genetic data gave a picture of the current genetic structure, but the paucity of ancient data did not allow so far to make predictions about the level of historical variation. In this work, we sequenced and analyzed the complete mitochondrial genomes of 36 individuals from five different locations in Sicily, spanning from Early Bronze Age to Iron Age, and with different cultural backgrounds. The comparison with coeval groups from the Mediterranean Basin highlighted structured genetic variation in Sicily since Early Bronze Age, thus supporting a demic impact of the cultural transitions within the Island. Explicit model testing through Approximate Bayesian Computation allowed us to make predictions about the origin of Sicanians, one of the three indigenous peoples of Sicily, whose foreign origin from Spain, historically attributed, was not confirmed by our analysis of genetic data. Sicilian modern mitochondrial data show a different, more homogeneous, genetic composition, calling for a recent genetic replacement in the Island of pre-Iron Age populations, that should be further investigated. [ABSTRACT FROM AUTHOR]

Understanding the basis of genetic gains in grain yield and yield-related traits is essential for designing future breeding strategies that lead to the development of higher-yielding wheat cultivars. The objectives of this study were to assess the changes in grain yield achieved by durum wheat breeding in Argentina and to identify the agronomic traits associated with these changes. To this end, a wide set of Argentinian cultivars was analyzed in three field trials. A significant linear trend (R2 = 0.55) was observed between the grain yield and the cultivar's release year, with an increase of 26.94 kg ha−1 yr−1 from 1934 to 2015. The harvest index and grain number were key traits that explained the increases in grain yield. The number of grains per plant increased with the cultivar's release year, while the thousand kernel weight remained unchanged. The grain yield showed an increase of 51% when comparing old cultivars (<1980) with intermediate ones (1980–1999), whereas the increase between intermediate and modern cultivars (2000+) was only 16%. Thus, the genetic gains were mostly associated with the incorporation of semi-dwarfism into the germplasm in the 1980s, with low genetic gains after that. [ABSTRACT FROM AUTHOR]

Chronic urticaria (CU) appears with daily or intermittent/recurrent wheals with/without angioedema for more than six weeks. When no specific eliciting factors are found, chronic urticaria is defined as spontaneous (CSU). Up to 50% of patients with CSU do not respond to therapy, leading to a prolonged disease course and the need for expensive therapies, impacting the quality of life (QoL) and healthcare resources. Diagnosis of CSU is made when other potential causes of chronic urticaria are excluded. CSU therapy aims to achieve complete control of symptoms and normalization of QoL. Current treatment options for urticaria aim to target mast cell mediators such as histamine, or activators, such as autoantibodies. Guidelines recommend starting with second generation antihistamines (sgAHs) and adding omalizumab therapy if symptoms are not controlled. This review aims to provide a practical guide for CSU in the pediatric population. Treatment options for pediatric CSU are primarily based on adult data that have been extrapolated for children. Current guidelines should be reevaluated based on pediatric data, new biological treatments, and the COVID-19 pandemic. Future research is needed to investigate strategies to personalize current treatments and identify potential predictive biomarkers. [ABSTRACT FROM AUTHOR]

Background: The correct extent of mesocolic dissection for right-sided colon cancer (RCC) is still under debate. Complete mesocolic excision (CME) has not gained wide diffusion, mainly due to its technical complexity and unclear oncological superiority. This study aims to evaluate oncological outcomes of CME compared with non-complete mesocolic excision (NCME) during resection for I-III stage RCC.Method: Prospectively collected data of patients who underwent surgery between 2010 and 2018 were retrospectively analysed. 1:1 Propensity score matching (PSM) was used to balance baseline characteristics of CME and NCME patients. The primary endpoint of the study was local recurrence-free survival (LRFS). The two groups were also compared in terms of short-term outcomes, distant recurrence-free survival, disease-free survival, and overall survival.Results: Of the 444 patients included in the study, 292 were correctly matched after PSM, 146 in each group. The median follow-up was 45 months (IQR 33-63). Conversion rate, complications, and 90-day mortality were comparable in both groups. The median number of lymph nodes harvested was higher in CME patients (23 vs 19, p = 0.034). 3-year LRFS rates for CME patients was 100% and 95.6% for NCME (log-rank p = 0.028). At 3 years, there were no differences between the groups in terms of overall survival, distant recurrence-free survival, and disease-free survival.Conclusion: Our PSM cohort study shows that CME is safe, provides a higher number of lymph nodes harvested, and is associated with better local recurrence-free survival. [ABSTRACT FROM AUTHOR]

Introduction: Medication adherence was defined by the WHO as "the extent to which a person's behavior coincides with the medical advice given" (WHO, 2003). Existing literature indicates that approximately 49% of patients with major psychiatric disorders do not fully adhere to their prescribed psychopharmacological therapy (Colom et al, 2002). Non-adherence can lead to partial therapeutic responses or treatment resistance, increased risk of relapse, re-hospitalization, elevated suicide risk, and overall poorer functioning, thereby compromising the patient-doctor therapeutic relationship (Garcìa et al, 2016). Objectives: The aim of the present study was to assess potential differences in terms of clinical features related to adherence to treatment in a large cohort of psychiatric patients of an Italian psychiatric department. Methods: The study included 307 psychiatric patients, of any gender or age, diagnosed with unipolar depression (UD), bipolar depression (BD), anxiety disorders (AD), schizophrenic spectrum disorders (SS) or a primary diagnosis of personality disorders (PD), based on DSM-5 criteria. Patients were consecutively recruited from the Department of Psychiatry at Luigi Sacco University Hospital, in Milan. The patient's adherence to treatment was evaluated using the Clinician Rating Scale (CRS), with a cut-off of ≥ 5 defining adherence subgroups (A+: score ≥ 5; A-: score < 5). Comparative and predictive analysis were performed for the whole sample and the two adherence subgroups. Results: Overall, nearly one-third of the whole sample reported suboptimal medication adherence. Specifically, rates were approximately 35.3% and 32.7% for BD and SS, respectively, followed by 30.8% for PD, 28% for AD and, 20.3% for UD (see Figure 1). Patients with A- showed significantly higher current substance abuse (17.8% vs 4.5%, p<.001), along with a higher rate of lifetime substance abuse, although with a trend towards significance (31.5% vs 20.5%; p=.057). Moreover, the A- group had a significantly higher number of lifetime hospitalizations (1.35 ± 1.8 vs 0.73 ± 1.11; p<.001) and higher rate of previous psychotropic treatment dropouts compared to the A+ group (90% vs. 36.2%; p<.001, see Figure 2). Image: Image 2: Conclusions: Approximately one-third of the whole sample reported a suboptimal medication adherence, with varying rates across different diagnoses. Current and lifetime substance abuse appears to be an unfavorable transdiagnostic factor. Additionally, severe outcomes such as increased hospitalizations and a more acute disease presentation are linked to poorer adherence. Recognizing the characteristics of adherence patterns within specific diagnostic categories is crucial for designing precise interventions to enhance patient outcomes and optimize the overall effectiveness of treatment. Disclosure of Interest: N. Girone: None Declared, B. Benatti Speakers bureau of: Angelini, Lundbeck, Janssen, Rovi., M. Cocchi: None Declared, F. Achilli: None Declared, C. Viganò: None Declared, M. Vismara: None Declared, B. Dell'Osso Grant / Research support from: Angelini, Lundbeck, Janssen, Pfizer, Otzuka, Neuraxpharm, and Livanova, Speakers bureau of: Angelini, Lundbeck, Janssen, Pfizer, Otzuka, Neuraxpharm, and Livanova [ABSTRACT FROM AUTHOR]

The tiger mosquito (Aedes albopictus) is one of the most invasive species in the world and a competent vector for numerous arboviruses, thus the study and monitoring of its fast worldwide spread is crucial for global public health. The small extra-nuclear and maternally-inherited mitochondrial DNA represents a key tool for reconstructing phylogenetic and phylogeographic relationships within a species, especially when analyzed at the mitogenome level. Here the mitogenome variation of 76 tiger mosquitoes, 37 of which new and collected from both wild adventive populations and laboratory strains, was investigated. This analysis significantly improved the global mtDNA phylogeny of Ae. albopictus, uncovering new branches and sub-branches within haplogroup A1, the one involved in its recent worldwide spread. Our phylogeographic approach shows that the current distribution of tiger mosquito mitogenome variation has been strongly affected by clonal and sub-clonal founder events, sometimes involving wide geographic areas, even across continents, thus shedding light on the Asian sources of worldwide adventive populations. In particular, different starting points for the two major clades within A1 are suggested, with A1a spreading mainly along temperate areas from Japanese and Chinese sources, and A1b arising and mainly diffusing in tropical areas from a South Asian source. [ABSTRACT FROM AUTHOR]

Multivalent ligands of the C‐type lectin receptor DC‐SIGN have emerged as effective antiadhesive agents against various pathogens. Some years ago, we described a hexavalent DC‐SIGN ligand, Polyman‐26, designed to bridge two of the four binding sites displayed by the receptor. In this work, we present our efforts to accomplish simultaneous coordination of all four carbohydrate binding sites of DC‐SIGN through the synthesis of cross‐shaped glycodendrimers. The tailored rigid scaffold allowed multivalent presentation of glycomimetics in a spatially defined fashion, while providing good water solubility to the constructs. Evaluation of the biological activity by SPR assays revealed strong binding avidity towards DC‐SIGN and increased selectivity over langerin. Inhibition of DC‐SIGN binding to SARS‐CoV‐2 spike protein and of DC‐SIGN mediated Ebola virus trans‐infection testifies for the glycodendrimers potential application in infection diseases. The tetravalent platform described here is easily accessible and can be used in modular fashion with different ligands, thus lending itself to multiple applications. [ABSTRACT FROM AUTHOR]

Stabilizing ordered assemblies of molecules represents the first step towards the construction of molecular devices featuring hybrid (organic–inorganic) interfaces where molecules can be easily functionalized in view of specific applications. Molecular layers of planar metal-tetraphenylporphyrins (MTPP) grown on an ultrathin iron oxide [namely Fe(001)–p(1 × 1)O] show indeed a high degree of structural order. The generality of such a picture is tested by exploiting non-planar porphyrins, such as vanadyl-TPP (VOTPP). These molecules feature a VO2+ ion in their center, with the O atom protruding out of the plane of the porphyrin ring. In this work, by employing diffraction, photoemission and X-ray absorption, we prove that non-planar VOTPP can nevertheless form a square and ordered superstructure, where porphyrin molecules lie flat with respect to the underlying substrate. Ab initio density functional theory simulations are used to elucidate the V＝O bond orientation with respect to the iron substrate. [ABSTRACT FROM AUTHOR]

Magnetic resonance imaging (MRI) is routinely used for preoperative tumor staging and to assess response to therapy in rectal cancer patients. The aim of our study was to evaluate the accuracy of MRI based restaging after neoadjuvant chemoradiotherapy (CRT) in predicting pathologic response. This multicenter cohort study included adult patients with histologically confirmed locally advanced rectal adenocarcinoma treated with neoadjuvant CRT followed by curative intent elective surgery between January 2014 and December 2019 at four academic high‐volume institutions. Magnetic resonance tumor regression grade (mrTRG) and pathologic tumor regression grade (pTRG) were reviewed and compared for all the patients. The agreement between radiologist and pathologist was assessed with the weighted k test. Risk factors for poor agreement were investigated using logistic regression. A total of 309 patients were included. Modest agreement was found between mrTRG and pTRG when regression was classified according to standard five‐tier systems (k = 0.386). When only two categories were considered for each regression system, (pTRG 0‐3 vs pTRG 4; mrTRG 2‐5 vs mrTRG 1) an accuracy of 78% (95% confidence interval [CI] 0.73‐0.83) was found between radiologic and pathologic assessment with a k value of 0.185. The logistic regression model revealed that "T3 greater than 5 mm extent" was the only variable significantly impacting on disagreement (OR 0.33, 95% CI 0.15‐0.68, P =.0034). Modest agreement exists between mrTRG and pTRG. The chances of appropriate assessment of the regression grade after neoadjuvant CRT appear to be higher in case of a T3 tumor with at least 5 mm extension in the mesorectal fat at the pretreatment MRI. [ABSTRACT FROM AUTHOR]

The high number of matching haplotypes of the most common mitochondrial (mt)DNA lineages are considered to be the greatest limitation for forensic applications. This study investigates the potential to solve this constraint by massively parallel sequencing a large number of mitogenomes that share the most common West Eurasian mtDNA control region (CR) haplotype motif (263G 315.1C 16519C). We augmented a pilot study on 29 to a total of 216 Italian mitogenomes that represents the largest set of the most common CR haplotype compiled from a single country. The extended population sample confirmed and extended the huge coding region diversity behind the most common CR motif. Complete mitogenome sequencing allowed for the detection of 163 distinct haplotypes, raising the power of discrimination from 0 (CR) to 99.6% (mitogenome). The mtDNAs were clustered into 61 named clades of haplogroup H and did not reveal phylogeographic trends within Italy. Rapid individualization approaches for investigative purposes are limited to the most frequent H clades of the dataset, viz. H1, H3, and H7. [ABSTRACT FROM AUTHOR]

Hybrid sp–sp2 structures can be efficiently obtained on metal substrates via on-surface synthesis. The choice of both the precursor and the substrate impacts on the effectiveness of the process and the stability of the formed structures. Here we demonstrate that using anthracene-based precursor molecules on Au(111) the formation of polymers hosting sp carbon chains is affected by the steric hindrance between aromatic groups. In particular, by scanning tunneling microscopy experiments and density functional theory simulations we show that the de-metalation of organometallic structures induces a lateral separation of adjacent polymers that prevents the formation of ordered domains. This study contributes to the understanding of the mechanisms driving the on-surface synthesis processes, a fundamental step toward the realization of novel carbon-based nanostructures with perspective applications in nanocatalysis, photoconversion, and nano-electronics. [ABSTRACT FROM AUTHOR]

Exploring the genetic variability in yield and yield-related traits is essential to continue improving genetic gains. Fifty-nine Argentinian durum wheat cultivars were analyzed for important agronomic traits in three field experiments. The collection was genotyped with 3565 genome-wide SNPs and functional markers in order to determine the allelic variation at Rht-B1 and Ppd-A1 genes. Population structure analyses revealed the presence of three main groups, composed by old, modern and genotypes with European or CIMMYT ancestry. The photoperiod sensitivity Ppd-A1b allele showed higher frequency (75%) than the insensitivity one Ppd-A1a (GS105). The semi-dwarfism Rht-B1b and the Ppd-A1a (GS105) alleles were associated with increases in harvest index and decreases in plant height, grain protein content and earlier heading date, although only the varieties carrying the Rht-B1 variants showed differences in grain yield. Out of the two main yield components, grain number per plant was affected by allelic variants at Rht-B1 and Ppd-A1 loci, while no differences were observed in thousand kernel weight. The increases in grain number per spike associated with Rht-B1b were attributed to a higher grain number per spikelet, whereas Ppd-A1a (GS105) was associated with higher grain number per spikelet, but also with lower spikelets per spike. [ABSTRACT FROM AUTHOR]

The peak of the "Europe migrant crisis" has witnessed a record number of unaccompanied and separated children crossing the Mediterranean Sea (UNICEF, [10]). Article 3 of the convention states: "In all actions concerning children, whether undertaken by public or private social welfare institutions, courts of law, administrative authorities or legislative bodies, the best interests of the child shall be a primary consideration." In September 2016, the member states of the UN reaffirmed their commitment to addressing the specific needs of children travelling as part of large movements of refugees and migrants, especially children who are unaccompanied or separated from their families, in the New York Declaration for Refugees and Migrants. [Extracted from the article]

Amid increasing terrorist violence in and beyond European countries, concerns have been raised about connections between illegal migration and terrorism. Regional armed conflicts in the Middle East have led to the massive migration of people in search of safe heavens and better livelihoods, pressing upon frontline countries in the Mediterranean and throughout the EU. Multiple government and intelligence agencies report that human smuggling networks have been identified as providing a readily available conduit through which terrorist groups such as the Islamic State and Al-Qaida can enter Europe and the U.S. These criminal travel networks are said to rely on highly effective transnational alliances involving service providers within source, transit and destination countries. There is also widespread consensus in the intelligence circles that terrorist groups rely on the practice of smuggling for financing of terrorist activity. Nonetheless, despite the region's geopolitical significance and its demonstrated potential for spillover effects, scant systematic field research has been conducted by independent researchers to understand the purported nexus between terrorism and human smugglers within the Middle East into the Mediterranean. This constitutes a severe gap in knowledge which our study will address. In this paper, we debunk the nexus human smuggling-terrorism by comparing the Islamic State's logistics with human smuggling networks' modus operandi and organizational structures. Based on a mixed research approach that combines the analysis of a unique date-set (U.S. Special Forces) and an empirical research carried out among smugglers and migrants in the Middle East and across the Eastern Mediterranean route over the past two years, this paper will tackle the alleged connection between human smuggling and terrorist groups. What will be argued is that smuggling networks and terrorist networks have fundamental operational and structural differences. These operational and structural differences need to be taken into account in order to deconstruct harmful stereotypes on irregular migration and, consequently, develop adequate responses to analytically distinct phenomena. [ABSTRACT FROM AUTHOR]

We present a joint experimental and theoretical characterization of the magnetic properties of coordination clusters with an antiferromagnetic core of four magnetic ions. Two different compounds are analyzed, with Co and Mn ions in the core. While both molecules are antiferromagnetic, they display different sensitivities to external magnetic field, according to the different atomic magnetic moments and strength of the intra-molecular magnetic couplings. In particular, the dependence of the magnetization versus field of the two molecules switches with temperature: at low temperature the magnetization is smaller in {Mn4} than in Co4, while the opposite happens at high temperature. Through a detailed analysis of the electronic and magnetic properties of the two compounds we identify a stronger magnetic interaction between the magnetic ions in {Mn4} with respect to {Co4}. Moreover {Co4} displays not negligible spin–orbit related effects that could affect the spin lifetime in future antiferromagnetic spintronic applications. We highlight the necessity to account for these spin–orbit effects together with electronic correlation effects for a reliable description of these compounds. [ABSTRACT FROM AUTHOR]

Purpose: The paper explores the process of construction of the "accountable self", particularly as this process engages with the spirituality of the self. This study examines the "space of accountability" within which the accountable self constructs itself as such and investigates how different accounts of the self are drawn upon in the making of this space, both defining and transcending it. Design/methodology/approach: The paper relies upon archival material concerning accounting and accountability practices about the project for building the altar of St. Ignatius in the Church of Gesù, Rome, Italy (1691–1706). This study examines calculative and narrative accounts about the project from the perspective of the superintendent, who was the sole person accountable for the building works. Findings: Whereas calculative accounts enabled the self to account for actions within the specific space of accountability of the project, narrative accounts opened up this space, providing for a testimony of actions and a gift of accountability towards future indefinite others. This process was prompted by the spirituality of the self and the narcissistic gratification of fulfilling this spirituality. Originality/value: The paper adds to the literature on the accountable self and to theological perspectives into accountability. This study suggests exploring how different accounts of the self engage with each other through testimony, gift, narcissism and spirituality in the construction of the accountable self, providing for a "transcendent" space of accountability. This research also adds to studies on narrative accounts by showing that they are drawn upon alongside calculative accounts in the construction of the transcendent, accountable self. [ABSTRACT FROM AUTHOR]