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The European Medicines Agency adopted their Geriatric Medicines Strategy more than a decade ago. The strategy aims at elucidating the evidence basis for marketing authorization of new medicines which will be used in the older population, and at ensuring the appropriate communication of findings to the patient and healthcare provider. During the past decade new tools and data sources have emerged to support the strategy goals, and their use should be considered. Possible concrete actions are presented to improve the design of clinical trials, the data collection both pre‐ and post‐approval, the assessment of the findings, and the communication to assist informed prescription and safe medicine taking. Implementation and prioritization of these actions should be done from the perspective of addressing the needs of patients while maximizing efficient use of resources, with the aim of integrating geriatric aspects into routine medicines development and assessment. [ABSTRACT FROM AUTHOR]

Mayflies (Ephemeroptera) are among the crucial water and habitat quality bioindicators. However, despite their intensive long‐term use in various studies, more reliable mayfly DNA barcode data have been produced in a negligible number of countries, and only ~40% of European species had been barcoded with less than 50% of families covered. Despite being carried out in a small area, our study presents the second‐most species‐rich DNA reference library of mayflies from Europe and the first comprehensive view from an important biodiversity hotspot such as the Western Carpathians. Within 1153 sequences, 76 morphologically determined species were recorded and added to the Barcode of Life Data System (BOLD) database. All obtained sequences were assigned to 97 BINs, 11 of which were unique and three represented species never barcoded before. Sequences of 16 species with high intraspecific variability were divided into 40 BINs, confirming the presence of cryptic lineages. Due to the low interspecific divergence and the non‐existing barcoding gap, sequences of six species were assigned to three shared BINs. Delimitation analyses resulted in 79 and 107 putative species respectively. Bayesian and maximum‐likelihood phylogenies confirmed the monophyly of almost all species and complexes of cryptic taxa and proved that DNA barcoding distinguishes almost all studied mayfly species. We have shown that it is still sufficient to thoroughly investigate the fauna of a small but geographically important area to enrich global databases greatly. In particular, the insights gained here transcend the local context and may have broader implications for advancing barcoding efforts. [ABSTRACT FROM AUTHOR]

Recent declines in insect abundances, especially populations of wild pollinators, pose a threat to many natural and agricultural ecosystems. Traditional species monitoring relies on morphological character identification and is inadequate for efficient and standardized surveys. DNA barcoding has become a standard approach for molecular identification of organisms, aiming to overcome the shortcomings of traditional biodiversity monitoring. However, its efficacy depends on the completeness of reference databases. Large DNA barcoding efforts are (almost entirely) lacking in many European countries and such patchy data limit Europe‐wide analyses of precisely how to apply DNA barcoding in wild bee identification. Here, we advance towards an effective molecular identification of European wild bees. We conducted a high‐effort survey of wild bees at the junction of central and southern Europe and DNA barcoded all collected morphospecies. For global analyses, we complemented our DNA barcode dataset with all relevant European species and conducted global analyses of species delimitation, general and genus‐specific barcoding gaps and examined the error rate in DNA data repositories. We found that (i) a sixth of all specimens from Slovenia could not be reliably identified, (ii) species delimitation methods show numerous systematic discrepancies, (iii) there is no general barcoding gap across all bees and (iv) the barcoding gap is genus specific, but only after curating for errors in DNA data repositories. Intense sampling and barcoding efforts in underrepresented regions and strict curation of DNA barcode repositories are needed to enhance the use of DNA barcoding for the identification of wild bees. [ABSTRACT FROM AUTHOR]

With a proliferation of scholarly work focusing on populist, far-left, and far-right parties, questions have arisen about the correct ways to ideologically classify such parties. To ensure transparency and uniformity in research, the discipline could benefit from a systematic procedure. In this letter, we discuss how we have employed the method of 'Expert-informed Qualitative Comparative Classification' (EiQCC) to construct the newest version of The PopuList (3.0) – a database of populist, far-left, and far-right parties in Europe since 1989. This method takes into account the in-depth knowledge of national party experts while allowing for systematic comparative analysis across cases and over time. We also examine how scholars have made use of the previous versions of the dataset, explain how the new version of The PopuList differs from previous ones, and compare it to other data. We conclude with a discussion of the strengths and limitations of The PopuList dataset. [ABSTRACT FROM AUTHOR]

Food Labeling is a critical communication mechanism to support consumers in making informed choices during purchase and to secure good health. The food safety standard authorities around the globe are working very hard to make food labeling world-class and user-friendly. In the present study, scientometric analysis is performed on the publication data extracted from the Web of Science (ClarivateTM) database on food labeling. The publications are analyzed by the years, keywords, prolific authors and evolution of the research field is traced. The analysis of publication data in the realm of food labeling shows that the food labeling research got attention of researchers during the first decade of 21st century as many new laws and regulations were formed in US and Europe during this time. It is observed that the researchers of developed countries are publishing majorly on different aspects of food labeling followed by developing countries. [ABSTRACT FROM AUTHOR]

For stock and index options in the United States, OptionMetrics records prices at 3:59 p.m., not 4:00 p.m. as assumed in previous literature. The resulting 1‐min time discrepancy with closing share prices creates artificial variability in implied volatility spreads and strongly affects market‐wide spreads. It leads to particularly large distortions at the onset of the COVID‐19 pandemic. For index options in Europe, OptionMetrics data show large deviations from put‐call parity even though the original option prices match the parity exactly. Finally, the implied volatilities of stock options in Europe show clusters of exceptional deviations due to incorrect dividend information. [ABSTRACT FROM AUTHOR]

Biological invasions pose a rapidly expanding threat to the persistence, functioning and service provisioning of ecosystems globally, and to socio‐economic interests. The stages of successful invasions are driven by the same mechanism that underlies adaptive changes across species in general—via natural selection on intraspecific variation in traits that influence survival and reproductive performance (i.e., fitness). Surprisingly, however, the rapid progress in the field of invasion science has resulted in a predominance of species‐level approaches (such as deny lists), often irrespective of natural selection theory, local adaptation and other population‐level processes that govern successful invasions. To address these issues, we analyse non‐native species dynamics at the population level by employing a database of European freshwater macroinvertebrate time series, to investigate spreading speed, abundance dynamics and impact assessments among populations. Our findings reveal substantial variability in spreading speed and abundance trends within and between macroinvertebrate species across biogeographic regions, indicating that levels of invasiveness and impact differ markedly. Discrepancies and inconsistencies among species‐level risk screenings and real population‐level data were also identified, highlighting the inherent challenges in accurately assessing population‐level effects through species‐level assessments. In recognition of the importance of population‐level assessments, we urge a shift in invasive species management frameworks, which should account for the dynamics of different populations and their environmental context. Adopting an adaptive, region‐specific and population‐focused approach is imperative, considering the diverse ecological contexts and varying degrees of susceptibility. Such an approach could improve and refine risk assessments while promoting mechanistic understandings of risks and impacts, thereby enabling the development of more effective conservation and management strategies. [ABSTRACT FROM AUTHOR]

Soil bulk density (BD) serves as a fundamental indicator of soil health and quality, exerting a significant influence on critical factors such as plant growth, nutrient availability, and water retention. Due to its limited availability in soil databases, the application of pedotransfer functions (PTFs) has emerged as a potent tool for predicting BD using other easily measurable soil properties, while the impact of these PTFs' performance on soil organic carbon (SOC) stock calculation has been rarely explored. In this study, we proposed an innovative local modeling approach for predicting BD of fine earth (BDfine) across Europe using the recently released BDfine data from the LUCAS Soil (Land Use and Coverage Area Frame Survey Soil) 2018 (0–20 cm) and relevant predictors. Our approach involved a combination of neighbor sample search, forward recursive feature selection (FRFS), and random forest (RF) models (local- RFFRFS). The results showed that local- RFFRFS had a good performance in predicting BDfine (R2 of 0.58, root mean square error (RMSE) of 0.19 gcm-3 , relative error (RE) of 16.27 %), surpassing the earlier-published PTFs (R2 of 0.40–0.45, RMSE of 0.22 gcm-3 , RE of 19.11 %–21.18 %) and global PTFs using RF models with and without FRFS (R2 of 0.56–0.57, RMSE of 0.19 gcm-3 , RE of 16.47 %–16.74 %). Interestingly, we found that the best earlier-published PTF (R2 = 0.84, RMSE = 1.39 kgm-2 , RE of 17.57 %) performed close to the local- RFFRFS (R2 = 0.85, RMSE = 1.32 kgm-2 , RE of 15.01 %) in SOC stock calculation using BDfine predictions. However, the local- RFFRFS still performed better (ΔR2 > 0.2) for soil samples with low SOC stocks (< 3 kgm-2). Therefore, we suggest that the local- RFFRFS is a promising method for BDfine prediction, while earlier-published PTFs would be more efficient when BDfine is subsequently utilized for calculating SOC stock. Finally, we produced two topsoil BDfine and SOC stock datasets (18 945 and 15 389 soil samples) at 0–20 cm for LUCAS Soil 2018 using the best earlier-published PTF and local- RFFRFS , respectively. This dataset is archived on the Zenodo platform at https://doi.org/10.5281/zenodo.10211884 (S. Chen et al., 2023). The outcomes of this study present a meaningful advancement in enhancing the predictive accuracy of BDfine , and the resultant BDfine and SOC stock datasets for topsoil across the Europe enable more precise soil hydrological and biological modeling. [ABSTRACT FROM AUTHOR]

Large hail (greater than 2 cm in diameter) can cause devastating damage to crops and property and can even cause loss of life. Because hail reports are often collected by individual countries, constructing a Europe-wide large-hail climatology has been challenging to date. However, the European Severe Storm Laboratory's European Severe Weather Database provides the only pan-European dataset for severe convective-storm reports. The database is comprised of 62 053 large-hail reports from 40 CE to September 2020, yet its characteristics have not been evaluated. Thus, the purpose of this study is to evaluate hail reports from this database for constructing a climatology of large hail. For the period 2000–2020, large-hail reports are most prominent in June, whereas large-hail days are most common in July. Large hail is mostly reported between 13:00–19:00 local time, a consistent pattern since 2010. The intensity, as measured by maximum hail size, shows decreasing frequency with increasing hailstone diameter and little change over the 20-year period. The quality of reports by country varies, with the most complete reporting being from central European countries. Thus, results suggest that despite its short record, many indications point to the dataset representing some reliable aspects of the European large-hail climatology, albeit with some limitations. [ABSTRACT FROM AUTHOR]

Open in new tab Download slide OBJECTIVES Compared to lung resections, airway procedures are relatively rare in thoracic surgery. Despite this, a growing number of dedicated airway centres have formed throughout Europe. These centres are characterized by a close interdisciplinary collaboration and they often act as supra-regional referring centres. To date, most evidence of airway surgery comes from retrospective, single-centre analysis as there is a lack of large-scale, multi-institutional databases. METHODS In 2018, an initiative was formed, which aimed to create an airway database within the framework of the ESTS database (ESTS-AIR). Five dedicated airway centres were asked to test the database in a pilot phase. A 1st descriptive analysis of ESTS-AIR was performed. RESULTS A total of 415 cases were included in the analysis. For adults, the most common indication for airway surgery was post-tracheostomy stenosis and idiopathic subglottic stenosis; in children, most resections/reconstructions had to be performed for post-intubation stenosis. Malignant indications required significantly longer resections [36.0 (21.4–50.6) mm] when compared to benign indications [26.6 (9.4–43.8) mm]. Length of hospital stay was 11.0 (4.1–17.3) days (adults) and 13.4 (7.6–19.6) days (children). Overall, the rates of complications were low with wound infections being reported as the most common morbidity. CONCLUSIONS This evaluation of the 1st cases in the ESTS-AIR database allowed a large-scale analysis of the practice of airway surgery in dedicated European airway centres. It provides proof for the functionality of ESTS-AIR and sets the basis for rolling out the AIR subsection to all centres participating in the ESTS database. [ABSTRACT FROM AUTHOR]

Objectives: The purpose of this systematic review was to examine how the scientific community in Europe that is involved with research with animals perceives and experiences the implementation of 3R (Replace, Reduce, Refine). Methods: A systematic search of the literature published in the past ten years was performed in PubMed, Web of Science and Scopus. Publications were screened for eligibility using a priori inclusion criteria, and only empirical evidence (quantitative, qualitative, or mixed methodologies) was retained. Quantitative survey items were investigated by conducting a meta-analysis, and the qualitative data was summarized using an inductive meta-synthetic approach. Included publications were assessed using the Quality Assessment for Diverse Studies tool. Results: 17 publications were included (eight quantitative, seven qualitative, two mixed-methods). The meta-analysis revealed that scientists are skeptical about achieving replacement, even if they believe that 3R improve the quality of experimental results. They are optimistic concerning the impact of 3R on research costs and innovation, and see education as highly valuable for the implementation of 3R. The meta-synthesis revealed four barriers (systemic dynamics, reification process, practical issues, insufficient knowledge) and four facilitators (efficient use of animals, caring for animals, regulatory uptake, supportive workplace environment). Conclusion: These findings show actionable levers at the local and systemic levels, and may inform regulators and institutions in their 3R policies. Trial registration: The protocol was registered into the PROSPERO database under the number CRD42023395769. [ABSTRACT FROM AUTHOR]

Background: The European Water Framework Directive foresees the establishment of emission inventories for micropollutants (MP) to facilitate an evidence-based development of mitigation measures. Regionalized pathway analysis constitutes a moderately data-intensive approach to quantify the contribution of different pathways to the total pollution of surface waters. So far, only few European member states have created an inventory that includes diffuse pathways. The fundamental basis to enable it is an accessible, well-structured and harmonized database with data on the concentration of MPs in multiple compartments, such as soils, groundwater, atmospheric deposition and urban systems. Combined with the water and suspended substance balance in river basins, such data enables the estimation of emission loads via specific pathways. In the Danube River Basin, but in general in Europe, a public data management platform with such scope and criteria is still lacking. Results: We collected and harmonized MP measurements across multiple compartments and countries together with key metadata, harmonized and combined them into a new database. The resulting tool, available for download, facilitates the assessment of current data availability, in terms of quantity and quality. For example, while the majority of available data stems from groundwater and surface water, other highly relevant compartments are scarcely represented. By examining differences in MP concentration level across compartments, the database can lead to understand the relevance of specific emission pathways and thus to prioritize data-retrieval and calculation efforts in modelling applications. Selected examples show how to exploit the metadata associated to the measurements to extrapolate the results to regions not covered by specific monitoring programmes. For example, PFAS concentrations in treated wastewater show significant dependence on the design capacity of the treatment plant. Conclusions: This study showcases how such database can support the setup of emission inventories, guide data providers and national authorities in prioritizing the allocation of resources for new surveys and in optimizing their national data collection and management systems. The process tested showed a great need for enhanced data literacy across countries and institutions to increase data availability and quality to secure the exploitation of the full information potential generated via monitoring programmes. [ABSTRACT FROM AUTHOR]

Aims: We introduce ReSurveyEurope — a new data source of resurveyed vegetation plots in Europe, compiled by a collaborative network of vegetation scientists. We describe the scope of this initiative, provide an overview of currently available data, governance, data contribution rules, and accessibility. In addition, we outline further steps, including potential research questions. Results: ReSurveyEurope includes resurveyed vegetation plots from all habitats. Version 1.0 of ReSurveyEurope contains 283,135 observations (i.e., individual surveys of each plot) from 79,190 plots sampled in 449 independent resurvey projects. Of these, 62,139 (78%) are permanent plots, that is, marked in situ, or located with GPS, which allow for high spatial accuracy in resurvey. The remaining 17,051 (22%) plots are from studies in which plots from the initial survey could not be exactly relocated. Four data sets, which together account for 28,470 (36%) plots, provide only presence/absence information on plant species, while the remaining 50,720 (64%) plots contain abundance information (e.g., percentage cover or cover–abundance classes such as variants of the Braun‐Blanquet scale). The oldest plots were sampled in 1911 in the Swiss Alps, while most plots were sampled between 1950 and 2020. Conclusions: ReSurveyEurope is a new resource to address a wide range of research questions on fine‐scale changes in European vegetation. The initiative is devoted to an inclusive and transparent governance and data usage approach, based on slightly adapted rules of the well‐established European Vegetation Archive (EVA). ReSurveyEurope data are ready for use, and proposals for analyses of the data set can be submitted at any time to the coordinators. Still, further data contributions are highly welcome. [ABSTRACT FROM AUTHOR]

Daridorexant (dari), as the first dual orexin receptor antagonist (DORA) marketed in Europe, offers a novel therapeutic approach to insomnia. However, data regarding its real-world safety are scarce. Thus, this study was aimed at assessing its safety profile using a large-scale pharmacovigilance database. Dari-related adverse drug reaction (ADR) reports from the Food and Drug Administration Adverse Event Reporting System were scrutinized, and ADRs were selected using reporting odds ratio (ROR) as a measure of disproportionality. Frequencies of events related to dari were compared to all other drugs (reference group, RG1) and only to other DORAs (RG2). Only significant disproportionalities to both RGs were evaluated in-depth. A total of 845 dari-related reports were selected; nightmares (n = 146; dari vs. RG1: ROR = 113.74; 95%CI [95.13, 136]; dari vs. RG2: ROR = 2.35; 95 CI% [1.93, 2.85]), depression (n = 22; dari vs. RG1: 2.13; [1.39, 3.25]; dari vs. RG2: ROR = 2.31; 95 CI% [1.45, 3.67]), and hangover (n = 20; dari vs. RG1: ROR = 127.92; 95 CI% [81.98, 199.62]; and dari vs. RG2: 3.38; [2.04, 5.61]) were considered as safety signals. These data provide valuable insights into the real-world safety profile of daridorexant, supporting the existence of safety signals related to nightmares, depression, and hangovers. [ABSTRACT FROM AUTHOR]

This paper presents the Positive Energy District Database (PED DB), a pivotal web tool developed collaboratively by the COST Action 'PED-EU-NET', in alignment with international initiatives such as JPI Urban Europe and IEA EBC Annex 83. The PED DB represents a crucial step towards sharing knowledge, promoting collaboration, reinforcing decision-making, and advancing the understanding of Positive Energy Districts (PEDs) in the pursuit of sustainable urban environments. The PED DB aims to comprehensively map and disseminate information on PEDs across Europe, serving as a dynamic resource for sustainable urban development according to the objective of making the EU climate-neutral by 2050. Indeed, PEDs imply an integrated approach for designing urban areas—the districts—where a cluster of interconnected buildings and energy communities produce net zero greenhouse gas emissions, managing an annual local/regional overflow production of renewable energy. The paper describes the collaborative step-by-step process leading to the PED DB implementation, the current results and potentials of the online platform, and introduces its future developments towards a more user-friendly and stakeholders-tailored tool. The interactive web map offers a customizable visualizations and filters on multiple information related to PED case studies, PED-relevant cases, and PED Labs. Users can access detailed information through a table view, facilitating comparisons across different PED projects and their implementation phase. The paper offers insights and detailed analysis from the initial dataset that includes 23 PED cases and 7 PED-related projects from 13 European countries, highlighting the key characteristics of surveyed PEDs. [ABSTRACT FROM AUTHOR]

This study provides new evidence on how historical patterns of household formation shape the present-day level of trust. We test two distinct features of historical family arrangements that might be harmful to trust towards out-groups: (a) family extendedness in terms of the number of household members, and (b) generational hierarchy and gender relations within the household. To conduct our study, we compiled a historical database that reflects family structure and socio-economic development, mostly in the 19th century. The analysis was performed on a sample of 94 historical subnational units within eight contemporary Western and Eastern European countries that participated in the Life in Transition Survey in 2010. We find that cohabitation of several generations within the historical family and power of older generations over the younger are detrimental for out-group trust today. By contrast, family extendedness per se was revealed to have no impact on trust. [ABSTRACT FROM AUTHOR]

Soil bulk density (BD) serves as a fundamental indicator of soil health and quality, exerting a significant influence on critical factors such as plant growth, nutrient availability, and water retention. Due to its limited availability in soil databases, the application of pedotransfer functions (PTFs) has emerged as a potent tool for predicting BD using other easily measurable soil properties, while the impact of these PTFs' accuracy on soil organic carbon (SOC) stock calculation has been rarely explored. In this study, we proposed an innovative local modelling approach for predicting BD across Europe using the recently released BD data from the LUCAS Soil 2018 (0-20 cm). Our approach involved a combination of neighbour sample search, Forward Recursive Feature Selection (FRFS) and Random Forest (RF) model (local-RFFRFS). The results showed that local-RFFRFS had a good performance in predicting BD (R² of 0.58, RMSE of 0.19 g cm-3), surpassing the traditional PTFs (R² of 0.40-0.45, RMSE of 0.22 g cm-3) and global PTFs using RF with and without FRFS (R² of 0.56-0.57, RMSE of 0.19 g cm-3). Interestingly, we found the best traditional PTF (R²=0.84, RMSE=1.39 kg m-2) performed close to the local-RFFRFS (R²=0.85, RMSE=1.32 kg m-2) in SOC stock calculation using BD predictions. However, the local-RFFRFS still performed better (ΔR²>0.2 and ΔRMSE>0.1 g cm-3) for soil samples with low SOC stock (<3 kg m-2). Therefore, we suggest that the local-RFFRFS is a promising method for BD prediction while traditional PTFs would be more efficient when BD is subsequently utilized for calculating SOC stock. Finally, we produced two BD and SOC stocks datasets (18,945 and 15,389 soil samples) for LUCAS Soil 2018 using the best traditional PTF and local-RFFRFS, respectively. This dataset is archived from the Zenodo platform at https://zenodo.org/records/10211884 (Chen et al., 2023). The outcomes of this study present a meaningful advancement in enhancing the predictive accuracy of BD, and the resultant BD and SOC stock datasets across the Europe enable more precise soil hydrological and biological modelling. [ABSTRACT FROM AUTHOR]

The first comprehensive phytosociological classification of all vegetation types in Europe (EuroVegChecklist; Applied Vegetation Science, 2016, 19, 3–264) contained brief descriptions of each type. However, these descriptions were not standardized and mentioned only the most distinct features of each vegetation type. The practical application of the vegetation classification system could be enhanced if users had the option to select sets of vegetation types based on various combinations of structural, ecological, and biogeographical attributes. Based on a literature review and expert knowledge, we created a new database that assigns standardized categorical attributes of 12 variables to each of the 1106 alliances dominated by vascular plants defined in EuroVegChecklist. These variables include dominant life form, phenological optimum, substrate moisture, substrate reaction, salinity, nutrient status, soil organic matter, vegetation region, elevational vegetation belt, azonality, successional status and naturalness. The new database has the potential to enhance the usefulness of phytosociological classification for researchers and practitioners and to help understand this classification to non‐specialists. [ABSTRACT FROM AUTHOR]

The connections of climatic variables to zoonotic and wildlife diseases remain uncertain. Here, we compiled a systematic database for the prevalence of 121 pathogenic microbial taxa in birds (ca 376 species) and bats (ca 39 species), including 11 939 observations from over 450 000 individuals across Europe and surrounding regions. We modelled the potential connection of climatic variables with the prevalence of 75 pathogenic microbial taxa at a multi‐pathogenic‐taxa level and of 17 most‐studied pathogenic taxa at a single‐pathogenic‐taxon level. According to the multi‐taxa model, the prevalence of bacterial taxa was positively associated with temperature, while this association was significantly weaker for eukaryotes and viruses. The prevalence of bacterial taxa was negatively associated with rainfall, while viruses showed a positive association with rainfall. These associations between climatic variables and prevalence of pathogenic taxa were not different between bird and bat hosts. According to the single‐taxon models, the prevalence of influenza A viruses, Plasmodium, and several bacterial taxa in birds and bats was positively associated with temperature. Rainfall showed positive associations with the prevalence of Usutu, Sindbis and Influenza A viruses but the directions of significant associations varied among bacterial taxa. Strikingly, this was evidenced also between bacterial taxa that share hosts and transmission mechanism hinting towards hitherto unknown features on pathogen ecology, e.g. Salmonella versus Campylobacter and Anaplasma versus Borrelia. Our results suggest that rising temperature and increasing precipitation will accelerate the threat of bird‐ and bat‐associated bacterial and viral pathogens to wildlife, domesticated animals and humans, respectively. However, the idiosyncratic relationships with climatic conditions among pathogenic taxa highlight the need for pathogen‐specific predictive models to understand future pathogen distributions. [ABSTRACT FROM AUTHOR]

Apropos of Spanish or Languedocien elements manifest in the late 13th-century Durandus Pontifical, this study explores the relationship between high medieval ritual and identity formation. It introduces the notion of liturgical use, an inclusive term for the body of customs that determined the way ceremonies were performed by lasting communities with a sense of belonging together. The primary challenge of comparing uses lies in selecting and systematizing the relevant information and interpreting the results. The authors argue that this challenge can be met by reducing the evidence to textual items and positions that lend themselves to large-scale comparative analysis in both time and space. As the main methodological contribution, they introduce the principle of mapping and drawing historical and cultural conclusions from their patterns. By summarizing a decade of careful research into thousands of sources accomplished by the team of the Usuarium database, they present four historical layers of medieval liturgical history, termed formative periods, and outline convergent geographical areas that they call liturgical landscapes. Since data on a lower level rarely correspond to smaller contiguous areas, they interpret the phenomenon called artificial diversity through medieval concepts of regionality and cultural transfer, formulating some thought experiments to understand the ways in which a Europe of uses once functioned. [ABSTRACT FROM AUTHOR]

Background: Investigating the role of late presenters (LPs) in HIV-1 transmission is important, as they can contribute to the onward spread of HIV-1 virus before diagnosis, when they are not aware of their HIV status. Objective: To characterize individuals living with HIV-1 followed up in Europe infected with subtypes A, B, and G and to compare transmission clusters (TC) in LP vs. non-late presenter (NLP) populations. Methods: Information from a convenience sample of 2679 individuals living with HIV-1 was collected from the EuResist Integrated Database between 2008 and 2019. Maximum likelihood (ML) phylogenies were constructed using FastTree. Transmission clusters were identified using Cluster Picker. Statistical analyses were performed using R. Results: 2437 (91.0%) sequences were from subtype B, 168 (6.3%) from subtype A, and 74 (2.8%) from subtype G. The median age was 39 y/o (IQR: 31.0–47.0) and 85.2% of individuals were males. The main transmission route was via homosexual (MSM) contact (60.1%) and 85.0% originated from Western Europe. In total, 54.7% of individuals were classified as LPs and 41.7% of individuals were inside TCs. In subtype A, individuals in TCs were more frequently males and natives with a recent infection. For subtype B, individuals in TCs were more frequently individuals with MSM transmission route and with a recent infection. For subtype G, individuals in TCs were those with a recent infection. When analyzing cluster size, we found that LPs more frequently belonged to small clusters (<8 individuals), particularly dual clusters (2 individuals). Conclusion: LP individuals are more present either outside or in small clusters, indicating a limited role of late presentation to HIV-1 transmission. [ABSTRACT FROM AUTHOR]

The manufacture and distribution of fraudulent identity documents (IDs) is a pervasive and prolific crime problem, enabling the activities of organized crime networks and terrorist cells. As reactive policing methods are ill-equipped to handle the transversal and repetitive nature of document fraud, in 2012 Baechler et al. suggested a complementary method that uses the systematic profiling and comparison of fraudulent IDs to identify those produced by the same source. While this method has been successful in Europe, it is yet to be implemented worldwide, and there is currently little known about the Australian fraudulent document climate. In this pilot study, 43 fraudulent IDs from Sydney-based New South Wales police stations were examined. Adapting the method used in Europe, these documents were imaged, and their visual characteristics were extracted before being organized into an excel database and manually compared. The characteristics chosen are fundamentally linked to the manufacturing process, including the printing methods and replication of security features. Of the documents examined 88% were linked to at least one other document, and five series emerged. These results suggest that the Australian document market may be structured, and that there may be prolific offenders operating at its core, much like in Europe. [ABSTRACT FROM AUTHOR]

Russula subgenus Compactae is a group of ectomycorrhizal basidiomycetes, usually with large pileate fruitbodies. European members of the group are characterised by the absence of bright colours on the surfaces of their pilei, the context turning grey to black after cutting, the abundance of short lamellulae in the hymenophore, and spores with an inamyloid suprahilar spot and with low reticulate ornamentation. Our multi-locus phylogenetic study confirmed that this morphological delimitation corresponds to a well-supported clade. Within this clade, 16 species are recognised in Europe, of which five belong to the R. albonigra lineage and were described in a previous study, while eleven are fully described in this study. The application of the names R. acrifolia, R. adusta, R. anthracina, R. atramentosa, R. densissima, R. nigricans and R. roseonigra is based on the position of sequences retrieved from types or authentic material. Based on type sequences, R. fuliginosa is synonymised with R. anthracina and two varieties of R. anthracina are considered synonyms of R. atramentosa. The application of the name R. densifolia is based on a morphological match with the traditional species interpretation and the neotype specimen. Three species are described as new, R. marxmuelleriana sp. nov., R. picrophylla sp. nov. and R. thuringiaca sp. nov. This study recognises three major lineages and two species with isolated positions within the European Compactae and a morphological barcode was assigned to the species using an analysis of 23 selected characters. A search of publicly available sequences from the UNITE database revealed that the majority of species are host tree generalists and widely distributed in temperate and Mediterranean areas of Europe. Russula adusta is the only species so far proven to form ectomycorrhiza exclusively with conifers. [ABSTRACT FROM AUTHOR]

Aim: The increasing availability of animal tracking datasets collected across many sites provides new opportunities to move beyond local assessments to enable detailed and consistent habitat mapping at biogeographical scales. However, integrating wildlife datasets across large areas and study sites is challenging, as species' varying responses to different environmental contexts must be reconciled. Here, we compare approaches for large‐area habitat mapping and assess available habitat for a recolonizing large carnivore, the Eurasian lynx (Lynx lynx). Location: Europe. Methods: We use a continental‐scale animal tracking database (450 individuals from 14 study sites) to systematically assess modelling approaches, comparing (1) global strategies that pool all data for training versus building local, site‐specific models and combining them, (2) different approaches for incorporating regional variation in habitat selection and (3) different modelling algorithms, testing nonlinear mixed effects models as well as machine‐learning algorithms. Results: Testing models on training sites and simulating model transfers, global and local modelling strategies achieved overall similar predictive performance. Model performance was the highest using flexible machine‐learning algorithms and when incorporating variation in habitat selection as a function of environmental variation. Our best‐performing model used a weighted combination of local, site‐specific habitat models. Our habitat maps identified large areas of suitable, but currently unoccupied lynx habitat, with many of the most suitable unoccupied areas located in regions that could foster connectivity between currently isolated populations. Main Conclusions: We demonstrate that global and local modelling strategies can achieve robust habitat models at the continental scale and that considering regional variation in habitat selection improves broad‐scale habitat mapping. More generally, we highlight the promise of large wildlife tracking databases for large‐area habitat mapping. Our maps provide the first high‐resolution, yet continental assessment of lynx habitat across Europe, providing a consistent basis for conservation planning for restoring the species within its former range. [ABSTRACT FROM AUTHOR]

Coastal flooding is recognized as one of the most devastating natural disasters, resulting in significant economic losses. Therefore, hazard assessment is crucial to support preparedness and response to such disasters. Toward this, flood map databases and catalogues are essential for the analysis of flood scenarios, and furthermore they can be integrated into disaster risk reduction studies. In this study and in the context of the European Coastal Flood Awareness System (ECFAS) project (GA 101004211), which aimed to propose the European Copernicus Coastal Flood Awareness System, a catalogue of flood maps was produced. The flood maps were generated from flood models developed with LISFLOOD-FP for defined coastal sectors along the entire European coastline. For each coastal sector, 15 synthetic scenarios were defined focusing on high-frequency events specific to the local area. These scenarios were constructed based on three distinct storm durations and five different total-water-level (TWL) peaks incorporating tide, mean sea level, surge and wave setup components. The flood model method was extensively validated against 12 test cases for which observed data were collated using satellite-derived flood maps and in situ flood markers. Half of the test cases represented well the flooding with hit scores higher than 80 %. The synthetic-scenario approach was assessed by comparing flood maps from real events and their closest identified scenarios, producing a good agreement and global skill scores higher than 70 %. Using the catalogue, flood scenarios across Europe were assessed, and the biggest flooding occurred in well-known low-lying areas. In addition, different sensitivities to the increase in the duration and TWL peak were noted. The storm duration impacts a few limited flood-prone areas such as the Dutch coast, for which the flooded area increases more than twice between 12 and 36 h storm scenarios. The influence of the TWL peak is more global, especially along the Mediterranean coast, for which the relative difference between a 2- and 20-year return period storm is around 80 %. Finally, at a European scale, the expansion of flood areas in relation to increases in TWL peaks demonstrated both positive and negative correlations with the presence of urban and wetland areas, respectively. This observation supports the concept of storm flood mitigation by wetlands. [ABSTRACT FROM AUTHOR]

The existing plant trait databases' applicability is limited for studies dealing with the flora and vegetation of the eastern and central part of Europe and for large-scale comparisons across regions, mostly because their geographical data coverage is limited and they incorporate records from several different sources, often from regions with markedly different climatic conditions. These problems motivated the compilation of a regional dataset for the flora of the Pannonian region (Eastern Central Europe). PADAPT, the Pannonian Dataset of Plant Traits relies on regional data sources and collates data on 54 traits and attributes of the plant species of the Pannonian region. The current version covers approximately 90% of the species of the region and consists of 126,337 records on 2745 taxa. By including species of the eastern part of Europe not covered by other databases, PADAPT can facilitate studying the flora and vegetation of the eastern part of the continent. Although data coverage is far from complete, PADAPT meets the longstanding need for a regional database of the Pannonian flora. [ABSTRACT FROM AUTHOR]

Named entity recognition (NER) is a widely used text-mining and natural language processing (NLP) subtask. In recent years, deep learning methods have superseded traditional dictionary- and rule-based NER approaches. A high-quality dataset is essential to fully leverage recent deep learning advancements. While several gold-standard corpora for biomedical entities in abstracts exist, only a few are based on full-text research articles. The Europe PMC literature database routinely annotates Gene/Proteins, Diseases, and Organisms entities. To transition this pipeline from a dictionary-based to a machine learning-based approach, we have developed a human-annotated full-text corpus for these entities, comprising 300 full-text open-access research articles. Over 72,000 mentions of biomedical concepts have been identified within approximately 114,000 sentences. This article describes the corpus and details how to access and reuse this open community resource. [ABSTRACT FROM AUTHOR]

Assessing long-term trends in flood losses and attributing them to climatic and socio-economic changes requires comprehensive and systematic collection of historical information. Here, we present flood impact data for Europe that is part of the HANZE (Historical Analysis of Natural HaZards) database. The dataset covers riverine, pluvial, coastal and compound floods that have occurred in 42 European countries between 1870 and 2020. The data was obtained by extensive data-collection from more than 800 sources ranging from news reports through government databases to scientific papers. The dataset includes 2521 events characterized by at least one impact statistic: area inundated, fatalities, persons affected or economic loss. Economic losses are presented both in the original currencies and price levels as well as inflation and exchange-rate adjusted to the 2020 value of the euro. The spatial footprint of affected areas is consistently recorded using more than 1400 subnational units corresponding, with minor exceptions, to the European Union's Nomenclature of Territorial Units for Statistics (NUTS), level 3. Daily start and end dates, information on causes of the event, notes on data quality issues or associated non-flood impacts, and full bibliography of each record supplement the dataset. Apart from the possibility to download the data (https://dx.doi.org/10.5281/zenodo.8410025), the database can be viewed, filtered and visualized online: https://naturalhazards.eu. The dataset is designed to be complementary to HANZE-Exposure, a high-resolution model of historical exposure changes (such as population and asset value), and be easily usable in statistical and spatial analyses, including multi-hazard studies. [ABSTRACT FROM AUTHOR]

During the Last Glacial Period, the climate shift to cold conditions associated with changes in atmospheric circulation and vegetation cover resulted in the development of large aeolian systems in Europe. On a regional scale, many factors may have influenced dust dynamics, such as the latitudinal difference between the various aeolian systems and the variability of the sources of wind-transported particles. Therefore, the assumption that the timing of aeolian deposition is strictly synchronous in Europe does not seem to be the most plausible hypothesis and needs to be evaluated. To test this assumption, the chronology of loess deposition in different European regions was investigated by studying 93 luminescence-dated loess–palaeosol sequences with their data recalculated and compiled in a single comma separated values (*.csv) file: the ChronoLoess database. Our study shows that the two major aeolian systems, the Northern European Loess Belt (NELB) on the one hand and the systems associated with the rivers draining the Alpine Ice Sheet on the other hand, developed asynchronously. The significant deposition started at about 32 kyr b2k for the NELB vs. 42 kyr b2k for the perialpine loess and peaked about 2 millennia later for the former (21.8 vs. 23.9 kyr b2k, respectively). This shift resulted mainly from the time lag between the maxima of the Alpine and Fennoscandian ice sheets, which acted as the primary sources of fine-grained particles through glacial abrasion. The major geomorphic changes that resulted from the development and decay of the Fennoscandian and British–Irish ice sheets also played an important role. Particularly, ice sheet coalescence during the Last Glacial Maximum (LGM) diverted meltwater fluxes through the Channel River and provided vast amounts of glacial particles available for deflation in the western NELB. The period during which the maximum mass accumulation rate was reached for each loess–palaeosol sequence is relatively homogeneous in the NELB and ranges from 30 to 19 kyr b2k, whereas it is more scattered in the perialpine systems (>60 to 14 kyr b2k). This probably resulted from a combination of factors, including the asynchrony of maximum valley glacier advances and local geomorphic factors. The ChronoLoess database is available at 10.5281/zenodo.7728616 (Bosq et al., 2023). [ABSTRACT FROM AUTHOR]

Background: Despite the availability of vaccination, TBE (tick-borne encephalitis) remains a global public health problem. Therefore, the aim of our study was to assess the long-term efficacy of vaccinations against tick-borne encephalitis using vaccines available on the European market. Methods: The analysis was conducted on the results of a systematic review conducted in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. The search was performed in three databases, namely Medline (via PubMed), EMBASE (via Ovid), and the Cochrane Library database. The authors followed the PRISMA method and the selection of the articles was performed with two independent researchers. Results: From a total of 199 citations, 9 studies were included in this review. According to the primary studies identified in the search, the efficacy of available anti-TBE vaccines ranges from 90.1% to 98.9%; however, in individuals above the age of 60, the protection wanes as early as one year after vaccination. Administration of a booster dose 3 years after completion of the basic vaccination schedule significantly extended the period of protection against TBE. Conclusions: Anti-TBE vaccines available in Europe have a high level of efficacy. However, the level of protection against TBE is decreasing after vaccination. Therefore, in addition to the conventional schedule, booster vaccines should be administered every 5 years in individuals before the age of 60 and more frequently, e.g. every 3 years, in individuals aged 60 and beyond. [ABSTRACT FROM AUTHOR]

Background: Social restrictions and vaccination seem to have shaped the pandemic development in Europe, but the influence of geographical position is still debated. This study aims to verify whether the pandemic spread through Europe following a particular direction, during the period between the start of the pandemic and November 2021. The existence of a spatial gradient for epidemic intensity is also hypothesized. Methods: Daily COVID-19 epidemiological data were extracted from Our World in Data COVID-19 database, which also included vaccination and non-pharmacological interventions data. Latitude and longitude of each country's centroid were used as geographic variables. Epidemic periods were delimited from epidemic surge data. Multivariable linear and Cox's regression models were performed for each epidemic period to test if geographical variables influenced surge dates. Generalized additive models (GAM) were used to test the spatial gradient hypothesis with three epidemic intensity measures. Results: Linear models suggest a possible west-east shift in the first epidemic period and features a significant association of NPIs with epidemic surge delay. Neither latitude nor longitude had significant associations with epidemic surge timing in both second and third periods. Latitude displays strong negative associations with all epidemic intensity measures in GAM models. Vaccination was also negatively associated with intensity. Conclusions: A longitudinal spread of the pandemic in Europe seems plausible, particularly concerning the first wave. However, a recurrent trend was not observed. Southern Europe countries may have experienced increased transmissibility and incidence, despite climatic conditions apparently unfavourable to the virus. [ABSTRACT FROM AUTHOR]

The influence of cultural background on the soundscape experience in public spaces has been widely acknowledged. However, most studies have not used standardized protocols for soundscape perception data collection, nor have they gathered large datasets across different regions of the world to investigate possible cultural differences. This study explored the relationships between soundscape descriptors, perceived dominance of sound sources, and overall soundscape qualities and whether these relationships differ across world regions. A database of over 2000 soundscape surveys was collected in situ in outdoor public spaces in Europe and China. Results highlighted differences in how European and Chinese participants perceived the pleasantness and dominance of different sound sources. Specifically, the positive correlation between perceived pleasantness and natural sounds was stronger for European participants. For Chinese participants, vibrant soundscapes were positively correlated with perceived dominance of natural sounds, whereas in Europe, they were associated more with human-generated sounds. Perceived loudness had a greater effect on the appropriateness dimension for the Chinese sample than that for the European sample. This study provides a deeper understanding of how the geographical/cultural context can influence soundscape perception in public spaces and suggests that such country-specific factors should be considered when designing urban soundscapes. [ABSTRACT FROM AUTHOR]

Purpose: The aim of the study was to evaluate the baseline data of women with breast cancer (BC) undergoing treatment in an intercontinental comparison. Methods: This study included 99,571 women with BC from Europe (70,834), Asia (18,208), and Latin America (10,529) enrolled between 2017 and 2021, based on data from IQVIA's Oncology Dynamics database. This source is supplied with information by means of a cross-sectional partially retrospective survey collecting anonymized data on inpatients and outpatients treated by a representative panel of oncologists. A multivariable logistic regression model was used to investigate the probability of metastases. Results: The data available in Asia (98%) and Latin America (100%) were hospital data, while in Europe, patients were treated both in hospitals and in office-based practices (62%, 38%). The mean age in Asia and Latin America (57 ± 13) was lower than in Europe (61 ± 13; p < 0.001). Lobular BC was diagnosed twice as often in Europe compared to Asia and Latin America (15.2%, 9.8%, 8.0%). The number of patients with metastasized hormone receptor-positive (HR +) BC was significantly higher in Europe and Latin America than in Asia (76%, 68%; p < 0.001). The highest number of women with metastasized BC was reported in Europe (26% compared to 14% and 20%, respectively, in Asia and Latin America). Across the continents, the percentage of women with BC who experienced metastases was 51–61% for bone, 30–39% for lung and 25–32% for liver, followed by 3–6% for skin and 3% for brain. Conclusion: Women with BC treated in Europe tend to be significantly older and more likely to develop metastases than women in Asia and Latin America, except for lung metastases. [ABSTRACT FROM AUTHOR]

The issue of polarization, as opposed to inequality, has been little explored in European countries. In this paper, using data provided by the Luxembourg Income Studies Database, we look at the trend of income polarization in 12 European countries, the only ones available with two comparable years, using the relative distribution method. The results clearly show a trend toward polarization in almost the cases analyzed, with a concentrated prevalence in the lower tail of the distribution, thus observing a worsening in the distribution. Next, we look at drivers that may have contributed to these changes, using the RIF-regression method. It is interesting to observe how these characteristics are in many cases common across all countries: the occupational sector, level of education and area of residence have the same impact, albeit with different intensities, in all countries. This suggests the possibility of coordinated intervention across these nations, acting on the same variables for all of them. [ABSTRACT FROM AUTHOR]

Aim: Faecal incontinence (FI) is a common problem, affecting about 9% of Western populations. However, only a few patients seek consultation and the number of such patients reaching hospital care is unknown. Current treatment pathways are poorly evidence based and are thought to vary greatly between different countries. This audit will study the incidence of patients presenting to coloproctologists with FI, current practice including diagnostics, conservative and surgical techniques across different units in Europe and worldwide. The aim is to explore the incidence of FI in patients attending colorectal surgical clinics, treatment choices and accessibility to diagnostic tools/advanced treatments across the international cohort. Outcomes to be measured include the volume of FI patients consulting clinical practice per surgeon, patient demographics, and diagnostics and intervention details. Method: An international multicentre snapshot audit will be performed. During the study period all consecutive eligible patients will be included over an 8‐week period between 9 January and 28 February. Data will be entered and saved in a Research Electronic Data Capture secured database. Moreover, two short physician and centre‐level surveys will be filled for current practice evaluation. The results will be published in international journals and will be prepared in accordance with guidelines set by the STROBE (strengthening the reporting of observational studies in epidemiology) statement for observational studies. Discussion: This multicentre, global prospective audit will be delivered by consultant colorectal and general surgeons as well as trainees. The data obtained will lead to a better understanding of the incidence of FI and treatment and diagnostic possibilities. This snapshot audit will be hypothesis generating and inform areas that need future prospective study. [ABSTRACT FROM AUTHOR]

In the current study, ground motion models (GMMs) are derived using the European Strong Motion (ESM) database for pseudo‐spectral acceleration (PSA), peak ground acceleration (PGA), peak ground velocity (PGV), peak ground displacement (PGD), cumulative absolute velocity (CAV), arias intensity (Ia), and significant duration. In addition to addressing random effects associated with ground motion regression, such as inter‐event, inter‐site, inter‐locality, and inter‐region variabilities, the current study also aims at reducing the standard deviations (STDs) of the GMMs through development of a hybrid non‐parametric GMM. The hybrid model is derived through an ensemble‐weighted method of five non‐parametric machine learning models: shallow neural network, deep neural network (DNN), gated recurrent unit (GRU), support vector, and random forest (RF) regression techniques; with weights based on model performances. The resulting hybrid model, which also accounts for epistemic uncertainty, is compared against other regional models and is found superior for all output variables. The inter‐event, inter‐site, inter‐locality, and inter‐region deviations, and total ergodic sigma of PSA for the ensemble model lies between 0.3164–0.4478, 0.4156–0.5339, 0.1449–0.3687, 0.0819–0.2421, and 0.668–0.8545, respectively. The coefficient of determination (R2) between predicted and recorded values lies between 0.8435–0.9114 for all the output variables. [ABSTRACT FROM AUTHOR]

Coastal flooding is recognized as one of the most devastating natural disasters, resulting in significant economic losses. Therefore, hazard assessment is crucial to support preparedness and response to such disasters. Toward this, flood map databases and catalogues are essential for the analysis of flood scenarios, and furthermore can be integrated into disaster risk reduction studies. In this study and in the context of the ECFAS project (GA 101004211), which aimed to propose a European Copernicus Coastal Flood Awareness System, a catalogue of flood maps was produced. The flood maps were generated from flood models developed with LISFLOOD-FP for defined coastal sectors along the entire European coastline. For each coastal sector, fifteen synthetic scenarios were defined focusing on high-frequency events specific to the local area. These scenarios were constructed based on three distinct storm durations and five different Total Water Level (TWL) peaks incorporating tide, mean sea level, surge and wave set-up components. The flood model method was extensively validated against twelve test cases for which observed data were collated using satellite-derived flood maps and in situ flood markers. Half of the test-cases well represented the flooding with hit scores higher than 80 %. The synthetic scenario approach was assessed by comparing flood maps from real events and their closest identified scenarios, producing a good agreement and global skill scores higher than 70 %. Using the catalogue, flood scenarios across Europe were assessed, and the biggest flooding occurred in well-known low-lying areas. In addition, different sensitivities to the increase of the duration and TWL peak were noted. The storm duration impacts a few limited flood prone areas such as the Dutch coast for which the flooded area increases more than twice between a 12 h and 36 h storm scenarios. The influence of the TWL peak is more global, especially along the Mediterranean coast for which the relative difference between a 2- and 20-year return period storm is around 80 %. Finally, at a European scale, the expansion of flood areas in relation to increases in TWL (Total Water Level) peaks demonstrated both positive and negative correlations with the presence of urban and wetland areas, respectively. This observation supports the concept of storm flood mitigation by wetlands. [ABSTRACT FROM AUTHOR]

This study investigates how the effect of employee stock ownership on financial performance may hinge on the diverse cultural and societal contexts of European countries. Based on agency and national culture theories, we hypothesize that the positive relationship between employee stock ownership and return on assets (ROA) is stronger in those nations with lower uncertainty avoidance and higher social trust. Using a multisource, time‐lagged, large‐scale dataset of 1,741 firms from 21 countries in Europe, our multilevel, random coefficient modeling analysis found evidence for these hypotheses, suggesting that uncertainty avoidance and social trust serve as important contextual cues in predicting the linkage between employee stock ownership and financial performance. Our supplemental analysis with distinction between the managerial and nonmanagerial employee stock ownership further indicates managerial employee stock ownership has a direct positive effect on ROA. Although nonmanagerial employee stock ownership had a nonsignificant association with ROA, the relationship was positive and significant when uncertainty avoidance was low and social trust was high. This research contributes to the existing literature by illuminating some of the contextual influences altering the effectiveness of employee stock ownership. Our findings also offer practical suggestions for effectively using employee stock ownership. [ABSTRACT FROM AUTHOR]

During the last glacial period, the climate shift to cold conditions associated with changes in atmospheric circulation and vegetation cover resulted in the development of large aeolian systems in Europe. On a regional scale, many factors may have influenced dust dynamics, such as the latitudinal difference between the various aeolian systems and the variability of the sources of wind-transported particles. Therefore, the assumption that the timing of aeolian deposition is strictly synchronous in Europe does not seem to be the most plausible hypothesis and needs to be evaluated. To test this assumption, the chronology of loess deposition in different European regions was investigated by studying 93 luminescence-dated loesspalaeosol sequences with their data recalculated and compiled in a single CSV file: the ChronoLoess database. Our study shows that the two major aeolian systems, the Northern European Loess Belt (NELB) on the one hand and the systems associated with the rivers draining the Alpine Ice Sheet on the other hand, developed asynchronously. The significant deposition started at about 32 ka for the NELB vs 40 ka for the perialpine loess and peaked about two millennia later for the former (21.8 ka vs 23.9 ka, respectively). This shift resulted mainly from the time lag between the maxima of the Alpine and Fennoscandian ice sheets, which acted as the primary sources of fine-grained particles through glacial abrasion. The major geomorphic changes that resulted from the development and decay of the Fennoscandian and British-Irish ice sheets also played an important role. Particularly, ice sheet coalescence during the LGM diverted meltwater fluxes through the Manche River and provided vast amounts of glacial particles available for deflation in the western NELB. The period during which the maximum Mass Accumulation Rate was reached for each loess-palaeosol sequence is relatively homogeneous in the NELB and ranges from 30 ka to 19 ka, whereas it is more scattered in the perialpine systems (>60 ka to 14 ka). This probably resulted from a combination of factors, including the asynchrony of maximum valley glacier advances and local geomorphic factors. [ABSTRACT FROM AUTHOR]

The recent reports of oral side effects (SEs) following COVID‐19 vaccination warrant further investigation into their prevalence, severity, and aetiology. This study was conducted to synthesize the first‐ever population‐level evidence about oral SEs of COVID‐19 vaccines in Europe. The European Union Drug Regulating Authorities Pharmacovigilance (EudraVigilance) database was accessed in August 2022 to extract summary data of all potential oral SEs reported after COVID‐19 vaccination. The data were reported descriptively and cross‐tabulated to facilitate sub‐group analysis per vaccine type, sex, and age group. Dysgeusia was the most commonly reported oral SE (0.381 case per each 100 received reports), followed by oral paraesthesia (0.315%), ageusia (0.296%), lip swelling (0.243%), dry mouth (0.215%), oral hypoaesthesia (0.210%), swollen tongue (0.207%), and taste disorder (0.173%). Females had significantly (Sig. < 0.001) a higher prevalence of all most common (top 20) oral SEs, except for salivary hypersecretion, which was equally prevalent among females and males. The present study revealed a low prevalence of oral SEs, with taste‐related, other sensory and anaphylactic SEs being the most common SEs in Europe, similar to what was found earlier among the US population. Future studies should explore the potential risk factors of oral sensory and anaphylactic SEs to verify whether they are causally linked to COVID‐19 vaccines. [ABSTRACT FROM AUTHOR]

Background: A growing number of studies point to a high mental health burden among children and adolescents during the COVID-19 pandemic, particularly concerning anxiety. However, the study quality and effect direction are heterogeneous in the existing primary studies with a lacking overview for the European continent. Therefore, this systematic review aims to critically synthesise the evidence regarding the impact of the COVID-19 pandemic on anxiety among children and adolescents in Europe compared to a pre-pandemic baseline. Methods: A systematic literature search will be performed in six databases (MEDLINE, EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, Web of Science, and WHO COVID-19 database) with a peer reviewed search strategy according to the evidence-based checklist Peer Review of Electronic Search Strategies (PRESS). Inclusion criteria are children and adolescents ≤ 19 years living in Europe and data report during the COVID-19 pandemic with an appropriate pre-pandemic baseline. Primary outcomes are general anxiety symptoms and clinically relevant anxiety rates. Risk of bias will be assessed using the 'Risk of Bias in Non-randomised Studies of Exposure' (ROBINS-E). Data extraction will systematically include information on study design, population characteristics, COVID-19 determinants, pre-pandemic baseline, diagnostic instruments and outcome. The certainty of evidence for each outcome will be evaluated by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach adapted to the use of non-randomised studies. All process steps will be performed independently by two reviewers; any discrepancies will be discussed and, if necessary, resolved by a third author. Also, subgroup analysis, sensitivity analysis, publication bias analysis, and meta-regression analysis, if applicable, will be performed. The systematic review was registered in the Prospective Register of Systematic Reviews (PROSPERO) and the protocol was prepared in accordance to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. Discussion: This systematic review will address the lack of a critical and comprehensive summary of findings on the COVID-19 pandemic impact on anxiety among children and adolescents in Europe. In addition, it aims to identify pandemic-policy differences, such as the effect of school-closures, and identify particularly vulnerable risk groups. Systematic review registration: CRD42022303714 (PROSPERO). [ABSTRACT FROM AUTHOR]

Europe has taken a world leadership position in setting policy priorities for Circular Bioeconomy (CBE) as a key determinant of economic, social, and environmental sustainability. Consequently, European R&D investment in this area keeps growing along with the societal pressure to demonstrate the return of investment of publicly funded projects. Thus, this work presents a pioneering exploratory analysis of the extent to which projects funded at the European level incorporate the policy priorities for which they are being designed in the context of CBE, and how can the impact they are having on society be assessed. Thence, project impact evaluation is carried out in the short- and medium-term, and categorized under Industrial Competitiveness, Sustainable Development, and Community and Public Policies. For this purpose, secondary information was gathered from the European projects database Cordis, as well as primary information through a questionnaire survey of project coordinators. The empirical data collected suggest that European Framework Programmes have been fulfilling their purpose, as they are increasingly societal challenges-driven and market-oriented. This is evidenced by market-related topics addressed in the projects analysed and by the active participation of companies that outnumber academic institutions. As far as impact is concerned, scientific publications continue to be the main result of this type of project in the short-term, whereas in the medium-term social and economic benefits were also identified. Notably, the creation of scientific jobs in the industry, of industrial joint ventures, and the generation of documents to support the improvement of public and EU policies on biobased products. [ABSTRACT FROM AUTHOR]

The GECEM Project Database stands out as a new Digital Humanities solution to accurately order and analyse the new historical Big Data gathered in Chinese and European historical archives. Traditional challenges such as capture, storage, analysis, data curation, searching, sharing, transfer, visualization, querying, updating, and information privacy are being tackled and solved within the design of this new multi-relational database. The implementation of this database has as its main innovative elements the capability of coding and cross-referring historical data in Chinese and Western languages. Thus, we present a new database as a digital solution to solve the long-lasting problem in historical research: the maximization and optimization of data collection when analysing historical sources and how to make use of a large amount of registers and information when developing case studies and work hypotheses for historical research. In this paper, we present a solution for data collection and analysis of probate inventories and trade records which is a relevant source when determining changes in patterns of consumption and global trade through the introduction of Chinese goods into Europe and vice versa during the early modern period. [ABSTRACT FROM AUTHOR]

Background: Globally, millions of people die and many more develop disabilities resulting from injuries each year. Most people who die from injuries do so before they are transported to hospital. Thus, reliable, pragmatic, and evidence-based prehospital guidance for various injuries is essential. We systematically mapped and described prehospital clinical practice guidelines (CPGs) for injuries in the global context, as well as prioritised injury topics for guidance development and adolopment. Methods: This study was sequentially conducted in three phases: a scoping review for CPGs (Phase I), identification and refinement of gaps in CPGs (Phase II), and ranking and prioritisation of gaps in CPGs (Phase III). For Phase I, we searched PubMed, SCOPUS, and Trip Database; guideline repositories and websites up to 23rd May 2021. Two authors in duplicate independently screened titles and abstract, and full-text as well as extracted data of eligible CPGs. Guidelines had to meet 60% minimum methodological quality according to rigour of development domain in AGREE II. The second and third phases involved 17 participants from 9 African countries and 1 from Europe who participated in a virtual stakeholder engagement workshop held on 5 April 2022, and followed by an online ranking process. Results: Fifty-eight CPGs were included out of 3,427 guidance documents obtained and screened. 39/58 (67%) were developed de novo compared to 19 that were developed using alternative approaches. Twenty-five out of 58 guidelines (43%) were developed by bodies in countries within the WHO European Region, while only one guideline was targeted to the African context. Twenty-five (43%) CPGs targeted emergency medical service providers, while 13 (22%) targeted first aid providers (laypeople). Forty-three CPGs (74%) targeted people of all ages. The 58 guidance documents contained 32 injury topics. Injuries linked to road traffic accidents such as traumatic brain injuries and chest injuries were among the top prioritised topics for future guideline development by the workshop participants. Conclusion: This study highlights the availability, gaps and priority injury topics for future guideline development/adolopment, especially for the African context. Further research is needed to evaluate the recommendations in the 58 included CPGs for possible adaptation to the African context. [ABSTRACT FROM AUTHOR]

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Bioavailability has been taken into account in the regulation of nickel in freshwater ecosystems in Europe for over a decade; during that time a significant amount of new information has become available covering both the sensitivity of aquatic organisms to nickel toxicity and bioavailability normalization. The ecotoxicity database for chronic nickel toxicity to freshwater organisms has been updated and now includes 358 individual data points covering a total of 53 different species, all of which are suitable for bioavailability normalization to different water chemistry conditions. The bioavailability normalization procedure has also been updated to include updates to the bioavailability models that enable more sensitive water chemistry conditions to be covered by the model predictions. The updated database and bioavailability normalization procedure are applicable to more than 95% of regulated European surface water conditions and have been used to calculate site‐specific criteria for a variety of different water chemistry scenarios, to provide an indication of how the sensitivity to nickel varies between different water types. The hazardous concentration for 5% of a species (HC5) values for this diverse selection of water types range from 1.6 to 36 µg L–1, clearly demonstrating the importance of accounting for nickel bioavailability in freshwaters. This updated database and bioavailability normalization procedure provide a robust basis for the derivation of regulatory thresholds for chronic nickel toxicity in freshwaters such as predicted no‐effect concentrations and Environmental Quality Standards and are protective of the results of several mesocosm studies. Environ Toxicol Chem 2023;42:566–580. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. [ABSTRACT FROM AUTHOR]

Droughts evolve in space and time without following borders or pre-determined temporal constraints. Here, we present a new database of drought events built with a three-dimensional density-based clustering algorithm. The chosen approach is able to identify and characterize the spatio-temporal evolution of drought events, and it was tuned with a supervised approach against a set of past global droughts characterized independently by multiple drought experts. About 200 events were detected over Europein the period 1981-2020 using SPI-3 (3-month cumulated Standardized Precipitation Index) maps derived from the ECMWF (European Centre for Medium-range Weather Forecasts) 5th generation reanalysis (ERA5) precipitation. The largest European meteorological droughts during this period occurred in 1996, 2003, 2002 and 2018. A general agreement between the major events identified by the algorithm and drought impact records was found, as well as with previous datasets based on pre-defined regions. [ABSTRACT FROM AUTHOR]

Large hail (greater than 2 cm in diameter) can cause devastating damage to crops and property, and can even cause loss of life. Because hail reports are often collected by individual countries, constructing a European-wide large-hail climatology has been challenging to date. However, the European Severe Storm Laboratory's European Severe Weather Database provides the only pan-European dataset for severe convective storms. The database is comprised of 62,053 large-hail reports from 40 C.E. to September 2020, yet its characteristics have not been evaluated. Thus, the purpose of this study is to evaluate this database for the purposes of constructing a climatology of large hail. For the period 2000–2020, large-hail reports are most prominent in June, whereas large-hail days are most common in July. Large hail is mostly reported between 1300–1900 local time, a consistent pattern since 2010. The intensity, as measured by maximum hail size, shows decreasing frequency with increasing hailstone diameter, and no change over the 20-year period. The quality of reports by country varies, with the most complete reporting being from central European countries. These results suggest that despite its short record, many indications are that the dataset represents some reliable aspects of European large-hail climatology, albeit with some limitations. [ABSTRACT FROM AUTHOR]