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Prosthodontics practice involves contact with restorative materials, auxiliary dental materials which are broadly of different composition. The leakage and transfer of the potent allergic components from these materials is the cause of hypersensitive reactions to patients, dental professionals and the lab technicians. The biological side-effects of the materials that are in dental practice are rare. All artificial materials release substances in the oral environment which are potent allergens that might cause side effects and adverse reactions. The current study gives a statically about the dental professional knowledge and also makes the aware of toxic biological side effects of these materials, also make them aware of the reporting of the cases. A cross sectional survey was conducted among 100 dental professionals about the Toxic Biological effects associated with materials used in prosthodontics. Questionnaires with 20 close ended questions were circulated among people. Results obtained analyzed using SPSS software. In this Study, almost 80% of them were aware that some components of the dental materials might cause a hypersensitivity reaction. 57% of the participants have not experienced any allergic resin, latex, gloves etc. The prevalence of allergic reaction among Dental staff is low and most reported are due to latex, acrylate & formaldehyde. The present study shows that there is a lack of knowledge on the toxic biological effects of dental material used in prosthodontics. [ABSTRACT FROM AUTHOR]