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Purpose. As a scientific field, bioinformatics has drawn remarkable attention from various fields, such as information technology, mathematics, and modern biological sciences, in recent years. The topic models originating from the field of natural language processing have become the focus of attention with the rapid accumulation of biological datasets. Thus, this research is aimed at modeling the topic content of the bioinformatics literature presented by Iranian researchers in the Scopus Citation Database. Methodology. This research was a descriptive-exploratory study, and the studied population included 3899 papers indexed in the Scopus database, which had been indexed in this database until March 9, 2022. The topic modeling was then performed on the abstracts and titles of the papers. A combination of LDA and TF-IDF was utilized for topic modeling. Findings. The data analysis with topic modeling resulted in identifying seven main topics "Molecular Modeling," "Gene Expression," "Biomarker," "Coronavirus," "Immunoinformatics," "Cancer Bioinformatics," and "Systems Biology." Moreover, "Systems Biology" and "Coronavirus" had the largest and smallest clusters, respectively. Conclusion. The present investigation demonstrated an acceptable performance for the LDA algorithm in classifying the topics included in this field. The extracted topic clusters indicated excellent consistency and topic connection with each other. [ABSTRACT FROM AUTHOR]

Background: Gastric cancer (GC) is a leading cause of cancer-related deaths, emphasizing the importance of timely diagnosis for effective treatment. Machine learning models have shown promise in assisting with GC diagnosis. Objectives: This study aimed at comparing the performance of various feature selection methods in identifying influential factors related to GC based on lifestyle using machine learning models. The ultimate goal was to enhance early detection and treatment of the disease. Methods: The data of patients from Shahid Ayatollah Modarres Hospital and Shohadaye Tajrish Hospital between 2013 and 2021 were utilized. Three feature selection methods (filter, wrapper, and filter-wrapper) were employed. The k-fold method validated each model. Four classifiers k Nearest Neighbor (kNN), Decision Tree (DT), Random Forest (RF), and Gradient-Boosted Decision Trees (GBDT) compared their outputs based on feature selection methods. Results: The filter-wrapper method outperformed others, achieving an area under the ROC curve and Fl score of 95.8% and 94.7%, respectively. GBDT also performed well. The wrapper and RF classifiers achieved an area under the ROC curve and Fl scores of 95.7% and 93.6%, respectively, after the filter-wrapper method. Without feature selection methods, the RF classifier had an area under the ROC curve and F1 scores of 95.6% and 91.7%, respectively, surpassing other classifiers. Conclusions: This study suggests that appropriate feature selection methods for identifying influential factors related to GC based on lifestyle can facilitate early diagnosis and treatment. The filter-wrapper method demonstrated the best performance in this regard. [ABSTRACT FROM AUTHOR]

The railroad blocking problem (RBP) is an important decision for freight railroad companies. The objective of this problem is to minimize the costs of delivering all commodities by deciding which interyard blocks to build and specifying the assignment of commodities to these blocks. In this paper, a mathematical model is presented for the RBP on Iran Railways. Its decision variables identify blocking scheme and demand assignment to these blocks. The RBP in medium and large sizes is not solvable with any commercial software available in the market. Therefore, a solution method based on tabu search algorithm is proposed for the suggested model. For evaluating the proposed algorithm, several simulated test problems are randomly generated and solved. The obtained results on the test problems are compared with those of solutions generated by CPLEX software. The comparison shows high efficiency and effectiveness of the proposed algorithm. The proposed model and solution method are applied to build a blocking plan for the Iranian railway. [ABSTRACT FROM AUTHOR]

Approximately 300 million people are afflicted with asthma around the world, with the estimated death rate of 250,000 cases, indicating the significance of this disease. If not treated, it can turn into a serious public health problem. The best method to treat asthma is to control it. Physicians recommend continuous monitoring on asthma symptoms and offering treatment preventive plans based on the patient's control level. Therefore, successful detection of the disease control level plays a critical role in presenting treatment plans. In view of this objective, we collected the data of 96 asthma patients within a 9-month period from a specialized hospital for pulmonary diseases in Tehran. A new ensemble learning algorithm with combining physicians' knowledge in the form of a rule-based classifier and supervised learning algorithms is proposed to detect asthma control level in a multivariate dataset with multiclass response variable. The model outcome resulting from the balancing operations and feature selection on data yielded the accuracy of 91.66%. Our proposed model combines medical knowledge with machine learning algorithms to classify asthma control level more accurately. This model can be applied in electronic self-care systems to support the real-time decision and personalized warnings on possible deterioration of asthma control level. Such tools can centralize asthma treatment from the current reactive care models into a preventive approach in which the physician's therapeutic actions would be based on control level. [ABSTRACT FROM AUTHOR]

In many developing countries, restructuring is usually started by dividing vertically integrated power systems into regional companies. Analysis of the procedure of restructuring requires appropriate analytical tools for modeling interactive behavior of the regional companies in a competitive energy market. The problem of generation expansion planning in the competitive environment becomes more complex where the new generation units are constructed on the basis of decentralized decisions. Recent studies of long term expansion planning show that market equilibrium modeling is an effective technique to analyze the long-term optimum development of the generation systems. In the present paper, a Nash-Cournot Market Equilibrium model has been developed to predict the long-term expansion of generation system. Similar to some previous works, the conventional model has some shortcomings in practical applications and is complex due to large number of parameters and variables. Thus, to find an approximate solution for the proposed model, an algorithm based on a bi-level equilibrium method has been developed. Discounted net profit of market players has been considered as the objective function for each generation company which is to be maximized during the long term horizon. Implementation of the algorithm and its application in a case study over the southeastern power generation system of Iran has been presented. Results of case study show that the efficiency of the method in finding the equilibrium is higher than solving a complicated planning problem in competitive situation. [ABSTRACT FROM AUTHOR]

Community Based Organizations (CBOs) are important health system stakeholders with the mission of addressing the social and economic needs of individuals and groups in a defined geographic area, usually no larger than a county. The access and success efforts of CBOs vary, depending on the integration between health care providers and CBOs but also in relation to the community participation level. To achieve widespread results, it is important to carefully design an efficient network which can serve as a bridge between the community and the health care system. This study addresses this challenge through a location-allocation model that deals with the hierarchical nature of the system explicitly. To reflect social welfare concerns of equity, local accessibility, and efficiency, we develop the model in a multi-objective framework, capturing the ambiguity in the decision makers' aspiration levels through a fuzzy goal programming approach. This study reports the findings for the real case of Shiraz city, Fars province, Iran, obtained by a thorough analysis of the results. [ABSTRACT FROM AUTHOR]