1. Neuromuscular diseases associated with COVID-19 vaccines: a systematic review and pooled analysis of 258 patients.
- Author
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Tayebi, Amirhossein, Samimisedeh, Parham, Jafari Afshar, Elmira, Mahmoudnia, Saeideh, Milan, Nesa, Ayati, Aryan, Madady, Aryan, and Rastad, Hadith
- Subjects
NEUROMUSCULAR diseases ,BRACHIAL plexus neuropathies ,COVID-19 vaccines ,VACCINATION complications ,GUILLAIN-Barre syndrome ,MYASTHENIA gravis - Abstract
Background: Neuromuscular diseases (NMD) emerged as one of the main side effects of the COVID-19 vaccination. We pooled and summarized the evidence on the clinical features and outcomes of NMD associated with COVID-19 vaccination. Methods: We comprehensively searched three databases, Medline, Embase, and Scopus, using the key terms covering "Neuromuscular disease" AND "COVID-19 vaccine", and pooled the individual patient data extracted from the included studies. Results: A total of 258 NMD cases following COVID-19 have been reported globally, of which 171 cases were Guillain-Barré syndrome (GBS), 40 Parsonage-Turner syndrome (PTS), 22 Myasthenia Gravis (MG), 19 facial nerve palsy (FNP), 5 single fiber neuropathy, and 1 Tolosa-Hunt syndrome. All (100%) SFN patients and 58% of FNP patients were female; in the remaining NMDs, patients were predominantly male, including MG (82%), GBS (63%), and PTS (62.5%). The median time from vaccine to symptom was less than 2 weeks in all groups. Symptoms mainly appeared following the first dose of vector vaccine, but there was no specific pattern for mRNA-based. Conclusion: COVID-19 vaccines might induce some NMDs, mainly in adults. The age distribution and gender characteristics of affected patients may differ based on the NMD type. About two-thirds of the cases probably occur less than 2 weeks after vaccination. Highlights: • Neuromuscular diseases (NMD) have emerged as a significant side effect of COVID-19 vaccination. • The study provides a comprehensive summary of the clinical features and outcomes of NMD associated with COVID-19 vaccination. • A total of 258 cases of NMD following COVID-19 vaccination were reported globally. • The most commonly reported NMDs were Guillain-Barré syndrome (GBS) and Parsonage-Turner syndrome (PTS). • Symptoms typically appeared within 2 weeks after vaccination, with a higher likelihood following the first dose of vector vaccine. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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